Inhibition of Oncogenic Epidermal Growth Factor Receptor Kinase Triggers Release of Exosome-like Extracellular Vesicles and Impacts Their Phosphoprotein and DNA Content

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Oncogenic ras-driven cancer cell vesiculation leads to emission of double-stranded DNA capable of interacting with target cells

(2014) Tae Hoon Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

Identification of Double-stranded Genomic DNA Spanning All Chromosomes with MutatedKRASandp53DNA in the Serum Exosomes of Patients with Pancreatic Cancer

(2014) Christoph Kahlert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coagulation and angiogenic gene expression profiles are defined by molecular subgroups of medulloblastoma: evidence for growth factor-thrombin cross-talk

(2014) E. D'Asti et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The emerging role of extracellular vesicles as biomarkers for urogenital cancers

(2014) Muhammad Nawaz et al.   Nature Reviews Urology

ErbB/HER protein-tyrosine kinases: Structures and small molecule inhibitors

(2014) Robert Roskoski   PHARMACOLOGICAL RESEARCH

The overexpression of a single oncogene (ERBB2/HER2) alters the proteomic landscape of extracellular vesicles

(2014) Maria Amorim et al.   PROTEOMICS

Post-Translational Modifications of Exosomal Proteins

(2014) Olga Moreno-Gonzalo et al.   Frontiers in Immunology

Exosomes and communication between tumours and the immune system: are all exosomes equal?

(2013) Angélique Bobrie et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Qualitative changes in the proteome of extracellular vesicles accompanying cancer cell transition to mesenchymal state

(2013) Delphine Garnier et al.   EXPERIMENTAL CELL RESEARCH

Dacomitinib, a new therapy for the treatment of non-small cell lung cancer

(2013) Christina Brzezniak et al.   EXPERT OPINION ON PHARMACOTHERAPY

Oncogenic H-Ras Reprograms Madin-Darby Canine Kidney (MDCK) Cell-derived Exosomal Proteins Following Epithelial-Mesenchymal Transition

(2013) Bow J. Tauro et al.   MOLECULAR & CELLULAR PROTEOMICS

Liquid biopsy: monitoring cancer-genetics in the blood

(2013) Emily Crowley et al.   Nature Reviews Clinical Oncology

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

EGF receptor trafficking: consequences for signaling and cancer

(2013) Alejandra Tomas et al.   TRENDS IN CELL BIOLOGY

Extracellular Vesicles – Biomarkers and Effectors of the Cellular Interactome in Cancer

(2013) Janusz Rak   Frontiers in Pharmacology

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

(2012) Valbona Luga et al.   CELL

Cancer Cells Induced to Express Mesenchymal Phenotype Release Exosome-like Extracellular Vesicles Carrying Tissue Factor

(2012) Delphine Garnier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic Analysis of Exosomes from Mutant KRAS Colon Cancer Cells Identifies Intercellular Transfer of Mutant KRAS

(2012) Michelle Demory Beckler et al.   MOLECULAR & CELLULAR PROTEOMICS

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells

(2012) U. Putz et al.   Science Signaling

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

(2011) Bence György et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Protein Expression Signatures for Inhibition of Epidermal Growth Factor Receptor-mediated Signaling

(2011) Matthew V. Myers et al.   MOLECULAR & CELLULAR PROTEOMICS

Pathway Analysis of Glioblastoma Tissue after Preoperative Treatment with the EGFR Tyrosine Kinase Inhibitor Gefitinib--A Phase II Trial

(2011) M. E. Hegi et al.   MOLECULAR CANCER THERAPEUTICS

Methodological and practical challenges for personalized cancer therapies

(2011) Ignacio I. Wistuba et al.   Nature Reviews Clinical Oncology

Feedback regulation of EGFR signalling: decision making by early and delayed loops

(2011) Roi Avraham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells

(2011) M. A. Antonyak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences

(2011) Leonora Balaj et al.   Nature Communications

Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

(2010) M.-d.-M. Inda et al.   GENES & DEVELOPMENT

Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling

(2010) Arthit Chairoungdua et al.   JOURNAL OF CELL BIOLOGY

Phosphotyrosine signaling analysis of site-specific mutations on EGFRvIII identifies determinants governing glioblastoma cell growth

(2010) Paul H. Huang et al.   Molecular BioSystems

Understanding resistance to EGFR inhibitors—impact on future treatment strategies

(2010) Deric L. Wheeler et al.   Nature Reviews Clinical Oncology

Epidermal Growth Factor Receptor Variant III-Induced Glioma Invasion Is Mediated through Myristoylated Alanine-Rich Protein Kinase C Substrate Overexpression

(2009) J. Micallef et al.   CANCER RESEARCH

Oncosome Formation in Prostate Cancer: Association with a Region of Frequent Chromosomal Deletion in Metastatic Disease

(2009) Dolores Di Vizio et al.   CANCER RESEARCH

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

(2009) Vandhana Muralidharan-Chari et al.   CURRENT BIOLOGY

Acid sphingomyelinase activity triggers microparticle release from glial cells

(2009) Fabio Bianco et al.   EMBO JOURNAL

P2X7 Receptor-Stimulated Secretion of MHC Class II-Containing Exosomes Requires the ASC/NLRP3 Inflammasome but Is Independent of Caspase-1

(2009) Y. Qu et al.   JOURNAL OF IMMUNOLOGY

Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR

(2009) K. Al-Nedawi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

(2008) Khalid Al-Nedawi et al.   NATURE CELL BIOLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

K-rasMutations and Benefit from Cetuximab in Advanced Colorectal Cancer

(2008) Christos S. Karapetis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Quantitative proteomics and phosphoproteomics reveal novel insights into complexity and dynamics of the EGFR signaling network

(2008) Sandra Morandell et al.   PROTEOMICS

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE