Crystal structure of a human GABAA receptor

Complex between α-bungarotoxin and an α7 nicotinic receptor ligand-binding domain chimaera

(2013) Sun Huang et al.   BIOCHEMICAL JOURNAL

Expression of recombinant glycoproteins in mammalian cells: towards an integrative approach to structural biology

(2013) A Radu Aricescu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels

(2013) Ludovic Sauguet et al.   EMBO JOURNAL

De novo mutations in epileptic encephalopathies

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A propofol binding site on mammalian GABAA receptors identified by photolabeling

(2013) Grace M S Yip et al.   Nature Chemical Biology

A Unified Model of the GABAA Receptor Comprising Agonist and Benzodiazepine Binding Sites

(2013) Rikke Bergmann et al.   PLoS One

Using molecular dynamics to elucidate the structural basis for function in pLGICs

(2013) M. H. Akabas   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploiting structure similarity in refinement: automated NCS and target-structure restraints inBUSTER

(2012) Oliver S. Smart et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure, Function, and Modulation of GABAAReceptors

(2012) Erwin Sigel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GABRB3Mutation, G32R, Associated with Childhood Absence Epilepsy Alters α1β3γ2L γ-Aminobutyric Acid Type A (GABAA) Receptor Expression and Channel Gating

(2012) Katharine N. Gurba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gating Movement of Acetylcholine Receptor Caught by Plunge-Freezing

(2012) Nigel Unwin et al.   JOURNAL OF MOLECULAR BIOLOGY

The  1K276E Startle Disease Mutation Reveals Multiple Intermediate States in the Gating of Glycine Receptors

(2012) R. Lape et al.   JOURNAL OF NEUROSCIENCE

Overexpressing human membrane proteins in stably transfected and clonal human embryonic kidney 293S cells

(2012) Sarika Chaudhary et al.   Nature Protocols

Current trends in α-helical membrane protein crystallization: An update

(2012) Joanne L. Parker et al.   PROTEIN SCIENCE

A Fluorescence-Detection Size-Exclusion Chromatography-Based Thermostability Assay for Membrane Protein Precrystallization Screening

(2012) Motoyuki Hattori et al.   STRUCTURE

CAVER 3.0: A Tool for the Analysis of Transport Pathways in Dynamic Protein Structures

(2012) Eva Chovancova et al.   PLoS Computational Biology

Single-Channel and Structural Foundations of Neuronal  7 Acetylcholine Receptor Potentiation

(2011) C. J. B. daCosta et al.   JOURNAL OF NEUROSCIENCE

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

(2011) Hugues Nury et al.   NATURE

Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes

(2011) Uwe Rudolph et al.   NATURE REVIEWS DRUG DISCOVERY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Glycosylation of β2 Subunits Regulates GABAAReceptor Biogenesis and Channel Gating

(2010) Wen-yi Lo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding, activation and modulation of Cys-loop receptors

(2010) Paul S. Miller et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Port-a-Patch and Patchliner: High Fidelity Electrophysiology for Secondary Screening and Safety Pharmacology

(2009) Niels Fertig et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

xia2: an expert system for macromolecular crystallography data reduction

(2009) G. Winter   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Identification of a fluorescent general anesthetic, 1-aminoanthracene

(2009) C. A. Butts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histamine Action on Vertebrate GABAAReceptors

(2008) Arunesh Saras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Ion Selectivity Filter in the Extracellular Domain of Cys-loop Receptors Reveals Determinants for Ion Conductance

(2008) Scott B. Hansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modular Design of Cys-loop Ligand-gated Ion Channels: Functional 5-HT3and GABA ρ1 Receptors Lacking the Large Cytoplasmic M3M4 Loop

(2008) Michaela Jansen et al.   JOURNAL OF GENERAL PHYSIOLOGY

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

(2008) Nicolas Bocquet et al.   NATURE

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

Potentiation of  7 nicotinic acetylcholine receptors via an allosteric transmembrane site

(2008) G. T. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A conserved salt bridge critical for GABAA receptor function and loop C dynamics

(2008) S. P. Venkatachalan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA