Gephyrin: a key regulatory protein of inhibitory synapses and beyond

A partnership with the proteasome; the destructive nature of GSK3

(2018) Holly Robertson et al.   BIOCHEMICAL PHARMACOLOGY

The phenotypic spectrum of ARHGEF9 includes intellectual disability, focal epilepsy and febrile seizures

(2017) Karl Martin Klein et al.   JOURNAL OF NEUROLOGY

Nanoscale Molecular Reorganization of the Inhibitory Postsynaptic Density Is a Determinant of GABAergic Synaptic Potentiation

(2017) Francesca Pennacchietti et al.   JOURNAL OF NEUROSCIENCE

ARHGEF9 mutations in epileptic encephalopathy/intellectual disability: toward understanding the mechanism underlying phenotypic variation

(2017) Jing-Yang Wang et al.   NEUROGENETICS

Comprehensive association analysis of 27 genes from the GABAergic system in Japanese individuals affected with schizophrenia

(2017) Shabeesh Balan et al.   SCHIZOPHRENIA RESEARCH

Alpha subunit-dependent glycine receptor clustering and regulation of synaptic receptor numbers

(2017) A. Patrizio et al.   Scientific Reports

Reduced Expression of the Inhibitory Synapse Scaffolding Protein Gephyrin in Alzheimer's Disease

(2017) Smriti Agarwal et al.   JOURNAL OF ALZHEIMERS DISEASE

Biphasic Alteration of the Inhibitory Synapse Scaffold Protein Gephyrin in Early and Late Stages of an Alzheimer Disease Model

(2016) Eva Kiss et al.   AMERICAN JOURNAL OF PATHOLOGY

Neuroprotective Mechanisms Mediated by CDK5 Inhibition

(2016) Gohar Mushtaq et al.   CURRENT PHARMACEUTICAL DESIGN

Endosomal Phosphatidylinositol 3-Phosphate Promotes Gephyrin Clustering and GABAergic Neurotransmission at Inhibitory Postsynapses

(2016) Theofilos Papadopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo transgenic expression of collybistin in neurons of the rat cerebral cortex

(2016) Christopher D. Fekete et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Quantification of immunohistochemical findings of neurofibrillary tangles and senile plaques for a diagnosis of dementia in forensic autopsy cases

(2016) Mio Takayama et al.   Legal Medicine

Forebrain-specific loss of synaptic GABAA receptors results in altered neuronal excitability and synaptic plasticity in mice

(2016) Gregory A. O'Sullivan et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Early GABAergic transmission defects in the external globus pallidus and rest/activity rhythm alteration in a mouse model of Huntington’s disease

(2016) Zhuowei Du et al.   NEUROSCIENCE

Identification of an elaborate complex mediating postsynaptic inhibition

(2016) A. Uezu et al.   SCIENCE

Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission

(2016) Himanish Ghosh et al.   Nature Communications

Quantification of immunohistochemical findings of neurofibrillary tangles and senile plaques for a diagnosis of dementia in forensic autopsy cases

(2016) Mio Takayama et al.   Legal Medicine

Counting numbers of synaptic proteins: absolute quantification and single molecule imaging techniques

(2016) Angela Patrizio et al.   Neurophotonics

Simultaneous impairment of neuronal and metabolic function of mutated gephyrin in a patient with epileptic encephalopathy

(2015) B. Dejanovic et al.   EMBO Molecular Medicine

GSK3 and KIF5 regulate activity-dependent sorting of gephyrin between axons and dendrites

(2015) Louisa Rathgeber et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Collybistin binds and inhibits mTORC1 signaling: a potential novel mechanism contributing to intellectual disability and autism

(2015) Camila Oliveira Freitas Machado et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Pathogenic mechanism of an autism-associated neuroligin mutation involves altered AMPA-receptor trafficking

(2015) S Chanda et al.   MOLECULAR PSYCHIATRY

Neuronal networks and energy bursts in epilepsy

(2015) Y. Wu et al.   NEUROSCIENCE

Traumatic brain injury and epilepsy: Underlying mechanisms leading to seizure

(2015) Brandon P. Lucke-Wold et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

The cellular and molecular landscape of neuroligins

(2015) Michael A. Bemben et al.   TRENDS IN NEUROSCIENCES

Perturbed Hippocampal Synaptic Inhibition and γ-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism

(2015) Matthieu Hammer et al.   Cell Reports

A conformational switch in collybistin determines the differentiation of inhibitory postsynapses

(2014) T. Soykan et al.   EMBO JOURNAL

GABAAreceptors and plasticity of inhibitory neurotransmission in the central nervous system

(2014) Jean-Marc Fritschy et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neuronal Nitric Oxide Synthase-Dependent S-Nitrosylation of Gephyrin Regulates Gephyrin Clustering at GABAergic Synapses

(2014) B. Dejanovic et al.   JOURNAL OF NEUROSCIENCE

Exonic microdeletions of the gephyrin gene impair GABAergic synaptic inhibition in patients with idiopathic generalized epilepsy

(2014) Borislav Dejanovic et al.   NEUROBIOLOGY OF DISEASE

Dihydromyricetin Ameliorates Behavioral Deficits and Reverses Neuropathology of Transgenic Mouse Models of Alzheimer’s Disease

(2014) Jing Liang et al.   NEUROCHEMICAL RESEARCH

Cyclin-Dependent Kinase 5 Is Involved in the Phosphorylation of Gephyrin and Clustering of GABAA Receptors at Inhibitory Synapses of Hippocampal Neurons

(2014) Heba Kalbouneh et al.   PLoS One

Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation

(2014) Carmen E. Flores et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives

(2014) Gabriele Deidda et al.   Frontiers in Cellular Neuroscience

Molecular basis of the alternative recruitment of GABAA versus glycine receptors through gephyrin

(2014) Hans Michael Maric et al.   Nature Communications

Palmitoylation of Gephyrin Controls Receptor Clustering and Plasticity of GABAergic Synapses

(2014) Borislav Dejanovic et al.   PLOS BIOLOGY

Structural characterization of gephyrin by AFM and SAXS reveals a mixture of compact and extended states

(2013) Bodo Sander et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Down-regulation of gephyrin and GABAAreceptor subunits during epileptogenesis in the CA1 region of hippocampus

(2013) Marco I. González et al.   EPILEPSIA

Effects of two elongation factor 1A isoforms on the formation of gephyrin clusters at inhibitory synapses in hippocampal neurons

(2013) Michal Becker et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Rare exonic deletions implicate the synaptic organizer Gephyrin (GPHN) in risk for autism, schizophrenia and seizures

(2013) Anath C. Lionel et al.   HUMAN MOLECULAR GENETICS

Extracellular Signal-regulated Kinase and Glycogen Synthase Kinase 3β Regulate Gephyrin Postsynaptic Aggregation and GABAergic Synaptic Function in a Calpain-dependent Mechanism

(2013) Shiva K. Tyagarajan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Abnormal Gephyrin Immunoreactivity Associated With Alzheimer Disease Pathologic Changes

(2013) Chadwick M. Hales et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Glycogen Synthase Kinase 3 Beta (GSK3β) at the Tip of Neuronal Development and Regeneration

(2013) Oscar Seira et al.   MOLECULAR NEUROBIOLOGY

Quantitative Nanoscopy of Inhibitory Synapses: Counting Gephyrin Molecules and Receptor Binding Sites

(2013) Christian G. Specht et al.   NEURON

Patterns of mRNA and protein expression for 12 GABAA receptor subunits in the mouse brain

(2013) H. Hörtnagl et al.   NEUROSCIENCE

The possible role of GABAA receptors and gephyrin in epileptogenesis

(2013) Marco I. González   Frontiers in Cellular Neuroscience

Stoichiometry and Subunit Arrangement of α1β Glycine Receptors As Determined by Atomic Force Microscopy

(2012) Zhe Yang et al.   BIOCHEMISTRY

Molecular and functional heterogeneity of GABAergic synapses

(2012) Jean-Marc Fritschy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Activity-dependent phosphorylation of GABAAreceptors regulates receptor insertion and tonic current

(2012) Richard S Saliba et al.   EMBO JOURNAL

Targeted next generation sequencing as a diagnostic tool in epileptic disorders

(2012) Johannes R. Lemke et al.   EPILEPSIA

Direct binding of GABAAreceptor β2 and β3 subunits to gephyrin

(2012) Sarah Kowalczyk et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Expression and subcellular distribution of gephyrin in non-neuronal tissues and cells

(2012) Ralph Nawrotzki et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Splice-specific Glycine Receptor Binding, Folding, and Phosphorylation of the Scaffolding Protein Gephyrin

(2012) Jens Herweg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Gephyrin in Hippocampal Neurons by Cyclin-dependent Kinase CDK5 at Ser-270 Is Dependent on Collybistin

(2012) Jochen Kuhse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Comprehensive Small Interfering RNA Screen Identifies Signaling Pathways Required for Gephyrin Clustering

(2012) J. Wuchter et al.   JOURNAL OF NEUROSCIENCE

Stoichiometry of the Human Glycine Receptor Revealed by Direct Subunit Counting

(2012) N. Durisic et al.   JOURNAL OF NEUROSCIENCE

Altered Synaptic Properties During Integration of Adult-Born Hippocampal Neurons Following a Seizure Insult

(2012) Johanna Jackson et al.   PLoS One

Loss of functional GABAA receptors in the Alzheimer diseased brain

(2012) A. Limon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De novo Xq11.11 microdeletion including ARHGEF9 in a boy with mental retardation, epilepsy, macrosomia, and dysmorphic features

(2011) Gaetan Lesca et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The trafficking proteins Vacuolar Protein Sorting 35 and Neurobeachin interact with the glycine receptor β-subunit

(2011) Isabel del Pino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular Basis of the γ-Aminobutyric Acid A Receptor α3 Subunit Interaction with the Clustering Protein Gephyrin

(2011) Verena Tretter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gephyrin-mediated γ-Aminobutyric Acid Type A and Glycine Receptor Clustering Relies on a Common Binding Site

(2011) Hans-Michael Maric et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Regulation of the Postsynaptic Clustering of γ-Aminobutyric Acid Type A (GABAA) Receptors by Collybistin Isoforms

(2011) Tzu-Ting Chiou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Collybistin splice variants differentially interact with gephyrin and Cdc42 to regulate gephyrin clustering at GABAergic synapses

(2011) S. K. Tyagarajan et al.   JOURNAL OF CELL SCIENCE

Loss-of-function mutation of collybistin is responsible for X-linked mental retardation associated with epilepsy

(2011) Keiko Shimojima et al.   JOURNAL OF HUMAN GENETICS

The Residence Time of GABAARs at Inhibitory Synapses Is Determined by Direct Binding of the Receptor  1 Subunit to Gephyrin

(2011) J. Mukherjee et al.   JOURNAL OF NEUROSCIENCE

Heat Shock Cognate Protein 70 Regulates Gephyrin Clustering

(2011) P. Machado et al.   JOURNAL OF NEUROSCIENCE

Distinct mechanisms regulate GABAAreceptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells

(2011) Patrizia Panzanelli et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cdk5 Is Required for Memory Function and Hippocampal Plasticity via the cAMP Signaling Pathway

(2011) Ji-Song Guan et al.   PLoS One

Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina

(2011) M. Hoon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SH3 Domain-Based Phototrapping in Living Cells Reveals Rho Family GAP Signaling Complexes

(2011) H. Okada et al.   Science Signaling

Downregulation of gephyrin in temporal lobe epilepsy neurons in humans and a rat model

(2011) Min Fang et al.   SYNAPSE

Irregular RNA splicing curtails postsynaptic gephyrin in the cornu ammonis of patients with epilepsy

(2010) Benjamin Förstera et al.   BRAIN

The cell biology of synaptic inhibition in health and disease

(2010) Katharine R Smith et al.   CURRENT OPINION IN NEUROBIOLOGY

Molybdenum cofactor deficiency: Mutations in GPHN, MOCS1, and MOCS2

(2010) Jochen Reiss et al.   HUMAN MUTATION

Complex Role of Collybistin and Gephyrin in GABAAReceptor Clustering

(2010) Leila Saiepour et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of postsynaptic gephyrin cluster size by protein phosphatase 1

(2010) Melanie Bausen et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Differences in the density of GABA-A receptor alpha-2 subunits and gephyrin in brain structures of rats selected for low and high anxiety in basal and fear-stimulated conditions, in a model of contextual fear conditioning

(2010) Małgorzata Lehner et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Regulation of GABAergic synapse formation and plasticity by GSK3 -dependent phosphorylation of gephyrin

(2010) S. K. Tyagarajan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Initial loss but later excess of GABAergic synapses with dentate granule cells in a rat model of temporal lobe epilepsy

(2009) Khushdev K. Thind et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Increased network excitability and impaired induction of long-term potentiation in the dentate gyrus of collybistin-deficient mice in vivo

(2009) Peter Jedlicka et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Molybdenum cofactors, enzymes and pathways

(2009) Günter Schwarz et al.   NATURE

Neuroligin 2 Drives Postsynaptic Assembly at Perisomatic Inhibitory Synapses through Gephyrin and Collybistin

(2009) Alexandros Poulopoulos et al.   NEURON

Synaptic activation modifies microtubules underlying transport of postsynaptic cargo

(2009) C. Maas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A balanced chromosomal translocation disruptingARHGEF9is associated with epilepsy, anxiety, aggression, and mental retardation

(2008) Vera M. Kalscheuer et al.   HUMAN MUTATION

Splice-specific Functions of Gephyrin in Molybdenum Cofactor Biosynthesis

(2008) Birthe Smolinsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gephyrin interacts with the glutamate receptor interacting protein 1 isoforms at GABAergic synapses

(2008) Wendou Yu et al.   JOURNAL OF NEUROCHEMISTRY

The Clustering of GABAA Receptor Subtypes at Inhibitory Synapses is Facilitated via the Direct Binding of Receptor  2 Subunits to Gephyrin

(2008) V. Tretter et al.   JOURNAL OF NEUROSCIENCE

Collybistin is required for both the formation and maintenance of GABAergic postsynapses in the hippocampus

(2008) Theofilos Papadopoulos et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Native glycine receptor subtypes and their physiological roles

(2008) Joseph W. Lynch   NEUROPHARMACOLOGY

GABAA receptors: Subtypes provide diversity of function and pharmacology

(2008) Richard W. Olsen et al.   NEUROPHARMACOLOGY