Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse

Autonomy declared by primary cilia through compartmentalization of membrane phosphoinositides

(2018) Siew Cheng Phua et al.   CURRENT OPINION IN CELL BIOLOGY

Actin filaments partition primary cilia membranes into distinct fluid corrals

(2018) Sungsu Lee et al.   JOURNAL OF CELL BIOLOGY

Integrins Modulate T Cell Receptor Signaling by Constraining Actin Flow at the Immunological Synapse

(2018) Katarzyna I. Jankowska et al.   Frontiers in Immunology

Regulation of actin assembly by PI(4,5)P2 and other inositol phospholipids: An update on possible mechanisms

(2018) Paul A. Janmey et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The regulation of cilium assembly and disassembly in development and disease

(2018) Lei Wang et al.   DEVELOPMENT

PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes

(2018) Christian M. Gawden-Bone et al.   IMMUNITY

Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus

(2018) Federico Andrea Moretti et al.   eLife

Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+CTLs

(2017) Senta M. Kapnick et al.   JOURNAL OF IMMUNOLOGY

A FRET sensor enables quantitative measurements of membrane charges in live cells

(2017) Yuanqing Ma et al.   NATURE BIOTECHNOLOGY

Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes

(2017) Alex T. Ritter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical Communication at the Immunological Synapse

(2017) Roshni Basu et al.   TRENDS IN CELL BIOLOGY

A recombinant BBSome core complex and how it interacts with ciliary cargo

(2017) Björn Udo Klink et al.   eLife

Introducing Membrane Charge and Membrane Potential to T Cell Signaling

(2017) Yuanqing Ma et al.   Frontiers in Immunology

Structure and lipid-binding properties of the kindlin-3 pleckstrin homology domain

(2016) Tao Ni et al.   BIOCHEMICAL JOURNAL

Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing

(2016) Roshni Basu et al.   CELL

Embracing the Enemy: Cell-to-Cell Force Transmission Enhances Cytotoxicity

(2016) Nathan H. Roy et al.   DEVELOPMENTAL CELL

Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling

(2016) Sandra Hakim et al.   HUMAN MOLECULAR GENETICS

Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability

(2016) Luís C Santos et al.   IMMUNOLOGY AND CELL BIOLOGY

INPP5E regulates phosphoinositide-dependent cilia transition zone function

(2016) Jennifer M. Dyson et al.   JOURNAL OF CELL BIOLOGY

The cytotoxic T lymphocyte immune synapse at a glance

(2016) Nele M. G. Dieckmann et al.   JOURNAL OF CELL SCIENCE

Phosphatidylinositol 4-Phosphate 5-Kinase β Controls Recruitment of Lipid Rafts into the Immunological Synapse

(2016) Marinos Kallikourdis et al.   JOURNAL OF IMMUNOLOGY

Deletion of the genePip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system

(2016) Hyeseok Shim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis

(2016) Qingwen Xu et al.   Nature Communications

Phosphatidylinositol 4-Phosphate 5-Kinases in the Regulation of T Cell Activation

(2016) Nicla Porciello et al.   Frontiers in Immunology

Dynamic Regulation of TCR–Microclusters and the Microsynapse for T Cell Activation

(2016) Akiko Hashimoto-Tane et al.   Frontiers in Immunology

The activation loop of PIP5K functions as a membrane sensor essential for lipid substrate processing

(2016) A. Liu et al.   Science Advances

Phosphoinositides in phagocytosis and macropinocytosis

(2015) Roni Levin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output

(2015) Marcelo Chávez et al.   DEVELOPMENTAL CELL

Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling

(2015) Francesc R. Garcia-Gonzalo et al.   DEVELOPMENTAL CELL

Formation of the transition zone by Mks5/Rpgrip1L establishes a ciliary zone of exclusion (CIZE) that compartmentalises ciliary signalling proteins and controls PIP2 ciliary abundance

(2015) V. L. Jensen et al.   EMBO JOURNAL

Actin Depletion Initiates Events Leading to Granule Secretion at the Immunological Synapse

(2015) Alex T. Ritter et al.   IMMUNITY

The Linker for Activation of T Cells (LAT) Signaling Hub: From Signaling Complexes to Microclusters

(2015) Lakshmi Balagopalan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Centrin2 regulates CP110 removal in primary cilium formation

(2015) Suzanna L. Prosser et al.   JOURNAL OF CELL BIOLOGY

F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse

(2015) William A. Comrie et al.   JOURNAL OF CELL BIOLOGY

The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobility

(2015) William A. Comrie et al.   JOURNAL OF CELL BIOLOGY

Redundant and specialized roles for diacylglycerol kinases   and   in the control of T cell functions

(2015) I. Merida et al.   Science Signaling

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

(2015) Sudha Kumari et al.   eLife

Redundant and specialized roles for diacylglycerol kinases   and   in the control of T cell functions

(2015) I. Merida et al.   Science Signaling

Signaling through C2 domains: More than one lipid target

(2014) Senena Corbalan-Garcia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The role of the cytoskeleton at the immunological synapse

(2014) Alex T. Ritter et al.   IMMUNOLOGICAL REVIEWS

Ezrin and Moesin Function Together to Promote T Cell Activation

(2014) M. H. Shaffer et al.   JOURNAL OF IMMUNOLOGY

Quantitative Phosphoproteomics of Cytotoxic T Cells to Reveal Protein Kinase D 2 Regulated Networks

(2014) María N. Navarro et al.   MOLECULAR & CELLULAR PROTEOMICS

Diacylglycerol kinase   establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse

(2014) A. Chauveau et al.   Science Signaling

Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL

(2014) Misty R Jenkins et al.   eLife

The calcium feedback loop and T cell activation: How cytoskeleton networks control intracellular calcium flux

(2013) Noah Joseph et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The  2 integrin-kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo

(2013) V. L. Morrison et al.   BLOOD

Annular PIP 3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse

(2013) Audrey Le Floc’h et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

In Silico Modeling of Itk Activation Kinetics in Thymocytes Suggests Competing Positive and Negative IP4 Mediated Feedbacks Increase Robustness

(2013) Sayak Mukherjee et al.   PLoS One

Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells

(2013) F. A. Moretti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II

(2013) X. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Emerging Role for PI5P in T Cell Biology

(2013) Jacques A. Nunès et al.   Frontiers in Immunology

Modification of Lipid Bilayer Structure by Diacylglycerol: A Comparative Study of Diacylglycerol and Cholesterol

(2012) Mohammad Alwarawrah et al.   Journal of Chemical Theory and Computation

Phosphatidylserine dynamics in cellular membranes

(2012) Jason G. Kay et al.   MOLECULAR BIOLOGY OF THE CELL

Stages of ciliogenesis and regulation of ciliary length

(2011) Prachee Avasthi et al.   DIFFERENTIATION

Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling

(2011) Søren T Christensen et al.   JOURNAL OF PATHOLOGY

A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells

(2011) Emily J Quann et al.   NATURE IMMUNOLOGY

Phosphatidylinositol (4,5) Bisphosphate Controls T Cell Activation by Regulating T Cell Rigidity and Organization

(2011) Yi Sun et al.   PLoS One

Natural Killer Cell Lytic Granule Secretion Occurs through a Pervasive Actin Network at the Immune Synapse

(2011) Gregory D. Rak et al.   PLOS BIOLOGY

Remodelling of Cortical Actin Where Lytic Granules Dock at Natural Killer Cell Immune Synapses Revealed by Super-Resolution Microscopy

(2011) Alice C. N. Brown et al.   PLOS BIOLOGY

The Conserved Bardet-Biedl Syndrome Proteins Assemble a Coat that Traffics Membrane Proteins to Cilia

(2010) Hua Jin et al.   CELL

Evidence for a positive role of PtdIns5P in T-cell signal transduction pathways

(2010) Geoffrey Guittard et al.   FEBS LETTERS

The primary cilium at a glance

(2010) P. Satir et al.   JOURNAL OF CELL SCIENCE

Rac controls PIP5K localisation and PtdIns(4,5)P2 synthesis, which modulates vinculin localisation and neurite dynamics

(2010) J. R. Halstead et al.   JOURNAL OF CELL SCIENCE

Altered Actin Centripetal Retrograde Flow in Physically Restricted Immunological Synapses

(2010) Cheng-han Yu et al.   PLoS One

The LAT Story: A Tale of Cooperativity, Coordination, and Choreography

(2010) L. Balagopalan et al.   Cold Spring Harbor Perspectives in Biology

An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis

(2009) Gregory D. Fairn et al.   JOURNAL OF CELL BIOLOGY

Phospholipase C–mediated hydrolysis of PIP2 releases ERM proteins from lymphocyte membrane

(2009) Jian-Jiang Hao et al.   JOURNAL OF CELL BIOLOGY

PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions

(2009) I. van den Bout et al.   JOURNAL OF CELL SCIENCE

Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells

(2009) Emily J Quann et al.   NATURE IMMUNOLOGY

β-Arrestin Scaffolding of Phosphatidylinositol 4-Phosphate 5-Kinase Iα Promotes Agonist-stimulated Sequestration of the β2-Adrenergic Receptor

(2008) Christopher D. Nelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane recognition by phospholipid-binding domains

(2008) Mark A. Lemmon   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization

(2008) T. Yeung et al.   SCIENCE