Structure–Function Relationships of Glycine and GABAA Receptors and Their Interplay With the Scaffolding Protein Gephyrin

Artemether Does Not Turn α Cells into β Cells

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Structure of a human synaptic GABAA receptor

(2018) Shaotong Zhu et al.   NATURE

Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin

(2018) Rochelle M. Hines et al.   Nature Communications

Channel opening and gating mechanism in AMPA-subtype glutamate receptors

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Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites

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Structural basis for GABAA receptor potentiation by neurosteroids

(2017) Paul S Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

GARLH Family Proteins Stabilize GABA A Receptors at Synapses

(2017) Tokiwa Yamasaki et al.   NEURON

Synaptic functions of the IQSEC family of ADP-ribosylation factor guanine nucleotide exchange factors

(2017) Ji Won Um   NEUROSCIENCE RESEARCH

Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABAAreceptors at inhibitory synapses

(2017) Jayanta Mukherjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structures of Human GlyRα3 Bound to Ivermectin

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Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites

(2017) Duncan Laverty et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for GABAA receptor potentiation by neurosteroids

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An Essential Role for the Tetraspanin LHFPL4 in the Cell-Type-Specific Targeting and Clustering of Synaptic GABA A Receptors

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Reduced Expression of the Inhibitory Synapse Scaffolding Protein Gephyrin in Alzheimer's Disease

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Artemisinin-A Gift from Traditional Chinese Medicine to the World (Nobel Lecture)

(2016) Youyou Tu   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dimerization of the plant molybdenum insertase Cnx1E is required for synthesis of the molybdenum cofactor

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IQ Motif and SEC7 Domain-containing Protein 3 (IQSEC3) Interacts with Gephyrin to Promote Inhibitory Synapse Formation

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Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission

(2016) Hans Michael Maric et al.   Nature Chemical Biology

Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators

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Structural basis for integration of GluD receptors within synaptic organizer complexes

(2016) Jonathan Elegheert et al.   SCIENCE

Identification of an elaborate complex mediating postsynaptic inhibition

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Structural Framework for Metal Incorporation during Molybdenum Cofactor Biosynthesis

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Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission

(2016) Himanish Ghosh et al.   Nature Communications

Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators

(2016) Xin Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synaptic localization of α5 GABA (A) receptors via gephyrin interaction regulates dendritic outgrowth and spine maturation

(2015) Megan L. Brady et al.   Developmental Neurobiology

Simultaneous impairment of neuronal and metabolic function of mutated gephyrin in a patient with epileptic encephalopathy

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Crystal structure of human glycine receptor-α3 bound to antagonist strychnine

(2015) Xin Huang et al.   NATURE

Glycine receptor mechanism elucidated by electron cryo-microscopy

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Modulation of Gephyrin-Glycine Receptor Affinity by Multivalency

(2014) Hans Michael Maric et al.   ACS Chemical Biology

Design and Synthesis of High-Affinity Dimeric Inhibitors Targeting the Interactions between Gephyrin and Inhibitory Neurotransmitter Receptors

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A conformational switch in collybistin determines the differentiation of inhibitory postsynapses

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Neuronal Nitric Oxide Synthase-Dependent S-Nitrosylation of Gephyrin Regulates Gephyrin Clustering at GABAergic Synapses

(2014) B. Dejanovic et al.   JOURNAL OF NEUROSCIENCE

Crystal structure of a human GABAA receptor

(2014) Paul S. Miller et al.   NATURE

X-ray structure of the mouse serotonin 5-HT3 receptor

(2014) Ghérici Hassaine et al.   NATURE

X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors

(2014) Thorsten Althoff et al.   NATURE

Gephyrin: a master regulator of neuronal function?

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Exonic microdeletions of the gephyrin gene impair GABAergic synaptic inhibition in patients with idiopathic generalized epilepsy

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Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation

(2014) Carmen E. Flores et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gephyrin phosphorylation in the functional organization and plasticity of GABAergic synapses

(2014) Paola Zacchi et al.   Frontiers in Cellular Neuroscience

Molecular basis of the alternative recruitment of GABAA versus glycine receptors through gephyrin

(2014) Hans Michael Maric et al.   Nature Communications

Pin1-dependent signalling negatively affects GABAergic transmission by modulating neuroligin2/gephyrin interaction

(2014) Roberta Antonelli et al.   Nature Communications

Palmitoylation of Gephyrin Controls Receptor Clustering and Plasticity of GABAergic Synapses

(2014) Borislav Dejanovic et al.   PLOS BIOLOGY

Structural characterization of gephyrin by AFM and SAXS reveals a mixture of compact and extended states

(2013) Bodo Sander et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Developmental changes in expression of inhibitory neuronal proteins in the Fragile X Syndrome mouse basolateral amygdala

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Extracellular Signal-regulated Kinase and Glycogen Synthase Kinase 3β Regulate Gephyrin Postsynaptic Aggregation and GABAergic Synaptic Function in a Calpain-dependent Mechanism

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The Molybdenum Cofactor

(2013) Ralf R. Mendel   JOURNAL OF BIOLOGICAL CHEMISTRY

Abnormal Gephyrin Immunoreactivity Associated With Alzheimer Disease Pathologic Changes

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Molecular and functional heterogeneity of GABAergic synapses

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Direct binding of GABAAreceptor β2 and β3 subunits to gephyrin

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Structure, Function, and Modulation of GABAAReceptors

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Splice-specific Glycine Receptor Binding, Folding, and Phosphorylation of the Scaffolding Protein Gephyrin

(2012) Jens Herweg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Motor KIF5A Is Essential for GABAA Receptor Transport, and KIF5A Deletion Causes Epilepsy

(2012) Kazuo Nakajima et al.   NEURON

Regulation of glycine receptor diffusion properties and gephyrin interactions by protein kinase C

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Molecular Basis of the γ-Aminobutyric Acid A Receptor α3 Subunit Interaction with the Clustering Protein Gephyrin

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Gephyrin-mediated γ-Aminobutyric Acid Type A and Glycine Receptor Clustering Relies on a Common Binding Site

(2011) Hans-Michael Maric et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug

(2011) Maria P. Crespo-Ortiz et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

The Residence Time of GABAARs at Inhibitory Synapses Is Determined by Direct Binding of the Receptor  1 Subunit to Gephyrin

(2011) J. Mukherjee et al.   JOURNAL OF NEUROSCIENCE

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

(2011) Hugues Nury et al.   NATURE

Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes

(2011) Uwe Rudolph et al.   NATURE REVIEWS DRUG DISCOVERY

Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina

(2011) M. Hoon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Downregulation of gephyrin in temporal lobe epilepsy neurons in humans and a rat model

(2011) Min Fang et al.   SYNAPSE

Neurosteroids and GABA-A Receptor Function

(2011) Mingde Wang   Frontiers in Endocrinology

Moonlighting proteins: An intriguing mode of multitasking

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Molybdenum cofactor deficiency: Mutations in GPHN, MOCS1, and MOCS2

(2010) Jochen Reiss et al.   HUMAN MUTATION

Complex Role of Collybistin and Gephyrin in GABAAReceptor Clustering

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Delivery of GABAARs to Synapses Is Mediated by HAP1-KIF5 and Disrupted by Mutant Huntingtin

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Regulation of GABAergic synapse formation and plasticity by GSK3 -dependent phosphorylation of gephyrin

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Molybdenum cofactors, enzymes and pathways

(2009) Günter Schwarz et al.   NATURE

Neuroligin 2 Drives Postsynaptic Assembly at Perisomatic Inhibitory Synapses through Gephyrin and Collybistin

(2009) Alexandros Poulopoulos et al.   NEURON

Synaptic activation modifies microtubules underlying transport of postsynaptic cargo

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Splice-specific Functions of Gephyrin in Molybdenum Cofactor Biosynthesis

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X-ray structure of a prokaryotic pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

Gephyrin: where do we stand, where do we go?

(2008) Jean-Marc Fritschy et al.   TRENDS IN NEUROSCIENCES

Hydrophobic Interactions Mediate Binding of the Glycine Receptor β-Subunit to Gephyrin

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