Phosphatidylinositol 4-Phosphate 5-Kinases in the Regulation of T Cell Activation

CD28 costimulatory signals in T lymphocyte activation: Emerging functions beyond a qualitative and quantitative support to TCR signalling

(2016) Nicla Porciello et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The multifaceted role of PIP2 in leukocyte biology

(2015) Loretta Tuosto et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Type I phosphatidylinositol 4-phosphate 5-kinase homo- and heterodimerization determines its membrane localization and activity

(2015) Rosa Ana Lacalle et al.   FASEB JOURNAL

TCR and CD28 activate the transcription factor NF-κB in T-cells via distinct adaptor signaling complexes

(2015) Youg Raj Thaker et al.   IMMUNOLOGY LETTERS

T cell metabolism and susceptibility to autoimmune diseases

(2015) Mario Galgani et al.   MOLECULAR IMMUNOLOGY

Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions

(2015) Clovis S. Palmer et al.   Frontiers in Immunology

CD28 ligation in the absence of TCR stimulation up-regulates IL-17A and pro-inflammatory cytokines in relapsing-remitting multiple sclerosis T lymphocytes

(2014) Cristina Camperio et al.   IMMUNOLOGY LETTERS

Phosphatidylinositol 4–Phosphate 5–Kinase α and Vav1 Mutual Cooperation in CD28-Mediated Actin Remodeling and Signaling Functions

(2014) Michela Muscolini et al.   JOURNAL OF IMMUNOLOGY

Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse

(2014) Kaushik Choudhuri et al.   NATURE

The role of PI3K/AKT-related PIP5K1  and the discovery of its selective inhibitor for treatment of advanced prostate cancer

(2014) J. Semenas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PIP2: choreographer of actin-adaptor proteins in the HIV-1 dance

(2014) Vera Rocha-Perugini et al.   TRENDS IN MICROBIOLOGY

Phosphatidylinositol 4-Phosphate 5-Kinase   Activation Critically Contributes to CD28-Dependent Signaling Responses

(2013) M. Muscolini et al.   JOURNAL OF IMMUNOLOGY

Rho family GTPases

(2012) Alan Hall   BIOCHEMICAL SOCIETY TRANSACTIONS

Transfer of extracellular vesicles during immune cell-cell interactions

(2012) Cristina Gutiérrez-Vázquez et al.   IMMUNOLOGICAL REVIEWS

Regulation of glucose metabolism in T cells: new insight into the role of Phosphoinositide 3-kinases

(2012) David K. Finlay   Frontiers in Immunology

Phosphatidylinositol-4-Phosphate-5-Kinase   Deficiency Alters Dynamics of Glucose-Stimulated Insulin Release to Improve Glucohomeostasis and Decrease Obesity in Mice

(2011) P. Huang et al.   DIABETES

A novel association between filamin A and NF-κB inducing kinase couples CD28 to inhibitor of NF-κB kinase α and NF-κB activation

(2011) Michela Muscolini et al.   IMMUNOLOGY LETTERS

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Phosphatidylinositol (4,5) Bisphosphate Controls T Cell Activation by Regulating T Cell Rigidity and Organization

(2011) Yi Sun et al.   PLoS One

One lipid, multiple functions: how various pools of PI(4,5)P2 are created in the plasma membrane

(2010) Katarzyna Kwiatkowska   CELLULAR AND MOLECULAR LIFE SCIENCES

NF-κB family of transcription factors: Biochemical players of CD28 co-stimulation

(2010) Loretta Tuosto   IMMUNOLOGY LETTERS

PIPKI 90 Negatively Regulates LFA-1-Mediated Adhesion and Activation in Antigen-Induced CD4+ T Cells

(2010) S. A. Wernimont et al.   JOURNAL OF IMMUNOLOGY

Revitalizing membrane rafts: new tools and insights

(2010) Kai Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of the Actin Cytoskeleton-Plasma Membrane Interplay by Phosphoinositides

(2010) Juha Saarikangas et al.   PHYSIOLOGICAL REVIEWS

Nck adapter proteins: functional versatility in T cells

(2009) Marcus Lettau et al.   Cell Communication and Signaling

PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions

(2009) I. van den Bout et al.   JOURNAL OF CELL SCIENCE

Phosphatidylinositol-4-phosphate 5-kinase 1α Mediates Extracellular Calcium-induced Keratinocyte Differentiation

(2009) Zhongjian Xie et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of conformer-specific activation of the integrin LFA-1 by a chemokine-triggered Rho signaling module

(2009) Matteo Bolomini-Vittori et al.   NATURE IMMUNOLOGY

The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-κB and activate T cells

(2009) Sung-Gyoo Park et al.   NATURE IMMUNOLOGY

Spatiotemporal Patterning During T Cell Activation Is Highly Diverse

(2009) K. L. Singleton et al.   Science Signaling

Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrum

(2009) Christy A. Barlow et al.   TRENDS IN CELL BIOLOGY

CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription

(2008) Helga Schneider et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CD28 ligation in the absence of TCR promotes RelA/NF-κB recruitment and trans-activation of the HIV-1 LTR

(2008) Alessandro Annibaldi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Spatiotemporal Regulation of T Cell Costimulation by TCR-CD28 Microclusters and Protein Kinase C θ Translocation

(2008) Tadashi Yokosuka et al.   IMMUNITY

A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs

(2008) David L. Mellman et al.   NATURE

The proteolytic activity of the paracaspase MALT1 is key in T cell activation

(2008) Fabien Rebeaud et al.   NATURE IMMUNOLOGY

Loss of PIP5KI  demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation

(2008) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of actin cytoskeleton dynamics by Arf-family GTPases

(2008) Kenneth R. Myers et al.   TRENDS IN CELL BIOLOGY

PI5KI-dependent signals are critical regulators of the cytolytic secretory pathway

(2007) F. Micucci et al.   BLOOD