Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling

Phosphatidylinositol (3,4) bisphosphate-specific phosphatases and effector proteins: A distinct branch of PI3K signaling

(2015) Hongzhao Li et al.   CELLULAR SIGNALLING

Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output

(2015) Marcelo Chávez et al.   DEVELOPMENTAL CELL

Classes of phosphoinositide 3-kinases at a glance

(2014) S. Jean et al.   JOURNAL OF CELL SCIENCE

Acquired resistance to temsirolimus in human renal cell carcinoma cells is mediated by the constitutive activation of signal transduction pathways through mTORC2

(2013) K Harada et al.   BRITISH JOURNAL OF CANCER

Inhibition of Rapamycin-Induced AKT Activation Elicits Differential Antitumor Response in Head and Neck Cancers

(2013) P. Radhakrishnan et al.   CANCER RESEARCH

An inducible knockout mouse to model the cell-autonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias

(2013) C. Mirantes et al.   Disease Models & Mechanisms

Phenotypic spectrum and prevalence of INPP5E mutations in Joubert Syndrome and related disorders

(2013) Lorena Travaglini et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Inhibition of 72 kDa inositol polyphosphate 5-phosphatase E improves insulin signal transduction in diet-induced obesity

(2013) Daniela F Bertelli et al.   JOURNAL OF ENDOCRINOLOGY

Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease

(2013) Ming Ma et al.   NATURE GENETICS

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

(2013) S. A. Kang et al.   SCIENCE

Role of PRAS40 in Akt and mTOR signaling in health and disease

(2012) Claudia Wiza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Animal Models for Human Polycystic Kidney Disease

(2012) Shizuko NAGAO et al.   EXPERIMENTAL ANIMALS

Endogenous viruses: insights into viral evolution and impact on host biology

(2012) Cédric Feschotte et al.   NATURE REVIEWS GENETICS

Current insights into renal ciliopathies: what can genetics teach us?

(2012) Heleen H. Arts et al.   PEDIATRIC NEPHROLOGY

Low-Dose Oral Sirolimus and the Risk of Menstrual-Cycle Disturbances and Ovarian Cysts: Analysis of the Randomized Controlled SUISSE ADPKD Trial

(2012) Matthias Braun et al.   PLoS One

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting

(2012) M. C. Humbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

(2011) Brian Magnuson et al.   BIOCHEMICAL JOURNAL

Putative roles of cilia in polycystic kidney disease

(2011) Paul Winyard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Educational paper

(2011) Carsten Bergmann   EUROPEAN JOURNAL OF PEDIATRICS

Regulation of IGF-1/PI3K/Akt signalling by the phosphoinositide phosphatase pharbin

(2011) F. Wang et al.   JOURNAL OF BIOCHEMISTRY

Loss of Primary Cilia Upregulates Renal Hypertrophic Signaling and Promotes Cystogenesis

(2011) P. D. Bell et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Ciliopathies

(2011) Friedhelm Hildebrandt et al.   NEW ENGLAND JOURNAL OF MEDICINE

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling

(2011) V. S. Rodrik-Outmezguine et al.   Cancer Discovery

Molecular Advances in Autosomal Dominant Polycystic Kidney Disease

(2010) Anna Rachel Gallagher et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Everolimus

(2010) P. J. Houghton   CLINICAL CANCER RESEARCH

Kidney-specific inactivation of Ofd1 leads to renal cystic disease associated with upregulation of the mTOR pathway

(2010) Alessandro Zullo et al.   HUMAN MOLECULAR GENETICS

Coordinate Control of Host Centrosome Position, Organelle Distribution, and Migratory Response byToxoplasma gondiivia Host mTORC2

(2010) Yubao Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases

(2010) Ana V. Miletic et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rapamycin Ameliorates PKD Resulting from Conditional Inactivation of Pkd1

(2010) J. M. Shillingford et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Primary cilia regulate mTORC1 activity and cell size through Lkb1

(2010) Christopher Boehlke et al.   NATURE CELL BIOLOGY

Tuberous Sclerosis Complex Renal Disease

(2010) Bradley P. Dixon et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Carboxy Terminal Tail of Polycystin-1 Regulates Localization of TSC2 to Repress mTOR

(2010) Ruhee Dere et al.   PLoS One

A complex interplay between Akt, TSC2 and the two mTOR complexes: Figure 1

(2009) Jingxiang Huang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Current Perspectives on Akt Akt-ivation and Akt-ions

(2009) Ronald W. Matheny et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Defects in cell polarity underlie TSC and ADPKD-associated cystogenesis

(2009) Cleo S. Bonnet et al.   HUMAN MOLECULAR GENETICS

Loss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1

(2009) Jing Zhou et al.   HUMAN MOLECULAR GENETICS

Late progression of renal pathology and cyst enlargement is reduced by rapamycin in a mouse model of nephronophthisis

(2009) Vincent H. Gattone et al.   KIDNEY INTERNATIONAL

Polycystin-1 Regulates Extracellular Signal-Regulated Kinase-Dependent Phosphorylation of Tuberin To Control Cell Size through mTOR and Its Downstream Effectors S6K and 4EBP1

(2009) G. Distefano et al.   MOLECULAR AND CELLULAR BIOLOGY

INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse

(2009) Monique Jacoby et al.   NATURE GENETICS

Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies

(2009) Stephanie L Bielas et al.   NATURE GENETICS

A Phosphoinositide 3-Kinase/Phospholipase Cgamma1 Pathway Regulates Fibroblast Growth Factor-Induced Capillary Tube Formation

(2009) Tania Maffucci et al.   PLoS One

Polycystic Kidney Disease

(2008) Peter C. Harris et al.   Annual Review of Medicine

Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia

(2008) Vishal Patel et al.   HUMAN MOLECULAR GENETICS

TRPP2 and TRPV4 form a polymodal sensory channel complex

(2008) Michael Köttgen et al.   JOURNAL OF CELL BIOLOGY

Sporadic clear cell renal cell carcinoma but not the papillary type is characterized by severely reduced frequency of primary cilia

(2008) Peter Schraml et al.   MODERN PATHOLOGY

Combined Vhlh and Pten Mutation Causes Genital Tract Cystadenoma and Squamous Metaplasia

(2008) I. J. Frew et al.   MOLECULAR AND CELLULAR BIOLOGY

Increased Insulin Action in SKIP Heterozygous Knockout Mice

(2008) T. Ijuin et al.   MOLECULAR AND CELLULAR BIOLOGY

An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice

(2008) Milena Traykova-Brauch et al.   NATURE MEDICINE

Autosomal Dominant Polycystic Kidney Disease

(2008) Jared J. Grantham   NEW ENGLAND JOURNAL OF MEDICINE

PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity

(2007) Kewei Ma et al.   CELLULAR SIGNALLING