Neuroinflammatory targets and treatments for epilepsy validated in experimental models

Extracellular proteasome-osteopontin circuit regulates cell migration with implications in multiple sclerosis

(2017) Chiara Dianzani et al.   Scientific Reports

Epilepsy, Seizures, and Inflammation: Role of the C-C Motif Ligand 2 Chemokine

(2016) Yuri Bozzi et al.   DNA AND CELL BIOLOGY

Effects of rapamycin and curcumin treatment on the development of epilepsy after electrically induced status epilepticus in rats

(2016) Cato M. Drion et al.   EPILEPSIA

Dysregulation of the (immuno)proteasome pathway in malformations of cortical development

(2016) J. van Scheppingen et al.   Journal of Neuroinflammation

Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy

(2016) Alba Jimenez-Pacheco et al.   JOURNAL OF NEUROSCIENCE

The Chemokine CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation

(2016) Chiara Cerri et al.   JOURNAL OF NEUROSCIENCE

A potential role for glia-derived extracellular matrix remodeling in postinjury epilepsy

(2016) Soo Young Kim et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Inhibition of the prostaglandin E2 receptor EP2 prevents status epilepticus-induced deficits in the novel object recognition task in rats

(2016) Asheebo Rojas et al.   NEUROPHARMACOLOGY

Inflammatory mediators in human epilepsy: A systematic review and meta-analysis

(2016) Evelien E. de Vries et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus

(2016) Nicholas H. Varvel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The immunoproteasome β5i subunit is a key contributor to ictogenesis in a rat model of chronic epilepsy

(2015) Michele Mishto et al.   BRAIN BEHAVIOR AND IMMUNITY

Antiepileptogenic effects of the selective COX-2 inhibitor etoricoxib, on the development of spontaneous absence seizures in WAG/Rij rats

(2015) Rita Citraro et al.   BRAIN RESEARCH BULLETIN

Blood-brain barrier leakage after status epilepticus in rapamycin-treated rats I: Magnetic resonance imaging

(2015) Erwin A. van Vliet et al.   EPILEPSIA

Differential expression and clinical significance of three inflammation-related microRNAs in gangliogliomas

(2015) A. S. Prabowo et al.   Journal of Neuroinflammation

Increased Expression and Cellular Localization of P2X7R in Cortical Lesions of Patients With Focal Cortical Dysplasia

(2015) Yu-Jia Wei et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Systemic effects of treatment with mTOR inhibitors in tuberous sclerosis complex: a comprehensive review

(2015) K. Sadowski et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Inhibition of monoacylglycerol lipase mediates a cannabinoid 1-receptor dependent delay of kindling progression in mice

(2015) E.L. von Rüden et al.   NEUROBIOLOGY OF DISEASE

GABA A currents are decreased by IL-1β in epileptogenic tissue of patients with temporal lobe epilepsy: implications for ictogenesis

(2015) Cristina Roseti et al.   NEUROBIOLOGY OF DISEASE

Inhibition of the prostaglandin EP2 receptor is neuroprotective and accelerates functional recovery in a rat model of organophosphorus induced status epilepticus

(2015) Asheebo Rojas et al.   NEUROPHARMACOLOGY

Immunity and Inflammation in Epilepsy

(2015) Annamaria Vezzani et al.   Cold Spring Harbor Perspectives in Medicine

Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes

(2015) Juliane Liepe et al.   eLife

Circulating 20S Proteasome Is Independently Associated with Abdominal Muscle Mass in Hemodialysis Patients

(2015) Hirotaka Fukasawa et al.   PLoS One

Losartan prevents acquired epilepsy via TGF-β signaling suppression

(2014) Guy Bar-Klein et al.   ANNALS OF NEUROLOGY

Standard and immunoproteasomes show similar peptide degradation specificities

(2014) Damien Zanker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Proteasome isoforms exhibit only quantitative differences in cleavage and epitope generation

(2014) Michele Mishto et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Development of second generation EP2 antagonists with high selectivity

(2014) Thota Ganesh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Intrinsic and Induced Regulation of the Age-Associated Onset of Spontaneous Experimental Autoimmune Encephalomyelitis

(2014) H. Zhang et al.   JOURNAL OF IMMUNOLOGY

The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus

(2014) Asheebo Rojas et al.   NEUROBIOLOGY OF DISEASE

Metalloproteinase inhibition prevents inhibitory synapse reorganization and seizure genesis

(2014) Emily Pollock et al.   NEUROBIOLOGY OF DISEASE

MicroRNAs: New Regulators of Toll-Like Receptor Signalling Pathways

(2014) Xiaobing He et al.   Biomed Research International

TORC1-dependent epilepsy caused by acute biallelicTsc1deletion in adult mice

(2013) Elisabeth Abs et al.   ANNALS OF NEUROLOGY

Relationship Between the Chemokine Receptor CCR5 and Microglia in Neurological Disorders: Consequences of Targeting CCR5 on Neuroinflammation, Neuronal Death and Regeneration in a Model of Epilepsy

(2013) Jean-Pierre Louboutin et al.   CNS & Neurological Disorders-Drug Targets

Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079

(2013) Alba Jimenez-Pacheco et al.   EPILEPSIA

Fractalkine/CX3CL1 modulates GABAAcurrents in human temporal lobe epilepsy

(2013) Cristina Roseti et al.   EPILEPSIA

Cyclooxygenase-2 in epilepsy

(2013) Asheebo Rojas et al.   EPILEPSIA

B7-H4Ig inhibits mouse and human T-cell function and treats EAE via IL-10/Treg-dependent mechanisms

(2013) Joseph R. Podojil et al.   JOURNAL OF AUTOIMMUNITY

EP2 Receptor Signaling Pathways Regulate Classical Activation of Microglia

(2013) Yi Quan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel anticonvulsant modulates voltage-gated sodium channel inactivation and prevents kindling-induced seizures

(2013) Muhammad N. Ashraf et al.   JOURNAL OF NEUROCHEMISTRY

Neuroprotective and antiepileptogenic effects of combination of anti-inflammatory drugs in the immature brain

(2013) Young Se Kwon et al.   Journal of Neuroinflammation

Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials

(2013)   LANCET

Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy

(2013) F.M. Noe et al.   NEUROBIOLOGY OF DISEASE

Hippocampal subregion-specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy

(2013) Jan A. Gorter et al.   NEUROBIOLOGY OF DISEASE

Cell adhesion and homeostatic synaptic plasticity

(2013) Agnes Thalhammer et al.   NEUROPHARMACOLOGY

Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation

(2013) Jianxiong Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P2X receptors as targets for the treatment of status epilepticus

(2013) David C. Henshall et al.   Frontiers in Cellular Neuroscience

P2X7 Receptors: Channels, Pores and More

(2012) C. Volonte et al.   CNS & Neurological Disorders-Drug Targets

Finding a better drug for epilepsy: The mTOR pathway as an antiepileptogenic target

(2012) Aristea S. Galanopoulou et al.   EPILEPSIA

Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation

(2012) Erwin A. van Vliet et al.   EPILEPSIA

Blood-brain barrier dysfunction-induced inflammatory signaling in brain pathology and epileptogenesis

(2012) Soo Young Kim et al.   EPILEPSIA

Blood-brain barrier dysfunction, TGFβ signaling, and astrocyte dysfunction in epilepsy

(2012) Uwe Heinemann et al.   GLIA

Astrocyte immune responses in epilepsy

(2012) Eleonora Aronica et al.   GLIA

Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures

(2012) Jayne Abraham et al.   NEUROBIOLOGY OF DISEASE

The perineuronal net component of the extracellular matrix in plasticity and epilepsy

(2012) Paulette A. McRae et al.   NEUROCHEMISTRY INTERNATIONAL

The role of inflammation in epileptogenesis

(2012) Annamaria Vezzani et al.   NEUROPHARMACOLOGY

MicroRNA-146a: A Key Regulator of Astrocyte-Mediated Inflammatory Response

(2012) Anand Iyer et al.   PLoS One

Immunoproteasome expression is induced in mesial temporal lobe epilepsy

(2011) Michele Mishto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inflammation in epilepsy: Clinical observations

(2011) Eleonora Aronica et al.   EPILEPSIA

Epilepsy and brain inflammation

(2011) Annamaria Vezzani et al.   EXPERIMENTAL NEUROLOGY

Ablation of Cyclooxygenase-2 in Forebrain Neurons is Neuroprotective and Dampens Brain Inflammation after Status Epilepticus

(2011) G. E. Serrano et al.   JOURNAL OF NEUROSCIENCE

Lymphocyte adhesion to CCR5 ligands is reduced by anti-CCR5 gene delivery

(2011) Elena Marusich et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

IL-1β is induced in reactive astrocytes in the somatosensory cortex of rats with genetic absence epilepsy at the onset of spike-and-wave discharges, and contributes to their occurrence

(2011) Demet Akin et al.   NEUROBIOLOGY OF DISEASE

Interleukin-1β Biosynthesis Inhibition Reduces Acute Seizures and Drug Resistant Chronic Epileptic Activity in Mice

(2011) Mattia Maroso et al.   Neurotherapeutics

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

(2011) D. K. Nomura et al.   SCIENCE

Inflammation induced by LPS enhances epileptogenesis in immature rat and may be partially reversed by IL1RA

(2010) Stéphane Auvin et al.   EPILEPSIA

The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy

(2010) Nadine Polascheck et al.   EXPERIMENTAL NEUROLOGY

Role of CCR5 and its ligands in the control of vascular inflammation and leukocyte recruitment required for acute excitotoxic seizure induction and neural damage

(2010) Jean-Pierre Louboutin et al.   FASEB JOURNAL

The emerging role for chemokines in epilepsy

(2010) Paolo F. Fabene et al.   JOURNAL OF NEUROIMMUNOLOGY

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy

(2010) Xiaoxing Huang et al.   NEUROBIOLOGY OF DISEASE

Immunoproteasome LMP2 60HH Variant Alters MBP Epitope Generation and Reduces the Risk to Develop Multiple Sclerosis in Italian Female Population

(2010) Michele Mishto et al.   PLoS One

Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy

(2009) L. Holtman et al.   EPILEPSY RESEARCH

Blood–brain barrier breakdown-inducing astrocytic transformation: Novel targets for the prevention of epilepsy

(2009) Alon Friedman et al.   EPILEPSY RESEARCH

The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy

(2009) L.-H. Zeng et al.   JOURNAL OF NEUROSCIENCE

Transcriptome Profiling Reveals TGF-  Signaling Involvement in Epileptogenesis

(2009) L. P. Cacheaux et al.   JOURNAL OF NEUROSCIENCE

Interleukin Converting Enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1β production

(2008) Teresa Ravizza et al.   NEUROBIOLOGY OF DISEASE

Antagonism of peripheral inflammation reduces the severity of status epilepticus

(2008) Nicola Marchi et al.   NEUROBIOLOGY OF DISEASE