Is There a Role of Autophagy in Depression and Antidepressant Action?

Is Autophagy Involved in the Diverse Effects of Antidepressants?

(2019) Theo Rein   Cells

Autophagy inhibition plays a protective role against 3, 4-methylenedioxymethamphetamine (MDMA)-induced loss of serotonin transporters and depressive-like behaviors in rats

(2019) Jui-Hu Shih et al.   PHARMACOLOGICAL RESEARCH

Mood-stabilizing effects of rapamycin and its analog temsirolimus

(2018) Nirit Z. Kara et al.   BEHAVIOURAL PHARMACOLOGY

The antidepressant effects of ɑ-tocopherol are related to activation of autophagy via the AMPK/mTOR pathway

(2018) Xiaoyan Huang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Extract of Euryale ferox Salisb exerts antidepressant effects and regulates autophagy through the adenosine monophosphate-activated protein kinase-UNC-51-like kinase 1 pathway

(2018) Zhiheng Huang et al.   IUBMB LIFE

Mechanisms of ketamine action as an antidepressant

(2018) P Zanos et al.   MOLECULAR PSYCHIATRY

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

(2018) Naomi R. Wray et al.   NATURE GENETICS

Nicotine alleviates chronic stress-induced anxiety and depressive-like behavior and hippocampal neuropathology via regulating autophagy signaling

(2018) Xi Xiao et al.   NEUROCHEMISTRY INTERNATIONAL

Corticosterone impairs gap junctions in the prefrontal cortical and hippocampal astrocytes via different mechanisms

(2018) Cong-Yuan Xia et al.   NEUROPHARMACOLOGY

Maternal Separation Induces Different Autophagic Responses in the Hippocampus and Prefrontal Cortex of Adult Rats

(2018) Chunhua Liu et al.   NEUROSCIENCE

Chronic restraint stress induces hippocampal memory deficits by impairing insulin signaling

(2018) Hanwoong Woo et al.   Molecular Brain

The effect of fasting or calorie restriction on autophagy induction: A review of the literature

(2018) Mohammad Bagherniya et al.   AGEING RESEARCH REVIEWS

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders

(2018) Larisa Ryskalin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ketamine induces reactive oxygen species and enhances autophagy in SV-HUC-1 human uroepithelial cells

(2018) Zhengfei Shan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide

(2018) Anne Gulbins et al.   MOLECULAR PSYCHIATRY

Interdependency Between Autophagy and Synaptic Vesicle Trafficking: Implications for Dopamine Release

(2018) Fiona Limanaqi et al.   Frontiers in Molecular Neuroscience

Genetics Factors in Major Depression Disease

(2018) Maria Shadrina et al.   Frontiers in Psychiatry

Prenatal stress-induced impairments of cognitive flexibility and bidirectional synaptic plasticity are possibly associated with autophagy in adolescent male-offspring

(2017) Hui Zhang et al.   EXPERIMENTAL NEUROLOGY

The FKBP51 Glucocorticoid Receptor Co-Chaperone: Regulation, Function, and Implications in Health and Disease

(2017) Gabriel Fries et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Salvianolic acid B protects against lipopolysaccharide-induced behavioral deficits and neuroinflammatory response: involvement of autophagy and NLRP3 inflammasome

(2017) Pei Jiang et al.   Journal of Neuroinflammation

Fluoxetine-enhanced autophagy ameliorates early brain injury via inhibition of NLRP3 inflammasome activation following subarachnoid hemorrhage in rats

(2017) Jian-ru Li et al.   Journal of Neuroinflammation

Sertraline exerts its antitumor functions through both apoptosis and autophagy pathways in acute myeloid leukemia cells

(2017) Di Xia et al.   LEUKEMIA & LYMPHOMA

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Protective effect of dapsone on cognitive impairment induced by propofol involves hippocampal autophagy

(2017) Ning Yang et al.   NEUROSCIENCE LETTERS

Antidepressants induce autophagy dependent-NLRP3-inflammasome inhibition in Major depressive disorder

(2017) Elísabet Alcocer-Gómez et al.   PHARMACOLOGICAL RESEARCH

Silibinin ameliorates anxiety/depression-like behaviors in amyloid β-treated rats by upregulating BDNF/TrkB pathway and attenuating autophagy in hippocampus

(2017) Xiaoyu Song et al.   PHYSIOLOGY & BEHAVIOR

Modelling depression in animals: at the interface of reward and stress pathways

(2017) D. A. Slattery et al.   PSYCHOPHARMACOLOGY

From Serotonin to Neuroplasticity: Evolvement of Theories for Major Depressive Disorder

(2017) Bangshan Liu et al.   Frontiers in Cellular Neuroscience

Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis

(2017) Zhan Zhao et al.   Frontiers in Molecular Neuroscience

miR-16 and Fluoxetine Both Reverse Autophagic and Apoptotic Change in Chronic Unpredictable Mild Stress Model Rats

(2017) Yang Yang et al.   Frontiers in Neuroscience

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

FK506 binding protein 51 integrates pathways of adaptation

(2016) Theo Rein   BIOESSAYS

Increased expression of endocytosis-Related proteins in rat hippocampus following 10-day electroconvulsive seizure treatment

(2016) Shingo Enomoto et al.   NEUROSCIENCE LETTERS

Azidobupramine, an Antidepressant-Derived Bifunctional Neurotransmitter Transporter Ligand Allowing Covalent Labeling and Attachment of Fluorophores

(2016) Thomas Kirmeier et al.   PLoS One

Changes of TSPO-mediated mitophagy signaling pathway in learned helplessness mice

(2016) Dongmei Li et al.   PSYCHIATRY RESEARCH

Hypericin-mediated sonodynamic therapy induces autophagy and decreases lipids in THP-1 macrophage by promoting ROS-dependent nuclear translocation of TFEB

(2016) Xuesong Li et al.   Cell Death & Disease

Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis

(2016) Xiaoting Wu et al.   Nature Communications

Mechanisms of Autophagy

(2015) Nobuo N. Noda et al.   Annual Review of Biophysics

FKBP5/FKBP51 enhances autophagy to synergize with antidepressant action

(2015) Nils C Gassen et al.   Autophagy

Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit

(2015) Ksenya Shchors et al.   CANCER CELL

The Effects of Calorie Restriction in Depression and Potential Mechanisms

(2015) Yifan Zhang et al.   Current Neuropharmacology

Decreased AKT1/mTOR pathway mRNA expression in short-term bipolar disorder

(2015) Rodrigo Machado-Vieira et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

A brief history of the development of antidepressant drugs: From monoamines to glutamate.

(2015) Todd M. Hillhouse et al.   EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY

Fluoxetine Decreases the Proliferation and Adipogenic Differentiation of Human Adipose-Derived Stem Cells

(2015) Bo Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development of autophagy inducers in clinical medicine

(2015) Beth Levine et al.   JOURNAL OF CLINICAL INVESTIGATION

Therapeutic targeting of autophagy in neurodegenerative and infectious diseases

(2015) David C. Rubinsztein et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Geldanamycin Reduces Aβ-Associated Anxiety and Depression, Concurrent with Autophagy Provocation

(2015) Nayereh Zare et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Eating Locally: Microautophagy and Protein Turnover at the Synapse

(2015) Peter S. McPherson   NEURON

Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy

(2015) Valerie Uytterhoeven et al.   NEURON

Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology

(2015) Beth Levine et al.   TRENDS IN CELL BIOLOGY

Molecular network of neuronal autophagy in the pathophysiology and treatment of depression

(2015) Jack Jia et al.   Neuroscience Bulletin

Lithium and Autophagy

(2014) Yumiko Motoi et al.   ACS Chemical Neuroscience

The autophagy regulators Ambra1 and Beclin 1 are required for adult neurogenesis in the brain subventricular zone

(2014) M Yazdankhah et al.   Cell Death & Disease

Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans

(2014) Nils C. Gassen et al.   PLOS MEDICINE

Plastic Changes in the Spinal Cord in Motor Neuron Disease

(2014) Francesco Fornai et al.   Biomed Research International

Antidepressant Desipramine Leads to C6 Glioma Cell Autophagy: Implication for the Adjuvant Therapy of Cancer

(2013) Jian Ma et al.   Anti-Cancer Agents in Medicinal Chemistry

Integration of Chemical and RNAi Multiparametric Profiles Identifies Triggers of Intracellular Mycobacterial Killing

(2013) Varadharajan Sundaramurthy et al.   Cell Host & Microbe

The role of cell signalling in the crosstalk between autophagy and apoptosis

(2013) Laurence A. Booth et al.   CELLULAR SIGNALLING

Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs

(2013) Erich Gulbins et al.   NATURE MEDICINE

Electroconvulsive seizures enhance autophagy signaling in rat hippocampus

(2013) Hiroyuki Otabe et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Trehalose induced antidepressant-like effects and autophagy enhancement in mice

(2013) N. Z. Kara et al.   PSYCHOPHARMACOLOGY

Mechanisms of Autophagosome Biogenesis

(2012) David C. Rubinsztein et al.   CURRENT BIOLOGY

Neuronal Stimulation Induces Autophagy in Hippocampal Neurons That Is Involved in AMPA Receptor Degradation after Chemical Long-Term Depression

(2012) M. Shehata et al.   JOURNAL OF NEUROSCIENCE

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

(2012) Congcong He et al.   NATURE

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Regulation of Presynaptic Neurotransmission by Macroautophagy

(2012) Daniela Hernandez et al.   NEURON

Antidepressants encounter autophagy in neural cells

(2011) Jürgen Zschocke et al.   Autophagy

The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells

(2011) Seung-Hyun Jeon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy induced by valproic acid is associated with oxidative stress in glioma cell lines

(2011) J. Fu et al.   NEURO-ONCOLOGY

Antidepressant Drugs Diversely Affect Autophagy Pathways in Astrocytes and Neurons—Dissociation from Cholesterol Homeostasis

(2011) Jürgen Zschocke et al.   NEUROPSYCHOPHARMACOLOGY

AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Psychiatry: Update 2011

(2011) C. Hiemke et al.   PHARMACOPSYCHIATRY

The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

(2011) Courtney S. Jernigan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The increasing burden of depression

(2011) Mike Briley et al.   Neuropsychiatric Disease and Treatment

Intracellular pathways underlying the effects of lithium

(2010) Livia Pasquali et al.   BEHAVIOURAL PHARMACOLOGY

The antidepressants maprotiline and fluoxetine induce Type II autophagic cell death in drug-resistant Burkitt's lymphoma

(2010) Suzanne M. Cloonan et al.   INTERNATIONAL JOURNAL OF CANCER

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Animal models of neuropsychiatric disorders

(2010) Eric J Nestler et al.   NATURE NEUROSCIENCE

Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux

(2009) M. Rossi et al.   JOURNAL OF CELL SCIENCE

Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy

(2009) Andreas Heiseke et al.   JOURNAL OF NEUROCHEMISTRY

Antidepressive-like effects of rapamycin in animal models: Implications for mTOR inhibition as a new target for treatment of affective disorders

(2008) C. Cleary et al.   BRAIN RESEARCH BULLETIN

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Major Depressive Disorder

(2008) R.H. Belmaker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lithium delays progression of amyotrophic lateral sclerosis

(2008) F. Fornai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of New Functional Inhibitors of Acid Sphingomyelinase Using a Structure−Property−Activity Relation Model

(2007) Johannes Kornhuber et al.   JOURNAL OF MEDICINAL CHEMISTRY