Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase

Capturing the mammalian Hippo: Elucidating its role in cancer

(2013) Miki Nishio et al.   CANCER SCIENCE

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1

(2013) R. Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

(2012) Joseph Rosenbluh et al.   CELL

Homeodomain-Interacting Protein Kinase Regulates Hippo Pathway-Dependent Tissue Growth

(2012) Carole L.C. Poon et al.   CURRENT BIOLOGY

A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling

(2012) Masamichi Imajo et al.   EMBO JOURNAL

Integrin-linked kinase (ILK) modulates wound healing through regulation of hepatocyte growth factor (HGF)

(2012) Isabel Serrano et al.   EXPERIMENTAL CELL RESEARCH

Quit your YAPing: a new target for cancer therapy

(2012) B. Z. Stanger   GENES & DEVELOPMENT

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

(2012) B. Zhao et al.   GENES & DEVELOPMENT

Yes-Associated Protein 1 Is Activated and Functions as an Oncogene in Meningiomas

(2012) G. S. Baia et al.   MOLECULAR CANCER RESEARCH

LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker

(2012) Dahu Chen et al.   NATURE MEDICINE

Role of the integrin-linked kinase (ILK)/Rictor complex in TGFβ-1-induced epithelial–mesenchymal transition (EMT)

(2012) I Serrano et al.   ONCOGENE

The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

(2012) J. M. Lamar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer

(2012) A. Kreso et al.   SCIENCE

The YAP and TAZ transcription co-activators: Key downstream effectors of the mammalian Hippo pathway

(2012) Wanjin Hong et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Validating the use of a luciferase labeled breast cancer cell line, MDA435LCC6, as a means to monitor tumor progression and to assess the therapeutic activity of an established anticancer drug, docetaxel (Dt) alone or in combination with the ILK inhibitor, QLT0267

(2011) Jessica Kalra et al.   CANCER BIOLOGY & THERAPY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Integrin-linked kinase: Not so ‘pseudo’ after all

(2011) G E Hannigan et al.   ONCOGENE

E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components

(2011) N.-G. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Merlin/NF2 Functions Upstream of the Nuclear E3 Ubiquitin Ligase CRL4DCAF1 to Suppress Oncogenic Gene Expression

(2011) J. Cooper et al.   Science Signaling

Merlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4DCAF1 in the Nucleus

(2010) Wei Li et al.   CELL

Merlin, a “Magic” Linker Between the Extracellular Cues and Intracellular Signaling Pathways that Regulate Cell Motility, Proliferation, and Survival

(2010) Ivan Stamenkovic et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Hippo signaling: growth control and beyond

(2010) G. Halder et al.   DEVELOPMENT

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version

(2010) B. Zhao et al.   GENES & DEVELOPMENT

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Targeting integrin linked kinase and FMS-like tyrosine kinase-3 is cytotoxic to acute myeloid leukemia stem cells but spares normal progenitors

(2010) Andrew L. Muranyi et al.   LEUKEMIA RESEARCH

A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells

(2010) A B Fielding et al.   ONCOGENE

Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer

(2010) S M Pontier et al.   ONCOGENE

Integrin-Linked Kinase Is a Functional Mn2+-Dependent Protein Kinase that Regulates Glycogen Synthase Kinase-3β (GSK-3β) Phosphorylation

(2010) Mykola Maydan et al.   PLoS One

Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase

(2009) Udayan Apte et al.   HEPATOLOGY

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

(2009) Sabrina L. Spencer et al.   NATURE

The Small Molecule Inhibitor QLT0267 Radiosensitizes Squamous Cell Carcinoma Cells of the Head and Neck

(2009) Iris Eke et al.   PLoS One

Merlin Is a Potent Inhibitor of Glioma Growth

(2008) Y.-K. I. Lau et al.   CANCER RESEARCH

A Role for TAZ in Migration, Invasion, and Tumorigenesis of Breast Cancer Cells

(2008) S. W. Chan et al.   CANCER RESEARCH

YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation

(2008) Toshihiko Yokoyama et al.   CARCINOGENESIS

Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

(2008) Victoria Sanz-Moreno et al.   CELL

Expression of Yes-associated protein in common solid tumors

(2008) Angela A. Steinhardt et al.   HUMAN PATHOLOGY

Integrin-linked kinase - essential roles in physiology and cancer biology

(2008) P. C. McDonald et al.   JOURNAL OF CELL SCIENCE