Hippo Pathway in Mammalian Adaptive Immune System

The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1

(2018) Helena J. Janse van Rensburg et al.   CANCER RESEARCH

Role of Hippo signaling in regulating immunity

(2018) Lixin Hong et al.   Cellular & Molecular Immunology

When worlds collide: Th17 and Treg cells in cancer and autoimmunity

(2018) Hannah M. Knochelmann et al.   Cellular & Molecular Immunology

Regulation of the Hippo pathway in cancer biology

(2018) Sungho Moon et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Hippo pathway effector proteins YAP and TAZ have both distinct and overlapping functions in the cell

(2018) Steven W. Plouffe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

YAP and TAZ are dispensable for physiological and malignant haematopoiesis

(2018) Elisa Donato et al.   LEUKEMIA

YAP/TAZ upstream signals and downstream responses

(2018) Antonio Totaro et al.   NATURE CELL BIOLOGY

Hippo Signaling in the Immune System

(2018) Yuchao Zhang et al.   TRENDS IN BIOCHEMICAL SCIENCES

YAP Is Essential for Treg-Mediated Suppression of Antitumor Immunity

(2018) Xuhao Ni et al.   Cancer Discovery

YAP-Induced PD-L1 Expression Drives Immune Evasion in BRAFi-Resistant Melanoma

(2018) Min Hwan Kim et al.   Cancer Immunology Research

The Hippo Pathway: Immunity and Cancer

(2018) Zaid Taha et al.   Cancers

Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells

(2018) Xingrong Du et al.   NATURE

RAP2 mediates mechanoresponses of the Hippo pathway

(2018) Zhipeng Meng et al.   NATURE

The Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae

(2018) Valentina Rausch et al.   CURRENT BIOLOGY

Loss of VGLL4 suppresses tumor PD‐L1 expression and immune evasion

(2018) Ailing Wu et al.   EMBO JOURNAL

Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine

(2018) Iván M. Moya et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell type-dependent function of LATS1/2 in cancer cell growth

(2018) Wei-Wei Pan et al.   ONCOGENE

PRKCI promotes immune suppression in ovarian cancer

(2017) Sharmistha Sarkar et al.   GENES & DEVELOPMENT

Single tumor-initiating cells evade immune clearance by recruiting type II macrophages

(2017) Xiaocan Guo et al.   GENES & DEVELOPMENT

Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways

(2017) Yan-Jiun Huang et al.   Journal of Hematology & Oncology

NDR1-Dependent Regulation of Kindlin-3 Controls High-Affinity LFA-1 Binding and Immune Synapse Organization

(2017) Naoyuki Kondo et al.   MOLECULAR AND CELLULAR BIOLOGY

Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade

(2017) Qian Zhang et al.   NATURE CELL BIOLOGY

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function

(2017) Congshan Sun et al.   STEM CELLS

YAP determines the cell fate of injured mouse hepatocytes in vivo

(2017) Norio Miyamura et al.   Nature Communications

Dendritic cell MST1 inhibits Th17 differentiation

(2017) Chunxiao Li et al.   Nature Communications

YAP regulates PD-L1 expression in human NSCLC cells

(2017) Jinbai Miao et al.   Oncotarget

The Hippo pathway in tissue homeostasis and regeneration

(2017) Yu Wang et al.   Protein & Cell

Transcriptional Control of Dendritic Cell Development

(2016) Theresa L. Murphy et al.   Annual Review of Immunology

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila

(2016) Bo Liu et al.   CELL

The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity

(2016) Toshiro Moroishi et al.   CELL

Roles and regulations of Hippo signaling during preimplantation mouse development

(2016) Hiroshi Sasaki   DEVELOPMENT GROWTH & DIFFERENTIATION

Enhanced cytotoxic T-cell function and inhibition of tumor progression by Mst1 deficiency

(2016) Kaneki Yasuda et al.   FEBS LETTERS

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation

(2016) Fansen Meng et al.   GENES & DEVELOPMENT

Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ

(2016) Jing Yi et al.   HEPATOLOGY

Dendritic cell maturation and cross-presentation: timing matters!

(2016) Andrés Alloatti et al.   IMMUNOLOGICAL REVIEWS

Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency

(2016) Tarana Singh Dang et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The Hippo effector TAZ (WWTR1) transforms myoblasts and TAZ abundance is associated with reduced survival in embryonal rhabdomyosarcoma

(2016) Abdalla Mohamed et al.   JOURNAL OF PATHOLOGY

Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow

(2016) Li Wang et al.   NATURE

Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma

(2016) S Murakami et al.   ONCOGENE

LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development

(2016) Da-Hye Lee et al.   Nature Communications

A critical role for NF2 and the Hippo pathway in branching morphogenesis

(2016) Antoine Reginensi et al.   Nature Communications

The MST/Hippo Pathway and Cell Death: A Non-Canonical Affair

(2016) Emma Fallahi et al.   Genes

The Roles of NDR Protein Kinases in Hippo Signalling

(2016) Alexander Hergovich   Genes

Mycobacterium tuberculosis-triggered Hippo pathway orchestrates CXCL1/2 expression to modulate host immune responses

(2016) Monoranjan Boro et al.   Scientific Reports

Hypermethylation of MST1 in IgG4-related autoimmune pancreatitis and rheumatoid arthritis

(2015) Takataro Fukuhara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

YAP activates the Hippo pathway in a negative feedback loop

(2015) Xiaoming Dai et al.   CELL RESEARCH

STK4 (MST1) deficiency in two siblings with autoimmune cytopenias: A novel mutation

(2015) Sevil Oskay Halacli et al.   CLINICAL IMMUNOLOGY

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis

(2015) Toshiro Moroishi et al.   GENES & DEVELOPMENT

Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP

(2015) Qian Chen et al.   GENES & DEVELOPMENT

Mammalian Sterile 20-like Kinase 1 (Mst1) Enhances the Stability of Forkhead Box P3 (Foxp3) and the Function of Regulatory T Cells by Modulating Foxp3 Acetylation

(2015) Jiang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway

(2015) Nam-Gyun Kim et al.   JOURNAL OF CELL BIOLOGY

The Mammalian Sterile 20–like 1 Kinase Controls Selective CCR7-Dependent Functions in Human Dendritic Cells

(2015) Jesús Torres-Bacete et al.   JOURNAL OF IMMUNOLOGY

Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity

(2015) Jing Geng et al.   NATURE IMMUNOLOGY

The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility

(2015) Fengyuan Tang et al.   Science Signaling

YAP and TAZ: a nexus for Hippo signaling and beyond

(2015) Carsten Gram Hansen et al.   TRENDS IN CELL BIOLOGY

Control of Organ Growth by Patterning and Hippo Signaling inDrosophila

(2015) Kenneth D. Irvine et al.   Cold Spring Harbor Perspectives in Biology

Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression

(2015) G. Wang et al.   Cancer Discovery

The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility

(2015) Fengyuan Tang et al.   Science Signaling

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

(2014) X. Varelas   DEVELOPMENT

The Hippo signaling pathway in stem cell biology and cancer

(2014) J.-S. Mo et al.   EMBO REPORTS

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

An Overview of the Intrathymic Intricacies of T Cell Development

(2014) D. K. Shah et al.   JOURNAL OF IMMUNOLOGY

Mst1/Mst2 Regulate Development and Function of Regulatory T Cells through Modulation of Foxo1/Foxo3 Stability in Autoimmune Disease

(2014) X. Du et al.   JOURNAL OF IMMUNOLOGY

Rescue of Hippo coactivator YAP1 triggers DNA damage–induced apoptosis in hematological cancers

(2014) Francesca Cottini et al.   NATURE MEDICINE

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

The Hippo superhighway: signaling crossroads converging on the Hippo/Yap pathway in stem cells and development

(2013) Evan R Barry et al.   CURRENT OPINION IN CELL BIOLOGY

MT1-MMP-Dependent Control of Skeletal Stem Cell Commitment via a β1-Integrin/YAP/TAZ Signaling Axis

(2013) Yi Tang et al.   DEVELOPMENTAL CELL

Defining the Protein–Protein Interaction Network of the Human Hippo Pathway

(2013) Wenqi Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

(2013) Randy Johnson et al.   NATURE REVIEWS DRUG DISCOVERY

Antigen-Specific Suppression and Immunological Synapse Formation by Regulatory T Cells Require the Mst1 Kinase

(2013) Takashi Tomiyama et al.   PLoS One

Hippo pathway effector Yap promotes cardiac regeneration

(2013) Mei Xin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo Signaling Pathway Interactome

(2013) Y. Kwon et al.   SCIENCE

Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions

(2013) A. L. Couzens et al.   Science Signaling

Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase

(2013) Isabel Serrano et al.   Nature Communications

Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development

(2013) Antoine Reginensi et al.   PLoS Genetics

The phenotype of human STK4 deficiency

(2012) H. Abdollahpour et al.   BLOOD

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

B-1 B Cell Development in the Fetus and Adult

(2012) Encarnacion Montecino-Rodriguez et al.   IMMUNITY

The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes

(2012) Fan Mou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Restriction of intestinal stem cell expansion and the regenerative response by YAP

(2012) Evan R. Barry et al.   NATURE

Inherited MST1 Deficiency Underlies Susceptibility to EV-HPV Infections

(2012) Amandine Crequer et al.   PLoS One

Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell

(2012) J. E. D. Thaventhiran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus

(2012) Yoshihiro Ueda et al.   Nature Communications

MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival

(2011) N. T. Nehme et al.   BLOOD

A Screen for Conditional Growth Suppressor Genes Identifies the Drosophila Homolog of HD-PTP as a Regulator of the Oncoprotein Yorkie

(2011) M. Melissa Gilbert et al.   DEVELOPMENTAL CELL

DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice

(2011) Katrina L. Randall et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance

(2011) D. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

Regulatory T cells in tumor immunity

(2010) Hiroyoshi Nishikawa et al.   INTERNATIONAL JOURNAL OF CANCER

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

(2010) H. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

(2010) L. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

(2009) Dawang Zhou et al.   CANCER CELL

Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes

(2009) Koko Katagiri et al.   EMBO JOURNAL

A Cell-Intrinsic Role for Mst1 in Regulating Thymocyte Egress

(2009) Y. Dong et al.   JOURNAL OF IMMUNOLOGY

Kindlin-3 is required for β2 integrin–mediated leukocyte adhesion to endothelial cells

(2009) Markus Moser et al.   NATURE MEDICINE

A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans

(2009) Nikolay L Malinin et al.   NATURE MEDICINE

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

(2009) Lena Svensson et al.   NATURE MEDICINE

Mst1-FoxO Signaling Protects Naïve T Lymphocytes from Cellular Oxidative Stress in Mice

(2009) Juhyun Choi et al.   PLoS One

Yes-associated protein (YAP) functions as a tumor suppressor in breast

(2008) M Yuan et al.   CELL DEATH AND DIFFERENTIATION

The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naive T cells

(2008) D. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA