Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans: an update

The Human Fecal Microbiota Metabolizes Deoxynivalenol and Deoxynivalenol-3-Glucoside and May Be Responsible for Urinary Deepoxy-Deoxynivalenol

(2013) Silvia W. Gratz et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis

(2013) Krishnendu Sinha et al.   ARCHIVES OF TOXICOLOGY

Neurotoxic Potential and Cellular Uptake of T-2 Toxin in Human Astrocytes in Primary Culture

(2013) Maria Weidner et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Trichothecenes: Structure-Toxic Activity Relationships

(2013) Qinghua Wu et al.   CURRENT DRUG METABOLISM

T-2 toxin is hydroxylated by chicken CYP3A37

(2013) Yiyang Yuan et al.   FOOD AND CHEMICAL TOXICOLOGY

The mycotoxin T-2 inhibits hepatic cytochrome P4503A activity in pigs

(2013) J. Goossens et al.   FOOD AND CHEMICAL TOXICOLOGY

Toxic effects of dietary exposure to T-2 toxin on intestinal and hepatic biotransformation enzymes and drug transporter systems in broiler chickens

(2013) A. Osselaere et al.   FOOD AND CHEMICAL TOXICOLOGY

Deoxynivalenol induced oxidative stress and genotoxicity in human peripheral blood lymphocytes

(2013) Wei Yang et al.   FOOD AND CHEMICAL TOXICOLOGY

Chicken Cytochrome P450 1A5 Is the Key Enzyme for Metabolizing T-2 Toxin to 3'OH-T-2

(2013) Shufeng Shang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enzyme-Assisted Synthesis and Structural Characterization of the 3-, 8-, and 15-Glucuronides of Deoxynivalenol

(2013) Silvio Uhlig et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Metabolic Pathways of T-2 Toxin in in Vivo and in Vitro Systems of Wistar Rats

(2013) Shupeng Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Characterization of Three Deoxynivalenol Sulfonates Formed by Reaction of Deoxynivalenol with Sulfur Reagents

(2013) Heidi Elisabeth Schwartz et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Metabolism, Distribution, and Excretion of Deoxynivalenol with Combined Techniques of Radiotracing, High-Performance Liquid Chromatography Ion Trap Time-of-Flight Mass Spectrometry, and Online Radiometric Detection

(2013) Dan Wan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Toxic effects of T-2 toxin and deoxynivalenol on the mitochondrial electron transport system of cardiomyocytes in rats

(2013) Suchitra Ngampongsa et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Mycotoxin-Containing Diet Causes Oxidative Stress in the Mouse

(2013) Yan-Jun Hou et al.   PLoS One

Influence of T-2 and HT-2 Toxin on the Blood-Brain Barrier In Vitro: New Experimental Hints for Neurotoxic Effects

(2013) Maria Weidner et al.   PLoS One

High Risk of Embryo-Fetal Toxicity: Placental Transfer of T-2 Toxin and Its Major Metabolite HT-2 Toxin in BeWo Cells

(2013) Xu Wang et al.   TOXICOLOGICAL SCIENCES

New insights into the human metabolism of the Fusarium mycotoxins deoxynivalenol and zearalenone

(2013) Benedikt Warth et al.   TOXICOLOGY LETTERS

Stable isotopic labelling-assisted untargeted metabolic profiling reveals novel conjugates of the mycotoxin deoxynivalenol in wheat

(2012) Bernhard Kluger et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

T-2 toxin induces apoptosis in differentiated murine embryonic stem cells through reactive oxygen species-mediated mitochondrial pathway

(2012) Haiqin Fang et al.   APOPTOSIS

Bacterial Cytochrome P450 System Catabolizing the Fusarium Toxin Deoxynivalenol

(2012) Michihiro Ito et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

T-2 Toxin Contamination in Grains and Selenium Concentration in Drinking Water and Grains in Kaschin–Beck Disease Endemic Areas of Qinghai Province

(2012) Li-Yan Sun et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Investigation of the Hepatic Glucuronidation Pattern of the Fusarium Mycotoxin Deoxynivalenol in Various Species

(2012) Ronald Maul et al.   CHEMICAL RESEARCH IN TOXICOLOGY

HT-2 Toxin 4-Glucuronide as New T-2 Toxin Metabolite: Enzymatic Synthesis, Analysis, and Species Specific Formation of T-2 and HT-2 Toxin Glucuronides by Rat, Mouse, Pig, and Human Liver Microsomes

(2012) Tanja Welsch et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Identification and Apoptotic Potential of T-2 Toxin Metabolites in Human Cells

(2012) Maria Weidner et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Oxidant damage in Kashin-Beck disease and a rat Kashin-Beck disease model by employing T-2 toxin treatment under selenium deficient conditions

(2012) Jing-hong Chen et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Masked mycotoxins: A review

(2012) Franz Berthiller et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Genotoxic effects of deoxynivalenol in broiler chickens fed low-protein feeds

(2012) W. A. Awad et al.   POULTRY SCIENCE

T-2 toxin induced skin inflammation and cutaneous injury in mice

(2012) Mona Agrawal et al.   TOXICOLOGY

Assessment of human deoxynivalenol exposure using an LC–MS/MS based biomarker method

(2012) Benedikt Warth et al.   TOXICOLOGY LETTERS

Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in rats

(2012) Veronika Nagl et al.   TOXICOLOGY LETTERS

Intestinal metabolism of T-2 toxin in the pig cecum model

(2012) Qinghua Wu et al.   Mycotoxin Research

Thioredoxin-1 contributes to protection against DON-induced oxidative damage in HepG2 cells

(2012) Kei-ichi Sugiyama et al.   Mycotoxin Research

Direct quantification of deoxynivalenol glucuronide in human urine as biomarker of exposure to the Fusarium mycotoxin deoxynivalenol

(2011) Benedikt Warth et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Contamination Level of T-2 and HT-2 Toxin in Cereal Crops from Aba Area in Sichuan Province, China

(2011) XiaoChun Wang et al.   BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY

Mechanisms of Mycotoxin-Induced Neurotoxicity through Oxidative Stress-Associated Pathways

(2011) Kunio Doi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

T-2 Toxin, a Trichothecene Mycotoxin: Review of Toxicity, Metabolism, and Analytical Methods

(2011) Yanshen Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Integrated Transcriptional and Proteomic Analysis withIn VitroBiochemical Assay Reveal the Important Role of CYP3A46 in T-2 Toxin Hydroxylation in Porcine Primary Hepatocytes

(2011) Jianshe Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

T-2 toxin is a cytochrome P450 1A1 inducer and leads to MAPK/p38- but not aryl hydrocarbon receptor-dependent interleukin-8 secretion in the human intestinal epithelial cell line Caco-2

(2011) Pierre Kruber et al.   TOXICOLOGY

T-2 toxin induces apoptosis in ovarian granulosa cells of rats through reactive oxygen species-mediated mitochondrial pathway

(2011) Jing Wu et al.   TOXICOLOGY LETTERS

Hydrolytic fate of deoxynivalenol-3-glucoside during digestion

(2011) Franz Berthiller et al.   TOXICOLOGY LETTERS

A comparison of hepaticin vitrometabolism of T-2 toxin in rats, pigs, chickens, and carp

(2011) Qinghua Wu et al.   XENOBIOTICA

The catalytic activity of cytochrome P450 3A22 is critical for the metabolism of T-2 toxin in porcine reservoirs

(2010) Xiaohu Ge et al.   CATALYSIS COMMUNICATIONS

Metabolic pathways of trichothecenes

(2010) Qinghua Wu et al.   DRUG METABOLISM REVIEWS

Brain oxidative stress after dermal and subcutaneous exposure of T-2 toxin in mice

(2010) Manjari Chaudhary et al.   FOOD AND CHEMICAL TOXICOLOGY

Studies on the toxicity of deoxynivalenol (DON), sodium metabisulfite, DON-sulfonate (DONS) and de-epoxy-DON for porcine peripheral blood mononuclear cells and the Intestinal Porcine Epithelial Cell lines IPEC-1 and IPEC-J2, and on effects of DON and DONS on piglets

(2010) S. Dänicke et al.   FOOD AND CHEMICAL TOXICOLOGY

Assessment of deoxynivalenol metabolite profiles in UK adults

(2010) Paul C. Turner et al.   FOOD AND CHEMICAL TOXICOLOGY

Lutein protects HT-29 cells against Deoxynivalenol-induced oxidative stress and apoptosis: Prevention of NF-κB nuclear localization and down regulation of NF-κB and Cyclo-Oxygenase – 2 expression

(2010) Rajashree Krishnaswamy et al.   FREE RADICAL BIOLOGY AND MEDICINE

Determinants of Urinary Deoxynivalenol and De-epoxy Deoxynivalenol in Male Farmers from Normandy, France

(2010) Paul C. Turner et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Comparative hepatotoxicity of deoxynivalenol in rat, mouse and human liver cells in culture

(2010) Saura C. Sahu et al.   JOURNAL OF APPLIED TOXICOLOGY

Structural Elucidation of T-2 Toxin Thermal Degradation Products and Investigations toward Their Occurrence in Retail Food

(2009) Marita Beyer et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Oxidative damage and gene expression profile of antioxidant enzymes after T-2 toxin exposure in mice

(2009) Manjari Chaudhari et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture

(2009) Maika Königs et al.   TOXICOLOGY

Pathway of deoxynivalenol-induced apoptosis in human colon carcinoma cells

(2009) Fatma Bensassi et al.   TOXICOLOGY

Oxidative stress induction by T-2 toxin causes DNA damage and triggers apoptosis via caspase pathway in human cervical cancer cells

(2009) Manjari Chaudhari et al.   TOXICOLOGY

The role of oxidative stress in deoxynivalenol-induced DNA damage in HepG2 cells

(2009) Xiaoou Zhang et al.   TOXICON

Metabolic Pathways of T-2 Toxin

(2008) Kamil Kuca et al.   CURRENT DRUG METABOLISM

Rat liver clone-9 cells in culture as a model for screening hepatotoxic potential of food-related products: hepatotoxicity of deoxynivalenol

(2008) Saura C. Sahu et al.   JOURNAL OF APPLIED TOXICOLOGY

In vitroevaluation of the chemoprotective action mechanisms of leontopodic acid against aflatoxin B1 and deoxynivalenol-induced cell damage

(2008) Stefano Costa et al.   JOURNAL OF APPLIED TOXICOLOGY

Subclinical doses of T-2 toxin impair acquired immune response and liver cytochrome P450 in pigs

(2008) G.M. Meissonnier et al.   TOXICOLOGY

The effect of vitamin E supplementation on reduction of lymphocyte DNA damage induced by T-2 toxin and deoxynivalenol in weaned pigs

(2007) T. Frankič et al.   ANIMAL FEED SCIENCE AND TECHNOLOGY