Rho kinase inhibitors: a patent review (2012 – 2013)

Phase 2 Randomized Clinical Study of a Rho Kinase Inhibitor, K-115, in Primary Open-Angle Glaucoma and Ocular Hypertension

(2013) Hidenobu Tanihara et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Enhanced Rho-Associated Protein Kinase Activation in Patients With Systemic Lupus Erythematosus

(2013) Josephine Isgro et al.   ARTHRITIS AND RHEUMATISM

3-[2-(Aminomethyl)-5-[(pyridin-4-yl)carbamoyl]phenyl] benzoates as soft ROCK inhibitors

(2013) Sandro Boland et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Amino acid derived quinazolines as Rock/PKA inhibitors

(2013) Sarwat Chowdhury et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Neuroprotective Potential of Rho-Kinase Inhibition in Promoting Cell Survival and Reducing Reactive Gliosis in Response to Hypoxia in Isolated Bovine Retina

(2013) Aizhan Alt et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Emerging targets for novel therapy of asthma

(2013) William T Gerthoffer et al.   CURRENT OPINION IN PHARMACOLOGY

The Rho-kinase inhibitor fasudil restores normal motor nerve conduction velocity in diabetic rats by assuring the proper localization of adhesion-related molecules in myelinating Schwann cells

(2013) Yasushi Kanazawa et al.   EXPERIMENTAL NEUROLOGY

Synthesis and Biological Evaluation of Urea Derivatives as Highly Potent and Selective Rho Kinase Inhibitors

(2013) Yan Yin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of Rho kinase mediates the neuroprotective effects of estrogen in the MPTP model of Parkinson's disease

(2013) Ana I. Rodriguez-Perez et al.   NEUROBIOLOGY OF DISEASE

Correlation between Rho-kinase pathway gene expressions and development and progression of glioblastoma multiforme

(2013) Ibrahim Erkutlu et al.   TUMOR BIOLOGY

Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease

(2012) L. Tonges et al.   BRAIN

RhoA Activation and Effect of Rho-kinase Inhibitor in the Development of Retinal Neovascularization in a Mouse Model of Oxygen-induced Retinopathy

(2012) Xiaoyun Fang et al.   CURRENT EYE RESEARCH

Rho Kinase Inhibitors: Potential Treatments for Diabetes and Diabetic Complications

(2012) Hong Zhou et al.   CURRENT PHARMACEUTICAL DESIGN

The Rho kinase inhibitor SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries

(2012) Olaf Grisk et al.   JOURNAL OF HYPERTENSION

Fragment-Based and Structure-Guided Discovery and Optimization of Rho Kinase Inhibitors

(2012) Rongshi Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enhanced ROCK1 dependent contractility in fibroblast from chronic obstructive pulmonary disease patients

(2012) Oskar Hallgren et al.   Journal of Translational Medicine

Inhibition of Rho-Kinase Improves Erectile Function, Increases Nitric Oxide Signaling and Decreases Penile Apoptosis in a Rat Model of Cavernous Nerve Injury

(2012) Johanna L. Hannan et al.   JOURNAL OF UROLOGY

Administration of fasudil, a ROCK inhibitor, attenuates disease in lupus-prone NZB/W F1 female mice

(2012) RA Stirzaker et al.   LUPUS

Synthesis and biological evaluation of 4-quinazolinones as Rho kinase inhibitors

(2011) Xingang Fang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)

(2011) Sarwat Chowdhury et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (Part-II)

(2011) E. Hampton Sessions et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel therapies for glaucoma: a patent review 2007 – 2011

(2011) Fabrizio Carta et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries

(2011) Hiroshi Watabe et al.   JAPANESE JOURNAL OF OPHTHALMOLOGY

LIM Kinase 1 Modulates Cortical Actin and CXCR4 Cycling and Is Activated by HIV-1 to Initiate Viral Infection

(2011) Paul J. Vorster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alleviating Effects of AS1892802, a Rho Kinase Inhibitor, on Osteoarthritic Disorders in Rodents

(2011) Nobuaki Takeshita et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Rhos and Rho kinases in the rat prostate: their possible functional roles and distributions

(2011) Motoaki Saito et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Measurement of Rho-associated kinase (ROCK) activity in humans: Validity of leukocyte p-MBS/t-MBS in comparison with vascular response to fasudil

(2010) Takaki Hata et al.   ATHEROSCLEROSIS

The development of benzimidazoles as selective rho kinase inhibitors

(2010) E. Hampton Sessions et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Benzothiophene containing Rho kinase inhibitors: Efficacy in an animal model of glaucoma

(2010) Robert L. Davis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitro and in vivo

(2010) Lin Deng et al.   CANCER BIOLOGY & THERAPY

Aberrant ROCK activation promotes the development of type I diabetes in NOD mice

(2010) Partha S. Biswas et al.   CELLULAR IMMUNOLOGY

Chikungunya virus mobilizes the apoptotic machinery to invade host cell defenses

(2010) Pascale Krejbich-Trotot et al.   FASEB JOURNAL

Tetrahydroisoquinoline Derivatives As Highly Selective and Potent Rho Kinase Inhibitors

(2010) Xingang Fang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antinociceptive Effects of AS1892802, a Novel Rho Kinase Inhibitor, in Rat Models of Inflammatory and Noninflammatory Arthritis

(2010) E. Yoshimi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

RhoA/Rho kinase pathway contributes to the pathogenesis of thermal hyperalgesia in diabetic mice

(2010) Masahiro Ohsawa et al.   PAIN

Reduced Expression of the ROCK Inhibitor Rnd3 Is Associated with Increased Invasiveness and Metastatic Potential in Mesenchymal Tumor Cells

(2010) Cristina Belgiovine et al.   PLoS One

Discovery of Potent and Selective Urea-Based ROCK Inhibitors and Their Effects on Intraocular Pressure in Rats

(2010) Yan Yin et al.   ACS Medicinal Chemistry Letters

Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors

(2009) Yan Yin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rho Kinase: An Important Mediator of Atherosclerosis and Vascular Disease

(2009) Qian Zhou et al.   CURRENT PHARMACEUTICAL DESIGN

Effects of ROCK inhibitor, Y-27632, on adhesion and mobility in esophageal squamous cell cancer cells

(2009) Lili Wang et al.   MOLECULAR BIOLOGY REPORTS

Intraocular Pressure–Lowering Effects and Safety of Topical Administration of a Selective ROCK Inhibitor, SNJ-1656, in Healthy Volunteers

(2008) Hidenobu Tanihara   ARCHIVES OF OPHTHALMOLOGY

Detection of myosin light chain phosphorylation—A cell-based assay for screening Rho-kinase inhibitors

(2008) Thomas Schröter et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Benzimidazole- and benzoxazole-based inhibitors of Rho kinase

(2008) E. Hampton Sessions et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chroman-3-amides as potent Rho kinase inhibitors

(2008) Yen Ting Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Differential effects of two ROCK inhibitors, Fasudil and Y-27632, on optic nerve regeneration in adult cats

(2008) Masahiro Ichikawa et al.   BRAIN RESEARCH

Nuclear Factor- B Induction by Visfatin in Human Vascular Endothelial Cells: Its role in MMP-2/9 production and activation

(2008) R. Adya et al.   DIABETES CARE

Rho kinase inhibitors: A novel therapeutical intervention in asthma?

(2008) Dedmer Schaafsma et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase

(2007) R Kast et al.   BRITISH JOURNAL OF PHARMACOLOGY