Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics

Epithelial Barriers in Intestinal Inflammation

(2011) Lena J. John et al.   ANTIOXIDANTS & REDOX SIGNALING

The Epithelial Barrier Is Maintained by In Vivo Tight Junction Expansion During Pathologic Intestinal Epithelial Shedding

(2011) Amanda M. Marchiando et al.   GASTROENTEROLOGY

Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in coeliac disease

(2011) Michael Schumann et al.   GUT

Transforming Growth Factor-β, a Whey Protein Component, Strengthens the Intestinal Barrier by Upregulating Claudin-4 in HT-29/B6 Cells

(2011) Nina A. Hering et al.   JOURNAL OF NUTRITION

Oral and Fecal Campylobacter concisus Strains Perturb Barrier Function by Apoptosis Induction in HT-29/B6 Intestinal Epithelial Cells

(2011) Hans Linde Nielsen et al.   PLoS One

Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes

(2010) Susanne Milatz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Loss of Claudin-15, but Not Claudin-2, Causes Na+ Deficiency and Glucose Malabsorption in Mouse Small Intestine

(2010) Atsushi Tamura et al.   GASTROENTEROLOGY

Epithelial Myosin Light Chain Kinase Activation Induces Mucosal Interleukin-13 Expression to Alter Tight Junction Ion Selectivity

(2010) Christopher R. Weber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caveolin-1–dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo

(2010) Amanda M. Marchiando et al.   JOURNAL OF CELL BIOLOGY

Claudin-2, a component of the tight junction, forms a paracellular water channel

(2010) R. Rosenthal et al.   JOURNAL OF CELL SCIENCE

TNFα-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFκB signaling

(2010) Maren Amasheh et al.   JOURNAL OF CELL SCIENCE

Cellular and molecular mechanism of interleukin-1β modulation of Caco-2 intestinal epithelial tight junction barrier

(2010) Rana Al-Sadi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Yersinia enterocolitica induces epithelial barrier dysfunction through regional tight junction changes in colonic HT-29/B6 cell monolayers

(2010) Nina A Hering et al.   LABORATORY INVESTIGATION

MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function

(2010) D. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis

(2009) Rudolf Mennigen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Supplemental zinc reduced intestinal permeability by enhancing occludin and zonula occludens protein-1 (ZO-1) expression in weaning piglets

(2009) Bingkun Zhang et al.   BRITISH JOURNAL OF NUTRITION

TNFα up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol-3-kinase signaling

(2009) J. Mankertz et al.   CELL AND TISSUE RESEARCH

Open-label study of adalimumab in patients with ulcerative colitis including those with prior loss of response or intolerance to infliximab

(2009) Waqqas Afif et al.   INFLAMMATORY BOWEL DISEASES

Enhanced translocation of bacteria across metabolically stressed epithelia is reduced by butyrate†

(2009) Kimberley Lewis et al.   INFLAMMATORY BOWEL DISEASES

Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function

(2009) D. Gunzel et al.   JOURNAL OF CELL SCIENCE

Arcobacter butzleriInduces Barrier Dysfunction in Intestinal HT‐29/B6 Cells

(2009) Roland Bücker et al.   JOURNAL OF INFECTIOUS DISEASES

Tricellulin Forms a Barrier to Macromolecules in Tricellular Tight Junctions without Affecting Ion Permeability

(2009) Susanne M. Krug et al.   MOLECULAR BIOLOGY OF THE CELL

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

Loss of Hepatocyte-Nuclear-Factor-4α Affects Colonic Ion Transport and Causes Chronic Inflammation Resembling Inflammatory Bowel Disease in Mice

(2009) Mathieu Darsigny et al.   PLoS One

Regulation of mucosal structure and barrier function in rat colon exposed to tumor necrosis factor alpha and interferon gammain vitro: A novel model for studying the pathomechanisms of inflammatory bowel disease cytokines

(2009) Maren Amasheh et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Na+ absorption defends from paracellular back-leakage by claudin-8 upregulation

(2008) Salah Amasheh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hepatocyte nuclear factor 4α in the intestinal epithelial cells protects against inflammatory bowel disease

(2008) Sung-Hoon Ahn et al.   INFLAMMATORY BOWEL DISEASES

Cellular and molecular mechanisms that mediate basal and tumour necrosis factor-α-induced regulation of myosin light chain kinase gene activity

(2008) Dongmei Ye et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TGF-β1 and Smad7 in the regulation of IBD

(2008) G Monteleone et al.   Mucosal Immunology