Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways

Ovatodiolide ofAnisomeles indicaExerts the Anticancer Potential on Pancreatic Cancer Cell Lines through STAT3 and NF-κB Regulation

(2016) Ya-Ju Hsieh et al.   Evidence-based Complementary and Alternative Medicine

Oncogenic KRAS signaling and YAP1/β-catenin: Similar cell cycle control in tumor initiation

(2016) Ruth Nussinov et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Ovatodiolide Inhibits Breast Cancer Stem/Progenitor Cells through SMURF2-Mediated Downregulation of Hsp27

(2016) Kuan-Ta Lu et al.   Toxins

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

(2016) Anthony J Covarrubias et al.   eLife

Ovatodiolide sensitizes aggressive breast cancer cells to doxorubicin, eliminates their cancer stem cell-like phenotype, and reduces doxorubicin-associated toxicity

(2015) Oluwaseun Adebayo Bamodu et al.   CANCER LETTERS

YAP enhances the pro‐proliferative transcriptional activity of mutant p53 proteins

(2015) Silvia Di Agostino et al.   EMBO REPORTS

Involvement of IGF-1 and Akt in M1/M2 activation state in bone marrow-derived macrophages

(2015) James P. Barrett et al.   EXPERIMENTAL CELL RESEARCH

β-Catenin destruction complex-independent regulation of Hippo–YAP signaling by APC in intestinal tumorigenesis

(2015) Jing Cai et al.   GENES & DEVELOPMENT

A basal-like breast cancer-specific role for SRF–IL6 in YAP-induced cancer stemness

(2015) Tackhoon Kim et al.   Nature Communications

Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner

(2014) Heyang Xu et al.   BMC CANCER

KRAS and YAP1 Converge to Regulate EMT and Tumor Survival

(2014) Diane D. Shao et al.   CELL

Significant Association of Oncogene YAP1 with Poor Prognosis and Cetuximab Resistance in Colorectal Cancer Patients

(2014) K.-W. Lee et al.   CLINICAL CANCER RESEARCH

Isolation of colorectal cancer stem-like cells

(2014) Eunice Dotse et al.   CYTOTECHNOLOGY

Hippo/YAP, β-Catenin, and the Cancer Cell: A “Ménage à Trois” in Hepatoblastoma

(2014) Karl G. Sylvester et al.   GASTROENTEROLOGY

Activation of β-Catenin and Yap1 in Human Hepatoblastoma and Induction of Hepatocarcinogenesis in Mice

(2014) Junyan Tao et al.   GASTROENTEROLOGY

Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour–stroma interaction

(2013) T Nagasaki et al.   BRITISH JOURNAL OF CANCER

Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survival

(2013) M. Cieslewicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor-associated macrophages: functional diversity, clinical significance, and open questions

(2013) Subhra K. Biswas et al.   Seminars in Immunopathology

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

Trifluoperazine, an Antipsychotic Agent, Inhibits Cancer Stem Cell Growth and Overcomes Drug Resistance of Lung Cancer

(2012) Chi-Tai Yeh et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Reciprocal Interactions between Tumor-Associated Macrophages and CD44-Positive Cancer Cells via Osteopontin/CD44 Promote Tumorigenicity in Colorectal Cancer

(2012) G. Rao et al.   CLINICAL CANCER RESEARCH

Aqueous extract of Anisomeles indica and its purified compound exerts anti-metastatic activity through inhibition of NF-κB/AP-1-dependent MMP-9 activation in human breast cancer MCF-7 cells

(2012) Ya-Fan Liao et al.   FOOD AND CHEMICAL TOXICOLOGY

Anti-tumour strategies aiming to target tumour-associated macrophages

(2012) Xiaoqiang Tang et al.   IMMUNOLOGY

Interleukin-6 - A Key Regulator of Colorectal Cancer Development

(2012) Maximilian J. Waldner et al.   International Journal of Biological Sciences

Antioxidative Characteristics of Anisomeles indica Extract and Inhibitory Effect of Ovatodiolide on Melanogenesis

(2012) Huey-Chun Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

The Distribution of Macrophages with a M1 or M2 Phenotype in Relation to Prognosis and the Molecular Characteristics of Colorectal Cancer

(2012) Sofia Edin et al.   PLoS One

Antimetastatic effect and mechanism of ovatodiolide in MDA-MB-231 human breast cancer cells

(2011) Kuei-Li Lin et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer

(2010) Qiang Zhou et al.   Journal of Translational Medicine

Role of macrophages in tumour progression

(2009) K.S. Siveen et al.   IMMUNOLOGY LETTERS

Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk Factors

(2009) Fatima Haggar et al.   Clinics in Colon and Rectal Surgery

The constituents of Anisomeles indica and their anti-inflammatory activities

(2008) Yerra Koteswara Rao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Tumor-Associated Macrophage-Induced Invasion and Angiogenesis of Human Basal Cell Carcinoma Cells by Cyclooxygenase-2 Induction

(2008) Jeng-Wei Tjiu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY