Monosodium Urate Activates Src/Pyk2/PI3 Kinase and Cathepsin Dependent Unconventional Protein Secretion From Human Primary Macrophages

Cytosolic Antiviral RNA Recognition Pathway Activates Caspases 1 and 3

(2014) J. Rintahaka et al.   JOURNAL OF IMMUNOLOGY

Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

(2012) Olaf Groß et al.   IMMUNITY

Global Secretome Characterization of Herpes Simplex Virus 1-Infected Human Primary Macrophages

(2012) J. J. Miettinen et al.   JOURNAL OF VIROLOGY

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

P2Y6 Receptor Signaling Pathway Mediates Inflammatory Responses Induced by Monosodium Urate Crystals

(2011) H. Uratsuji et al.   JOURNAL OF IMMUNOLOGY

IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA

(2011) Andreas Pichlmair et al.   NATURE IMMUNOLOGY

SignalP 4.0: discriminating signal peptides from transmembrane regions

(2011) Thomas Nordahl Petersen et al.   NATURE METHODS

ExoCarta 2012: database of exosomal proteins, RNA and lipids

(2011) S. Mathivanan et al.   NUCLEIC ACIDS RESEARCH

Fungal recognition is mediated by the association of dectin-1 and galectin-3 in macrophages

(2011) A. Esteban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative Subcellular Proteome and Secretome Profiling of Influenza A Virus-Infected Human Primary Macrophages

(2011) Niina Lietzén et al.   PLoS Pathogens

The Sterile Inflammatory Response

(2010) Kenneth L. Rock et al.   Annual Review of Immunology

Induction of type I interferons by bacteria

(2010) Kathryn M. Monroe et al.   CELLULAR MICROBIOLOGY

Pathways of unconventional protein secretion

(2010) Walter Nickel   CURRENT OPINION IN BIOTECHNOLOGY

(1,3)- -Glucans Activate Both Dectin-1 and NLRP3 Inflammasome in Human Macrophages

(2010) P. Kankkunen et al.   JOURNAL OF IMMUNOLOGY

Secretome Analysis of Multiple Pancreatic Cancer Cell Lines Reveals Perturbations of Key Functional Networks

(2010) Silvia Schiarea et al.   JOURNAL OF PROTEOME RESEARCH

Cytosolic RNA Recognition Pathway Activates 14-3-3 Protein Mediated Signaling and Caspase-Dependent Disruption of Cytokeratin Network in Human Keratinocytes

(2010) Tiina Öhman et al.   JOURNAL OF PROTEOME RESEARCH

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

Cytokine secretion in macrophages and other cells: Pathways and mediators

(2009) Jennifer L. Stow et al.   IMMUNOBIOLOGY

Mechanisms of uric acid crystal-mediated autoinflammation

(2009) Fabio Martinon   IMMUNOLOGICAL REVIEWS

Alterations in cellular proteome and secretome upon differentiation from monocyte to macrophage by treatment with phorbol myristate acetate: Insights into biological processes

(2009) Kitisak Sintiprungrat et al.   Journal of Proteomics

Serum Uric Acid Is Independently Associated with Metabolic Syndrome in Subjects with and without a Low Estimated Glomerular Filtration Rate

(2009) L.-C. SEE et al.   JOURNAL OF RHEUMATOLOGY

From Secretome Analysis to Immunology

(2009) Christian Villiers et al.   MOLECULAR & CELLULAR PROTEOMICS

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL

Receptor-Independent, Direct Membrane Binding Leads to Cell-Surface Lipid Sorting and Syk Kinase Activation in Dendritic Cells

(2008) Gilbert Ng et al.   IMMUNITY

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

(2008) Mirjam Kool et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

INTERFEROME: the database of interferon regulated genes

(2008) Shamith A. Samarajiwa et al.   NUCLEIC ACIDS RESEARCH

Proteomic profiling of exosomes: Current perspectives

(2008) Richard J. Simpson et al.   PROTEOMICS