Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the KidneyNovelty and Significance

(2017) Louise V. Wain et al.   HYPERTENSION

Collider scope: when selection bias can substantially influence observed associations

(2017) Marcus R Munafò et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Global Burden of Hypertension and Systolic Blood Pressure of at Least 110 to 115 mm Hg, 1990-2015

(2017) Mohammad H. Forouzanfar et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Novel Paradigms of Salt and Hypertension

(2017) Wenguang Feng et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Phosphatidylinositol 3-kinase inhibition induces vasodilator effect of sevoflurane via reduction of Rho kinase activity

(2017) Yasunori Miyamoto et al.   LIFE SCIENCES

Rare and low-frequency coding variants alter human adult height

(2017) Eirini Marouli et al.   NATURE

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

(2017) Helen R Warren et al.   NATURE GENETICS

WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit

(2017) Jing Wang et al.   NUCLEIC ACIDS RESEARCH

Cardiovascular effects of exogenous adrenomedullin and CGRP in Ramp and Calcrl deficient mice

(2017) J.B. Pawlak et al.   PEPTIDES

Genetic Predisposition to High Blood Pressure and Lifestyle Factors

(2017) Raha Pazoki et al.   CIRCULATION

PhenoScanner: a database of human genotype–phenotype associations

(2016) James R. Staley et al.   BIOINFORMATICS

Worldwide Exposures to Cardiovascular Risk Factors and Associated Health Effects

(2016) Ioanna Tzoulaki et al.   CIRCULATION

Resetting the bar: Statistical significance in whole-genome sequencing-based association studies of global populations

(2016) Sara L. Pulit et al.   GENETIC EPIDEMIOLOGY

Million Veteran Program: A mega-biobank to study genetic influences on health and disease

(2016) John Michael Gaziano et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Mohammad H Forouzanfar et al.   LANCET

Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci

(2016) Chunyu Liu et al.   NATURE GENETICS

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

(2016) Praveen Surendran et al.   NATURE GENETICS

Evaluating the contribution of genetics and familial shared environment to common disease using the UK Biobank

(2016) María Muñoz et al.   NATURE GENETICS

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

(2016) Georg B Ehret et al.   NATURE GENETICS

Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation

(2016) Thomas J Hoffmann et al.   NATURE GENETICS

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

Relaxin in paraventricular nucleus contributes to sympathetic overdrive and hypertension via PI3K-Akt pathway

(2016) Hai-Jian Sun et al.   NEUROPHARMACOLOGY

DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants

(2016) Janet Piñero et al.   NUCLEIC ACIDS RESEARCH

The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)

(2016) Jacqueline MacArthur et al.   NUCLEIC ACIDS RESEARCH

A Compendium of Chromatin Contact Maps Reveals Spatially Active Regions in the Human Genome

(2016) Anthony D. Schmitt et al.   Cell Reports

Circulating Apolipoprotein E Concentration and Cardiovascular Disease Risk: Meta-analysis of Results from Three Studies

(2016) Reecha Sofat et al.   PLOS MEDICINE

Polymorphisms in VEGFA gene affect the antihypertensive responses to enalapril

(2015) G. H. Oliveira-Paula et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Hypertension

(2015) Neil R Poulter et al.   LANCET

Adrenal cortex tissue homeostasis and zonation: A WNT perspective

(2015) Coralie Drelon et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Efficient Bayesian mixed-model analysis increases association power in large cohorts

(2015) Po-Ru Loh et al.   NATURE GENETICS

Predicting effects of noncoding variants with deep learning–based sequence model

(2015) Jian Zhou et al.   NATURE METHODS

Pregnancy, Primary Aldosteronism, and Adrenal CTNNB1 Mutations

(2015) Ada E.D. Teo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Exploring hypertension genome-wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics

(2015) Claudia P Cabrera et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes

(2015) J. Pinero et al.   Database-The Journal of Biological Databases and Curation

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank

(2015) Louise V Wain et al.   Lancet Respiratory Medicine

A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping

(2014) Suhas S.P. Rao et al.   CELL

The Airwave Health Monitoring Study of police officers and staff in Great Britain: Rationale, design and methods

(2014) Paul Elliott et al.   ENVIRONMENTAL RESEARCH

Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu

(2014) Liis Leitsalu et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Blood pressure-lowering treatment based on cardiovascular risk: a meta-analysis of individual patient data

(2014)   LANCET

Genes for blood pressure: an opportunity to understand hypertension

(2013) Georg B. Ehret et al.   EUROPEAN HEART JOURNAL

Meta-analysis methods for genome-wide association studies and beyond

(2013) Evangelos Evangelou et al.   NATURE REVIEWS GENETICS

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

(2011) Georg B. Ehret et al.   NATURE

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

(2011) Louise V Wain et al.   NATURE GENETICS

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Unveiling the Vasodilatory Actions and Mechanisms of Relaxin

(2010) Kirk P. Conrad   HYPERTENSION

The Wnt/beta-catenin pathway in adrenocortical development and cancer

(2010) Abeer El Wakil et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Prevalence of primary hyperaldosteronism in resistant hypertension: a retrospective observational study

(2008) Stella Douma et al.   LANCET