From the Gut to the Brain: Journey and Pathophysiological Effects of the Food-Associated Trichothecene Mycotoxin Deoxynivalenol
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
From the Gut to the Brain: Journey and Pathophysiological Effects of the Food-Associated Trichothecene Mycotoxin Deoxynivalenol
Authors
Keywords
-
Journal
Toxins
Volume 5, Issue 4, Pages 784-820
Publisher
MDPI AG
Online
2013-04-23
DOI
10.3390/toxins5040784
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Modulation of Porcine β-Defensins 1 and 2 upon Individual and Combined Fusarium Toxin Exposure in a Swine Jejunal Epithelial Cell Line
- (2013) Murphy Lam-Yim Wan et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- The Human Fecal Microbiota Metabolizes Deoxynivalenol and Deoxynivalenol-3-Glucoside and May Be Responsible for Urinary Deepoxy-Deoxynivalenol
- (2013) Silvia W. Gratz et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- Masked Mycotoxins Are Efficiently Hydrolyzed by Human Colonic Microbiota Releasing Their Aglycones
- (2013) Andrea Dall’Erta et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Enzyme-Assisted Synthesis and Structural Characterization of the 3-, 8-, and 15-Glucuronides of Deoxynivalenol
- (2013) Silvio Uhlig et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Resveratrol inhibits reproductive toxicity induced by deoxynivalenol
- (2013) Adriana Kolesarova et al. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
- Deoxynivalenol as a New Factor in the Persistence of Intestinal Inflammatory Diseases: An Emerging Hypothesis through Possible Modulation of Th17-Mediated Response
- (2013) Patricia M. Cano et al. PLoS One
- Global protein phosphorylation dynamics during deoxynivalenol-induced ribotoxic stress response in the macrophage
- (2013) Xiao Pan et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Stable isotopic labelling-assisted untargeted metabolic profiling reveals novel conjugates of the mycotoxin deoxynivalenol in wheat
- (2012) Bernhard Kluger et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Perspectives on tight junction research
- (2012) Jörg-Dieter Schulzke et al. Annals of the New York Academy of Sciences
- Investigation of the Hepatic Glucuronidation Pattern of the Fusarium Mycotoxin Deoxynivalenol in Various Species
- (2012) Ronald Maul et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Pathological changes in tight junctions and potential applications into therapies
- (2012) Azusa Takahashi et al. DRUG DISCOVERY TODAY
- Study of the interaction of deoxynivalenol with human serum albumin by spectroscopic technique and molecular modelling
- (2012) Yuqin Li et al. Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment
- Comparison of murine anorectic responses to the 8-ketotrichothecenes 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, fusarenon X and nivalenol
- (2012) Wenda Wu et al. FOOD AND CHEMICAL TOXICOLOGY
- Toxicokinetic study and absolute oral bioavailability of deoxynivalenol, T-2 toxin and zearalenone in broiler chickens
- (2012) Ann Osselaere et al. FOOD AND CHEMICAL TOXICOLOGY
- Deoxynivalenol Oligoglycosides: New “Masked” Fusarium Toxins Occurring in Malt, Beer, and Breadstuff
- (2012) Milena Zachariasova et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Masked mycotoxins: A review
- (2012) Franz Berthiller et al. MOLECULAR NUTRITION & FOOD RESEARCH
- c-Fos immunoreactivity in the pig brain following deoxynivalenol intoxication: Focus on NUCB2/nesfatin-1 expressing neurons
- (2012) Stéphanie Gaigé et al. NEUROTOXICOLOGY
- The role of biomarkers in evaluating human health concerns from fungal contaminants in food
- (2012) Paul C. Turner et al. NUTRITION RESEARCH REVIEWS
- Gene Regulation of Intestinal Porcine Epithelial Cells IPEC-J2 Is Dependent on the Site of Deoxynivalenol Toxicological Action
- (2012) Anne-Kathrin Diesing et al. PLoS One
- Nivalenol and Deoxynivalenol Affect Rat Intestinal Epithelial Cells: A Concentration Related Study
- (2012) Giuseppe Bianco et al. PLoS One
- Development and validation of a rapid multi-biomarker liquid chromatography/tandem mass spectrometry method to assess human exposure to mycotoxins
- (2012) Benedikt Warth et al. RAPID COMMUNICATIONS IN MASS SPECTROMETRY
- Anorexia Induction by the Trichothecene Deoxynivalenol (Vomitoxin) Is Mediated by the Release of the Gut Satiety Hormone Peptide YY
- (2012) Brenna M. Flannery et al. TOXICOLOGICAL SCIENCES
- Toxicity of Deoxynivalenol and Its Acetylated Derivatives on the Intestine: Differential Effects on Morphology, Barrier Function, Tight Junction Proteins, and Mitogen-Activated Protein Kinases
- (2012) Philippe Pinton et al. TOXICOLOGICAL SCIENCES
- JAK/STAT Pathway Plays a Critical Role in the Proinflammatory Gene Expression and Apoptosis of RAW264.7 Cells Induced by Trichothecenes as DON and T-2 Toxin
- (2012) Xu Wang et al. TOXICOLOGICAL SCIENCES
- Targets and Intracellular Signaling Mechanisms for Deoxynivalenol-Induced Ribosomal RNA Cleavage
- (2012) Kaiyu He et al. TOXICOLOGICAL SCIENCES
- Mechanisms for ribotoxin-induced ribosomal RNA cleavage
- (2012) Kaiyu He et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- An in vitro investigation of endocrine disrupting effects of trichothecenes deoxynivalenol (DON), T-2 and HT-2 toxins
- (2012) D.G. Ndossi et al. TOXICOLOGY LETTERS
- Assessment of human deoxynivalenol exposure using an LC–MS/MS based biomarker method
- (2012) Benedikt Warth et al. TOXICOLOGY LETTERS
- Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in rats
- (2012) Veronika Nagl et al. TOXICOLOGY LETTERS
- The interactions between endogenous bacteria, dietary components and the mucus layer of the large bowel
- (2012) Alicia M. Barnett et al. Food & Function
- Advances in Deoxynivalenol Toxicity Mechanisms: The Brain as a Target
- (2012) Marion Bonnet et al. Toxins
- Current Situation of Mycotoxin Contamination and Co-occurrence in Animal Feed—Focus on Europe
- (2012) Elisabeth Streit et al. Toxins
- Biological detoxification of the mycotoxin deoxynivalenol and its use in genetically engineered crops and feed additives
- (2011) Petr Karlovsky APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Chronic ingestion of deoxynivalenol and fumonisin, alone or in interaction, induces morphological and immunological changes in the intestine of piglets
- (2011) Ana-Paula F. L. Bracarense et al. BRITISH JOURNAL OF NUTRITION
- Morphofunctional Aspects of the Blood-Brain Barrier
- (2011) Beatrice Nico et al. CURRENT DRUG METABOLISM
- Thirteen novel deoxynivalenol-degrading bacteria are classified within two genera with distinct degradation mechanisms
- (2011) Ikuo Sato et al. FEMS MICROBIOLOGY LETTERS
- The ribotoxin deoxynivalenol affects the viability and functions of glial cells
- (2011) Helisoa Razafimanjato et al. GLIA
- The effect of deoxynivalenol on the secretion activity, proliferation and apoptosis of porcine ovarian granulosa cells in vitro
- (2011) Marina Medvedova et al. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
- Vulnerability of Polarised Intestinal Porcine Epithelial Cells to Mycotoxin Deoxynivalenol Depends on the Route of Application
- (2011) Anne-Kathrin Diesing et al. PLoS One
- The Mycotoxin Deoxynivalenol Potentiates Intestinal Inflammation by Salmonella Typhimurium in Porcine Ileal Loops
- (2011) Virginie Vandenbroucke et al. PLoS One
- The Food-Contaminant Deoxynivalenol Modifies Eating by Targeting Anorexigenic Neurocircuitry
- (2011) Clémence Girardet et al. PLoS One
- Central Inflammation and Sickness-Like Behavior Induced by the Food Contaminant Deoxynivalenol: A PGE2-Independent Mechanism
- (2011) Clémence Girardet et al. TOXICOLOGICAL SCIENCES
- Aerobic and anaerobic de-epoxydation of mycotoxin deoxynivalenol by bacteria originating from agricultural soil
- (2011) Rafiqul Islam et al. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
- The Human Gut Microbiome: Ecology and Recent Evolutionary Changes
- (2010) Jens Walter et al. Annual Review of Microbiology
- Comparative aspects ofin vitroproliferation of human and porcine lymphocytes exposed to mycotoxins
- (2010) Ionelia Taranu et al. ARCHIVES OF ANIMAL NUTRITION
- Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance
- (2010) James J. Pestka ARCHIVES OF TOXICOLOGY
- Glial cells of the nucleus tractus solitarius as partners of the dorsal hindbrain regulation of energy balance: A proposal for a working hypothesis
- (2010) Michel Dallaporta et al. BRAIN RESEARCH
- Studies on the toxicity of deoxynivalenol (DON), sodium metabisulfite, DON-sulfonate (DONS) and de-epoxy-DON for porcine peripheral blood mononuclear cells and the Intestinal Porcine Epithelial Cell lines IPEC-1 and IPEC-J2, and on effects of DON and DONS on piglets
- (2010) S. Dänicke et al. FOOD AND CHEMICAL TOXICOLOGY
- Assessment of deoxynivalenol metabolite profiles in UK adults
- (2010) Paul C. Turner et al. FOOD AND CHEMICAL TOXICOLOGY
- Lutein protects HT-29 cells against Deoxynivalenol-induced oxidative stress and apoptosis: Prevention of NF-κB nuclear localization and down regulation of NF-κB and Cyclo-Oxygenase – 2 expression
- (2010) Rajashree Krishnaswamy et al. FREE RADICAL BIOLOGY AND MEDICINE
- Determinants of Urinary Deoxynivalenol and De-epoxy Deoxynivalenol in Male Farmers from Normandy, France
- (2010) Paul C. Turner et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Repression of Peroxisome Proliferator-Activated Receptor by Mucosal Ribotoxic Insult-Activated CCAAT/Enhancer-Binding Protein Homologous Protein
- (2010) S.-H. Park et al. JOURNAL OF IMMUNOLOGY
- The food-associated fungal neurotoxin ochratoxin A inhibits the absorption of glutamate by astrocytes through a decrease in cell surface expression of the excitatory amino-acid transporters GLAST and GLT-1
- (2010) Helisoa Razafimanjato et al. NEUROTOXICOLOGY
- Endogenous versus Exogenous DNA Adducts: Their Role in Carcinogenesis, Epidemiology, and Risk Assessment
- (2010) J. A. Swenberg et al. TOXICOLOGICAL SCIENCES
- Physio-pathological parameters affect the activation of inflammatory pathways by deoxynivalenol in Caco-2 cells
- (2010) Jacqueline Van De Walle et al. TOXICOLOGY IN VITRO
- Mycotoxin deoxynivalenol (DON) mediates biphasic cellular response in intestinal porcine epithelial cell lines IPEC-1 and IPEC-J2
- (2010) Anne-Kathrin Diesing et al. TOXICOLOGY LETTERS
- Some food-associated mycotoxins as potential risk factors in humans predisposed to chronic intestinal inflammatory diseases
- (2010) Marc Maresca et al. TOXICON
- Deoxynivalenol-Induced Proinflammatory Gene Expression: Mechanisms and Pathological Sequelae
- (2010) James J. Pestka Toxins
- Mycotoxins and human disease: a largely ignored global health issue
- (2009) C. P. Wild et al. CARCINOGENESIS
- Implications of the Dominant Role of Transporters in Drug Uptake by Cells (Supplementary Material)
- (2009) Paul Dobson et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Overexpression of human histone methylase MLL1 upon exposure to a food contaminant mycotoxin, deoxynivalenol
- (2009) Khairul I. Ansari et al. FEBS Journal
- Comparison of human health risks resulting from exposure to fungicides and mycotoxins via food
- (2009) Stefan D. Muri et al. FOOD AND CHEMICAL TOXICOLOGY
- Occurrence of Mycotoxins in Feed as Analyzed by a Multi-Mycotoxin LC-MS/MS Method
- (2009) Sofie Monbaliu et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Suppression of Insulin-Like Growth Factor Acid-Labile Subunit Expression—A Novel Mechanism for Deoxynivalenol-Induced Growth Retardation
- (2009) Chidozie J. Amuzie et al. TOXICOLOGICAL SCIENCES
- A New Perspective on Deoxynivalenol and Growth Suppression
- (2009) Kenneth A. Voss TOXICOLOGICAL SCIENCES
- The mycotoxin Deoxynivalenol inhibits the cell surface expression of activation markers in human macrophages
- (2009) Yann J. Waché et al. TOXICOLOGY
- HuR/ELAVL1 RNA binding protein modulates interleukin-8 induction by muco-active ribotoxin deoxynivalenol
- (2009) Hye Jin Choi et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression
- (2009) Philippe Pinton et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Deoxynivalenol and nivalenol inhibit lipopolysaccharide-induced nitric oxide production by mouse macrophage cells
- (2009) Kei-ichi Sugiyama et al. TOXICOLOGY LETTERS
- The mycotoxin deoxynivalenol promotes uptake ofSalmonellaTyphimurium in porcine macrophages, associated with ERK1/2 induced cytoskeleton reorganization
- (2009) Virginie Vandenbroucke et al. VETERINARY RESEARCH
- Epithelial cell survival by activating transcription factor 3 (ATF3) in response to chemical ribosome-inactivating stress
- (2008) Hyun Yang et al. BIOCHEMICAL PHARMACOLOGY
- Tight junctions as targets of infectious agents
- (2008) Julian A. Guttman et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Lipopolysaccharide Induces Inhibition of Galactose Intestinal Transport in Rabbits in vitro
- (2008) Pilar Amador et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Neuron–glia crosstalk gets serious: role in pain hypersensitivity
- (2008) Ke Ren et al. Current Opinion in Anesthesiology
- Mechanisms of deoxynivalenol-induced gene expression and apoptosis
- (2008) J.J. Pestka Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment
- Impact of Deoxynivalenol on the Intestinal Microflora of Pigs
- (2008) Yann Waché et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Effects of B-trichothecenes on luminal glucose transport across the isolated jejunal epithelium of broiler chickens
- (2008) W. A. Awad et al. JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
- Functions of natural killer cells
- (2008) Eric Vivier et al. NATURE IMMUNOLOGY
- Astrocytic involvement in learning and memory consolidation
- (2008) Marie E. Gibbs et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Influence of deoxynivalenol on NF-κB activation and IL-8 secretion in human intestinal Caco-2 cells
- (2008) Jacqueline Van De Walle et al. TOXICOLOGY LETTERS
- Ingestion of deoxynivalenol (DON) contaminated feed alters the pig vaccinal immune responses
- (2008) Philippe Pinton et al. TOXICOLOGY LETTERS
- Immunochemical assessment of deoxynivalenol tissue distribution following oral exposure in the mouse
- (2008) James J. Pestka et al. TOXICOLOGY LETTERS
- Deoxynivalenol-induced cytotoxicity, cytokines and related genes in unstimulated or lipopolysaccharide stimulated primary porcine macrophages
- (2008) Susanne Döll et al. TOXICOLOGY LETTERS
- In vitro evaluation of feed-grade enzyme activity at pH levels simulating various parts of the avian digestive tract
- (2007) T. Ao et al. ANIMAL FEED SCIENCE AND TECHNOLOGY
- Both direct and indirect effects account for the pro-inflammatory activity of enteropathogenic mycotoxins on the human intestinal epithelium: Stimulation of interleukin-8 secretion, potentiation of interleukin-1β effect and increase in the transepithelial passage of commensal bacteria
- (2007) Marc Maresca et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started