Targeting Rho GTPase signaling for cancer therapy

The diverse roles of Rac signaling in tumorigenesis

(2011) Natalie A. Mack et al.   CELL CYCLE

Cdc42 in oncogenic transformation, invasion, and tumorigenesis

(2011) Kristy Stengel et al.   CELLULAR SIGNALLING

Design, synthesis, and characterization of piperazinedione-based dual protein inhibitors for both farnesyltransferase and geranylgeranyltransferase-I

(2011) Yuqin Qiao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase

(2011) Ivan Tan et al.   FEBS LETTERS

Mechanistic Insights into Specificity, Activity, and Regulatory Elements of the Regulator of G-protein Signaling (RGS)-containing Rho-specific Guanine Nucleotide Exchange Factors (GEFs) p115, PDZ-RhoGEF (PRG), and Leukemia-associated RhoGEF (LARG)

(2011) Mamta Jaiswal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design and Synthesis of Small Molecule RhoA Inhibitors: A New Promising Therapy for Cardiovascular Diseases?

(2011) Jing Deng et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Phase I/IIa Clinical Trial of a Recombinant Rho Protein Antagonist in Acute Spinal Cord Injury

(2011) Michael G. Fehlings et al.   JOURNAL OF NEUROTRAUMA

Inhibition of Rho-associated coiled-coil containing protein kinase enhances the activation of epidermal growth factor receptor in pancreatic cancer cells

(2011) Masanori Nakashima et al.   Molecular Cancer

Bacterial protein toxins that modify host regulatory GTPases

(2011) Klaus Aktories   NATURE REVIEWS MICROBIOLOGY

Development of substituted 7-phenyl-4-aminobenzothieno[3,2-d] pyrimidines as potent LIMK1 inhibitors

(2011) Brad E. Sleebs et al.   MedChemComm

Identification of 3-aminothieno[2,3-b]pyridine-2-carboxamides and 4-aminobenzothieno[3,2-d]pyrimidines as LIMK1 inhibitors

(2011) Brad E. Sleebs et al.   MedChemComm

Dynamics of the Rho-family small GTPases in actin regulation and motility

(2011) Désirée Spiering et al.   Cell Adhesion & Migration

Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors

(2010) Peter Ray et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival

(2010) Daniel R Croft et al.   CELL RESEARCH

Dying Alone: A Tale of Rho

(2010) Michael S. Samuel et al.   Cell Stem Cell

Guanine nucleotide exchange factors for RhoGTPases: Good therapeutic targets for cancer therapy?

(2010) Galit Lazer et al.   CELLULAR SIGNALLING

LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells

(2010) Rebecca W. Scott et al.   JOURNAL OF CELL BIOLOGY

Tetrahydroisoquinoline Derivatives As Highly Selective and Potent Rho Kinase Inhibitors

(2010) Xingang Fang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Blockade of Rac1 Activity Induces G1 Cell Cycle Arrest or Apoptosis in Breast Cancer Cells through Downregulation of Cyclin D1, Survivin, and X-Linked Inhibitor of Apoptosis Protein

(2010) T. Yoshida et al.   MOLECULAR CANCER THERAPEUTICS

Collective cell migration requires suppression of actomyosin at cell–cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6

(2010) Cristina Hidalgo-Carcedo et al.   NATURE CELL BIOLOGY

Activating ROCK1 somatic mutations in human cancer

(2010) P A Lochhead et al.   ONCOGENE

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

(2010) B. W. Murray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of Rac1 in leukemia patients and its role in leukemia cell migration and growth

(2009) Jiying Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity

(2009) C. Hahmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Aptamer-Derived Peptides as Potent Inhibitors of the Oncogenic RhoGEF Tgat

(2009) Nathalie Bouquier et al.   CHEMISTRY & BIOLOGY

A Cell Active Chemical GEF Inhibitor Selectively Targets the Trio/RhoG/Rac1 Signaling Pathway

(2009) Nathalie Bouquier et al.   CHEMISTRY & BIOLOGY

Novel Class of LIM-Kinase 2 Inhibitors for the Treatment of Ocular Hypertension and Associated Glaucoma

(2009) Bryce A. Harrison et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Guanine Nucleotide Exchange Factors Trio, Ect2, and Vav3 Mediate the Invasive Behavior of Glioblastoma

(2008) Bodour Salhia et al.   AMERICAN JOURNAL OF PATHOLOGY

Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin

(2008) Marjan Boerma et al.   BLOOD COAGULATION & FIBRINOLYSIS

Phase I pharmacokinetic and pharmacodynamic study of the prenyl transferase inhibitor AZD3409 in patients with advanced cancer

(2008) N M G M Appels et al.   BRITISH JOURNAL OF CANCER

An Isoform-Selective, Small-Molecule Inhibitor Targets the Autoregulatory Mechanism of p21-Activated Kinase

(2008) Sean W. Deacon et al.   CHEMISTRY & BIOLOGY

Applications for ROCK kinase inhibition

(2008) Michael F Olson   CURRENT OPINION IN CELL BIOLOGY

Local Inhibition of Rho Signaling by Cell-Permeable Recombinant Protein BA-210 Prevents Secondary Damage and Promotes Functional Recovery following Acute Spinal Cord Injury

(2008) Stephanie Lord-Fontaine et al.   JOURNAL OF NEUROTRAUMA

RhoA Silencing Reverts the Resistance to Doxorubicin in Human Colon Cancer Cells

(2008) S. Doublier et al.   MOLECULAR CANCER RESEARCH

Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors

(2008) P. Ross-Macdonald et al.   MOLECULAR CANCER THERAPEUTICS

Scaffolding function of PAK in the PDK1–Akt pathway

(2008) Maiko Higuchi et al.   NATURE CELL BIOLOGY

Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro

(2008) K. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA