The MST/Hippo Pathway and Cell Death: A Non-Canonical Affair

Analysis of Liver Tumor-Prone Mouse Models of the Hippo Kinase Scaffold Proteins RASSF1A and SAV1

(2016) X. Zhang et al.   CANCER RESEARCH

RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway

(2016) Fatéméh Dubois et al.   CANCER RESEARCH

MST1: a promising therapeutic target to restore functional beta cell mass in diabetes

(2016) Amin Ardestani et al.   DIABETOLOGIA

Hippo pathway and protection of genome stability in response to DNA damage

(2016) Dafni E. Pefani et al.   FEBS Journal

The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation

(2016) Yael Aylon et al.   GENES & DEVELOPMENT

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

Yes-Associated Protein Contributes to the Development of Human Cutaneous Squamous Cell Carcinoma via Activation of RAS

(2016) Jinjing Jia et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The rise and fall of insulin signaling in Alzheimer’s disease

(2016) B. Chami et al.   METABOLIC BRAIN DISEASE

The Hippo pathway in intestinal regeneration and disease

(2016) Audrey W. Hong et al.   Nature Reviews Gastroenterology & Hepatology

Targeting the Hippo pathway: Clinical implications and therapeutics

(2016) Shuai Ye et al.   PHARMACOLOGICAL RESEARCH

Beyond canonical: The Wnt and β-catenin story

(2016) Randall T. Moon et al.   Science Signaling

Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP

(2016) Duyen Amy Bui et al.   Science Signaling

Control of YAP/TAZ Activity by Metabolic and Nutrient-Sensing Pathways

(2016) Giulia Santinon et al.   TRENDS IN CELL BIOLOGY

Major apoptotic mechanisms and genes involved in apoptosis

(2016) Yağmur Kiraz et al.   TUMOR BIOLOGY

Beyond canonical: The Wnt and β-catenin story

(2016) Randall T. Moon et al.   Science Signaling

Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP

(2016) Duyen Amy Bui et al.   Science Signaling

The Roles of NDR Protein Kinases in Hippo Signalling

(2016) Alexander Hergovich   Genes

Mst1 inhibition rescues β1-adrenergic cardiomyopathy by reducing myocyte necrosis and non-myocyte apoptosis rather than myocyte apoptosis

(2015) Grace J. Lee et al.   BASIC RESEARCH IN CARDIOLOGY

MST2-RASSF protein–protein interactions through SARAH domains

(2015) Goar Sánchez-Sanz et al.   BRIEFINGS IN BIOINFORMATICS

Clinical utility of RASSF1A methylation in human malignancies

(2015) A M Grawenda et al.   BRITISH JOURNAL OF CANCER

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

YAP enhances the pro‐proliferative transcriptional activity of mutant p53 proteins

(2015) Silvia Di Agostino et al.   EMBO REPORTS

Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP

(2015) Qian Chen et al.   GENES & DEVELOPMENT

Phosphorylation of LC3 by the Hippo Kinases STK3/STK4 Is Essential for Autophagy

(2015) Deepti S. Wilkinson et al.   MOLECULAR CELL

Erratum: RASSF1A–LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2

(2015) Dafni-Eleftheria Pefani et al.   NATURE CELL BIOLOGY

The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

(2015) Luping Lin et al.   NATURE GENETICS

Targeted Therapies in Melanoma

(2015) Stergios J. Moschos et al.   Surgical Oncology Clinics of North America

Control of Organ Growth by Patterning and Hippo Signaling inDrosophila

(2015) Kenneth D. Irvine et al.   Cold Spring Harbor Perspectives in Biology

YAP1 and AR interactions contribute to the switch from androgen-dependent to castration-resistant growth in prostate cancer

(2015) Gamze Kuser-Abali et al.   Nature Communications

NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition

(2015) M. E. R. Garcia-Rendueles et al.   Cancer Discovery

Transcriptional Co-repressor Function of the Hippo Pathway Transducers YAP and TAZ

(2015) Minchul Kim et al.   Cell Reports

Two-signal requirement for growth-promoting function of Yap in hepatocytes

(2015) Tian Su et al.   eLife

WW Domains of the Yes-Kinase-Associated-Protein (YAP) Transcriptional Regulator Behave as Independent Units with Different Binding Preferences for PPxY Motif-Containing Ligands

(2015) Manuel Iglesias-Bexiga et al.   PLoS One

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health

(2015) William H. Chappell et al.   Oncotarget

The ubiquitin E3 ligase ITCH enhances breast tumor progression by inhibiting the Hippo tumor suppressor pathway

(2015) Zaidoun Salah et al.   Oncotarget

Oncotargeting G proteins: The Hippo in the room

(2015) Xiaodong Feng et al.   Oncotarget

Pathways and therapeutic targets in melanoma

(2015) Emma Shtivelman et al.   Oncotarget

The non-canonical Hippo/Mst pathway in lymphocyte development and functions

(2014) X. Du et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Label-free quantitative proteomic analysis of the YAP/TAZ interactome

(2014) Priyanka Kohli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

One Hippo and many masters: differential regulation of the Hippo pathway in cancer: Figure 1

(2014) David Romano et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

(2014) Avnish Kapoor et al.   CELL

c-Abl antagonizes the YAP oncogenic function

(2014) R Keshet et al.   CELL DEATH AND DIFFERENTIATION

The mammalian Hippo pathway: regulation and function of YAP1 and TAZ

(2014) Manami Kodaka et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

(2014) X. Varelas   DEVELOPMENT

Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnover

(2014) X. Hong et al.   EMBO JOURNAL

The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation

(2014) Katarzyna Brodowska et al.   EXPERIMENTAL EYE RESEARCH

RASSF tumor suppressor gene family: Biological functions and regulation

(2014) Natalia Volodko et al.   FEBS LETTERS

HGF Induces Epithelial-to-Mesenchymal Transition by Modulating the Mammalian Hippo/MST2 and ISG15 Pathways

(2014) Jennifer Farrell et al.   JOURNAL OF PROTEOME RESEARCH

Mst1 Promotes Cardiac Myocyte Apoptosis through Phosphorylation and Inhibition of Bcl-xL

(2014) Dominic P. Del Re et al.   MOLECULAR CELL

c-Abl Tyrosine Kinase Mediates Neurotoxic Prion Peptide-Induced Neuronal Apoptosis via Regulating Mitochondrial Homeostasis

(2014) Bo Pan et al.   MOLECULAR NEUROBIOLOGY

Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling

(2014) David Romano et al.   NATURE CELL BIOLOGY

Rescue of Hippo coactivator YAP1 triggers DNA damage–induced apoptosis in hematological cancers

(2014) Francesca Cottini et al.   NATURE MEDICINE

RASSF5 inhibits growth and invasion and induces apoptosis in osteosarcoma cells through activation of MST1/LATS1 signaling

(2014) XU-HUI ZHOU et al.   ONCOLOGY REPORTS

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

AIF Downregulation and Its Interaction with STK3 in Renal Cell Carcinoma

(2014) Shengqiang Xu et al.   PLoS One

Non-Canonical Roles for Yorkie and Drosophila Inhibitor of Apoptosis 1 in Epithelial Tube Size Control

(2014) Renée M. Robbins et al.   PLoS One

Downstream of Mutant KRAS, the Transcription Regulator YAP Is Essential for Neoplastic Progression to Pancreatic Ductal Adenocarcinoma

(2014) W. Zhang et al.   Science Signaling

Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment

(2014) H Matsumoto et al.   Cell Death & Disease

The dual functions of YAP-1 to promote and inhibit cell growth in human malignancy

(2013) Hai Wang et al.   CANCER AND METASTASIS REVIEWS

NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation

(2013) Zaidoun Salah et al.   CELL CYCLE

ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence

(2013) F Fausti et al.   CELL DEATH AND DIFFERENTIATION

The neuronal transcription factor erect wing regulates specification and maintenance of Drosophila R8 photoreceptor subtypes

(2013) Hui-Yi Hsiao et al.   DEVELOPMENTAL BIOLOGY

Defining the Protein–Protein Interaction Network of the Human Hippo Pathway

(2013) Wenqi Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

The Differential Effects of Wild-Type and Mutated K-Ras on MST2 Signaling Are Determined by K-Ras Activation Kinetics

(2013) David Romano et al.   MOLECULAR AND CELLULAR BIOLOGY

Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1

(2013) Simon Hauri et al.   Molecular Systems Biology

The Cancer Genome Atlas Pan-Cancer analysis project

(2013) John N Weinstein et al.   NATURE GENETICS

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

(2013) Randy Johnson et al.   NATURE REVIEWS DRUG DISCOVERY

MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS

(2013) J. K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo Signaling Pathway Interactome

(2013) Y. Kwon et al.   SCIENCE

Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions

(2013) A. L. Couzens et al.   Science Signaling

Hippo Unleashed! Proteome-Scale Analysis Reveals New Views of Hippo Pathway Biology

(2013) E. L. Weiss   Science Signaling

FoxO3a is activated and executes neuron death via Bim in response to β-amyloid

(2013) P Sanphui et al.   Cell Death & Disease

Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling

(2013) Alexander Hergovich   Cell and Bioscience

The Hippo pathway acts via p53 and microRNAs to control proliferation and proapoptotic gene expression during tissue growth

(2013) W. Zhang et al.   Biology Open

Methylation of multiple genes in hepatitis C virus associated hepatocellular carcinoma

(2013) Abdel-Rahman N. Zekri et al.   Journal of Advanced Research

Mammalian Hippo signalling: a kinase network regulated by protein–protein interactions: Figure 1

(2012) Alexander Hergovich   BIOCHEMICAL SOCIETY TRANSACTIONS

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

(2012) Joseph Rosenbluh et al.   CELL

A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling

(2012) Masamichi Imajo et al.   EMBO JOURNAL

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

(2012) Y. Liu-Chittenden et al.   GENES & DEVELOPMENT

Colorectal cancer and RASSF family-A special emphasis on RASSF1A

(2012) Maria Sofia Fernandes et al.   INTERNATIONAL JOURNAL OF CANCER

Identification of Mechanism That Couples Multisite Phosphorylation of Yes-associated Protein (YAP) with Transcriptional Coactivation and Regulation of Apoptosis

(2012) Kyung-Kwon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PTEN at a glance

(2012) Y. Shi et al.   JOURNAL OF CELL SCIENCE

Restriction of intestinal stem cell expansion and the regenerative response by YAP

(2012) Evan R. Barry et al.   NATURE

YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29

(2012) Karen Tumaneng et al.   NATURE CELL BIOLOGY

YAP1 oncogene and its eight isoforms

(2012) M Sudol   ONCOGENE

Regulation of Neuronal Cell Death by c-Abl-Hippo/MST2 Signaling Pathway

(2012) Weizhe Liu et al.   PLoS One

Alteration of TEAD1 Expression Levels Confers Apoptotic Resistance through the Transcriptional Up-Regulation of Livin

(2012) André Landin Malt et al.   PLoS One

Protein kinases of the Hippo pathway: Regulation and substrates

(2012) Joseph Avruch et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Methylation-associated down-regulation of RASSF1A and up-regulation of RASSF1Cin pancreatic endocrine tumors

(2011) Giorgio Malpeli et al.   BMC CANCER

Loss of Yes-associated protein (YAP) expression is associated with estrogen and progesterone receptors negativity in invasive breast carcinomas

(2011) Rozina Tufail et al.   BREAST CANCER RESEARCH AND TREATMENT

Hippo/Mst1 Stimulates Transcription of the Proapoptotic Mediator NOXA in a FoxO1-Dependent Manner

(2011) K. Valis et al.   CANCER RESEARCH

YAP: At the crossroad between transformation and tumor suppression

(2011) Efrem Bertini et al.   CELL CYCLE

Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador–Warts–Hippo pathway

(2011) X Zhang et al.   CELL DEATH AND DIFFERENTIATION

A Screen for Conditional Growth Suppressor Genes Identifies the Drosophila Homolog of HD-PTP as a Regulator of the Oncoprotein Yorkie

(2011) M. Melissa Gilbert et al.   DEVELOPMENTAL CELL

The Sterile 20-like Kinase Tao-1 Controls Tissue Growth by Regulating the Salvador-Warts-Hippo Pathway

(2011) Carole L.C. Poon et al.   DEVELOPMENTAL CELL

Hippo signaling inDrosophila: Recent advances and insights

(2011) Binnaz Kucuk Staley et al.   DEVELOPMENTAL DYNAMICS

Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling

(2011) Hee Jae Yun et al.   EMBO JOURNAL

The growing role of the Hippo-NDR kinase signalling in neuronal development and disease

(2011) K. Emoto   JOURNAL OF BIOCHEMISTRY

MST1 Promotes Apoptosis through Regulating Sirt1-dependent p53 Deacetylation

(2011) Fang Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways

(2011) James A. McCubrey et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Apoptosis in cancer: from pathogenesis to treatment

(2011) Rebecca SY Wong   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The c-Abl-MST1 Signaling Pathway Mediates Oxidative Stress-Induced Neuronal Cell Death

(2011) L. Xiao et al.   JOURNAL OF NEUROSCIENCE

Mutant K-Ras Activation of the Proapoptotic MST2 Pathway Is Antagonized by Wild-Type K-Ras

(2011) David Matallanas et al.   MOLECULAR CELL

Integrating developmental signals: a Hippo in the (path)way

(2011) A Mauviel et al.   ONCOGENE

Cross-Regulation between Oncogenic BRAFV600E Kinase and the MST1 Pathway in Papillary Thyroid Carcinoma

(2011) Seong Jin Lee et al.   PLoS One

Yki/YAP, Sd/TEAD and Hth/MEIS Control Tissue Specification in the Drosophila Eye Disc Epithelium

(2011) Tianyi Zhang et al.   PLoS One

Zyxin Links Fat Signaling to the Hippo Pathway

(2011) Cordelia Rauskolb et al.   PLOS BIOLOGY

MicroRNA-602 regulating tumor suppressive gene RASSF1A is over-expressed in hepatitis B virus-infected liver and hepatocellular carcinoma

(2010) Lian Yang et al.   CANCER BIOLOGY & THERAPY

Heterogeneous Nuclear Ribonucleoprotein H Blocks MST2-Mediated Apoptosis in Cancer Cells by Regulating a-raf Transcription

(2010) J. Rauch et al.   CANCER RESEARCH

Proapoptotic Kinase MST2 Coordinates Signaling Crosstalk between RASSF1A, Raf-1, and Akt

(2010) D. Romano et al.   CANCER RESEARCH

A Hippo in the ointment: MST signalling beyond the fly

(2010) David Matallanas et al.   CELL CYCLE

LATS tumor suppressor: A new governor of cellular homeostasis

(2010) Stacy Visser et al.   CELL CYCLE

The Hippo Pathway Regulates Wnt/β-Catenin Signaling

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1

(2010) Y. Aylon et al.   GENES & DEVELOPMENT

The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version

(2010) B. Zhao et al.   GENES & DEVELOPMENT

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Mammalian Ste20-like Kinase (Mst2) Indirectly Supports Raf-1/ERK Pathway Activity via Maintenance of Protein Phosphatase-2A Catalytic Subunit Levels and Consequent Suppression of Inhibitory Raf-1 Phosphorylation

(2010) Geoffrey K. Kilili et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combined Functional Genomic and Proteomic Approaches Identify a PP2A Complex as a Negative Regulator of Hippo Signaling

(2010) Paulo S. Ribeiro et al.   MOLECULAR CELL

Regulation of Proapoptotic Mammalian ste20–Like Kinase MST2 by the IGF1-Akt Pathway

(2010) Donghwa Kim et al.   PLoS One

JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis

(2010) V Tomlinson et al.   Cell Death & Disease

The RASSF proteins in cancer; from epigenetic silencing to functional characterization

(2009) Antje M. Richter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

(2009) Dawang Zhou et al.   CANCER CELL

The DeMSTification of Mammalian Ste20 Kinases

(2009) Maria Radu et al.   CURRENT BIOLOGY

ATM Regulates a RASSF1A-Dependent DNA Damage Response

(2009) Garth Hamilton et al.   CURRENT BIOLOGY

Identification of LATS transcriptional targets in HeLa cells using whole human genome oligonucleotide microarray

(2009) Stacy Visser et al.   GENE

Transcription factor choice in the Hippo signaling pathway: homothorax and yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal disc

(2009) H. W. Peng et al.   GENES & DEVELOPMENT

Regulation of Neuronal Cell Death by MST1-FOXO1 Signaling

(2009) Zengqiang Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

"What kills neurons in neurodegenerative diseases?", a review series in an open access journal

(2009) Todd E Golde et al.   Molecular Neurodegeneration

Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation

(2009) Y Aylon et al.   ONCOGENE

EGR-1 forms a complex with YAP-1 and upregulates Bax expression in irradiated prostate carcinoma cells

(2009) M Zagurovskaya et al.   ONCOGENE

In vivo analysis of Yorkie phosphorylation sites

(2009) H Oh et al.   ONCOGENE

RASSF2 associates with and stabilizes the proapoptotic kinase MST2

(2009) W N Cooper et al.   ONCOGENE

Kpm/Lats2 is linked to chemosensitivity of leukemic cells through the stabilization of p73

(2008) M. Kawahara et al.   BLOOD

Yes-associated protein (YAP) functions as a tumor suppressor in breast

(2008) M Yuan et al.   CELL DEATH AND DIFFERENTIATION

Death through a tragedy: mitotic catastrophe

(2008) H Vakifahmetoglu et al.   CELL DEATH AND DIFFERENTIATION

Differential cleavage of Mst1 by caspase-7/-3 is responsible for TRAIL-induced activation of the MAPK superfamily

(2008) Jae J. Song et al.   CELLULAR SIGNALLING

NDR Kinase Is Activated by RASSF1A/MST1 in Response to Fas Receptor Stimulation and Promotes Apoptosis

(2008) Anton Vichalkovski et al.   CURRENT BIOLOGY

The PTEN/PI3K/AKT Signalling Pathway in Cancer, Therapeutic Implications

(2008) Amancio Carnero et al.   CURRENT CANCER DRUG TARGETS

The Hippo–YAP pathway: new connections between regulation of organ size and cancer

(2008) Bin Zhao et al.   CURRENT OPINION IN CELL BIOLOGY

In vivo regulation of Yorkie phosphorylation and localization

(2008) H. Oh et al.   DEVELOPMENT

A crucial role of WW45 in developing epithelial tissues in the mouse

(2008) Joo-Hyeon Lee et al.   EMBO JOURNAL

The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2–DAXX–HAUSP complex

(2008) Min Sup Song et al.   EMBO JOURNAL

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

Mst2 and Lats Kinases Regulate Apoptotic Function of Yes Kinase-associated Protein (YAP)

(2008) Tsutomu Oka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Progressive decrease in the level of YAPdeltaCs, prosurvival isoforms of YAP, in the spinal cord of transgenic mouse carrying a mutantSOD1gene

(2008) Nobutoshi Morimoto et al.   JOURNAL OF NEUROSCIENCE RESEARCH

PML, YAP, and p73 Are Components of a Proapoptotic Autoregulatory Feedback Loop

(2008) Eleonora Lapi et al.   MOLECULAR CELL

Proteomics and phosphoproteomics for the mapping of cellular signalling networks

(2008) Christian Preisinger et al.   PROTEOMICS