Redundant and specialized roles for diacylglycerol kinases   and   in the control of T cell functions

Diacylglycerol lipaseregulates lifespan and oxidative stress response by inversely modulating TOR signaling inDrosophilaandC. elegans

(2014) Yen-Hung Lin et al.   AGING CELL

Immune modulation for cancer therapy

(2014) J Naidoo et al.   BRITISH JOURNAL OF CANCER

Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor-Transduced Human T cells in Solid Tumors

(2014) E. K. Moon et al.   CLINICAL CANCER RESEARCH

NK-cell dysfunction in human renal carcinoma reveals diacylglycerol kinase as key regulator and target for therapeutic intervention

(2014) Petra U. Prinz et al.   INTERNATIONAL JOURNAL OF CANCER

Diacylglycerol Kinase α Regulates Tubular Recycling Endosome Biogenesis and Major Histocompatibility Complex Class I Recycling

(2014) Shuwei Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lck-Dependent Tyrosine Phosphorylation of Diacylglycerol Kinase α Regulates Its Membrane Association in T Cells

(2014) Ernesto Merino et al.   JOURNAL OF IMMUNOLOGY

Mammalian Target of Rapamycin Complex 2 Regulates Invariant NKT Cell Development and Function Independent of Promyelocytic Leukemia Zinc-Finger

(2014) Nicolas Prevot et al.   JOURNAL OF IMMUNOLOGY

Insights into the initiation of TCR signaling

(2014) Arup K Chakraborty et al.   NATURE IMMUNOLOGY

Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function

(2014) J. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diacylglycerol kinase   establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse

(2014) A. Chauveau et al.   Science Signaling

EF-hand motifs of diacylglycerol kinase α interact intra-molecularly with its C1 domains

(2014) Tatsuya Yamamoto et al.   FEBS Open Bio

Chimeric Antigen Receptor Therapy for Cancer

(2013) David M. Barrett et al.   Annual Review of Medicine

Enhanced Effector Responses in Activated CD8+ T Cells Deficient in Diacylglycerol Kinases

(2013) M. J. Riese et al.   CANCER RESEARCH

The Role of Diacylglycerol Kinase ζ and Phosphatidic Acid in the Mechanical Activation of Mammalian Target of Rapamycin (mTOR) Signaling and Skeletal Muscle Hypertrophy

(2013) Jae-Sung You et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient PKC  shuttling to the immunological synapse is governed by DGK  and regulates L-selectin shedding

(2013) S. I. Gharbi et al.   JOURNAL OF CELL SCIENCE

Phosphatidylinositol 4-Phosphate 5-Kinase   Activation Critically Contributes to CD28-Dependent Signaling Responses

(2013) M. Muscolini et al.   JOURNAL OF IMMUNOLOGY

A miR-297/hypoxia/DGK-α axis regulating glioblastoma survival

(2013) Benjamin Kefas et al.   NEURO-ONCOLOGY

MicroRNA-34a Enhances T Cell Activation by Targeting Diacylglycerol Kinase ζ

(2013) Jinwook Shin et al.   PLoS One

An initial and rapid step of lytic granule secretion precedes microtubule organizing center polarization at the cytotoxic T lymphocyte/target cell synapse

(2013) F. Bertrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog Signaling Controls T Cell Killing at the Immunological Synapse

(2013) M. de la Roche et al.   SCIENCE

The   Isoform of Diacylglycerol Kinase Plays a Predominant Role in Regulatory T Cell Development and TCR-Mediated Ras Signaling

(2013) R. P. Joshi et al.   Science Signaling

Diacylglycerol Kinase   Limits the Generation of Natural Regulatory T Cells

(2013) A. M. Schmidt et al.   Science Signaling

Diacylglycerol metabolism attenuates T-cell receptor signaling and alters thymocyte differentiation

(2013) M Almena et al.   Cell Death & Disease

Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies

(2013) Stephen R Daley et al.   eLife

Coinhibitory molecules in hematologic malignancies: targets for therapeutic intervention

(2012) W. J. Norde et al.   BLOOD

Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration

(2012) Elena Rainero et al.   JOURNAL OF CELL BIOLOGY

Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo

(2012) Yan Zheng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High DGK-  and Disabled MAPK Pathways Cause Dysfunction of Human Tumor-Infiltrating CD8+ T Cells That Is Reversible by Pharmacologic Intervention

(2012) P. U. Prinz et al.   JOURNAL OF IMMUNOLOGY

Differential Regulation of Primary and Memory CD8 T Cell Immune Responses by Diacylglycerol Kinases

(2012) J. Shin et al.   JOURNAL OF IMMUNOLOGY

FoxO-Dependent Regulation of Diacylglycerol Kinase   Gene Expression

(2012) M. Martinez-Moreno et al.   MOLECULAR AND CELLULAR BIOLOGY

SLAM Family Receptors and SAP Adaptors in Immunity

(2011) Jennifer L. Cannons et al.   Annual Review of Immunology

Negative regulation of mTOR activation by diacylglycerol kinases

(2011) B. K. Gorentla et al.   BLOOD

Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape

(2011) S.-R. Woo et al.   CANCER RESEARCH

Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes

(2011) R Alonso et al.   CELL DEATH AND DIFFERENTIATION

Protein Kinase B Controls Transcriptional Programs that Direct Cytotoxic T Cell Fate but Is Dispensable for T Cell Metabolism

(2011) Andrew N. Macintyre et al.   IMMUNITY

Translocation dynamics of sorting nexin 27 in activated T cells

(2011) E. Rincon et al.   JOURNAL OF CELL SCIENCE

SAP-Mediated Inhibition of Diacylglycerol Kinase   Regulates TCR-Induced Diacylglycerol Signaling

(2011) G. Baldanzi et al.   JOURNAL OF IMMUNOLOGY

Critical Roles of RasGRP1 for Invariant NKT Cell Development

(2011) S. Shen et al.   JOURNAL OF IMMUNOLOGY

Tight Regulation of Diacylglycerol-Mediated Signaling Is Critical for Proper Invariant NKT Cell Development

(2011) S. Shen et al.   JOURNAL OF IMMUNOLOGY

Diacylglycerol kinase ζ controls diacylglycerol metabolism at the immunological synapse

(2011) Severine I. Gharbi et al.   MOLECULAR BIOLOGY OF THE CELL

A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells

(2011) Emily J Quann et al.   NATURE IMMUNOLOGY

A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28

(2011) Kok-Fai Kong et al.   NATURE IMMUNOLOGY

Phosphatidylinositol (4,5) Bisphosphate Controls T Cell Activation by Regulating T Cell Rigidity and Organization

(2011) Yi Sun et al.   PLoS One

Becoming self-aware: the thymic education of regulatory T cells

(2010) Chan-Wang J Lio et al.   CURRENT OPINION IN IMMUNOLOGY

Decreased Diacylglycerol Metabolism Enhances ERK Activation and Augments CD8+T Cell Functional Responses

(2010) Matthew J. Riese et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Putting the brakes on BTLA in T cell–mediated cancer immunotherapy

(2010) Chrystal M. Paulos et al.   JOURNAL OF CLINICAL INVESTIGATION

Diacylglycerol kinase   mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI

(2010) F. Chianale et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stability of the Regulatory T Cell Lineage in Vivo

(2010) Y. P. Rubtsov et al.   SCIENCE

Functional Anatomy of T Cell Activation and Synapse Formation

(2009) David R. Fooksman et al.   Annual Review of Immunology

Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells

(2009) Jayajit Das et al.   CELL

Regulation of T-cell tolerance by calcium/NFAT signaling

(2009) Ian Baine et al.   IMMUNOLOGICAL REVIEWS

Impact of Epitope Escape on PD-1 Expression and CD8 T-Cell Exhaustion during Chronic Infection

(2009) J. N. Blattman et al.   JOURNAL OF VIROLOGY

Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells

(2009) Emily J Quann et al.   NATURE IMMUNOLOGY

The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells

(2009) Vanja Lazarevic et al.   NATURE IMMUNOLOGY

Foxp3+ regulatory T cells: differentiation, specification, subphenotypes

(2009) Markus Feuerer et al.   NATURE IMMUNOLOGY

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

Synergistic control of T cell development and tumor suppression by diacylglycerol kinase   and  

(2008) R. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diacylglycerol kinases: at the hub of cell signalling

(2007) Isabel Mérida et al.   BIOCHEMICAL JOURNAL