Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL

Super-resolution imaging of remodeled synaptic actin reveals different synergies between NK cell receptors and integrins

(2012) A. C. N. Brown et al.   BLOOD

Positive and Negative Signaling through SLAM Receptors Regulate Synapse Organization and Thresholds of Cytolysis

(2012) Fang Zhao et al.   IMMUNITY

F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation

(2012) Alexander Babich et al.   JOURNAL OF CELL BIOLOGY

Cytokine Secretion by CD4+ T Cells at the Immunological Synapse Requires Cdc42-Dependent Local Actin Remodeling but Not Microtubule Organizing Center Polarity

(2012) K. Chemin et al.   JOURNAL OF IMMUNOLOGY

Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cells

(2012) Jason Yi et al.   MOLECULAR BIOLOGY OF THE CELL

Integration of the movement of signaling microclusters with cellular motility in immunological synapses

(2012) Peter Beemiller et al.   NATURE IMMUNOLOGY

The integrin LFA-1 signals through ZAP-70 to regulate expression of high-affinity LFA-1 on T lymphocytes

(2011) R. Evans et al.   BLOOD

Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems

(2011) Jane C Stinchcombe et al.   BMC BIOLOGY

Minimal Engagement of CD103 on Cytotoxic T Lymphocytes with an E-Cadherin-Fc Molecule Triggers Lytic Granule Polarization via a Phospholipase Cγ–Dependent Pathway

(2011) Audrey Le Floc'h et al.   CANCER RESEARCH

Centrosome docking at the immunological synapse is controlled by Lck signaling

(2011) Andy Tsun et al.   JOURNAL OF CELL BIOLOGY

Contact-Dependent T Cell Activation and T Cell Stopping Require Talin1

(2011) S. A. Wernimont et al.   JOURNAL OF IMMUNOLOGY

 2 Integrin Induces TCR -Syk-Phospholipase C-  Phosphorylation and Paxillin-Dependent Granule Polarization in Human NK Cells

(2011) M. E. March et al.   JOURNAL OF IMMUNOLOGY

CD4+ T-cell synapses involve multiple distinct stages

(2011) H. Ueda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The synapse and cytolytic machinery of cytotoxic T cells

(2010) Misty R Jenkins et al.   CURRENT OPINION IN IMMUNOLOGY

A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity

(2010) Byron B Au-Yeung et al.   NATURE IMMUNOLOGY

Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors

(2009) Y. T. Bryceson et al.   BLOOD

Chemokine-Induced Zap70 Kinase-Mediated Dissociation of the Vav1-Talin Complex Activates α4β1 Integrin for T Cell Adhesion

(2009) David García-Bernal et al.   IMMUNITY

The Strength of T Cell Receptor Signal Controls the Polarization of Cytotoxic Machinery to the Immunological Synapse

(2009) Misty R. Jenkins et al.   IMMUNITY

The structure, regulation, and function of ZAP-70

(2009) Byron B. Au-Yeung et al.   IMMUNOLOGICAL REVIEWS

Inhibition of ZAP-70 Kinase Activity via an Analog-sensitive Allele Blocks T Cell Receptor and CD28 Superagonist Signaling

(2008) Susan E. Levin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY