Review
Chemistry, Multidisciplinary
Chunling Wang, Junchao Xu, Yinlong Zhang, Guangjun Nie
Summary: Abnormal angiogenesis is a significant characteristic of malignant tumors, and nanomedicine provides a precise approach to regulate tumor blood vessels. Nanomedicines have the advantage of reducing systemic toxicity and enhancing therapeutic efficacy, as well as enabling more precise drug delivery and release through specific structural designs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Jisoo Kim, Jungmin Kim, Ge Gao, Yoo-mi Choi, Jaewook Kim, Dong-Woo Cho, Jae-Ho Cheong, Jinah Jang
Summary: The study presents a vascularized organoid model that accurately predicts the clinical response of gastric cancer patients to targeted therapy. This model reproduces patient treatment outcomes and provides a valuable platform for personalized testing and drug discovery.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jia Heng Teoh, Sook Muay Tay, Jerry Fuh, Chi-Hwa Wang
Summary: This study investigates the application of 3D printing to fabricate hydrogel wound dressings with customizable architectures and drug dosages. Results show that 3D printing has the ability to customize drug dosages and drug release rates through co-loading different drugs at various positions and varying the thickness of drug-free layers over drug-loaded layers in the wound dressing.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Pharmacology & Pharmacy
Mayank Handa, Obaid Afzal, Sarwar Beg, Sachin Nashik Sanap, Ravinder K. Kaundal, Rahul K. Verma, Awanish Mishra, Rahul Shukla
Summary: Tailoring drug products to personalized medicines is challenging due to limited availability of flexible dosage strengths in the market. Inappropriate dosage strengths can lead to adverse reactions or compromised therapeutic effects, especially for drugs with narrow therapeutic windows. To overcome these challenges, data-enriched edible pharmaceuticals (DEEP) are novel concepts for designing solid oral products.
DRUG DISCOVERY TODAY
(2023)
Article
Genetics & Heredity
Loren Saulsberry, Keith Danahey, Brittany A. Borden, Elizabeth Lipschultz, Maimouna Traore, Mark J. Ratain, David O. Meltzer, Peter H. O'Donnell
Summary: Black patients have less confidence in personalized treatment decisions made by their providers and overwhelmingly want their genetic information to play a larger role in clinical care. White patients are more likely to discuss the impact of personal/genetic makeup on medication response with providers, while Black patients initiate these discussions much less frequently. Opportunities exist for enhanced communication with underrepresented patients to ensure equitable benefits from pharmacogenomically guided medication treatment.
NPJ GENOMIC MEDICINE
(2021)
Article
Oncology
Andrew J. Armstrong, Xiaotong Li, Matthew Tucker, Shantao Li, Xinmeng Jasmine Mu, Kenneth Wha Eng, Andrea Sboner, Mark Rubin, Mark Gerstein
Summary: Molecular profiling of cancer is becoming common in oncology care, providing insights and potential treatment targets for patients with metastatic prostate cancer. This case study of a patient with advanced prostate cancer undergoing whole-genome sequencing revealed actionable genomic lesions and highlighted the importance of personalized medicine in cancer treatment. The patient's outstanding response to combined modality treatment showcases the potential benefits of integrating medical oncology and genomics approaches.
PROSTATE CANCER AND PROSTATIC DISEASES
(2021)
Article
Health Care Sciences & Services
Arushi Agarwal, Daryl Pritchard, Laura Gullett, Kristen Garner Amanti, Gary Gustavsen
Summary: Research has shown significant heterogeneity in the adoption levels of personalized medicine in the US, with high-performing organizations sharing common themes such as the sophistication of data collection, data sharing practices, and internal funding commitment to supporting personalized medicine initiatives. A longitudinal approach to data collection will be valuable for tracking progress and adapting to new challenges and barriers to personalized medicine adoption.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Abdulsalam A. Alqahtani, Mohammed Muqtader Ahmed, Abdul Aleem Mohammed, Javed Ahmad
Summary: The current healthcare system is limited by the concept of one size fits all, resulting in varied responses and adverse reactions in patients. Personalized medicine (PM) offers customized therapy for individual patients, potentially revolutionizing the healthcare system. 3D printing techniques can be used to design PM in metabolic syndrome, delivering the desired dose and drug release profile for optimal efficacy and safety.
Review
Pharmacology & Pharmacy
A. Amruta, Dalila Iannotta, Seth W. Cheetham, Twan Lammers, Joy Wolfram
Summary: In recent decades, there has been a significant increase in the development of nanodelivery systems for preclinical and clinical applications, particularly in delivering RNA and protein-based therapeutics. The specific vasculature of organs provides a promising avenue for targeted delivery of nanoparticles and extracellular vesicles to interstitial cells. This article emphasizes the properties of organ-specific vasculature, the strategies for nanodelivery that exploit the organotropism of vasculature, and the challenges and opportunities in targeting and overcoming the endothelial barrier. The impediments in the clinical translation of vasculature organotropism in drug delivery are also discussed.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Ethan Hau Yin Lam, Fengqing Yu, Sabrina Zhu, Zongjie Wang
Summary: In the past decade, personalized medicine has made significant progress in addressing patient-specific disease complexities and developing individualized treatment strategies. The emergence of 3D bioprinting has provided novel opportunities for personalized medicine, although current bioprinted constructs have limitations in achieving anatomically realistic organs with mature biological functions. This review discusses the principles and realizations of bioprinting, focusing on techniques such as extrusion printing and digital light processing (DLP). It also explores the applications of bioprinted constructs in regenerative medicine and drug discovery. Despite the challenges, bioprinting shows promise as an empowering technology to overcome critical obstacles in personalized medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Engineering, Biomedical
Shadaan Ahmad, Nazeer Hasan, Fauziya, Akash Gupta, Arif Nadaf, Lubna Ahmad, Mohd. Aqil, Prashant Kesharwani
Summary: CAD and CAM are widely used in the manufacturing of automated, personalized dental devices and treatment plans. 3D printing, with its high productivity and cost-effectiveness, has various applications in healthcare, pharmaceuticals, and engineering. This review discusses the applications, fabrication methods, and critical process parameters of 3D printed materials in dentistry.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2022)
Review
Biochemistry & Molecular Biology
Shubhangi Shukla, Jacek Jakowski, Sachin Kadian, Roger J. Narayan
Summary: This article summarizes the research progress and challenges in using nanomaterials as carriers for cancer therapeutics. The combination of simulation techniques and experimental methods provides a comprehensive understanding of molecular behavior and structure.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Raudel Avila, Chenhang Li, Yeguang Xue, John A. Rogers, Yonggang Huang
Summary: Drug delivery systems with electrochemical actuation offer programmable volume/flowrate capabilities for localized delivery. A new analytical model considering microfluidic resistance and membrane stiffness provides scalable understanding of key variables influencing the delivery process, allowing faster system optimization. The results show relevance to emerging applications of programmable delivery in clinical studies within the neuroscience and biomedical communities.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Oncology
Li-Feng Hu, Xue Yang, Huan-Rong Lan, Xing-Liang Fang, Xiao-Yi Chen, Ke-Tao Jin
Summary: Personalized cancer medicine involves specific treatment for each patient, as the heterogeneous tumor microenvironment and individual differences can significantly impact therapy response and clinical outcomes. Current in vitro and in vivo models inadequately replicate the native tumor microenvironment, highlighting the need for native tumor microenvironment mimicking models. The development of 3D culture models has allowed for better evaluation of chemoresistance and drug functionality in the presence of cell-cell interactions, such as patient-derived tumor xenografts and organoid cultures.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Oncology
Tohru Yoneyama, Shingo Hatakeyama, Mihoko Sutoh-Yoneyama, Taku Yoshiya, Tsuyoshi Uemura, Takehiro Ishizu, Minoru Suzuki, Shingo Hachinohe, Shintaro Ishiyama, Motohiro Nonaka, Michiko N. Fukuda, Chikara Ohyama
Summary: The study demonstrates that IF7 can serve as an efficient delivery vehicle for B-10 by targeting tumor tissues via the tumor vasculature, which could be relevant for BNCT drugs. Multiple treatments at ultralow doses of IF7-B-10 significantly suppressed tumor growth in mouse models of human bladder cancer, suggesting its potential for clinical applications in the future.
Article
Biochemical Research Methods
Qiong Wang, Charles H. Chen, Cheng-yu Chung, Joseph Priola, Jeffrey H. Chu, Juechun Tang, Martin B. Ulmschneider, Michael J. Betenbaugh
BIOTECHNOLOGY JOURNAL
(2018)
Review
Chemistry, Multidisciplinary
Jakob P. Ulmschneider, Martin B. Ulmschneider
ACCOUNTS OF CHEMICAL RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
James C. Gumbart, Martin B. Ulmschneider, Anthony Hazel, Stephen H. White, Jakob P. Ulmschneider
JOURNAL OF MEMBRANE BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Jakob P. Ulmschneider, Jeremy C. Smith, Stephen H. White, Martin B. Ulmschneider
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2018)
Article
Chemistry, Multidisciplinary
Charles H. Chen, Charles G. Starr, Evan Troendle, Gregory Wiedman, William C. Wimley, Jakob P. Ulmschneider, Martin B. Ulmschneider
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Multidisciplinary Sciences
Yukun Wang, Erin Gallagher, Christian Jorgensen, Evan P. Troendle, Dan Hu, Peter C. Searson, Martin B. Ulmschneider
SCIENTIFIC REPORTS
(2019)
Review
Biochemistry & Molecular Biology
Charles H. Chen, Marcelo C. R. Melo, Nils Berglund, Ayesha Khan, Cesar de la Fuente-Nunez, Jakob P. Ulmschneider, Martin B. Ulmschneider
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Charles H. Chen, Charles G. Starr, Shantanu Guha, William C. Wimley, Martin B. Ulmschneider, Jakob P. Ulmschneider
Summary: The use of designed antimicrobial peptides as drugs is hindered by the lack of simple sequence-structure-function relationships and design rules. Through high-throughput library screening and atomistic computer simulations, a general pore-forming peptide can be tailored into a selective pore-former for different lipid types. Predicting the propensity to aggregate and assemble in a given environment from sequence alone holds the key to functional prediction of membrane permeabilization.
JOURNAL OF MEMBRANE BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Josy Augustine, Evan P. Troendle, Peter Barabas, Corey A. McAleese, Thomas Friedel, Alan W. Stitt, Tim M. Curtis
Summary: Lipid peroxidation can lead to the production of reactive aldehyde species, forming ALEs that play a role in diabetic retinopathy complications. Further research and potential therapeutic approaches are being explored to prevent irreversible damage from occurring.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Christian Jorgensen, Martin B. Ulmschneider, Peter C. Searson
Summary: The study used atomistic MD simulations to visualize the translocation of solutes across a lipid bilayer representative of brain microvascular endothelial cells. Solutes were classified into three groups based on free-energy surface profiles, revealing distinct transport mechanisms. The simulations demonstrated the potential for MD simulations to provide new insight into brain penetration mechanisms and drug discovery approaches.
Article
Chemistry, Multidisciplinary
Charles H. Chen, Yu-Han Liu, Arvin Eskandari, Jenisha Ghimire, Leon Chien-Wei Lin, Zih-Syun Fang, William C. Wimley, Jakob P. Ulmschneider, Kogularamanan Suntharalingam, Che-Ming Jack Hu, Martin B. Ulmschneider
Summary: This study developed a new class of anticancer peptides that selectively perforate cancer cell membranes with superior cytotoxicity against breast cancer. The researchers also demonstrated efficient encapsulation of these peptides in polymeric nanocarriers and their effective inhibition of tumor growth in a mouse model of triple-negative breast cancer.
Meeting Abstract
Neurosciences
Paul A. Wadsworth, Aditya Singh, Nolan M. Dvorak, Nghi Nguyen, Giuseppe Aceto, Evan Troendle, Cynthia M. Tapia, Pingyuan Wang, Annie Wadsworth, Oluwarotimi Folorunso, Haiying Chen, Reid Powell, Martin Ulmschneider, Jia Zhou, Marcello D'Ascenzo, Clifford Stephan, Fernanda Laezza
NEUROPSYCHOPHARMACOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Charles H. Chen, Jakob P. Ulmschneider, Martin B. Ulmschneider
AUSTRALIAN JOURNAL OF CHEMISTRY
(2020)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)