Journal
HEPATITIS MONTHLY
Volume 12, Issue 10, Pages -Publisher
KOWSAR PUBL
DOI: 10.5812/hepatmon.7238
Keywords
Aflatoxins; Aflatoxin-albumin Adducts; Hepatitis B Virus; Hepatocellular Carcinoma
Categories
Funding
- National Institutes of Health [RO1ES005116, P30ES009089]
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Context: Hepatocellular carcinoma (HCC) is one of the most common cancers in the world but with a striking geographical variation in incidence; most of the burden is in developing countries. This geographic variation in HCC incidence might be due to geographic differences in the prevalence of various etiological factors. Evidence Acquisition: Here, we review the epidemiological evidence linking dietary exposure to aflatoxin B1 (AFB1) and risk of HCC, possible interactions between AFB1 and hepatitis B virus (HBV) or polymorphisms of genes involved in AFB1-related metabolism as well as DNA repair. Results: Ecological, case-control and cohort studies that used various measures of aflatoxin exposure including dietary questionnaires, food surveys and biomarkers are summarized. Conclusions: Taken together, the data suggest that dietary exposure to aflatoxins is an important contributor to the high incidence of HCC in Asia and sub-Saharan Africa, where almost 82% of the cases occur. Published by Kowsar Corp, 2012. cc 3.0.
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