How theories evolved concerning the mechanism of action of barbiturates

Mapping General Anesthetic Binding Site(s) in Human α1β3 γ-Aminobutyric Acid Type A Receptors with [3H]TDBzl-Etomidate, a Photoreactive Etomidate Analogue

(2012) David C. Chiara et al.   BIOCHEMISTRY

Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments

(2012) Wolfgang Löscher et al.   NEUROPHARMACOLOGY

Characteristics of concatemeric GABAA receptors containing α4/δ subunits expressed in Xenopus oocytes

(2011) Hong-Jin Shu et al.   BRITISH JOURNAL OF PHARMACOLOGY

A novel GABAA receptor pharmacology: drugs interacting with the α+β- interface

(2011) Werner Sieghart et al.   BRITISH JOURNAL OF PHARMACOLOGY

Phenobarbital but Not Diazepam Reduces AMPA/kainate Receptor Mediated Currents and Exerts Opposite Actions on Initial Seizures in the Neonatal Rat Hippocampus

(2011) Romain Nardou et al.   Frontiers in Cellular Neuroscience

Anesthetic Binding in a Pentameric Ligand-Gated Ion Channel: GLIC

(2010) Qiang Chen et al.   BIOPHYSICAL JOURNAL

Pentobarbital inhibition of human recombinant α1A P/Q-type voltage-gated calcium channels involves slow, open channel block

(2010) A Schober et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pharmacology of structural changes at the GABAA receptor transmitter binding site

(2010) Gustav Akk et al.   BRITISH JOURNAL OF PHARMACOLOGY

GABAA receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation

(2010) Richard W. Olsen et al.   Canadian Journal of Anesthesia-Journal canadien d anesthesie

Barbiturates Require the N Terminus and First Transmembrane Domain of the δ Subunit for Enhancement of α1β3δ GABAAReceptor Currents

(2010) Hua-Jun Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photochemical Proteolysis of an Unstructured Linker of the GABAAR Extracellular Domain Prevents GABA but Not Pentobarbital Activation

(2010) A. P. Hanek et al.   MOLECULAR PHARMACOLOGY

Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor

(2010) Feyza Sancar et al.   NEUROPHARMACOLOGY

Binding, activation and modulation of Cys-loop receptors

(2010) Paul S. Miller et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Distinct Structural Changes in the GABA A Receptor Elicited by Pentobarbital and GABA

(2009) Yukiko Muroi et al.   BIOPHYSICAL JOURNAL

γ-Aminobutyric Acid (GABA) and Pentobarbital Induce Different Conformational Rearrangements in the GABAAReceptor α1and β2Pre-M1 Regions

(2008) Jose Mercado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

(2008) Nicolas Bocquet et al.   NATURE

Antiepileptic drug resistant rats differ from drug responsive rats in GABAA receptor subunit expression in a model of temporal lobe epilepsy

(2008) Kerstin Bethmann et al.   NEUROBIOLOGY OF DISEASE

The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures

(2008) Kristopher T. Kahle et al.   Neurosurgical Focus

Intravenous anaesthetics inhibit nicotinic acetylcholine receptor-mediated currents and Ca2+ transients in rat intracardiac ganglion neurons

(2005) Martin Weber et al.   BRITISH JOURNAL OF PHARMACOLOGY