Evaluating Nanoparticles in Preclinical Research Using Microfluidic Systems

Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications

(2019) Seyed Mohammadali Dadfar et al.   ADVANCED DRUG DELIVERY REVIEWS

High-Content and High-Throughput In Vivo Drug Screening Platforms Using Microfluidics

(2019) Adela Ben-Yakar   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

In Vitro Vascularized Liver and Tumor Tissue Microenvironments on a Chip for Dynamic Determination of Nanoparticle Transport and Toxicity

(2019) Alican Ozkan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Effect of surface charge on the size-dependent cellular internalization of liposomes

(2019) Kumiko Sakai-Kato et al.   CHEMISTRY AND PHYSICS OF LIPIDS

In-vitro haemocompatibility of dextran-protein submicron particles

(2019) Chiraphat Kloypan et al.   Artificial Cells Nanomedicine and Biotechnology

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

(2019) Ana Maria Ortega-Prieto et al.   Jove-Journal of Visualized Experiments

Liposome-encapsulated fish oil protein-tagged gold nanoparticles for intra-articular therapy in osteoarthritis

(2019) Amrita Sarkar et al.   Nanomedicine

New insights into designing hybrid nanoparticles for lung cancer: Diagnosis and treatment

(2019) Fatemeh Mottaghitalab et al.   JOURNAL OF CONTROLLED RELEASE

Droplet‐based Microfluidics Systems in Biomedical Applications

(2019) Huanhuan Feng et al.   ELECTROPHORESIS

Single-cell RNA sequencing unveils the shared and the distinct cytotoxic hallmarks of human TCRVδ1 and TCRVδ2 γδ T lymphocytes

(2019) Gabriele Pizzolato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

User-Friendly and Parallelized Generation of Human Induced Pluripotent Stem Cell-Derived Microtissues in a Centrifugal Heart-on-a-Chip

(2019) Oliver Schneider et al.   TISSUE ENGINEERING PART A

Microfluidic Fabrication of Biomimetic Helical Hydrogel Microfibers for Blood‐Vessel‐on‐a‐Chip Applications

(2019) Luanluan Jia et al.   Advanced Healthcare Materials

Phthalimide Derivative Shows Anti-angiogenic Activity in a 3D Microfluidic Model and No Teratogenicity in Zebrafish Embryos

(2019) Annalisa Mercurio et al.   Frontiers in Pharmacology

Study on uptake of gold nanoparticles by single cells using droplet microfluidic chip-inductively coupled plasma mass spectrometry

(2019) Han Wang et al.   TALANTA

Microfluidics in nanoparticle drug delivery; From synthesis to pre-clinical screening

(2018) Jungho Ahn et al.   ADVANCED DRUG DELIVERY REVIEWS

Mussel-inspired 3D fiber scaffolds for heart-on-a-chip toxicity studies of engineered nanomaterials

(2018) Seungkuk Ahn et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Gut-liver on a chip towards an in vitro model of hepatic steatosis

(2018) Seung Yeon Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Blood-Vessel-on-a-Chip Platforms for Evaluating Nanoparticle Drug Delivery Systems

(2018) Yuancheng Li et al.   CURRENT DRUG METABOLISM

Kidney-on-a-Chip: A New Technology for Predicting Drug Efficacy, Interactions, and Drug-induced Nephrotoxicity

(2018) Jeonghwan Lee et al.   CURRENT DRUG METABOLISM

A Three-Dimensional Arrayed Microfluidic Blood–Brain Barrier Model With Integrated Electrical Sensor Array

(2018) Sehoon Jeong et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Natural polymer functionalized graphene oxide for co-delivery of anticancer drugs: In-vitro and in-vivo

(2018) Ananya Deb et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Nanofiber membrane supported lung-on-a-chip microdevice for anti-cancer drug testing

(2018) Xingyuan Yang et al.   LAB ON A CHIP

NemaFlex: a microfluidics-based technology for standardized measurement of muscular strength of C. elegans

(2018) Mizanur Rahman et al.   LAB ON A CHIP

Microfluidics for Cancer Nanomedicine: From Fabrication to Evaluation

(2018) Hao Zhang et al.   Small

Improved microfluidic platform for simultaneous multiple drug screening towards personalized treatment

(2018) Oihane Mitxelena-Iribarren et al.   BIOSENSORS & BIOELECTRONICS

Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery

(2018) Raquel O. Rodrigues et al.   Materials Science & Engineering C-Materials for Biological Applications

Evaluating nanomedicine in microfluidics

(2018) Ziyi He et al.   NANOTECHNOLOGY

Effect of flow on targeting and penetration of angiopep-decorated nanoparticles in a microfluidic model blood-brain barrier

(2018) Iason Papademetriou et al.   PLoS One

A 3D human lung-on-a-chip model for nanotoxicity testing

(2018) Min Zhang et al.   Toxicology Research

Predicting drug delivery efficiency into tumor tissues through molecular simulation of transport in complex vascular networks

(2018) Evan P. Troendle et al.   JOURNAL OF CONTROLLED RELEASE

Vessel-on-a-chip with Hydrogel-based Microfluidics

(2018) Jing Nie et al.   Small

Blood–brain barrier-on-a-chip: Microphysiological systems that capture the complexity of the blood–central nervous system interface

(2017) Duc TT Phan et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Nanoparticles as Theranostic Vehicles in Experimental and Clinical Applications—Focus on Prostate and Breast Cancer

(2017) Jörgen Elgqvist   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Influence of shear stress and size on viability of endothelial cells exposed to gold nanoparticles

(2017) C. Fede et al.   JOURNAL OF NANOPARTICLE RESEARCH

Tumour-vessel-on-a-chip models for drug delivery

(2017) David Caballero et al.   LAB ON A CHIP

Hybrid polymer microfluidic platform to mimic varying vascular compliance and topology

(2017) M. L. Rathod et al.   LAB ON A CHIP

Why microfluidics? Merits and trends in chemical synthesis

(2017) Yong Liu et al.   LAB ON A CHIP

A 3D neurovascular microfluidic model consisting of neurons, astrocytes and cerebral endothelial cells as a blood–brain barrier

(2017) Giulia Adriani et al.   LAB ON A CHIP

Nanoparticles Penetrate into the Multicellular Spheroid-on-Chip: Effect of Surface Charge, Protein Corona, and Exterior Flow

(2017) Ke Huang et al.   MOLECULAR PHARMACEUTICS

Biocompatibility assessment of silk nanoparticles: hemocompatibility and internalization by human blood cells

(2017) Manfred F. Maitz et al.   Nanomedicine-Nanotechnology Biology and Medicine

Gold nanoparticle interactions in human blood: a model evaluation

(2017) Niloofar Ajdari et al.   Nanomedicine-Nanotechnology Biology and Medicine

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Pathway to Personalizing Therapy for Metastases Using Liver-on-a-Chip Platforms

(2017) A. S. Khazali et al.   Stem Cell Reviews and Reports

High-Content Assessment of Cardiac Function Using Heart-on-a-Chip Devices as Drug Screening Model

(2017) Genevieve Conant et al.   Stem Cell Reviews and Reports

In vitro microfluidic models of tumor microenvironment to screen transport of drugs and nanoparticles

(2017) Altug Ozcelikkale et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

A microfluidic model of the blood–brain barrier to study permeabilization by pulsed electric fields

(2017) M. Bonakdar et al.   RSC Advances

A Biomimetic Microfluidic Tumor Microenvironment Platform Mimicking the EPR Effect for Rapid Screening of Drug Delivery Systems

(2017) Yuan Tang et al.   Scientific Reports

C. elegans-on-a-chip for in situ and in vivo Ag nanoparticles’ uptake and toxicity assay

(2017) Jin Ho Kim et al.   Scientific Reports

Biomaterials Meet Microfluidics: From Synthesis Technologies to Biological Applications

(2017) Jingyun Ma et al.   Micromachines

A Pathway to Personalizing Therapy for Metastases Using Liver-on-a-Chip Platforms

(2017) A. S. Khazali et al.   Stem Cell Reviews and Reports

High-Content Assessment of Cardiac Function Using Heart-on-a-Chip Devices as Drug Screening Model

(2017) Genevieve Conant et al.   Stem Cell Reviews and Reports

A Membrane-integrated Microfluidic Device to Study Permeation of Nanoparticles through Straight Micropores toward Rational Design of Nanomedicines

(2016) Naoki SASAKI et al.   ANALYTICAL SCIENCES

In vitro screening of nanomedicines through the blood brain barrier: A critical review

(2016) Juan Aparicio-Blanco et al.   BIOMATERIALS

Recent advances in electrochemical biosensors based on graphene two-dimensional nanomaterials

(2016) Yang Song et al.   BIOSENSORS & BIOELECTRONICS

Shuttle-mediated nanoparticle transport across an in vitro brain endothelium under flow conditions

(2016) Andrea P. Falanga et al.   BIOTECHNOLOGY AND BIOENGINEERING

Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening

(2016) Ying I. Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Recapitulation of complex transport and action of drugs at the tumor microenvironment using tumor-microenvironment-on-chip

(2016) Bumsoo Han et al.   CANCER LETTERS

Nanochemistry and Nanomedicine for Nanoparticle-based Diagnostics and Therapy

(2016) Guanying Chen et al.   CHEMICAL REVIEWS

Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination

(2016) Yi-Nan Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Uptake of silver nanoparticles by monocytic THP-1 cells depends on particle size and presence of serum proteins

(2016) Katja Kettler et al.   JOURNAL OF NANOPARTICLE RESEARCH

Haemocompatibility of iron oxide nanoparticles synthesized for theranostic applications: a high-sensitivity microfluidic tool

(2016) Raquel O. Rodrigues et al.   JOURNAL OF NANOPARTICLE RESEARCH

Evaluation of nanoencapsulated verteporfin’s cytotoxicity using a microfluidic system

(2016) Katarzyna Tokarska et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Fish-on-a-chip: microfluidics for zebrafish research

(2016) Fan Yang et al.   LAB ON A CHIP

Real-time assessment of nanoparticle-mediated antigen delivery and cell response

(2016) Carlota A. Cunha-Matos et al.   LAB ON A CHIP

A Retrospective 30 Years After Discovery of the Enhanced Permeability and Retention Effect of Solid Tumors: Next-Generation Chemotherapeutics and Photodynamic Therapy-Problems, Solutions, and Prospects

(2016) Hiroshi Maeda et al.   MICROCIRCULATION

Why I’m Holding onto Hope for Nano in Oncology

(2016) Christine Allen   MOLECULAR PHARMACEUTICS

Characterization of Cell-Type-Specific Drug Transport and Resistance of Breast Cancers Using Tumor-Microenvironment-on-Chip

(2016) Kyeonggon Shin et al.   MOLECULAR PHARMACEUTICS

Organization of Endothelial Cells, Pericytes, and Astrocytes into a 3D Microfluidic in Vitro Model of the Blood–Brain Barrier

(2016) Jack D. Wang et al.   MOLECULAR PHARMACEUTICS

From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery

(2016) William A. Banks   NATURE REVIEWS DRUG DISCOVERY

Patterned Fibers Embedded Microfluidic Chips Based on PLA and PDMS for Ag Nanoparticle Safety Testing

(2016) Yaowen Liu et al.   Polymers

High-Throughput Assessment of Drug Cardiac Safety Using a High-Speed Impedance Detection Technology-Based Heart-on-a-Chip

(2016) Xi Zhang et al.   Micromachines

Drug testing and flow cytometry analysis on a large number of uniform sized tumor spheroids using a microfluidic device

(2016) Bishnubrata Patra et al.   Scientific Reports

Drug cytotoxicity and signaling pathway analysis with three-dimensional tumor spheroids in a microwell-based microfluidic chip for drug screening

(2015) Yongli Chen et al.   ANALYTICA CHIMICA ACTA

Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors

(2015) A. F. Bagley et al.   CANCER RESEARCH

Liposomal doxorubicin extravasation controlled by phenotype-specific transport properties of tumor microenvironment and vascular barrier

(2015) Kenji Yokoi et al.   JOURNAL OF CONTROLLED RELEASE

Towards personalized medicine: chemosensitivity assays of patient lung cancer cell spheroids in a perfused microfluidic platform

(2015) Janine Ruppen et al.   LAB ON A CHIP

A lung-on-a-chip array with an integrated bio-inspired respiration mechanism

(2015) Andreas O. Stucki et al.   LAB ON A CHIP

The influence of flow, shear stress and adhesion molecule targeting on gold nanoparticle uptake in human endothelial cells

(2015) Henrik Klingberg et al.   Nanoscale

Digital detection of biomarkers assisted by nanoparticles: application to diagnostics

(2015) Marina Cretich et al.   TRENDS IN BIOTECHNOLOGY

Polymeric nanoparticles: the future of nanomedicine

(2015) Brittany L. Banik et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology

(2015) Hansang Cho et al.   Scientific Reports

Three-Dimensional Microfluidic Tri-Culture Model of the Bone Marrow Microenvironment for Study of Acute Lymphoblastic Leukemia

(2015) Allison Bruce et al.   PLoS One

In Vitro and in Vivo Studies on the Transport of PEGylated Silica Nanoparticles across the Blood–Brain Barrier

(2014) Dan Liu et al.   ACS Applied Materials & Interfaces

High-Throughput Screening Platform for Engineered Nanoparticle-Mediated Genotoxicity Using CometChip Technology

(2014) Christa Watson et al.   ACS Nano

A microfluidic digital single-cell assay for the evaluation of anticancer drugs

(2014) Yao Wang et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Permeability Analysis of Neuroactive Drugs Through a Dynamic Microfluidic In Vitro Blood–Brain Barrier Model

(2014) R. Booth et al.   ANNALS OF BIOMEDICAL ENGINEERING

Microfluidic System Based High Throughput Drug Screening System for Curcumin/TRAIL Combinational Chemotherapy in Human Prostate Cancer PC3 Cells

(2014) Dami An et al.   Biomolecules & Therapeutics

Cell-Based in Vitro Blood–Brain Barrier Model Can Rapidly Evaluate Nanoparticles’ Brain Permeability in Association with Particle Size and Surface Modification

(2014) Sanshiro Hanada et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Simulation of complex transport of nanoparticles around a tumor using tumor-microenvironment-on-chip

(2014) Bongseop Kwak et al.   JOURNAL OF CONTROLLED RELEASE

Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury

(2014) Mandy B. Esch et al.   LAB ON A CHIP

Characterization of nanoparticle delivery in microcirculation using a microfluidic device

(2014) Antony Thomas et al.   MICROVASCULAR RESEARCH

Combining Motion Analysis and Microfluidics – A Novel Approach for Detecting Whole-Animal Responses to Test Substances

(2014) Tabitha S. Rudin-Bitterli et al.   PLoS One

Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis

(2014) Y. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Statistical single-cell analysis of cell cycle-dependent quantum dot cytotoxicity and cellular uptake using a microfluidic system

(2014) Jing Wu et al.   RSC Advances

Investigations on Agglomeration and Haemocompatibility of Vitamin E TPGS Surface Modified Berberine Chloride Nanoparticles

(2014) Parameswara Rao Vuddanda et al.   Biomed Research International

Delivering Nanoparticles to Lungs while Avoiding Liver and Spleen through Adsorption on Red Blood Cells

(2013) Aaron C. Anselmo et al.   ACS Nano

On-chip evaluation of platelet adhesion and aggregation upon exposure to mesoporous silica nanoparticles

(2013) Donghyuk Kim et al.   ANALYST

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

The internalization of fluorescence-labeled PLA nanoparticles by macrophages

(2013) Fengjuan Li et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Margination Propensity of Vascular-Targeted Spheres from Blood Flow in a Microfluidic Model of Human Microvessels

(2013) Katawut Namdee et al.   LANGMUIR

Adhesive interaction of functionalized particles and endothelium in idealized microvascular networks

(2013) Giuseppina Lamberti et al.   MICROVASCULAR RESEARCH

Multifaceted Transport Characteristics of Nanomedicine: Needs for Characterization in Dynamic Environment

(2013) Altug Ozcelikkale et al.   MOLECULAR PHARMACEUTICS

Tumour-on-a-chip provides an optical window into nanoparticle tissue transport

(2013) Alexandre Albanese et al.   Nature Communications

Microfluidic System for Facilitated Quantification of Nanoparticle Accumulation to Cells Under Laminar Flow

(2012) Jiro Kusunose et al.   ANNALS OF BIOMEDICAL ENGINEERING

Reliable permeability assay system in a microfluidic device mimicking cerebral vasculatures

(2012) Ju Hun Yeon et al.   BIOMEDICAL MICRODEVICES

Targeted polymeric therapeutic nanoparticles: design, development and clinical translation

(2012) Nazila Kamaly et al.   CHEMICAL SOCIETY REVIEWS

Multifactorial determinants that govern nanoparticle uptake by human endothelial cells under flow

(2012) Adriele Prina-Mello et al.   International Journal of Nanomedicine

Cytotoxicity of quantum dots assay on a microfluidic 3D-culture device based on modeling diffusion process between blood vessels and tissues

(2012) Jing Wu et al.   LAB ON A CHIP

SyM-BBB: a microfluidic blood brain barrier model

(2012) Balabhaskar Prabhakarpandian et al.   LAB ON A CHIP

Microfluidic technologies for accelerating the clinical translation of nanoparticles

(2012) Pedro M. Valencia et al.   Nature Nanotechnology

Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels

(2012) N. Korin et al.   SCIENCE

Tumor Accumulation of NIR Fluorescent PEG–PLA Nanoparticles: Impact of Particle Size and Human Xenograft Tumor Model

(2011) Andreas Schädlich et al.   ACS Nano

On-Chip Evaluation of Shear Stress Effect on Cytotoxicity of Mesoporous Silica Nanoparticles

(2011) Donghyuk Kim et al.   ANALYTICAL CHEMISTRY

The effect of particle size on the cytotoxicity, inflammation, developmental toxicity and genotoxicity of silver nanoparticles

(2011) Margriet V.D.Z. Park et al.   BIOMATERIALS

A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance

(2011) Qianjun He et al.   BIOMATERIALS

Size dependent macrophage responses and toxicological effects of Ag nanoparticles

(2011) Jeongsin Park et al.   CHEMICAL COMMUNICATIONS

Methylmethacrylate–sulfopropylmethacrylate nanoparticles with surface RMP-7 for targeting delivery of antiretroviral drugs across the blood–brain barrier

(2011) Yung-Chih Kuo et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Transcytosis of CRM197-grafted polybutylcyanoacrylate nanoparticles for delivering zidovudine across human brain-microvascular endothelial cells

(2011) Yung-Chih Kuo et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Comparative study of the in vitro and in vivo characteristics of cationic and neutral liposomes

(2011) Xian-Rong Qi et al.   International Journal of Nanomedicine

Size-dependent in vivo toxicity of PEG-coated gold nanoparticles

(2011) Xiao-Dong Zhang et al.   International Journal of Nanomedicine

Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake

(2011) Carl D. Walkey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bifurcations: Focal Points of Particle Adhesion in Microvascular Networks

(2011) BALABHASKAR PRABHAKARPANDIAN et al.   MICROCIRCULATION

Design and potential application of PEGylated gold nanoparticles with size-dependent permeation through brain microvasculature

(2011) Arnold B. Etame et al.   Nanomedicine-Nanotechnology Biology and Medicine

The effects of particle size, density and shape on margination of nanoparticles in microcirculation

(2011) Randall Toy et al.   NANOTECHNOLOGY

The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles

(2011) Eun Chul Cho et al.   Nature Nanotechnology

Quantitative Assessment of the Comparative Nanoparticle-Uptake Efficiency of a Range of Cell Lines

(2011) Tiago dos Santos et al.   Small

The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

(2010) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Single and repeated dose toxicity of mesoporous hollow silica nanoparticles in intravenously exposed mice

(2010) Tianlong Liu et al.   BIOMATERIALS

A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices

(2010) Paul M. van Midwoud et al.   LAB ON A CHIP

The Effects of Particle Size and Molecular Targeting on the Intratumoral and Subcellular Distribution of Polymeric Nanoparticles

(2010) Helen Lee et al.   MOLECULAR PHARMACEUTICS

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Biodegradable polymeric nanoparticles based drug delivery systems

(2009) Avnesh Kumari et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Mediating Tumor Targeting Efficiency of Nanoparticles Through Design

(2009) Steven D. Perrault et al.   NANO LETTERS

PEGylated PLGA nanoparticles for the improved delivery of doxorubicin

(2009) Jason Park et al.   Nanomedicine-Nanotechnology Biology and Medicine

The role of nanoparticle size in hemocompatibility

(2009) Andrea Mayer et al.   TOXICOLOGY

Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats

(2008) Michelle Longmire et al.   Nanomedicine

Intravascular Delivery of Particulate Systems: Does Geometry Really Matter?

(2008) Paolo Decuzzi et al.   PHARMACEUTICAL RESEARCH

The impact of different nanoparticle surface chemistry and size on uptake and toxicity in a murine macrophage cell line

(2008) Martin J.D. Clift et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY