Tumour-vessel-on-a-chip models for drug delivery

A guide to light-sheet fluorescence microscopy for multiscale imaging

(2017) Rory M Power et al.   NATURE METHODS

In vitro microfluidic models of tumor microenvironment to screen transport of drugs and nanoparticles

(2017) Altug Ozcelikkale et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Microvasculature on a chip: study of the Endothelial Surface Layer and the flow structure of Red Blood Cells

(2017) Daria Tsvirkun et al.   Scientific Reports

Microvessels-on-a-Chip to Assess Targeted Ultrasound-Assisted Drug Delivery

(2016) Yoonjee C. Park et al.   ACS Applied Materials & Interfaces

Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling

(2016) Aleksander Skardal et al.   DRUG DISCOVERY TODAY

Emerging Frontiers in Drug Delivery

(2016) Mark W. Tibbitt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multi-casting approach for vascular networks in cellularized hydrogels

(2016) Alexander W. Justin et al.   Journal of the Royal Society Interface

An on-chip microfluidic pressure regulator that facilitates reproducible loading of cells and hydrogels into microphysiological system platforms

(2016) Xiaolin Wang et al.   LAB ON A CHIP

3D-printed fluidic networks as vasculature for engineered tissue

(2016) Ian S. Kinstlinger et al.   LAB ON A CHIP

Engineering anastomosis between living capillary networks and endothelial cell-lined microfluidic channels

(2016) Xiaolin Wang et al.   LAB ON A CHIP

Intraoperative intravital microscopy permits the study of human tumour vessels

(2016) Daniel T. Fisher et al.   Nature Communications

Bioprinting the Cancer Microenvironment

(2016) Yu Shrike Zhang et al.   ACS Biomaterials-Science & Engineering

Bioprinting the Cancer Microenvironment

(2016) Yu Shrike Zhang et al.   ACS Biomaterials Science & Engineering

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

Dense nanoparticles exhibit enhanced vascular wall targeting over neutrally buoyant nanoparticles in human blood flow

(2015) Alex J. Thompson et al.   Acta Biomaterialia

Differential Impact of Plasma Proteins on the Adhesion Efficiency of Vascular-Targeted Carriers (VTCs) in Blood of Common Laboratory Animals

(2015) Katawut Namdee et al.   BIOCONJUGATE CHEMISTRY

A microfluidically perfused three dimensional human liver model

(2015) Knut Rennert et al.   BIOMATERIALS

Understanding and exploiting nanoparticles' intimacy with the blood vessel and blood

(2015) Magdiel Inggrid Setyawati et al.   CHEMICAL SOCIETY REVIEWS

Red blood cells affect the margination of microparticles in synthetic microcapillaries and intravital microcirculation as a function of their size and shape

(2015) Rosa D'Apolito et al.   JOURNAL OF CONTROLLED RELEASE

Synthetic tumor networks for screening drug delivery systems

(2015) Balabhaskar Prabhakarpandian et al.   JOURNAL OF CONTROLLED RELEASE

The 2015 super-resolution microscopy roadmap

(2015) Stefan W Hell et al.   JOURNAL OF PHYSICS D-APPLIED PHYSICS

Review: in vitro microvessel models

(2015) Max I. Bogorad et al.   LAB ON A CHIP

An artificial blood vessel implanted three-dimensional microsystem for modeling transvascular migration of tumor cells

(2015) Xue-Ying Wang et al.   LAB ON A CHIP

The influence of flow, shear stress and adhesion molecule targeting on gold nanoparticle uptake in human endothelial cells

(2015) Henrik Klingberg et al.   Nanoscale

The biomolecular corona of nanoparticles in circulating biological media

(2015) D. Pozzi et al.   Nanoscale

Personalized medicine: Time for one-person trials

(2015) Nicholas J. Schork   NATURE

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Microcirculation-on-a-Chip: A Microfluidic Platform for Assaying Blood- and Lymphatic-Vessel Permeability

(2015) Miwa Sato et al.   PLoS One

Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle

(2015) Miles A. Miller et al.   Science Translational Medicine

Component-Specific Analysis of Plasma Protein Corona Formation on Gold Nanoparticles Using Multiplexed Surface Plasmon Resonance

(2015) Abhijeet Patra et al.   Small

Particle Margination and Its Implications on Intravenous Anticancer Drug Delivery

(2014) Erik Carboni et al.   AAPS PHARMSCITECH

Vascular Targeting of Nanocarriers: Perplexing Aspects of the Seemingly Straightforward Paradigm

(2014) Melissa Howard et al.   ACS Nano

Microfluidic techniques for development of 3D vascularized tissue

(2014) Anwarul Hasan et al.   BIOMATERIALS

Cells as Active Particles in Asymmetric Potentials: Motility under External Gradients

(2014) Jordi Comelles et al.   BIOPHYSICAL JOURNAL

Tissue-engineered microenvironment systems for modeling human vasculature

(2014) Anna Tourovskaia et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Organ-on-a-chip platforms for studying drug delivery systems

(2014) Nupura S. Bhise et al.   JOURNAL OF CONTROLLED RELEASE

A functional microengineered model of the human splenon-on-a-chip

(2014) L. G. Rigat-Brugarolas et al.   LAB ON A CHIP

Characterization of nanoparticle delivery in microcirculation using a microfluidic device

(2014) Antony Thomas et al.   MICROVASCULAR RESEARCH

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis

(2014) Y. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium

(2013) P. Kolhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumour-on-a-chip provides an optical window into nanoparticle tissue transport

(2013) Alexandre Albanese et al.   Nature Communications

Tumor Endothelial Cells

(2013) A. C. Dudley   Cold Spring Harbor Perspectives in Medicine

Determination of Critical Parameters in Platelet Margination

(2012) Daniel A. Reasor et al.   ANNALS OF BIOMEDICAL ENGINEERING

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

Nanoparticle Hydrophobicity Dictates Immune Response

(2012) Daniel F. Moyano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Blood vessels on a chip

(2012) Claudio Franco et al.   NATURE

Biomolecular coronas provide the biological identity of nanosized materials

(2012) Marco P. Monopoli et al.   Nature Nanotechnology

In vitro microvessels for the study of angiogenesis and thrombosis

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels

(2012) N. Korin et al.   SCIENCE

Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile

(2012) J. Hrkach et al.   Science Translational Medicine

Effect of flow on endothelial endocytosis of nanocarriers targeted to ICAM-1

(2011) Tridib Bhowmick et al.   JOURNAL OF CONTROLLED RELEASE

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

Flow and adhesion of drug carriers in blood vessels depend on their shape: A study using model synthetic microvascular networks

(2010) Nishit Doshi et al.   JOURNAL OF CONTROLLED RELEASE

Microfluidic cell culture systems for drug research

(2010) Min-Hsien Wu et al.   LAB ON A CHIP

Tumor Microvasculature and Microenvironment: Novel Insights Through Intravital Imaging in Pre-Clinical Models

(2010) DAI FUKUMURA et al.   MICROCIRCULATION

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

A physiologically realistic in vitro model of microvascular networks

(2009) Jenna M. Rosano et al.   BIOMEDICAL MICRODEVICES

Why are tumour blood vessels abnormal and why is it important to know?

(2009) J A Nagy et al.   BRITISH JOURNAL OF CANCER

Direct-write assembly of biomimetic microvascular networks for efficient fluid transport

(2009) Willie Wu et al.   Soft Matter

Molecular Characterization of Human Breast Tumor Vascular Cells

(2008) Rajendra Bhati et al.   AMERICAN JOURNAL OF PATHOLOGY

The margination propensity of spherical particles for vascular targeting in the microcirculation

(2008) Francesco Gentile et al.   JOURNAL OF NANOBIOTECHNOLOGY