Article
Biochemistry & Molecular Biology
Hua-Chun Weng, Xin-Yu Lu, Yu-Peng Xu, Yi-Hong Wang, Dan Wang, Yi-Ling Feng, Zhang Chi, Xiao-Qing Yan, Chao-Sheng Lu, Hong-Wei Wang
Summary: FGF21 has shown to reverse salt-sensitive hypertension-induced nephropathy by inhibiting inflammation and oxidative stress, suggesting it as a promising pharmacological strategy for treatment.
MOLECULAR MEDICINE
(2021)
Review
Physiology
Dina Maaliki, Maha M. Itani, Hana A. Itani
Summary: Most cases of hypertension are primary and closely related to modifiable risk factors such as salt intake. Studies have shown that even small reductions in salt consumption can lower blood pressure in people of all ages. Salt-sensitivity has been identified as an independent risk factor for cardiovascular events and mortality. However, the pathogenesis of salt-sensitive hypertension is still unclear due to its multifactorial etiology, complex genetic influences, and the lack of a diagnostic tool.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
John D. Imig, Md Abdul Hye Khan, Anna Stavniichuk, Wojciech K. Jankiewicz, Samaneh Goorani, Michael M. Yeboah, Ashraf El-Meanawy
Summary: The incidence of ureter obstruction is increasing and recovery from this kidney injury can lead to long-term consequences such as an increased risk for salt-sensitive hypertension. A study using a RUUO model found that mice with unilateral ureteral obstruction had elevated blood pressure and decreased sodium excretion, along with renal tubular injury, inflammation, decreased vascular density, and renal fibrosis. These findings highlight the importance of addressing ureter obstruction and its potential impact on sodium excretion and hypertension.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Li Zeng, Zerong Liu, Luxin Zhou, Meng Chen, Xuewei Zheng, Pengfei Yang, Xinrui Zhao, Zhongmin Tian
Summary: The study found that protein-rich almond supplementation can prevent salt-induced hypertension by regulating amino acid metabolism, increasing nitric oxide content, and alleviating oxidative stress.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Review
Biochemistry & Molecular Biology
Wakako Kawarazaki, Toshiro Fujita
Summary: High salt intake can result in increased blood pressure, especially in individuals with impaired renal sodium excretion, leading to salt-sensitive hypertension. Activation of Rho in the central nervous system and vascular smooth muscle cells plays a crucial role in this process, contributing to increased vascular resistance and tone, ultimately impacting blood pressure control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Shuijie Li, Wenyu Li, Juan Yuan, Petra Bullova, Jieyu Wu, Xuepei Zhang, Yong Liu, Monika Plescher, Javier Rodriguez, Oscar C. Bedoya-Reina, Paulo R. Jannig, Paula Valente-Silva, Meng Yu, Marie Arsenian Henriksson, Roman A. Zubarev, Anna Smed-Sorensen, Carolyn K. Suzuki, Jorge L. Ruas, Johan Holmberg, Catharina Larsson, C. Christofer Juhlin, Alex von Kriegsheim, Yihai Cao, Susanne Schlisio
Summary: This study reveals the oxygen-sensitive regulation of TFAM, an activator of mitochondrial transcription and replication, and its connection to tumorigenesis in von Hippel-Lindau syndrome. The findings suggest that impaired mitochondrial biogenesis is linked to VHL tumorigenesis, and targeting mitochondria could sensitize therapy-resistant VHL tumors.
Article
Biochemistry & Molecular Biology
Ya-nan Ou-Yang, Meng-di Yuan, Zheng-mao Yang, Zhuo Min, Yue-xin Jin, Zhong-min Tian
Summary: Salt-induced renal metabolism dysfunction is a significant mechanism of salt-sensitive hypertension. This study aimed to investigate the extra-renal mechanism involving hepatic metabolism and gut microbiota, and the potential protective effects of curcumin. The results showed that a high-salt diet led to alterations in hepatic metabolic pathways and changes in gut microbial composition, which were associated with metabolic disorders. The dysfunction in hepatic metabolism was correlated with enhanced lipopolysaccharide (LPS) biosynthesis and apoptosis in gut microbes. Curcumin administration alleviated the salt-induced metabolic dysfunctions and protected against salt-sensitive hypertension.
Article
Cardiac & Cardiovascular Systems
Tao Zhuang, Yu Lei, Jin-Jia Chang, Yan-Ping Zhou, Yan Li, Yan-Xiu Li, Yong-Feng Yang, Mei-Hua Chen, Ting Meng, Shi-Man Fu, Li-Hao Huang, Wai-San Cheang, John P. Cooke, Zhi-Hui Dong, Ying-Nan Bai, Cheng-Chao Ruan
Summary: Excess sodium intake leads to hypertension. The study reveals that A(2A) receptor plays a crucial role in lymphangiogenesis and sodium balance in the skin. Activation of A(2A) receptor promotes lymphatic capillary density and decreases blood pressure.
EUROPEAN HEART JOURNAL
(2023)
Review
Urology & Nephrology
Nobuhiro Ayuzawa, Toshiro Fujita
Summary: Hypertension and its comorbidities are major public health concerns related to modern lifestyle factors. Aldosterone and its receptor, MR, play crucial roles in salt-sensitive hypertension and renal injuries. Obesity-related overproduction of aldosterone and ligand-independent signaling are identified as novel mechanisms of MR activation.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Peripheral Vascular Disease
David L. Mattson, John Henry Dasinger, Justine M. Abais-Battad
Summary: Salt-sensitive hypertension in patients with high blood pressure is associated with higher morbidity, mortality, and renal damage compared to those with normal blood pressure or salt-resistant hypertension. Dietary components other than salt play a role in modulating hypertension, and immunity and inflammation are key factors that amplify the development of salt-sensitive hypertension.
Article
Cardiac & Cardiovascular Systems
Jing Wu, Larry N. Agbor, Shi Fang, Masashi Mukohda, Anand R. Nair, Pablo Nakagawa, Avika Sharma, Donald A. Morgan, Justin L. Grobe, Kamal Rahmouni, Robert M. Weiss, James A. McCormick, Curt D. Sigmund
Summary: Our study found that mice expressing a dominant-negative mutation of peroxisome proliferator-activated receptor gamma in vascular smooth muscle developed salt-sensitive hypertension during a high salt diet, with impaired vasodilation in systemic and renal vessels occurring before hypertension onset. The impairment of vasodilation after salt loading led to increased peripheral vascular resistance.
CARDIOVASCULAR RESEARCH
(2021)
Article
Nutrition & Dietetics
Yueyuan Liao, Chao Chu, Yu Yan, Dan Wang, Qiong Ma, Ke Gao, Yue Sun, Jiawen Hu, Wenling Zheng, Jianjun Mu
Summary: This study found that a high salt diet increases serum levels of H3K4me1 and Set7 in salt-sensitive individuals, but not in salt-resistant individuals.
FRONTIERS IN NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Suzan A. Khodir, Eman Sweed, Marwa Gadallah, Anwaar Shabaan
Summary: This study aimed to investigate the cardiovascular protective effect of astaxanthin (ASX) in DOCA-salt-induced hypertension and its possible underlying mechanisms. The results showed that ASX has beneficial protective effects on DOCA-salt-induced hypertension via DNA fragmentation protection, apoptosis inhibition, antioxidant, anti-inflammatory, and its effects on lipid levels.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Peripheral Vascular Disease
Javaid Chachoo, Nausheen Mushtaq, Sami Jan, Sabhiya Majid, Iqbal Mohammad
Summary: This study analyzed clinical variables accompanying salt-sensitive hypertension among the Kashmiri population and found that a salt-restricted diet can significantly lower blood pressure. Women, urban inhabitants, and non-smokers are more prone to developing salt-sensitive hypertension. Physical activity has no effect on salt sensitivity.
JOURNAL OF HYPERTENSION
(2022)
Article
Cardiac & Cardiovascular Systems
Jacqueline C. Potter, Shannon A. Whiles, Conor B. Miles, Jenna B. Whiles, Mark A. Mitchell, Brianna E. Biederman, Febronia M. Dawoud, Kevin F. Breuel, Geoffrey A. Williamson, Maria M. Picken, Aaron J. Polichnowski
Summary: The study found that high salt intake significantly increased blood pressure and exacerbated renal injury in salt-sensitive rats, while salt-resistant rats showed less severe symptoms. In consomic rats, high salt intake significantly decreased renal vascular resistance and increased renal blood flow, whereas these changes did not occur in salt-sensitive rats.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)