Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation

LC3 is a novel substrate for the mammalian Hippo kinases, STK3/STK4

(2015) Deepti S Wilkinson et al.   Autophagy

Hypermethylation of MST1 in IgG4-related autoimmune pancreatitis and rheumatoid arthritis

(2015) Takataro Fukuhara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

STK4 (MST1) deficiency in two siblings with autoimmune cytopenias: A novel mutation

(2015) Sevil Oskay Halacli et al.   CLINICAL IMMUNOLOGY

Viral RNA detection by RIG-I-like receptors

(2015) Mitsutoshi Yoneyama et al.   CURRENT OPINION IN IMMUNOLOGY

MST kinases in development and disease

(2015) Barry J. Thompson et al.   JOURNAL OF CELL BIOLOGY

RIG-I-like receptor regulation in virus infection and immunity

(2015) Ying Kai Chan et al.   Current Opinion in Virology

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

Interplay of Cell Shape and Division Orientation Promotes Robust Morphogenesis of Developing Epithelia

(2014) Fengzhu Xiong et al.   CELL

Danger, diversity and priming in innate antiviral immunity

(2014) Susan E. Collins et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Mst1/Mst2 Regulate Development and Function of Regulatory T Cells through Modulation of Foxo1/Foxo3 Stability in Autoimmune Disease

(2014) X. Du et al.   JOURNAL OF IMMUNOLOGY

Mst1 Promotes Cardiac Myocyte Apoptosis through Phosphorylation and Inhibition of Bcl-xL

(2014) Dominic P. Del Re et al.   MOLECULAR CELL

Innate Antiviral Host Defense Attenuates TGF-β Function through IRF3-Mediated Suppression of Smad Signaling

(2014) Pinglong Xu et al.   MOLECULAR CELL

Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation

(2013) Weilin Chen et al.   CELL

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

(2013) Pu Gao et al.   CELL

Dephosphorylation of the RNA Sensors RIG-I and MDA5 by the Phosphatase PP1 Is Essential for Innate Immune Signaling

(2013) Effi Wies et al.   IMMUNITY

Cytosolic Sensing of Viruses

(2013) Delphine Goubau et al.   IMMUNITY

Structural mechanism of cytosolic DNA sensing by cGAS

(2013) Filiz Civril et al.   NATURE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Proteome-wide profiling of activated transcription factors with a concatenated tandem array of transcription factor response elements

(2013) C. Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity

(2013) Chang Shu et al.   STRUCTURE

The phenotype of human STK4 deficiency

(2012) H. Abdollahpour et al.   BLOOD

Thioredoxin-1 functions as a molecular switch regulating the oxidative stress-induced activation of MST1

(2012) Ji Soo Chae et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response

(2012) Xiaomo Jiang et al.   IMMUNITY

Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila

(2012) Michael C. Wehr et al.   NATURE CELL BIOLOGY

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival

(2011) N. T. Nehme et al.   BLOOD

Genome-wide methylation profiling in Crohnʼs disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway

(2011) Elaine R. Nimmo et al.   INFLAMMATORY BOWEL DISEASES

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

Oligomeric peroxiredoxin-I is an essential intermediate for p53 to activate MST1 kinase and apoptosis

(2011) A Morinaka et al.   ONCOGENE

Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity

(2010) Wenwen Zeng et al.   CELL

The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Distinct and overlapping genetic loci in crohnʼs disease and ulcerative colitis: Correlations with pathogenesis

(2010) Matti Waterman et al.   INFLAMMATORY BOWEL DISEASES

Negative Role of RIG-I Serine 8 Phosphorylation in the Regulation of Interferon-β Production

(2010) Estanislao Nistal-Villán et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation-Mediated Negative Regulation of RIG-I Antiviral Activity

(2010) M. U. Gack et al.   JOURNAL OF VIROLOGY

Direct Activation of TACE-Mediated Ectodomain Shedding by p38 MAP Kinase Regulates EGF Receptor-Dependent Cell Proliferation

(2010) Pinglong Xu et al.   MOLECULAR CELL

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

(2010) H. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

(2009) Dawang Zhou et al.   CANCER CELL

MST Kinases Monitor Actin Cytoskeletal Integrity and Signal via c-Jun N-Terminal Kinase Stress-Activated Kinase To Regulate p21Waf1/Cip1 Stability

(2009) R. M. Densham et al.   MOLECULAR AND CELLULAR BIOLOGY

Biosignaling of mammalian Ste20-related kinases

(2008) Pin Ling et al.   CELLULAR SIGNALLING

The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naive T cells

(2008) D. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linear Motif Atlas for Phosphorylation-Dependent Signaling

(2008) M. L. Miller et al.   Science Signaling