Targeting GABAAR-Associated Proteins: New Modulators, Labels and Concepts

GABAAR Modulator for Postpartum Depression

(2019) Istvan Mody   CELL

Fractional occupancy of synaptic binding sites and the molecular plasticity of inhibitory synapses

(2019) Christian G. Specht   NEUROPHARMACOLOGY

Mutation p.R356Q in the Collybistin Phosphoinositide Binding Site Is Associated With Mild Intellectual Disability

(2019) Tzu-Ting Chiou et al.   Frontiers in Molecular Neuroscience

Alterations in GABAA-Receptor Trafficking and Synaptic Dysfunction in Brain Disorders

(2019) Miranda Mele et al.   Frontiers in Cellular Neuroscience

Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins

(2019) Vikram Babu Kasaragod et al.   NEURON

Modulation of GABAA Receptors in the Treatment of Epilepsy

(2018) Eleonora Palma et al.   CURRENT PHARMACEUTICAL DESIGN

Diazepam-induced loss of inhibitory synapses mediated by PLCδ/ Ca2+/calcineurin signalling downstream of GABAA receptors

(2018) Martin W. Nicholson et al.   MOLECULAR PSYCHIATRY

GABA A receptor: Positive and negative allosteric modulators

(2018) Richard W. Olsen   NEUROPHARMACOLOGY

Common Ribs of Inhibitory Synaptic Dysfunction in the Umbrella of Neurodevelopmental Disorders

(2018) Rachel Ali Rodriguez et al.   Frontiers in Molecular Neuroscience

Gephyrin: a key regulatory protein of inhibitory synapses and beyond

(2018) Femke L. Groeneweg et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Structure of a human synaptic GABAA receptor

(2018) Shaotong Zhu et al.   NATURE

Postacute Delivery of GABA A α5 Antagonist Promotes Postischemic Neurological Recovery and Peri-infarct Brain Remodeling

(2018) Ya-chao Wang et al.   STROKE

Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin

(2018) Rochelle M. Hines et al.   Nature Communications

A unique intracellular tyrosine in neuroligin-1 regulates AMPA receptor recruitment during synapse differentiation and potentiation

(2018) Mathieu Letellier et al.   Nature Communications

Structure–Function Relationships of Glycine and GABAA Receptors and Their Interplay With the Scaffolding Protein Gephyrin

(2018) Vikram B. Kasaragod et al.   Frontiers in Molecular Neuroscience

Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer

(2018) Duncan Laverty et al.   NATURE

GABAA receptor signalling mechanisms revealed by structural pharmacology

(2018) Simonas Masiulis et al.   NATURE

Towards a Better Understanding of GABAergic Remodeling in Alzheimer’s Disease

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nanoscale Molecular Reorganization of the Inhibitory Postsynaptic Density Is a Determinant of GABAergic Synaptic Potentiation

(2017) Francesca Pennacchietti et al.   JOURNAL OF NEUROSCIENCE

Structural basis for GABAA receptor potentiation by neurosteroids

(2017) Paul S Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

GARLH Family Proteins Stabilize GABA A Receptors at Synapses

(2017) Tokiwa Yamasaki et al.   NEURON

Getting a Handle on Neuropharmacology by Targeting Receptor-Associated Proteins

(2017) Michael P. Maher et al.   NEURON

Structural basis for GABAA receptor potentiation by neurosteroids

(2017) Paul S Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An Essential Role for the Tetraspanin LHFPL4 in the Cell-Type-Specific Targeting and Clustering of Synaptic GABA A Receptors

(2017) Elizabeth C. Davenport et al.   Cell Reports

GABAergic Mechanisms in Schizophrenia: Linking Postmortem and In Vivo Studies

(2017) Jeroen C. de Jonge et al.   Frontiers in Psychiatry

Proteomic Characterization of Inhibitory Synapses Using a Novel pHluorin-tagged γ-Aminobutyric Acid Receptor, Type A (GABAA), α2 Subunit Knock-in Mouse

(2016) Yasuko Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of the Selective α5-GABAAR Antagonist S44819 on Excitability in the Human Brain: A TMS–EMG and TMS–EEG Phase I Study

(2016) Ghazaleh Darmani et al.   JOURNAL OF NEUROSCIENCE

Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission

(2016) Hans Michael Maric et al.   Nature Chemical Biology

An E3-ligase-based method for ablating inhibitory synapses

(2016) Garrett G Gross et al.   NATURE METHODS

Inhibitory Synapses Are Repeatedly Assembled and Removed at Persistent Sites In Vivo

(2016) Katherine L. Villa et al.   NEURON

Identification of an elaborate complex mediating postsynaptic inhibition

(2016) A. Uezu et al.   SCIENCE

Distinct roles for extracellular and intracellular domains in neuroligin function at inhibitory synapses

(2016) Quynh-Anh Nguyen et al.   eLife

Missense Mutation R338W in ARHGEF9 in a Family with X-linked Intellectual Disability with Variable Macrocephaly and Macro-Orchidism

(2016) Philip Long et al.   Frontiers in Molecular Neuroscience

Synaptic localization of α5 GABA (A) receptors via gephyrin interaction regulates dendritic outgrowth and spine maturation

(2015) Megan L. Brady et al.   Developmental Neurobiology

Specificity of Collybistin-Phosphoinositide Interactions

(2015) Michaela Ludolphs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders

(2015) Thuy N. Vien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory

(2015) Torben J. Hausrat et al.   Nature Communications

Design and Synthesis of High-Affinity Dimeric Inhibitors Targeting the Interactions between Gephyrin and Inhibitory Neurotransmitter Receptors

(2014) Hans Michael Maric et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A conformational switch in collybistin determines the differentiation of inhibitory postsynapses

(2014) T. Soykan et al.   EMBO JOURNAL

GABAAreceptors and plasticity of inhibitory neurotransmission in the central nervous system

(2014) Jean-Marc Fritschy et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A Combined Transgenic Proteomic Analysis and Regulated Trafficking of Neuroligin-2

(2014) Yunhee Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of a human GABAA receptor

(2014) Paul S. Miller et al.   NATURE

Gephyrin: a master regulator of neuronal function?

(2014) Shiva K. Tyagarajan et al.   NATURE REVIEWS NEUROSCIENCE

Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation

(2014) Carmen E. Flores et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of GABAA receptors influences receptor trafficking and neurosteroid actions

(2014) Eydith Comenencia-Ortiz et al.   PSYCHOPHARMACOLOGY

The impact of tonic GABAA receptor-mediated inhibition on neuronal excitability varies across brain region and cell type

(2014) Vallent Lee et al.   Frontiers in Neural Circuits

Molecular basis of the alternative recruitment of GABAA versus glycine receptors through gephyrin

(2014) Hans Michael Maric et al.   Nature Communications

Extracellular Signal-regulated Kinase and Glycogen Synthase Kinase 3β Regulate Gephyrin Postsynaptic Aggregation and GABAergic Synaptic Function in a Calpain-dependent Mechanism

(2013) Shiva K. Tyagarajan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurobeachin regulates neurotransmitter receptor trafficking to synapses

(2013) Ramya Nair et al.   JOURNAL OF CELL BIOLOGY

Interaction between autism-linked MDGAs and neuroligins suppresses inhibitory synapse development

(2013) Katherine L. Pettem et al.   JOURNAL OF CELL BIOLOGY

Quantitative Nanoscopy of Inhibitory Synapses: Counting Gephyrin Molecules and Receptor Binding Sites

(2013) Christian G. Specht et al.   NEURON

Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission

(2013) S. Mayer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How theories evolved concerning the mechanism of action of barbiturates

(2012) Wolfgang Löscher et al.   EPILEPSIA

Direct binding of GABAAreceptor β2 and β3 subunits to gephyrin

(2012) Sarah Kowalczyk et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Stabilization of GABAA Receptors at Endocytic Zones Is Mediated by an AP2 Binding Motif within the GABAA Receptor  3 Subunit

(2012) K. R. Smith et al.   JOURNAL OF NEUROSCIENCE

Clustered Dynamics of Inhibitory Synapses and Dendritic Spines in the Adult Neocortex

(2012) Jerry L. Chen et al.   NEURON

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

(2012) A. Bach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gephyrin, the enigmatic organizer at GABAergic synapses

(2012) Verena Tretter et al.   Frontiers in Cellular Neuroscience

Regulation of glycine receptor diffusion properties and gephyrin interactions by protein kinase C

(2011) Christian G Specht et al.   EMBO JOURNAL

Molecular Basis of the γ-Aminobutyric Acid A Receptor α3 Subunit Interaction with the Clustering Protein Gephyrin

(2011) Verena Tretter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gephyrin-mediated γ-Aminobutyric Acid Type A and Glycine Receptor Clustering Relies on a Common Binding Site

(2011) Hans-Michael Maric et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Collybistin splice variants differentially interact with gephyrin and Cdc42 to regulate gephyrin clustering at GABAergic synapses

(2011) S. K. Tyagarajan et al.   JOURNAL OF CELL SCIENCE

Cell-Permeable and Plasma-Stable Peptidomimetic Inhibitors of the Postsynaptic Density-95/N-Methyl-d-Aspartate Receptor Interaction

(2011) Anders Bach et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Residence Time of GABAARs at Inhibitory Synapses Is Determined by Direct Binding of the Receptor  1 Subunit to Gephyrin

(2011) J. Mukherjee et al.   JOURNAL OF NEUROSCIENCE

Muskelin Regulates Actin Filament- and Microtubule-Based GABAA Receptor Transport in Neurons

(2011) Frank F. Heisler et al.   NEURON

GABAA Receptor Trafficking-Mediated Plasticity of Inhibitory Synapses

(2011) Bernhard Luscher et al.   NEURON

Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor

(2011) S. D. Yogesha et al.   PROTEIN SCIENCE

The cell biology of synaptic inhibition in health and disease

(2010) Katharine R Smith et al.   CURRENT OPINION IN NEUROBIOLOGY

PH-Domain-driven targeting of collybistin but not Cdc42 activation is required for synaptic gephyrin clustering

(2010) Suneel Reddy-Alla et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Complex Role of Collybistin and Gephyrin in GABAAReceptor Clustering

(2010) Leila Saiepour et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biomimetic divalent ligands for the acute disruption of synaptic AMPAR stabilization

(2010) Matthieu Sainlos et al.   Nature Chemical Biology

Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor

(2010) Feyza Sancar et al.   NEUROPHARMACOLOGY

Regulation of GABAergic synapse formation and plasticity by GSK3 -dependent phosphorylation of gephyrin

(2010) S. K. Tyagarajan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroligin 2 Drives Postsynaptic Assembly at Perisomatic Inhibitory Synapses through Gephyrin and Collybistin

(2009) Alexandros Poulopoulos et al.   NEURON

Deficits in spatial memory correlate with modified  -aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus

(2009) V. Tretter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystallographic characterization of the radixin FERM domain bound to the cytoplasmic tail of membrane-type 1 matrix metalloproteinase (MT1-MMP)

(2008) Shin-ichi Terawaki et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

The Clustering of GABAA Receptor Subtypes at Inhibitory Synapses is Facilitated via the Direct Binding of Receptor  2 Subunits to Gephyrin

(2008) V. Tretter et al.   JOURNAL OF NEUROSCIENCE

Calcium-modulating cyclophilin ligand regulates membrane trafficking of postsynaptic GABAA receptors

(2008) Xu Yuan et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Collybistin is required for both the formation and maintenance of GABAergic postsynapses in the hippocampus

(2008) Theofilos Papadopoulos et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

GABAA receptors: Subtypes provide diversity of function and pharmacology

(2008) Richard W. Olsen et al.   NEUROPHARMACOLOGY

Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor  2 subunit

(2008) J. T. Kittler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA