Article
Medical Laboratory Technology
Yun Xie, Zhidong Guo, Fanghui Chen, Chen Xiao, Jianping Xu, Dezhi Bo
Summary: The study found that serum netrin-1 concentrations in TBI patients are closely related to prognosis, and may serve as a potential biomarker for predicting outcomes in TBI patients.
CLINICA CHIMICA ACTA
(2021)
Article
Immunology
William A. Banks, Kim M. Hansen, Michelle A. Erickson, Fulton T. Crews
Summary: High-mobility group box 1 (HMGB1) is a protein that regulates transcription in the cell nucleus and activates the innate immune system. It can cross the blood-brain barrier (BBB) and affect neuroimmune signaling in the brain and periphery. In this study, the ability of radioactively labeled HMGB1 to cross the BBB was examined. The results showed that HMGB1 could bidirectionally cross the BBB and its transport rates were enhanced by inflammation. This finding suggests that HMGB1 levels have an impact on neuroimmune signaling in various conditions.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Clinical Neurology
Brian E. Powers, Son T. Ton, Robert G. Farrer, Suhani Chaudhary, Russ P. Nockels, Gwendolyn L. Kartje, Shih-Yen Tsai
Summary: This study suggests that anti-Nogo-A antibody treatment may improve functional recovery by promoting axonal growth and neuronal plasticity in individuals with traumatic brain injury. The experiments conducted on rats showed significant improvement in motor deficits after receiving the treatment, indicating the potential efficacy of anti-Nogo-A Ab therapy for patients with TBI.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Multidisciplinary Sciences
Eujene Jung, Hyun Ho Ryu, Cha Won Ko, Yong Deok Lim
Summary: This study evaluated the relationship between the C-reactive protein-to-albumin ratio (CAR) and long-term functional outcomes in patients with mild traumatic brain injury (mTBI), and found that elevated CAR with fever increased the risk of poor functional recovery.
Article
Pharmacology & Pharmacy
Chao Ren, Ren-qi Yao, Li-xue Wang, Jun-cong Li, Kun-wei Chen, Yao Wu, Ning Dong, Yong-wen Feng, Yong-ming Yao
Summary: This study found that HMGB1 plays a critical role in dysregulating immune response in sepsis, with the relationship between cerebral HMGB1 and splenic DC dysfunction being dependent on cholinergic system activity. The findings shed light on the mechanisms of immune dysfunction in sepsis and the potential therapeutic targets involving HMGB1 and cholinergic pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Geriatrics & Gerontology
Yan Zhao, Si-Wei Tan, Zhi-Zhong Huang, Fa-Bo Shan, Ping Li, Ya-Lei Ning, Shi-Yang Ye, Zi-Ai Zhao, Hao Du, Ren-Ping Xiong, Nan Yang, Yan Peng, Xing Chen, Yuan-Guo Zhou
Summary: Tau hyperphosphorylation and HMGB1 interactions play a crucial role in neuroinflammation and spatial memory, suggesting that HMGB1 inhibitors may be a promising therapeutic strategy for tauopathies.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Kazuki Hatayama, Ray H. Chen, Jordan Hanson, Kiyoshi Teshigawara, Joseph Qiu, Andre Santoso, Clemence Disdier, Sakura Nakada, Xiaodi Chen, Masahiro Nishibori, Yow-Pin Lim, Barbara S. Stonestreet
Summary: The study confirmed specific binding characteristics between IAIPs and HMGB1 in vitro and demonstrated their co-localization in neonatal rats exposed to HI brain injury, suggesting a potential anti-inflammatory effect. The results indicate that HMGB1 could be a target of IAIPs, showing promise for future therapeutic interventions in neuroinflammation.
Article
Pharmacology & Pharmacy
Lei Li, Fanjian Li, Xuesong Bai, Haoran Jia, Cong Wang, Peng Li, Qiaoling Zhang, Siyu Guan, Ruilong Peng, Shu Zhang, Jing-fei Dong, Jianning Zhang, Xin Xu
Summary: Endothelial dysfunction plays a crucial role in the pathophysiology of traumatic brain injury (TBI). Previously, it was shown that extracellular vesicles (EVs) released from injured brains contribute to endothelial barrier disruption and vascular leakage. In this study, plasma EVs were enriched from TBI patients and high mobility group box 1 (HMGB1) was detected on a significant proportion of these EVs. The number of HMGB1-positive EVs correlated with injury severity. Moreover, it was found that these EVs induced dysfunction of endothelial cells in culture and mediated endothelial dysfunction in normal and TBI mice through the HMGB1-activated receptor for advanced glycation end products (RAGE)/Cathepsin B signaling pathway, NLRP3 inflammasome activation, and caspase1/gasdermin D (GSDMD)-dependent pyroptosis. The presence of von Willebrand factor (VWF) on HMGB1-positive EVs suggested that VWF might facilitate HMGB1-induced endothelial dysfunction by tethering EVs to endothelial cells.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Cindy Santiago-Castaneda, Saul Huerta de la Cruz, Christopher Martinez-Aguirre, Sandra Adela Orozco-Suarez, Luisa Rocha
Summary: This study demonstrates that orally administered cannabidiol (CBD) can reduce the excessive release of glutamate caused by traumatic brain injury (TBI) and facilitate functional recovery. CBD pretreatment significantly reduces glutamate concentration and improves survival rate and body weight gain. Long-term treatment also shows a reduction in glutamate concentration and improvement in sensorimotor function.
Article
Medicine, General & Internal
Mila M. Paul, Hannah J. Mieden, Rolf Lefering, Eva K. Kupczyk, Martin C. Jordan, Fabian Gilbert, Rainer H. Meffert, Anna-Leena Siren, Stefanie Hoelscher-Doht
Summary: A retrospective matched-pair analysis was conducted to analyze the impact of concomitant femoral fracture on the outcome of traumatic brain injury (TBI) patients. The results showed that patients with combined TBI and femoral fracture had higher mortality, worse outcome, increased risk of multi-organ failure, and more neurosurgical interventions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Orli Thau-Zuchman, Linda Svendsen, Simon C. Dyall, Ursula Paredes-Esquivel, Molly Rhodes, John Priestley, Rene G. Feichtinger, Barbara Kofler, Susanne Lotstra, J. Martin Verkuyl, Robert J. Hageman, Laus M. Broersen, Nick van Wijk, Jose P. Silva, Jordi L. Tremoleda, Adina T. Michael-Titus
Summary: The new ketogenic diet (KD) with a ratio of 2:1 of fat to carbohydrate plus protein showed neuroprotective potential in adult traumatic brain injury (TBI). It significantly improved sensorimotor deficits and spatial memory, reduced lesion size, inflammation, oxidation, and oligodendrocyte loss. The new formulation demonstrated therapeutic potential in adult TBI by enhancing the mTOR pathway and histone modifications.
Article
Neurosciences
Mecca B. A. R. Islam, Booker T. Davis IV, Mary J. Kando, Qinwen Mao, Daniele Procissi, Craig Weiss, Steven J. Schwulst
Summary: The study found that young adult mice showed more severe neuropathology and greater loss of white matter connectivity after TBI compared to aged mice. Differential functional outcomes were also observed in anxiety response, learning, and memory between young adult and aged mice after TBI.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Critical Care Medicine
Peter Ferrazzano, Benjamin Yeske, Jeanette Mumford, Gregory Kirk, Erin D. Bigler, Katherine Bowen, Nicole O'Brien, Bedda Rosario, Sue R. Beers, Paul Rathouz, Michael J. Bell, Andrew L. Alexander
Summary: Adolescent traumatic brain injury is a significant public health issue, with neuroimaging being a primary diagnostic tool. This study aimed to identify imaging biomarkers for long-term neurocognitive outcomes after severe adolescent TBI, finding associations between VBR and corpus callosum cross-sectional area with overall functional and neurocognitive outcomes.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Rehabilitation
Marie-Julie Potvin, Pauline Brayet, Veronique Paradis, Charles Overbeek, Erik Therrien, Laurie-Anne Dion, Francis Bernard, Nadia Gosselin, Isabelle Rouleau, Olivier Boucher, Jean-Francois Giguere
Summary: The study aimed to predict long-term functional outcomes in traumatic brain injury patients using the new test EXACT and found that EXACT, in some cases, may predict functional outcomes more accurately than PTA, suggesting it could be a promising tool for future TBI recovery research.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Neurosciences
Jing Wang, Yujiao Lu, Christopher Carr, Krishnan M. Dhandapani, Darrell W. Brann
Summary: This study found that long-term (months) after traumatic brain injury (TBI), there is a significant presence of proinflammatory senescent cells in the brain. The administration of senolytic drugs can improve long-term functional outcomes by reducing inflammation and neurodegeneration.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)