Rho-Kinase in Development and Heart Failure: Insights From Genetic Models

RhoA/Rho-kinase and vascular diseases: what is the link?

(2010) Kenia Pedrosa Nunes et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial Infarction

(2010) Eric M. Small et al.   CIRCULATION RESEARCH

Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity

(2010) Mutsuki Amano et al.   Cytoskeleton

Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases

(2010) Ming Dong et al.   DRUG DISCOVERY TODAY

RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis

(2010) Brad A. Bryan et al.   FASEB JOURNAL

Rho Kinase-2 Activation in Human Endothelial Cells Drives Lysophosphatidic Acid-mediated Expression of Cell Adhesion Molecules via NF-κB p65

(2010) Hideaki Shimada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice

(2010) Jianjian Shi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The role of Rho protein signaling in hypertension

(2010) Gervaise Loirand et al.   Nature Reviews Cardiology

Revisited and Revised: Is RhoA Always a Villain in Cardiac Pathophysiology?

(2010) Shigeki Miyamoto et al.   Journal of Cardiovascular Translational Research

ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability

(2009) S. Vemula et al.   BLOOD

Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation

(2009) S. B. Haudek et al.   CARDIOVASCULAR RESEARCH

Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity

(2009) C. Hahmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ROCK Isoform Regulation of Myosin Phosphatase and Contractility in Vascular Smooth Muscle Cells

(2009) Yuepeng Wang et al.   CIRCULATION RESEARCH

Targeted Disruption of ROCK1 Causes Insulin Resistancein Vivo

(2009) Dae Ho Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-term Inhibition of Rho-kinase Ameliorates Diastolic Heart Failure in Hypertensive Rats

(2009) Shigefumi Fukui et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Activation of Rho Kinase Isoforms in Lung Endothelial Cells during Inflammation

(2009) P. Y. Mong et al.   JOURNAL OF IMMUNOLOGY

Rho-Associated Kinase II (ROCKII) Limits Axonal Growth after Trauma within the Adult Mouse Spinal Cord

(2009) P. Duffy et al.   JOURNAL OF NEUROSCIENCE

Decreased Intraocular Pressure in Mice Following Either Pharmacological or Genetic Inhibition of ROCK

(2009) N. Andrew Whitlock et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Distinct Roles for ROCK1 and ROCK2 in the Regulation of Keratinocyte Differentiation

(2009) Frances E. Lock et al.   PLoS One

Effects of a Rho kinase inhibitor on pressure overload induced cardiac hypertrophy and associated diastolic dysfunction

(2008) Arintaya Phrommintikul et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin

(2008) Marjan Boerma et al.   BLOOD COAGULATION & FIBRINOLYSIS

Focal Adhesion Kinase as a RhoA-activable Signaling Scaffold Mediating Akt Activation and Cardiomyocyte Protection

(2008) Dominic P. Del Re et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury

(2008) Kensuke Noma et al.   JOURNAL OF CLINICAL INVESTIGATION

Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy

(2008) Jianjian Shi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE

(2008) Sophie Pinner et al.   NATURE CELL BIOLOGY

A critical role of Rho-kinase ROCK2 in the regulation of spine and synaptic function

(2008) Zikai Zhou et al.   NEUROPHARMACOLOGY

Identification of ROCK1 as an Upstream Activator of the JIP-3 to JNK Signaling Axis in Response to UVB Damage

(2008) P. P. Ongusaha et al.   Science Signaling