Molecular network of neuronal autophagy in the pathophysiology and treatment of depression

mTOR's role in ageing: protein synthesis or autophagy?

(2016) Sarah L. Hands et al.   Aging-US

FKBP5/FKBP51 enhances autophagy to synergize with antidepressant action

(2015) Nils C Gassen et al.   Autophagy

Decreased AKT1/mTOR pathway mRNA expression in short-term bipolar disorder

(2015) Rodrigo Machado-Vieira et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Autophagosome dynamics in neurodegeneration at a glance

(2015) Y. C. Wong et al.   JOURNAL OF CELL SCIENCE

Too much or not enough of a good thing — The Janus faces of autophagy in cardiac fuel and protein homeostasis

(2015) Jun Ren et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD

(2015) Antonella Tramutola et al.   JOURNAL OF NEUROCHEMISTRY

A53T Human  -Synuclein Overexpression in Transgenic Mice Induces Pervasive Mitochondria Macroautophagy Defects Preceding Dopamine Neuron Degeneration

(2015) L. Chen et al.   JOURNAL OF NEUROSCIENCE

Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death

(2015) S Liu et al.   Cell Death & Disease

PATHOPHYSIOLOGY OF DEPRESSION: DO WE HAVE ANY SOLID EVIDENCE OF INTEREST TO CLINICIANS?

(2015) GREGOR HASLER   World Psychiatry

Autophagy in neuronal cells: general principles and physiological and pathological functions

(2014) Markus Damme et al.   ACTA NEUROPATHOLOGICA

Autophagy in the physiology and pathology of the central nervous system

(2014) V Nikoletopoulou et al.   CELL DEATH AND DIFFERENTIATION

Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons

(2014) Sung Woo Park et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Apoptosis-related proteins and proliferation markers in the orbitofrontal cortex in major depressive disorder

(2014) Jose J. Miguel-Hidalgo et al.   JOURNAL OF AFFECTIVE DISORDERS

Rapamycin and Interleukin-1β Impair Brain-derived Neurotrophic Factor-dependent Neuron Survival by Modulating Autophagy

(2014) Erica D. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired autophagy: a link between neurodegenerative and neuropsychiatric diseases

(2014) Mira Polajnar et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The role of mTOR in depression and antidepressant responses

(2014) Helena M. Abelaira et al.   LIFE SCIENCES

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fear Extinction as a Model for Synaptic Plasticity in Major Depressive Disorder

(2014) Marion Kuhn et al.   PLoS One

Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans

(2014) Nils C. Gassen et al.   PLOS MEDICINE

The Role of Brain-Derived Neurotrophic Factor in Comorbid Depression: Possible Linkage with Steroid Hormones, Cytokines, and Nutrition

(2014) Tadahiro Numakawa et al.   Frontiers in Psychiatry

Antidepressant Desipramine Leads to C6 Glioma Cell Autophagy: Implication for the Adjuvant Therapy of Cancer

(2013) Jian Ma et al.   Anti-Cancer Agents in Medicinal Chemistry

Trehalose induced antidepressant-like effects and autophagy enhancement in mice

(2013) N. Z. Kara et al.   PSYCHOPHARMACOLOGY

Neuronal Autophagy and Neurodevelopmental Disorders

(2013) Kyung-Min Lee et al.   Experimental Neurobiology

Neuronal autophagy and neurodegenerative diseases

(2012) Jin H. Son et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Neuronal Stimulation Induces Autophagy in Hippocampal Neurons That Is Involved in AMPA Receptor Degradation after Chemical Long-Term Depression

(2012) M. Shehata et al.   JOURNAL OF NEUROSCIENCE

Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity

(2012) Jae-Kyo Jeong et al.   NEUROBIOLOGY OF AGING

A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists

(2012) R. S. Duman et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

SQSTM1 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2011) Faisal Fecto   ARCHIVES OF NEUROLOGY

Antidepressants encounter autophagy in neural cells

(2011) Jürgen Zschocke et al.   Autophagy

The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells

(2011) Seung-Hyun Jeon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A dual role for Ca2+ in autophagy regulation

(2011) Jean-Paul Decuypere et al.   CELL CALCIUM

Loss of Tsc1 In Vivo Impairs Hippocampal mGluR-LTD and Increases Excitatory Synaptic Function

(2011) H. S. Bateup et al.   JOURNAL OF NEUROSCIENCE

Juvenile Administration of Concomitant Methylphenidate and Fluoxetine Alters Behavioral Reactivity to Reward- and Mood-Related Stimuli and Disrupts Ventral Tegmental Area Gene Expression in Adulthood

(2011) B. L. Warren et al.   JOURNAL OF NEUROSCIENCE

UBQLN2/P62 cellular recycling pathways in amyotrophic lateral sclerosis and frontotemporal dementia

(2011) Faisal Fecto et al.   MUSCLE & NERVE

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

(2011) Han-Xiang Deng et al.   NATURE

Antidepressant Drugs Diversely Affect Autophagy Pathways in Astrocytes and Neurons—Dissociation from Cholesterol Homeostasis

(2011) Jürgen Zschocke et al.   NEUROPSYCHOPHARMACOLOGY

Functional Biomarkers of Depression: Diagnosis, Treatment and Pathophysiology

(2011) Heath D Schmidt et al.   NEUROPSYCHOPHARMACOLOGY

The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

(2011) Courtney S. Jernigan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Reward and Punishment Processing in Depression

(2010) Neir Eshel et al.   BIOLOGICAL PSYCHIATRY

Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy

(2010) C. Rothenberg et al.   HUMAN MOLECULAR GENETICS

Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression

(2010) R C Shelton et al.   MOLECULAR PSYCHIATRY

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Autophagy promotes synapse development inDrosophila

(2009) Wei Shen et al.   JOURNAL OF CELL BIOLOGY

Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy

(2009) Andreas Heiseke et al.   JOURNAL OF NEUROCHEMISTRY

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

(2009) Maria Xilouri et al.   PLoS One

Antidepressive-like effects of rapamycin in animal models: Implications for mTOR inhibition as a new target for treatment of affective disorders

(2008) C. Cleary et al.   BRAIN RESEARCH BULLETIN

A Brief Review of Antidepressant Efficacy, Effectiveness, Indications, and Usage for Major Depressive Disorder

(2008) Andrew A. Nierenberg et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Regulation of macroautophagy by mTOR and Beclin 1 complexes

(2007) Sophie Pattingre et al.   BIOCHIMIE

Roles of autophagy and mTOR signaling in neuronal differentiation of mouse neuroblastoma cells

(2007) Mei Zeng et al.   CELLULAR SIGNALLING