Disulfide-Containing High Mobility Group Box-1 Promotes N-Methyl-d-Aspartate Receptor Function and Excitotoxicity by Activating Toll-Like Receptor 4-Dependent Signaling in Hippocampal Neurons

HMGB1 Develops Enhanced Proinflammatory Activity by Binding to Cytokines

(2014) Y. Sha et al.   JOURNAL OF IMMUNOLOGY

Unknown

(2013) Daolin Tang et al.   MOLECULAR MEDICINE

Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures

(2013) Valentina Iori et al.   NEUROBIOLOGY OF DISEASE

Anti-high mobility group box-1 antibody therapy for traumatic brain injury

(2012) Yu Okuma et al.   ANNALS OF NEUROLOGY

High Mobility Group Box 1/Toll-like Receptor Danger Signaling Increases Brain Neuroimmune Activation in Alcohol Dependence

(2012) Fulton T. Crews et al.   BIOLOGICAL PSYCHIATRY

Estradiol-induced increase in novel object recognition requires hippocampal NR2B-containing NMDA receptors

(2012) Lindsey C. Vedder et al.   HIPPOCAMPUS

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

(2012) Emilie Venereau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Electroacupuncture pretreatment attenuates cerebral ischemic injury through α7 nicotinic acetylcholine receptor-mediated inhibition of high-mobility group box 1 release in rats

(2012) Qiang Wang et al.   Journal of Neuroinflammation

The role of receptor for advanced glycation end products (RAGE) in neuronal differentiation

(2012) Joanne Kim et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Expression of HMGB1 and RAGE in rat and human brains after traumatic brain injury

(2012) Tie-Lei Gao et al.   Journal of Trauma and Acute Care Surgery

HMGB1 and leukocyte migration during trauma and sterile inflammation

(2012) Emilie Venereau et al.   MOLECULAR IMMUNOLOGY

Unknown

(2012) Huan Yang et al.   MOLECULAR MEDICINE

HMGB1 in Development and Diseases of the Central Nervous System

(2012) Ping Fang et al.   MOLECULAR NEUROBIOLOGY

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC α2δ-1 Subunit

(2012) Assunta Senatore et al.   NEURON

Potentiation of NMDA Receptor-Dependent Cell Responses by Extracellular High Mobility Group Box 1 Protein

(2012) Marco Pedrazzi et al.   PLoS One

Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential

(2011) Mark L. Hanke et al.   CLINICAL SCIENCE

High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and Receptor for Advanced Glycation End Products

(2011) Andréy Mazarati et al.   EXPERIMENTAL NEUROLOGY

LPS Sensitizes TRPV1 via Activation of TLR4 in Trigeminal Sensory Neurons

(2011) A. Diogenes et al.   JOURNAL OF DENTAL RESEARCH

Introduction: HMGB1 in inflammation and innate immunity

(2011) U. Andersson et al.   JOURNAL OF INTERNAL MEDICINE

Neuron-Specific Effects of Interleukin-1  Are Mediated by a Novel Isoform of the IL-1 Receptor Accessory Protein

(2011) Y. Huang et al.   JOURNAL OF NEUROSCIENCE

HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration

(2011) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

Beneficial Effects of Ethyl Pyruvate through Inhibiting High-Mobility Group Box 1 Expression and TLR4/NF-κB Pathway after Traumatic Brain Injury in the Rat

(2011) Xingfen Su et al.   MEDIATORS OF INFLAMMATION

Misplaced NMDA receptors in epileptogenesis contribute to excitotoxicity

(2011) Angelisa Frasca et al.   NEUROBIOLOGY OF DISEASE

High-Mobility Group Box 1, Oxidative Stress, and Disease

(2010) Daolin Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

Extracellular HMGB1 Released by NMDA Treatment Confers Neuronal Apoptosis via RAGE-p38 MAPK/ERK Signaling Pathway

(2010) Seung-Woo Kim et al.   NEUROTOXICITY RESEARCH

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

(2010) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiological and pathophysiological outcomes of the interactions of HMGB1 with cell surface receptors

(2009) Heikki Rauvala et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Intracellular Ca2+ stores modulate SOCCs and NMDA receptors via tyrosine kinases in rat hippocampal neurons

(2009) David J. Koss et al.   CELL CALCIUM

Mitochondria, oxidative stress, and temporal lobe epilepsy

(2009) Simon Waldbaum et al.   EPILEPSY RESEARCH

Neuroprotection by biodegradable PAMAM ester (e-PAM-R)-mediated HMGB1 siRNA delivery in primary cortical cultures and in the postischemic brain

(2009) Il-Doo Kim et al.   JOURNAL OF CONTROLLED RELEASE

The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation

(2009) Hulda Sigridur Hreggvidsdottir et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1 

(2008) S. Balosso et al.   BRAIN

High-Mobility Group Box-1 in Ischemia-Reperfusion Injury of the Heart

(2008) Martin Andrassy et al.   CIRCULATION

Redox properties of the A-domain of the HMGB1 protein

(2008) Debashish Sahu et al.   FEBS LETTERS

NMDA receptors in clinical neurology: excitatory times ahead

(2008) Lorraine V Kalia et al.   LANCET NEUROLOGY

Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism

(2008) Kazuhide Hayakawa et al.   NEUROPHARMACOLOGY

Postsynaptic mechanisms of excitotoxicity: Involvement of postsynaptic density proteins, radicals, and oxidant molecules

(2008) J.P. Forder et al.   NEUROSCIENCE

Toll-Like Receptor 4 Is Involved in Subacute Stress–Induced Neuroinflammation and in the Worsening of Experimental Stroke

(2008) Javier R. Caso et al.   STROKE

Interleukin-1-induced interleukin-6 synthesis is mediated by the neutral sphingomyelinase/Src kinase pathway in neurones

(2007) N Tsakiri et al.   BRITISH JOURNAL OF PHARMACOLOGY