Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans

Pharmacogenetics Studies in STAR*D: Strengths, Limitations, and Results

(2014) Gonzalo Laje et al.   PSYCHIATRIC SERVICES

Antidepressant Desipramine Leads to C6 Glioma Cell Autophagy: Implication for the Adjuvant Therapy of Cancer

(2013) Jian Ma et al.   Anti-Cancer Agents in Medicinal Chemistry

Scopolamine Rapidly Increases Mammalian Target of Rapamycin Complex 1 Signaling, Synaptogenesis, and Antidepressant Behavioral Responses

(2013) Bhavya Voleti et al.   BIOLOGICAL PSYCHIATRY

Treatment of bipolar disorder

(2013) John R Geddes et al.   LANCET

Trehalose induced antidepressant-like effects and autophagy enhancement in mice

(2013) N. Z. Kara et al.   PSYCHOPHARMACOLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Fluoxetine Upregulates Phosphorylated-AKT and Phosphorylated-ERK1/2 Proteins in Neural Stem Cells: Evidence for a Crosstalk between AKT and ERK1/2 Pathways

(2012) Wen Huang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions

(2012) Torsten Klengel et al.   NATURE NEUROSCIENCE

Enhancement of Dorsal Hippocampal Activity by Knockdown of HCN1 Channels Leads to Anxiolytic- and Antidepressant-like Behaviors

(2012) Chung Sub Kim et al.   NEURON

Regulation of Presynaptic Neurotransmission by Macroautophagy

(2012) Daniela Hernandez et al.   NEURON

Differences in FKBP51 Regulation Following Chronic Social Defeat Stress Correlate with Individual Stress Sensitivity: Influence of Paroxetine Treatment

(2012) Klaus V Wagner et al.   NEUROPSYCHOPHARMACOLOGY

Accumulation of an Antidepressant in Vesiculogenic Membranes of Yeast Cells Triggers Autophagy

(2012) Jingqiu Chen et al.   PLoS One

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells

(2011) Seung-Hyun Jeon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FK506 Binding Protein 5 Shapes Stress Responsiveness: Modulation of Neuroendocrine Reactivity and Coping Behavior

(2011) Chadi Touma et al.   BIOLOGICAL PSYCHIATRY

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Neuropsin cleaves EphB2 in the amygdala to control anxiety

(2011) Benjamin K. Attwood et al.   NATURE

A standardized protocol for repeated social defeat stress in mice

(2011) Sam A Golden et al.   Nature Protocols

Control of autophagy as a therapy for neurodegenerative disease

(2011) Harry Harris et al.   Nature Reviews Neurology

Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling

(2011) Xiao-Dong Wang et al.   NEUROBIOLOGY OF DISEASE

Selective modulation of the PKCɛ/p38MAP kinase signalling pathway for the antidepressant-like activity of amitriptyline

(2011) Nicoletta Galeotti et al.   NEUROPHARMACOLOGY

The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress

(2011) Jakob Hartmann et al.   NEUROPHARMACOLOGY

Antidepressant Drugs Diversely Affect Autophagy Pathways in Astrocytes and Neurons—Dissociation from Cholesterol Homeostasis

(2011) Jürgen Zschocke et al.   NEUROPSYCHOPHARMACOLOGY

AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Psychiatry: Update 2011

(2011) C. Hiemke et al.   PHARMACOPSYCHIATRY

A New Anti-Depressive Strategy for the Elderly: Ablation of FKBP5/FKBP51

(2011) John C. O'Leary et al.   PLoS One

Sigma-1 receptor stimulation with fluvoxamine activates Akt–eNOS signaling in the thoracic aorta of ovariectomized rats with abdominal aortic banding

(2010) Md. Shenuarin Bhuiyan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A Small Molecule Inhibits Akt through Direct Binding to Akt and Preventing Akt Membrane Translocation

(2010) Donghwa Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Hsp90 Cochaperone, FKBP51, Increases Tau Stability and Polymerizes Microtubules

(2010) U. K. Jinwal et al.   JOURNAL OF NEUROSCIENCE

Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters

(2010) Gabriela Schumann Burkard et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Animal models of neuropsychiatric disorders

(2010) Eric J Nestler et al.   NATURE NEUROSCIENCE

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Snapin-Regulated Late Endosomal Transport Is Critical for Efficient Autophagy-Lysosomal Function in Neurons

(2010) Qian Cai et al.   NEURON

Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders

(2010) Yan-Feng Zou et al.   NEUROSCIENCE LETTERS

Pituitary glucocorticoid receptor deletion reduces vulnerability to chronic stress

(2010) Klaus V. Wagner et al.   PSYCHONEUROENDOCRINOLOGY

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

FKBP51 Affects Cancer Cell Response to Chemotherapy by Negatively Regulating Akt

(2009) Huadong Pei et al.   CANCER CELL

Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy

(2009) E Laane et al.   CELL DEATH AND DIFFERENTIATION

Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux

(2009) M. Rossi et al.   JOURNAL OF CELL SCIENCE

Long-term anxiolytic and antidepressant-like behavioural effects of tiagabine, a selective GABA transporter-1 (GAT-1) inhibitor, coincide with a decrease in HPA system activity in C57BL/6 mice

(2009) CK Thoeringer et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Dynamics and diversity in autophagy mechanisms: lessons from yeast

(2009) Hitoshi Nakatogawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Antidepressant like effect of selective serotonin reuptake inhibitors involve modulation of imidazoline receptors by agmatine

(2009) Brijesh G. Taksande et al.   NEUROPHARMACOLOGY

Valproate and Amitriptyline Exert Common and Divergent Influences on Global and Gene Promoter-Specific Chromatin Modifications in Rat Primary Astrocytes

(2009) Tatjana Perisic et al.   NEUROPSYCHOPHARMACOLOGY

The FKBP5-Gene in Depression and Treatment Response—an Association Study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort

(2008) Magnus Lekman et al.   BIOLOGICAL PSYCHIATRY

Antidepressive-like effects of rapamycin in animal models: Implications for mTOR inhibition as a new target for treatment of affective disorders

(2008) C. Cleary et al.   BRAIN RESEARCH BULLETIN

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Clinical characteristics and treatment outcome in a representative sample of depressed inpatients – Findings from the Munich Antidepressant Response Signature (MARS) project

(2008) Johannes M. Hennings et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Genetic Dissection of Neural Circuits

(2008) Liqun Luo et al.   NEURON