Noncanonical NOTCH Signaling Limits Self-Renewal of Human Epithelial and Induced Pluripotent Stem Cells through ROCK Activation

An extracellular region of Serrate is essential for ligand-induced cis-inhibition of Notch signaling

(2013) R. J. Fleming et al.   DEVELOPMENT

NOTCH1 Nuclear Interactome Reveals Key Regulators of Its Transcriptional Activity and Oncogenic Function

(2012) Ahmad Yatim et al.   MOLECULAR CELL

Cutaneous  -human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling

(2012) M. J. A. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Spatial and Molecular Features of Notch Pathway Assembly in Regulatory T Cells

(2012) L. R. Perumalsamy et al.   Science Signaling

The double-edged sword of Notch signaling in cancer

(2012) Andrew P. South et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Non-canonical Notch signaling: emerging role and mechanism

(2012) Peter Andersen et al.   TRENDS IN CELL BIOLOGY

ROCK Inhibitor and Feeder Cells Induce the Conditional Reprogramming of Epithelial Cells

(2011) Xuefeng Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53

(2011) G Melino   CELL DEATH AND DIFFERENTIATION

RhoA and RhoC have distinct roles in migration and invasion by acting through different targets

(2011) Francisco M. Vega et al.   JOURNAL OF CELL BIOLOGY

17β-Estradiol Enhances Breast Cancer Cell Motility and Invasion via Extra-Nuclear Activation of Actin-Binding Protein Ezrin

(2011) Shuhui Zheng et al.   PLoS One

Lonely death dance of human pluripotent stem cells: ROCKing between metastable cell states

(2011) Masatoshi Ohgushi et al.   TRENDS IN CELL BIOLOGY

DNA Methylation Dynamics in Human Induced Pluripotent Stem Cells over Time

(2011) Koichiro Nishino et al.   PLoS Genetics

 Np63  Repression of the Notch1 Gene Supports the Proliferative Capacity of Normal Human Keratinocytes and Cervical Cancer Cells

(2010) T. Yugawa et al.   CANCER RESEARCH

Actin-Myosin Contractility Is Responsible for the Reduced Viability of Dissociated Human Embryonic Stem Cells

(2010) Guokai Chen et al.   Cell Stem Cell

Molecular Pathway and Cell State Responsible for Dissociation-Induced Apoptosis in Human Pluripotent Stem Cells

(2010) Masatoshi Ohgushi et al.   Cell Stem Cell

Non-canonical activation of Notch signaling/target genes in vertebrates

(2010) Rajendran Sanalkumar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Human keratinocytes are efficiently immortalized by a Rho kinase inhibitor

(2010) Sandra Chapman et al.   JOURNAL OF CLINICAL INVESTIGATION

Cis-interactions between Notch and Delta generate mutually exclusive signalling states

(2010) David Sprinzak et al.   NATURE

Defining Hypo-Methylated Regions of Stem Cell-Specific Promoters in Human iPS Cells Derived from Extra-Embryonic Amnions and Lung Fibroblasts

(2010) Koichiro Nishino et al.   PLoS One

Human embryonic stem cells: caught between a ROCK inhibitor and a hard place

(2009) Roman J. Krawetz et al.   BIOESSAYS

Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion

(2009) Shuh Narumiya et al.   CANCER AND METASTASIS REVIEWS

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

cis-Inhibition of Notch by Endogenous Delta Biases the Outcome of Lateral Inhibition

(2009) Adam C. Miller et al.   CURRENT BIOLOGY

The Jekyll and Hyde Functions of Caspases

(2009) Caroline H. Yi et al.   DEVELOPMENTAL CELL

Rho-kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion

(2009) Carmen Chak-Lui Wong et al.   HEPATOLOGY

Targeted Disruption of ROCK1 Causes Insulin Resistancein Vivo

(2009) Dae Ho Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metalloprotease ADAM10 Is Required for Notch1 Site 2 Cleavage

(2009) Geert van Tetering et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic expression of epidermal caspase 8 simulates a wound healing response

(2009) Pedro Lee et al.   NATURE

Epidermal homeostasis: a balancing act of stem cells in the skin

(2009) Cédric Blanpain et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Distinct Roles for ROCK1 and ROCK2 in the Regulation of Keratinocyte Differentiation

(2009) Frances E. Lock et al.   PLoS One

Notch signaling and diseases: An evolutionary journey from a simple beginning to complex outcomes

(2008) Claudio Talora et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

An In vitro Multistep Carcinogenesis Model for Human Cervical Cancer

(2008) M. Narisawa-Saito et al.   CANCER RESEARCH

miR-203 represses ‘stemness’ by repressing ΔNp63

(2008) A M Lena et al.   CELL DEATH AND DIFFERENTIATION

Itch: a HECT-type E3 ligase regulating immunity, skin and cancer

(2008) G Melino et al.   CELL DEATH AND DIFFERENTIATION

Epidermal Notch signalling: differentiation, cancer and adhesion

(2008) Fiona M Watt et al.   CURRENT OPINION IN CELL BIOLOGY

The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response

(2008) Anna Mandinova et al.   EMBO JOURNAL

RhoE Is Required for Keratinocyte Differentiation and Stratification

(2008) Timo Liebig et al.   MOLECULAR BIOLOGY OF THE CELL

A skin microRNA promotes differentiation by repressing ‘stemness’

(2008) Rui Yi et al.   NATURE