The Fungal CYP51s: Their Functions, Structures, Related Drug Resistance, and Inhibitors
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Title
The Fungal CYP51s: Their Functions, Structures, Related Drug Resistance, and Inhibitors
Authors
Keywords
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Journal
Frontiers in Microbiology
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2019-04-24
DOI
10.3389/fmicb.2019.00691
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Note: Only part of the references are listed.- Novel Point Mutations in cyp51A and cyp51B Genes Associated with Itraconazole and Posaconazole Resistance in Aspergillus clavatus Isolates
- (2019) Mahdi Abastabar et al. Microbial Drug Resistance
- Prospective multicenter surveillance of clinically isolated Aspergillus species revealed azole-resistant Aspergillus fumigatus isolates with TR34/L98H mutation in the Kyoto and Shiga regions of Japan
- (2019) Yasuhiro Tsuchido et al. MEDICAL MYCOLOGY
- Dynamic ploidy changes drive fluconazole resistance in human cryptococcal meningitis
- (2019) Neil R.H. Stone et al. JOURNAL OF CLINICAL INVESTIGATION
- A phase 2, randomized, double-blind, placebo-controlled, dose-ranging study to evaluate the efficacy and safety of orally administered VT-1161 in the treatment of recurrent vulvovaginal candidiasis
- (2018) Stephen R. Brand et al. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Identification of 14 alpha-lanosterol demethylase (CYP51) in Scedosporium species
- (2018) Anne Bernhardt et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Cas9/CRISPR genome editing to demonstrate the contribution of Cyp51A Gly138Ser to azole resistance in Aspergillus fumigatus
- (2018) Takashi Umeyama et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The Fungal Cyp-51 Inhibitor VT-1129 is Efficacious in an Experimental Model of Cryptococcal Meningitis
- (2018) Nathan P. Wiederhold et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The Novel Fungal Cyp51 Inhibitor VT-1598 Is Efficacious in Experimental Models of Central Nervous System Coccidioidomycosis Caused by Coccidioides posadasii and Coccidioides immitis
- (2018) Nathan P. Wiederhold et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Investigation of Multiple Resistance Mechanisms in Voriconazole-Resistant Aspergillus flavus Clinical Isolates from a Chest Hospital Surveillance in Delhi, India
- (2018) Cheshta Sharma et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Elevated MIC Values of Imidazole Drugs against Aspergillus fumigatus Isolates with TR 34 /L98H/S297T/F495I Mutation
- (2018) Yong Chen et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Structure and function of the cytochrome P450 peroxygenase enzymes
- (2018) Andrew W. Munro et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Macular toxicity and blind spot enlargement during a treatment by voriconazole: A case report
- (2018) Anaïs Mounier et al. EUROPEAN JOURNAL OF OPHTHALMOLOGY
- Isavuconazole: A new broad-spectrum azole. Part 1: In vitro activity
- (2018) J. Denis et al. JOURNAL DE MYCOLOGIE MEDICALE
- Isavuconazole: A new broad-spectrum azole. Part 2: pharmacokinetics and clinical activity
- (2018) M.-P. Ledoux et al. JOURNAL DE MYCOLOGIE MEDICALE
- The novel fungal CYP51 inhibitor VT-1598 is efficacious alone and in combination with liposomal amphotericin B in a murine model of cryptococcal meningitis
- (2018) E P Garvey et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- VT-1598 inhibits the in vitro growth of mucosal Candida strains and protects against fluconazole-susceptible and -resistant oral candidiasis in IL-17 signalling-deficient mice
- (2018) Timothy J Break et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- A systematic review of fluconazole resistance in clinical isolates of Cryptococcus species
- (2018) Felix Bongomin et al. MYCOSES
- Azole-Resistance in Aspergillus terreus and Related Species: An Emerging Problem or a Rare Phenomenon?
- (2018) Tamara Zoran et al. Frontiers in Microbiology
- Determination of the Prevalence of Triazole Resistance in Environmental Aspergillus fumigatus Strains Isolated in South Wales, UK
- (2018) Alexandra Tsitsopoulou et al. Frontiers in Microbiology
- Invasive candidiasis
- (2018) Peter G. Pappas et al. Nature Reviews Disease Primers
- Crystal structures of full-length lanosterol 14α-demethylases of prominent fungal pathogens Candida albicans and Candida glabrata provide tools for antifungal discovery
- (2018) Mikhail V. Keniya et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- In Vivo Efficacy of VT-1129 against Experimental Cryptococcal Meningitis with the Use of a Loading Dose-Maintenance Dose Administration Strategy
- (2018) Nathan P. Wiederhold et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- First Clinical Isolation of an Azole-Resistant Aspergillus fumigatus Isolate Harboring a TR46 Y121F T289A Mutation in South America
- (2018) Guillermina Isla et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Aspergillus Species and Antifungals Susceptibility in Clinical Setting in the North of Portugal: Cryptic Species and Emerging Azoles Resistance in A. fumigatus
- (2018) Eugénia Pinto et al. Frontiers in Microbiology
- Multidrug-Resistant Aspergillus fumigatus Carrying Mutations Linked to Environmental Fungicide Exposure — Three States, 2010–2017
- (2018) Karlyn D. Beer et al. MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
- Cryptococcus neoformans, Unlike Candida albicans, Forms Aneuploid Clones Directly from Uninucleated Cells under Fluconazole Stress
- (2018) Yun C. Chang et al. mBio
- A Novel Sterol-Signaling Pathway Governs Azole Antifungal Drug Resistance and Hypoxic Gene Repression inSaccharomyces cerevisiae
- (2017) Nina D. Serratore et al. GENETICS
- Intensive care medicine research agenda on invasive fungal infection in critically ill patients
- (2017) Matteo Bassetti et al. INTENSIVE CARE MEDICINE
- Molecular basis of antifungal drug resistance in yeasts
- (2017) Florent Morio et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- VT-1161 protects mice against oropharyngeal candidiasis caused by fluconazole-susceptible and -resistant Candida albicans
- (2017) Timothy J Break et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Pan-azole-resistantCandida tropicaliscarrying homozygouserg11mutations at position K143R: a new emerging superbug?
- (2017) Mariana I. D. S. Xisto et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Fungal-specific Cyp51 inhibitor VT-1598 demonstrates in vitro activity against Candida and Cryptococcus species, endemic fungi, including Coccidioides species, Aspergillus species and Rhizopus arrhizus
- (2017) Nathan P Wiederhold et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Structural analyses ofCandida albicanssterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis
- (2017) Tatiana Y. Hargrove et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The influence of combination use of CYP450 inducers on the pharmacokinetics of voriconazole: a systematic review
- (2017) T.-y. Li et al. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
- Azole-Resistant Aspergillosis: Epidemiology, Molecular Mechanisms, and Treatment
- (2017) Anuradha Chowdhary et al. JOURNAL OF INFECTIOUS DISEASES
- Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi
- (2017) Matthew W McCarthy et al. JOURNAL OF INFECTIOUS DISEASES
- Multi-azole-resistant strains of Cryptococcus neoformans var. grubii isolated from a FLZ-resistant strain by culturing in medium containing voriconazole
- (2017) Rui Kano et al. MEDICAL MYCOLOGY
- Voriconazole-induced periostitis deformans: serial imaging in a patient with ANCA vasculitis
- (2017) S. Cormican et al. SKELETAL RADIOLOGY
- A Novel Zn2-Cys6 Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B Expressions
- (2017) Daisuke Hagiwara et al. PLoS Pathogens
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- (2017) Afsaneh Behtash et al. Current Drug Delivery
- A Novel Sterol-Signaling Pathway Governs Azole Antifungal Drug Resistance and Hypoxic Gene Repression inSaccharomyces cerevisiae
- (2017) Nina D. Serratore et al. GENETICS
- Fluconazole resistance in Candida species: a current perspective
- (2017) Elizabeth Berkow et al. Infection and Drug Resistance
- Fluconazole-Induced Ploidy Change in Cryptococcus neoformans Results from the Uncoupling of Cell Growth and Nuclear Division
- (2017) Sophie Altamirano et al. mSphere
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- (2016) Andrew G. S. Warrilow et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
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- (2016) W. A. Schell et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Simultaneous Emergence of Multidrug-ResistantCandida aurison 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses
- (2016) Shawn R. Lockhart et al. CLINICAL INFECTIOUS DISEASES
- Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America
- (2016) Thomas F. Patterson et al. CLINICAL INFECTIOUS DISEASES
- Adverse effects of voriconazole: Over a decade of use
- (2016) Miriam T. Levine et al. CLINICAL TRANSPLANTATION
- Pharmacodynamic studies of voriconazole: informing the clinical management of invasive fungal infections
- (2016) Kathleen M. Job et al. Expert Review of Anti-Infective Therapy
- Impact of CYP2C19 genetic polymorphisms on voriconazole dosing and exposure in adult patients with invasive fungal infections
- (2016) Fabien Lamoureux et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- The development of fluconazole resistance in Candida albicans – an example of microevolution of a fungal pathogen
- (2016) Joachim Morschhäuser JOURNAL OF MICROBIOLOGY
- Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial
- (2016) Johan A Maertens et al. LANCET
- Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida species
- (2016) Danielly Beraldo dos Santos Silva et al. MEMORIAS DO INSTITUTO OSWALDO CRUZ
- New Progress in Azole Compounds as Antimicrobial Agents
- (2016) Hui-Zhen Zhang et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- The Role of UPC2 Gene in Azole-Resistant Candida tropicalis
- (2016) Cen Jiang et al. MYCOPATHOLOGIA
- Inhibiting fungal multidrug resistance by disrupting an activator–Mediator interaction
- (2016) Joy L. Nishikawa et al. NATURE
- The Aspergillus fumigatus Damage Resistance Protein Family Coordinately Regulates Ergosterol Biosynthesis and Azole Susceptibility
- (2016) Jinxing Song et al. mBio
- Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex
- (2016) Fabio Gsaller et al. PLoS Pathogens
- Transcriptional Control of Drug Resistance, Virulence and Immune System Evasion in Pathogenic Fungi: A Cross-Species Comparison
- (2016) Pedro Pais et al. Frontiers in Cellular and Infection Microbiology
- Sensitisation of an Azole-Resistant Aspergillus fumigatus Strain containing the Cyp51A-Related Mutation by Deleting the SrbA Gene
- (2016) Daisuke Hagiwara et al. Scientific Reports
- Isavuconazonium sulfate approved for invasive fungal infections
- (2015) K. Traynor AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
- Isavuconazole
- (2015) Natasha N. Pettit et al. ANNALS OF PHARMACOTHERAPY
- Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase
- (2015) Alia A. Sagatova et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Evaluation of VT-1161 for Treatment of Coccidioidomycosis in Murine Infection Models
- (2015) Lisa F. Shubitz et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Efficacy of the Clinical Agent VT-1161 against Fluconazole-Sensitive and -Resistant Candida albicans in a Murine Model of Vaginal Candidiasis
- (2015) E. P. Garvey et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Population Pharmacokinetic Modeling of Itraconazole and Hydroxyitraconazole for Oral SUBA-Itraconazole and Sporanox Capsule Formulations in Healthy Subjects in Fed and Fasted States
- (2015) Ahmad Y. Abuhelwa et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Targeting the Adaptability of Heterogeneous Aneuploids
- (2015) Guangbo Chen et al. CELL
- Isavuconazonium: First Global Approval
- (2015) Paul L. McCormack DRUGS
- Genotype–phenotype complexity of the TR46/Y121F/T289A cyp51A azole resistance mechanism in Aspergillus fumigatus
- (2015) Eveline Snelders et al. FUNGAL GENETICS AND BIOLOGY
- Antifungal activity of compounds targeting the Hsp90-calcineurin pathway against various mould species: Table 1.
- (2015) Frédéric Lamoth et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) fromAspergillus fumigatusand Molecular Basis for the Development of Antifungal Drugs
- (2015) Tatiana Y. Hargrove et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Rise and Fall of Oral Ketoconazole
- (2015) Aditya K. Gupta et al. JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
- Trisomy of chromosome R confers resistance to triazoles in Candida albicans
- (2015) Xingxing Li et al. MEDICAL MYCOLOGY
- Posaconazole: Use in the Prophylaxis and Treatment of Fungal Infections
- (2015) Shellee Grim et al. SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
- Voriconazole: How to Use This Antifungal Agent and What to Expect
- (2015) Lisa Kerr et al. SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
- Structural mechanism of ergosterol regulation by fungal sterol transcription factor Upc2
- (2015) Huiseon Yang et al. Nature Communications
- Pharmacologic and clinical evaluation of posaconazole
- (2015) Jason N Moore et al. Expert Review of Clinical Pharmacology
- Manipulation of Host Diet To Reduce Gastrointestinal Colonization by the Opportunistic Pathogen Candida albicans
- (2015) Kearney T. W. Gunsalus et al. mSphere
- UPC2AIs Required for High-Level Azole Antifungal Resistance in Candida glabrata
- (2014) Sarah G. Whaley et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The Clinical Candidate VT-1161 Is a Highly Potent Inhibitor of Candida albicans CYP51 but Fails To Bind the Human Enzyme
- (2014) A. G. S. Warrilow et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Contribution of Clinically Derived Mutations inERG11to Azole Resistance in Candida albicans
- (2014) Stephanie A. Flowers et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Design and optimization of highly-selective fungal CYP51 inhibitors
- (2014) William J. Hoekstra et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- UPC2 Is Universally Essential for Azole Antifungal Resistance in Candida albicans
- (2014) Erin M. Vasicek et al. EUKARYOTIC CELL
- Drug safety assessment of oral formulations of ketoconazole
- (2014) Aditya K Gupta et al. Expert Opinion On Drug Safety
- Combination of fluconazole with non-antifungal agents: A promising approach to cope with resistant Candida albicans infections and insight into new antifungal agent discovery
- (2014) Shuyuan Liu et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Liver injury associated with ketoconazole: Review of the published evidence
- (2014) H. Karl Greenblatt et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Paralog Re-Emergence: A Novel, Historically Contingent Mechanism in the Evolution of Antimicrobial Resistance
- (2014) Nichola J. Hawkins et al. MOLECULAR BIOLOGY AND EVOLUTION
- CYP2C19Polymorphisms and Therapeutic Drug Monitoring of Voriconazole: Are We Ready for Clinical Implementation of Pharmacogenomics?
- (2014) Aniwaa Owusu Obeng et al. PHARMACOTHERAPY
- Incidence of Cyp51 A Key Mutations in Aspergillus fumigatus—A Study on Primary Clinical Samples of Immunocompromised Patients in the Period of 1995–2013
- (2014) Birgit Spiess et al. PLoS One
- Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer
- (2014) B. C. Monk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fungal Biofilms, Drug Resistance, and Recurrent Infection
- (2014) J. V. Desai et al. Cold Spring Harbor Perspectives in Medicine
- A Tetraploid Intermediate Precedes Aneuploid Formation in Yeasts Exposed to Fluconazole
- (2014) Benjamin D. Harrison et al. PLOS BIOLOGY
- Molecular Mechanisms of Drug Resistance in Clinical Candida Species Isolated from Tunisian Hospitals
- (2013) Jamel Eddouzi et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Azole Resistance in Cryptococcus gattii from the Pacific Northwest: Investigation of the Role ofERG11
- (2013) Charles E. Gast et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Aspergillosis in Intensive Care Unit (ICU) patients: epidemiology and economic outcomes
- (2013) John W Baddley et al. BMC INFECTIOUS DISEASES
- Aspergillosis due to Voriconazole Highly Resistant Aspergillus fumigatus and Recovery of Genetically Related Resistant Isolates From Domiciles
- (2013) Jan W. M. van der Linden et al. CLINICAL INFECTIOUS DISEASES
- Itraconazole: an update on pharmacology and clinical use for treatment of invasive and allergic fungal infections
- (2013) Jodi Lestner et al. Expert Opinion on Drug Metabolism & Toxicology
- A Prospective Longitudinal Study of the Clinical Outcomes from Cryptococcal Meningitis following Treatment Induction with 800 mg Oral Fluconazole in Blantyre, Malawi
- (2013) Camilla Rothe et al. PLoS One
- Emergence of Azole-Resistant Aspergillus fumigatus Strains due to Agricultural Azole Use Creates an Increasing Threat to Human Health
- (2013) Anuradha Chowdhary et al. PLoS Pathogens
- STB5 Is a Negative Regulator of Azole Resistance in Candida glabrata
- (2012) J. A. Noble et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Cryptococcus neoformans-Cryptococcus gattii Species Complex: an International Study of Wild-Type Susceptibility Endpoint Distributions and Epidemiological Cutoff Values for Fluconazole, Itraconazole, Posaconazole, and Voriconazole
- (2012) A. Espinel-Ingroff et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens
- (2012) Rayko Becher et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Azole Antimycotics - A Highway to New Drugs or a Dead End?
- (2012) R. Musiol et al. CURRENT MEDICINAL CHEMISTRY
- Gain-of-Function Mutations in UPC2 Are a Frequent Cause of ERG11 Upregulation in Azole-Resistant Clinical Isolates of Candida albicans
- (2012) Stephanie A. Flowers et al. EUKARYOTIC CELL
- The cellular and molecular defense mechanisms of the Candida yeasts against azole antifungal drugs
- (2012) T. Noël JOURNAL DE MYCOLOGIE MEDICALE
- Molecular Epidemiology of Aspergillus fumigatus Isolates Harboring the TR34/L98H Azole Resistance Mechanism
- (2012) S. M. T. Camps et al. JOURNAL OF CLINICAL MICROBIOLOGY
- The stepwise acquisition of fluconazole resistance mutations causes a gradual loss of fitness inCandida albicans
- (2012) Christoph Sasse et al. MOLECULAR MICROBIOLOGY
- Aneuploidy and Drug Resistance in Pathogenic Fungi
- (2012) Kyung J. Kwon-Chung et al. PLoS Pathogens
- Global Analysis of the Evolution and Mechanism of Echinocandin Resistance in Candida glabrata
- (2012) Sheena D. Singh-Babak et al. PLoS Pathogens
- Interrogation of Related Clinical Pan-Azole-Resistant Aspergillus fumigatus Strains: G138C, Y431C, and G434C Single Nucleotide Polymorphisms incyp51A, Upregulation ofcyp51A, and Integration and Activation of TransposonAtf1in thecyp51APromoter
- (2011) Ahmed M. Albarrag et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Identification of a Cryptococcus neoformans Cytochrome P450 Lanosterol 14α-Demethylase (Erg11) Residue Critical for Differential Susceptibility between Fluconazole/Voriconazole and Itraconazole/Posaconazole
- (2011) Edward Sionov et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- SREBP-Dependent Triazole Susceptibility in Aspergillus fumigatus Is Mediated through Direct Transcriptional Regulation oferg11A(cyp51A)
- (2011) Sara J. Blosser et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Using RNA-seq to determine the transcriptional landscape and the hypoxic response of the pathogenic yeast Candida parapsilosis
- (2011) Alessandro Guida et al. BMC GENOMICS
- Development of a novel multiplex DNA microarray for Fusarium graminearum and analysis of azole fungicide responses
- (2011) Rayko Becher et al. BMC GENOMICS
- The structure–function relationship of the Aspergillus fumigatus cyp51A L98H conversion by site-directed mutagenesis: The mechanism of L98H azole resistance
- (2011) Eveline Snelders et al. FUNGAL GENETICS AND BIOLOGY
- Azole resistance inAspergillus: a growing public health menace
- (2011) David W Denning et al. Future Microbiology
- First Three Reported Cases of Nosocomial Fungemia Caused by Candida auris
- (2011) Wee Gyo Lee et al. JOURNAL OF CLINICAL MICROBIOLOGY
- Mechanism of cytochrome P450-3A inhibition by ketoconazole
- (2011) David J. Greenblatt et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Deletion of Cryptococcus neoformans AIF Ortholog Promotes Chromosome Aneuploidy and Fluconazole-Resistance in a Metacaspase-Independent Manner
- (2011) Camile P. Semighini et al. PLoS Pathogens
- An A643V Amino Acid Substitution in Upc2p Contributes to Azole Resistance in Well-Characterized Clinical Isolates ofCandida albicans
- (2010) Samantha J. Hoot et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Identification and Characterization of Four Azole-Resistant erg3 Mutants of Candida albicans
- (2010) C. M. Martel et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Genetic Dissection of Azole Resistance Mechanisms in Candida albicans and Their Validation in a Mouse Model of Disseminated Infection
- (2010) D. M. MacCallum et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Structural basis for conservation in the CYP51 family
- (2010) Galina I. Lepesheva et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Sterol Regulatory Element Binding Proteins in Fungi: Hypoxic Transcription Factors Linked to Pathogenesis
- (2010) Clara M. Bien et al. EUKARYOTIC CELL
- Genomic Plasticity of the Human Fungal Pathogen Candida albicans
- (2010) Anna Selmecki et al. EUKARYOTIC CELL
- Structural Basis of Human CYP51 Inhibition by Antifungal Azoles
- (2010) Natallia Strushkevich et al. JOURNAL OF MOLECULAR BIOLOGY
- Probing the role of point mutations in thecyp51A genefrom Aspergillus fumigatusin the model yeastSaccharomyces cerevisiae
- (2010) L. Alcazar-Fuoli et al. MEDICAL MYCOLOGY
- Efflux-Mediated Antifungal Drug Resistance
- (2009) R. D. Cannon et al. CLINICAL MICROBIOLOGY REVIEWS
- Conservation of the Sterol Regulatory Element-Binding Protein Pathway and Its Pathobiological Importance inCryptococcus neoformans
- (2009) Yun C. Chang et al. EUKARYOTIC CELL
- Cryptococcus neoformansSite-2 protease is required for virulence and survival in the presence of azole drugs
- (2009) Clara M. Bien et al. MOLECULAR MICROBIOLOGY
- Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease
- (2009) Leah E. Cowen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Gain-of-Function Mutation in the Transcription Factor Upc2p Causes Upregulation of Ergosterol Biosynthesis Genes and Increased Fluconazole Resistance in a ClinicalCandida albicansIsolate
- (2008) Nico Dunkel et al. EUKARYOTIC CELL
- The Parasexual Cycle in Candida albicans Provides an Alternative Pathway to Meiosis for the Formation of Recombinant Strains
- (2008) Anja Forche et al. PLOS BIOLOGY
- A Sterol-Regulatory Element Binding Protein Is Required for Cell Polarity, Hypoxia Adaptation, Azole Drug Resistance, and Virulence in Aspergillus fumigatus
- (2008) Sven D. Willger et al. PLoS Pathogens
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