A guide to using functional magnetic resonance imaging to study Alzheimer's disease in animal models

Linking brain vascular physiology to hemodynamic response in ultra-high field MRI

(2018) Kâmil Uludağ et al.   NEUROIMAGE

Functional MRI of Mnemonic Networks Across the Spectrum of Normal Aging, Mild Cognitive Impairment, and Alzheimer's Disease

(2018) Jasmeer P. Chhatwal et al.   JOURNAL OF ALZHEIMERS DISEASE

A Preliminary Study Targeting Neuronal Pathways Activated Following Environmental Enrichment by Resting State Functional Magnetic Resonance Imaging

(2018) Deborah M. Little et al.   JOURNAL OF ALZHEIMERS DISEASE

Multimodal Imaging in Rat Model Recapitulates Alzheimer's Disease Biomarkers Abnormalities

(2017) Maxime J. Parent et al.   JOURNAL OF NEUROSCIENCE

GABAergic effect on resting-state functional connectivity: Dynamics under pharmacological antagonism

(2017) Fatima A. Nasrallah et al.   NEUROIMAGE

A novel approach to map induced activation of neuronal networks using chemogenetics and functional neuroimaging in rats: A proof-of-concept study on the mesocorticolimbic system

(2017) Theresia J.M. Roelofs et al.   NEUROIMAGE

Functional circuit mapping of striatal output nuclei using simultaneous deep brain stimulation and fMRI

(2017) Nathalie Van Den Berge et al.   NEUROIMAGE

Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology

(2017) Tal Nuriel et al.   Nature Communications

Hypertension, cerebrovascular impairment, and cognitive decline in aged AβPP/PS1 mice

(2017) Maximilian Wiesmann et al.   Theranostics

Cardiac Disorders as Risk Factors for Alzheimer's Disease

(2017) Tânia Corrêa de Toledo Ferraz Alves et al.   JOURNAL OF ALZHEIMERS DISEASE

Early pathologic amyloid induces hypersynchrony of BOLD resting-state networks in transgenic mice and provides an early therapeutic window before amyloid plaque deposition

(2016) Disha Shah et al.   Alzheimers & Dementia

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

Physiological effects of a habituation procedure for functional MRI in awake mice using a cryogenic radiofrequency probe

(2016) Keitaro Yoshida et al.   JOURNAL OF NEUROSCIENCE METHODS

Gamma frequency entrainment attenuates amyloid load and modifies microglia

(2016) Hannah F. Iaccarino et al.   NATURE

Complex interplay between brain function and structure during cerebral amyloidosis in APP transgenic mouse strains revealed by multi-parametric MRI comparison

(2016) Joanes Grandjean et al.   NEUROIMAGE

Large-scale functional connectivity networks in the rodent brain

(2016) Alessandro Gozzi et al.   NEUROIMAGE

Activation of Direct and Indirect Pathway Medium Spiny Neurons Drives Distinct Brain-wide Responses

(2016) Hyun Joo Lee et al.   NEURON

Magnetic Resonance Q Mapping Reveals a Decrease in Microvessel Density in the arcAβ Mouse Model of Cerebral Amyloidosis

(2016) Giovanna D. Ielacqua et al.   Frontiers in Aging Neuroscience

A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice

(2016) Maximilian Wiesmann et al.   NEURAL PLASTICITY

Normothermic Mouse Functional MRI of Acute Focal Thermostimulation for Probing Nociception

(2016) Henning Matthias Reimann et al.   Scientific Reports

Imaging learned fear circuitry in awake mice using fMRI

(2015) Anjanette P. Harris et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Rodent models of neuroinflammation for Alzheimer’s disease

(2015) Amir Nazem et al.   Journal of Neuroinflammation

Intracerebroventricular Streptozotocin Injections as a Model of Alzheimer’s Disease: in Search of a Relevant Mechanism

(2015) Paweł Grieb   MOLECULAR NEUROBIOLOGY

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Dependence of BOLD signal fluctuation on arterial blood CO2 and O2: Implication for resting-state functional connectivity

(2015) Fatima A. Nasrallah et al.   NEUROIMAGE

MRI compatible optrodes for simultaneous LFP and optogenetic fMRI investigation of seizure-like afterdischarges

(2015) Ben A. Duffy et al.   NEUROIMAGE

Mapping the functional network of medial prefrontal cortex by combining optogenetics and fMRI in awake rats

(2015) Zhifeng Liang et al.   NEUROIMAGE

Optogenetic fMRI reveals distinct, frequency-dependent networks recruited by dorsal and intermediate hippocampus stimulations

(2015) Andrew J. Weitz et al.   NEUROIMAGE

The neural basis of one's own conscious and unconscious emotional states

(2015) Ryan Smith et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Frequency-selective control of cortical and subcortical networks by central thalamus

(2015) Jia Liu et al.   eLife

I'll take the low road: the evolutionary underpinnings of visually triggered fear

(2015) James A. Carr   Frontiers in Neuroscience

New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathway

(2015) Rosely O. Godinho et al.   Frontiers in Pharmacology

Optogenetic Activation of CA1 Pyramidal Neurons at the Dorsal and Ventral Hippocampus Evokes Distinct Brain-Wide Responses Revealed by Mouse fMRI

(2015) Norio Takata et al.   PLoS One

Functional MRI during Hippocampal Deep Brain Stimulation in the Healthy Rat Brain

(2015) Nathalie Van Den Berge et al.   PLoS One

Behavioral assays with mouse models of Alzheimer's disease: Practical considerations and guidelines

(2014) Daniela Puzzo et al.   BIOCHEMICAL PHARMACOLOGY

Pittsburgh compound B retention and progression of cognitive status - a meta-analysis

(2014) X. Chen et al.   EUROPEAN JOURNAL OF NEUROLOGY

Toward systems neuroscience in mild cognitive impairment and Alzheimer's disease: A meta-analysis of 75 fMRI studies

(2014) Hui-Jie Li et al.   HUMAN BRAIN MAPPING

Natural Whisker-Guided Behavior by Head-Fixed Mice in Tactile Virtual Reality

(2014) N. J. Sofroniew et al.   JOURNAL OF NEUROSCIENCE

Early Alterations in Functional Connectivity and White Matter Structure in a Transgenic Mouse Model of Cerebral Amyloidosis

(2014) Joanes Grandjean et al.   JOURNAL OF NEUROSCIENCE

Optimization of anesthesia protocol for resting-state fMRI in mice based on differential effects of anesthetics on functional connectivity patterns

(2014) Joanes Grandjean et al.   NEUROIMAGE

Pharmacological insight into neurotransmission origins of resting-state functional connectivity: α2-adrenergic agonist vs antagonist

(2014) Fatima A. Nasrallah et al.   NEUROIMAGE

Fine-grained mapping of mouse brain functional connectivity with resting-state fMRI

(2014) Anna E. Mechling et al.   NEUROIMAGE

Specificity of stimulus-evoked fMRI responses in the mouse: The influence of systemic physiological changes associated with innocuous stimulation under four different anesthetics

(2014) Aileen Schroeter et al.   NEUROIMAGE

Engagement of Neural Circuits Underlying 2D Spatial Navigation in a Rodent Virtual Reality System

(2014) Dmitriy Aronov et al.   NEURON

Functional Brain Connectivity Using fMRI in Aging and Alzheimer’s Disease

(2014) Emily L. Dennis et al.   NEUROPSYCHOLOGY REVIEW

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease

(2014) Oyinkan Sofola-Adesakin et al.   Frontiers in Aging Neuroscience

Designing drug trials for Alzheimer’s disease: What we have learned from the release of the phase III antibody trials: A report from the EU/US/CTAD Task Force

(2013) Bruno Vellas et al.   Alzheimers & Dementia

Spontaneous and Induced Nontransgenic Animal Models of AD

(2013) Alka Kaushal et al.   American Journal of Alzheimers Disease and Other Dementias

High-throughput optogenetic functional magnetic resonance imaging with parallel computations

(2013) Zhongnan Fang et al.   JOURNAL OF NEUROSCIENCE METHODS

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Modeling Alzheimer’s disease in transgenic rats

(2013) Sonia Do Carmo et al.   Molecular Neurodegeneration

Functional MRI and neural responses in a rat model of Alzheimer's disease

(2013) Basavaraju G. Sanganahalli et al.   NEUROIMAGE

Detection of functional connectivity in the resting mouse brain

(2013) Fatima A. Nasrallah et al.   NEUROIMAGE

Neural correlate of resting-state functional connectivity under α2 adrenergic receptor agonist, medetomidine

(2013) Fatima A Nasrallah et al.   NEUROIMAGE

Functional MRI reveals frequency-dependent responses during deep brain stimulation at the subthalamic nucleus or internal globus pallidus

(2013) Hsin-Yi Lai et al.   NEUROIMAGE

Meta-analysis of amyloid-cognition relations in cognitively normal older adults

(2013) T. Hedden et al.   NEUROLOGY

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

Comparison of fMRI BOLD Response Patterns by Electrical Stimulation of the Ventroposterior Complex and Medial Thalamus of the Rat

(2013) Pai-Feng Yang et al.   PLoS One

Resting State fMRI Reveals Diminished Functional Connectivity in a Mouse Model of Amyloidosis

(2013) Disha Shah et al.   PLoS One

New animal models of Alzheimer’s disease that display insulin desensitization in the brain

(2013) Chong Gao et al.   REVIEWS IN THE NEUROSCIENCES

Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome

(2013) Benjamin Lam et al.   Alzheimers Research & Therapy

Microvascular cerebral blood volume changes in aging APPswe/PS1dE9 AD mouse model: a voxel-wise approach

(2012) Valerio Zerbi et al.   Brain Structure & Function

Early memory deficits precede plaque deposition in APPswe/PS1dE9 mice: Involvement of oxidative stress and cholinergic dysfunction

(2012) Wei Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer’s disease, about the therapeutic strategies in Alzheimer’s research

(2012) Melita Salkovic-Petrisic et al.   JOURNAL OF NEURAL TRANSMISSION

Intrinsic Organization of the Anesthetized Brain

(2012) Z. Liang et al.   JOURNAL OF NEUROSCIENCE

A Non-transgenic Mouse Model (icv-STZ Mouse) of Alzheimer’s Disease: Similarities to and Differences from the Transgenic Model (3xTg-AD Mouse)

(2012) Yanxing Chen et al.   MOLECULAR NEUROBIOLOGY

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

RETRACTED: Multiple inflammatory pathways are involved in the development and progression of cognitive deficits in APPswe/PS1dE9 mice

(2012) Wei Zhang et al.   NEUROBIOLOGY OF AGING

Variations in the temporal pattern of perforant pathway stimulation control the activity in the mesolimbic pathway

(2012) Cornelia Helbing et al.   NEUROIMAGE

Hyperalgesia by low doses of the local anesthetic lidocaine involves cannabinoid signaling: An fMRI study in mice

(2012) Simone C. Bosshard et al.   PAIN

Perceptions and Experiences of Research Participants on Gender-Based Violence Community Based Survey: Implications for Ethical Guidelines

(2012) Yandisa Sikweyiya et al.   PLoS One

Insulin-resistant brain state: The culprit in sporadic Alzheimer's disease?

(2011) Sónia C. Correia et al.   AGEING RESEARCH REVIEWS

The Alzheimer’s Disease Neuroimaging Initiative: A review of papers published since its inception

(2011) Michael W. Weiner et al.   Alzheimers & Dementia

Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease

(2011) Victor L. Villemagne et al.   ANNALS OF NEUROLOGY

Dementia: Alzheimer pathology and vascular factors: From mutually exclusive to interaction

(2011) Anouk G.W. van Norden et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Functional magnetic resonance imaging of semantic memory as a presymptomatic biomarker of Alzheimer's disease risk

(2011) Michael A. Sugarman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mouse models of Alzheimer's disease

(2011) Alicia M. Hall et al.   BRAIN RESEARCH BULLETIN

Proteolytic processing of Alzheimer’s β-amyloid precursor protein

(2011) Han Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Mapping cortical representations of the rodent forepaw and hindpaw with BOLD fMRI reveals two spatial boundaries

(2011) Artem G. Goloshevsky et al.   NEUROIMAGE

Pharmacological modulation of functional connectivity: α2-adrenergic receptor agonist alters synchrony but not neural activation

(2011) Fatima A. Nasrallah et al.   NEUROIMAGE

Default mode network connectivity in stable vs progressive mild cognitive impairment

(2011) J. R. Petrella et al.   NEUROLOGY

Default-Mode-Like Network Activation in Awake Rodents

(2011) Jaymin Upadhyay et al.   PLoS One

Understanding Glioma Invasion: A Necessity for Effective Therapy

(2011) Pierpaolo Peruzzi et al.   World Neurosurgery

Mapping brain networks in awake mice using combined optical neural control and fMRI

(2010) M. Desai et al.   JOURNAL OF NEUROPHYSIOLOGY

Global and local fMRI signals driven by neurons defined optogenetically by type and wiring

(2010) Jin Hyung Lee et al.   NATURE

Functional imaging of hippocampal place cells at cellular resolution during virtual navigation

(2010) Daniel A Dombeck et al.   NATURE NEUROSCIENCE

Cerebrospinal fluid and plasma biomarkers in Alzheimer disease

(2010) Kaj Blennow et al.   Nature Reviews Neurology

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Vascular response to acetazolamide decreases as a function of age in the arcAβ mouse model of cerebral amyloidosis

(2010) Felicitas L. Princz-Kranz et al.   NEUROBIOLOGY OF DISEASE

High field BOLD response to forepaw stimulation in the mouse

(2010) Joanna M. Adamczak et al.   NEUROIMAGE

A Neural Switch for Active and Passive Fear

(2010) Alessandro Gozzi et al.   NEURON

Assessment of brain responses to innocuous and noxious electrical forepaw stimulation in mice using BOLD fMRI

(2010) Simone C. Bosshard et al.   PAIN

Amyloid Plaques Disrupt Resting State Default Mode Network Connectivity in Cognitively Normal Elderly

(2009) Yvette I. Sheline et al.   BIOLOGICAL PSYCHIATRY

Cortical hypoperfusion in the B6.PS2APP mouse model for Alzheimer's disease: Comprehensive phenotyping of vascular and tissular parameters by MRI

(2009) Claudia Weidensteiner et al.   MAGNETIC RESONANCE IN MEDICINE

Micro MRI of the mouse brain using a novel 400 MHz cryogenic quadrature RF probe

(2009) Christof Baltes et al.   NMR IN BIOMEDICINE

Reviews: Current Concepts in Alzheimer's Disease: A Multidisciplinary Review

(2008) Ludovico Minati et al.   American Journal of Alzheimers Disease and Other Dementias

Detection of PCC functional connectivity characteristics in resting-state fMRI in mild Alzheimer’s disease

(2008) H ZHANG et al.   BEHAVIOURAL BRAIN RESEARCH

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

Electric stimulation fMRI of the perforant pathway to the rat hippocampus

(2008) Santiago Canals et al.   MAGNETIC RESONANCE IMAGING

Regional homogeneity, functional connectivity and imaging markers of Alzheimer's disease: A review of resting-state fMRI studies

(2008) Yong Liu et al.   NEUROPSYCHOLOGIA

Coupling between simultaneously recorded BOLD response and neuronal activity in the rat somatosensory cortex

(2007) Joanna K. Huttunen et al.   NEUROIMAGE

Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer's disease: Insights from functional MRI studies

(2007) Bradford C. Dickerson et al.   NEUROPSYCHOLOGIA