Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi

Triazole resistance in Aspergillus fumigatus isolates from patients with cystic fibrosis in Italy

(2017) Anna Prigitano et al.   Journal of Cystic Fibrosis

Preclinical Evaluation of the Stability, Safety, and Efficacy of CD101, a Novel Echinocandin

(2016) Voon Ong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

CD101: a novel long-acting echinocandin

(2016) Yanan Zhao et al.   CELLULAR MICROBIOLOGY

Identification and characterization of haemofungin, a novel antifungal compound that inhibits the final step of haem biosynthesis

(2016) Dafna Ben Yaakov et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Activity of a long-acting echinocandin, CD101, determined using CLSI and EUCAST reference methods, againstCandidaandAspergillusspp., including echinocandin- and azole-resistant isolates

(2016) Michael A. Pfaller et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Epidemiology of invasive fungal infections during induction therapy in adults with acute lymphoblastic leukemia: a GRAALL-2005 study

(2016) Clara Mariette et al.   LEUKEMIA & LYMPHOMA

The anti-Aspergillusdrug pipeline: Is the glass half full or empty?: Table 1.

(2016) Nir Osherov et al.   MEDICAL MYCOLOGY

Antitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase

(2016) Kristy Koselny et al.   ACS Infectious Diseases

Evaluation of VT-1161 for Treatment of Coccidioidomycosis in Murine Infection Models

(2015) Lisa F. Shubitz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Potential Targets for Antifungal Drug Discovery Based on Growth and Virulence in Candida albicans

(2015) Xiuyun Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification and Characterization of a Novel Family of Selective Antifungal Compounds (CANBEFs) That Interfere with Fungal Protein Synthesis

(2015) Gabriel Mircus et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroActivity of ASP2397 against Aspergillus Isolates with or without Acquired Azole Resistance Mechanisms

(2015) Maiken Cavling Arendrup et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antifungal Activities of SCY-078 (MK-3118) and Standard Antifungal Agents against Clinical Non-Aspergillus Mold Isolates

(2015) Frédéric Lamoth et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genomic profiling of fungal cell wall-interfering compounds: identification of a common gene signature

(2015) Raúl García et al.   BMC GENOMICS

The discovery of novel antifungal scaffolds by structural simplification of the natural product sampangine

(2015) Zhigan Jiang et al.   CHEMICAL COMMUNICATIONS

In vitro activity of a Hos2 deacetylase inhibitor, MGCD290, in combination with echinocandins against echinocandin-resistant Candida species

(2015) M.A. Pfaller et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Cell wall protection by the Candida albicans class I chitin synthases

(2015) Kanya Preechasuth et al.   FUNGAL GENETICS AND BIOLOGY

Model-driven mapping of transcriptional networks reveals the circuitry and dynamics of virulence regulation

(2015) Ezekiel J. Maier et al.   GENOME RESEARCH

The novel arylamidine T-2307 demonstratesin vitroandin vivoactivity against echinocandin-resistantCandida glabrata

(2015) Nathan P. Wiederhold et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

OSU-03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood-Brain Barrier: Implications for Anti-Cancer Therapies

(2015) Laurence Booth et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Sampangine (a Copyrine Alkaloid) Exerts Biological Activities through Cellular Redox Cycling of Its Quinone and Semiquinone Intermediates

(2015) Fakhri Mahdi et al.   JOURNAL OF NATURAL PRODUCTS

Mohangamides A and B, New Dilactone-Tethered Pseudo-Dimeric Peptides Inhibiting Candida albicans Isocitrate Lyase

(2015) Munhyung Bae et al.   ORGANIC LETTERS

How to bolster the antifungal pipeline

(2015) D. W. Denning et al.   SCIENCE

Systematic functional profiling of transcription factor networks in Cryptococcus neoformans

(2015) Kwang-Woo Jung et al.   Nature Communications

Exploiting Fungal Virulence-Regulating Transcription Factors As Novel Antifungal Drug Targets

(2015) Yong-Sun Bahn   PLoS Pathogens

Pharmacodynamic Target Evaluation of a Novel Oral Glucan Synthase Inhibitor, SCY-078 (MK-3118), Using anIn VivoMurine Invasive Candidiasis Model

(2014) Alexander J. Lepak et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Clinical Candidate VT-1161 Is a Highly Potent Inhibitor of Candida albicans CYP51 but Fails To Bind the Human Enzyme

(2014) A. G. S. Warrilow et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Design and optimization of highly-selective fungal CYP51 inhibitors

(2014) William J. Hoekstra et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Calcineurin-Crz1 Signaling in Lower Eukaryotes

(2014) S. Thewes   EUKARYOTIC CELL

New and emerging HDAC inhibitors for cancer treatment

(2014) Alison C. West et al.   JOURNAL OF CLINICAL INVESTIGATION

Modeling Nikkomycin Z Dosing and Pharmacology in Murine Pulmonary Coccidioidomycosis Preparatory to Phase 2 Clinical Trials

(2014) L. F. Shubitz et al.   JOURNAL OF INFECTIOUS DISEASES

Novel nikkomycin analogues generated by mutasynthesis in Streptomyces ansochromogenes

(2014) Chi Feng et al.   Microbial Cell Factories

The Calcium Channel Blocker Verapamil Inhibits Oxidative Stress Response in Candida albicans

(2014) Qilin Yu et al.   MYCOPATHOLOGIA

Emerging drugs and vaccines for Candidemia

(2014) Brad Moriyama et al.   MYCOSES

Inhibitors of the Glyoxylate Cycle Enzyme ICL1 in Candida albicans for Potential Use as Antifungal Agents

(2014) Hong-Leong Cheah et al.   PLoS One

Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection

(2014) P. R. Kumaresan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Antifungal Drug Discovery Based on Targeting Pathways Regulating the Fungus-Conserved Upc2 Transcription Factor

(2013) Christina Gallo-Ebert et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Stress Signaling Pathways for the Pathogenicity of Cryptococcus

(2013) Yong-Sun Bahn et al.   EUKARYOTIC CELL

Distinct Roles of Candida albicans Drug Resistance Transcription Factors TAC1 , MRR1 , and UPC2 in Virulence

(2013) Andrea Lohberger et al.   EUKARYOTIC CELL

The HOG signal transduction pathway in the halophilic fungus Wallemia ichthyophaga: identification and characterisation of MAP kinases WiHog1A and WiHog1B

(2013) Tilen Konte et al.   EXTREMOPHILES

A comprehensive regulatory framework to address the unmet need for new antibacterial treatments

(2013) John H Rex et al.   LANCET INFECTIOUS DISEASES

Systems-level antimicrobial drug and drug synergy discovery

(2013) Terry Roemer et al.   Nature Chemical Biology

Fungal-specific transcription factorAbPf2activates pathogenicity inAlternaria brassicicola

(2013) Yangrae Cho et al.   PLANT JOURNAL

Fingolimod (FTY720) Stimulates Ca2+/Calcineurin Signaling in Fission Yeast

(2013) Kanako Hagihara et al.   PLoS One

Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity

(2012) Catherine A. McLellan et al.   ACS Chemical Biology

T-2307 Causes Collapse of Mitochondrial Membrane Potential in Yeast

(2012) Tatsuya Shibata et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Recently Evolved Transcriptional Network Controls Biofilm Development in Candida albicans

(2012) Clarissa J. Nobile et al.   CELL

Divergent Targets of Candida albicans Biofilm Regulator Bcr1 In Vitro and In Vivo

(2012) Saranna Fanning et al.   EUKARYOTIC CELL

The transmembrane protein Opy2 mediates activation of the Cek1 MAP kinase in Candida albicans

(2012) Carmen Herrero de Dios et al.   FUNGAL GENETICS AND BIOLOGY

Structural and Functional Characterization of NikO, an Enolpyruvyl Transferase Essential in Nikkomycin Biosynthesis

(2012) Gustav Oberdorfer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antifungal Drug Discovery: Something Old and Something New

(2012) Arielle Butts et al.   PLoS Pathogens

Identification,in VitroActivity and Mode of Action of Phosphoinositide-Dependent-1 Kinase Inhibitors as Antifungal Molecules

(2011) Bonnie K. Baxter et al.   ACS Chemical Biology

Efficacy of Oral E1210, a New Broad-Spectrum Antifungal with a Novel Mechanism of Action, in Murine Models of Candidiasis, Aspergillosis, and Fusariosis

(2011) Katsura Hata et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroActivity of E1210, a Novel Antifungal, against Clinically Important Yeasts and Molds

(2011) Mamiko Miyazaki et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

E1210, a New Broad-Spectrum Antifungal, Suppresses Candida albicans Hyphal Growth through Inhibition of Glycosylphosphatidylinositol Biosynthesis

(2011) Nao-aki Watanabe et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

How I treat mucormycosis

(2011) D. P. Kontoyiannis et al.   BLOOD

The Aspergillus giganteus antifungal protein AFPNN5353 activates the cell wall integrity pathway and perturbs calcium homeostasis

(2011) Ulrike Binder et al.   BMC MICROBIOLOGY

Confronting the Challenges of Natural Product-Based Antifungal Discovery

(2011) Terry Roemer et al.   CHEMISTRY & BIOLOGY

Sampangine Inhibits Heme Biosynthesis in both Yeast and Human

(2011) Zhiwei Huang et al.   EUKARYOTIC CELL

Functional Analyses of Two Acetyl Coenzyme A Synthetases in the Ascomycete Gibberella zeae

(2011) Seunghoon Lee et al.   EUKARYOTIC CELL

Pre-clinical development of antifungal susceptibility test methods for the testing of the novel antifungal agent E1210 versus Candida: comparison of CLSI and European Committee on Antimicrobial Susceptibility Testing methods

(2011) M. A. Pfaller et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Survival Strategies of Yeast and Filamentous Fungi against the Antifungal Protein AFP

(2011) Jean Paul Ouedraogo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design, Synthesis, and Characterization of a Highly Effective Hog1 Inhibitor: A Powerful Tool for Analyzing MAP Kinase Signaling in Yeast

(2011) Peter Dinér et al.   PLoS One

T-2307 Shows Efficacy in a Murine Model of Candida glabrata Infection despite In Vitro Trailing Growth Phenomena

(2010) E. Yamada et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A complex task? Direct modulation of transcription factors with small molecules

(2010) Angela N Koehler   CURRENT OPINION IN CHEMICAL BIOLOGY

Interaction between the Candida albicans High-Osmolarity Glycerol (HOG) Pathway and the Response to Human β-Defensins 2 and 3

(2010) Silvia Argimón et al.   EUKARYOTIC CELL

Transcriptional Switches: Chemical Approaches to Gene Regulation

(2010) Lori W. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity

(2010) Suzanne M Noble et al.   NATURE GENETICS

An insight into the antifungal pipeline: selected new molecules and beyond

(2010) Luis Ostrosky-Zeichner et al.   NATURE REVIEWS DRUG DISCOVERY

Small-molecule chromatin-modifying agents: therapeutic applications

(2010) Antonello Mai   Epigenomics

PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90

(2010) Shantelle L. LaFayette et al.   PLoS Pathogens

5-Hydroxyindole-type alkaloids, as Candida albicans isocitrate lyase inhibitors, from the tropical sponge Hyrtios sp.

(2009) Hyi-Seung Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Cek1 MAPK is a short-lived protein regulated by quorum sensing in the fungal pathogenCandida albicans

(2009) Elvira Román et al.   FEMS YEAST RESEARCH

A comparative genomic analysis of calcium and proton signaling/homeostasis in Aspergillus species

(2009) Mojca Benčina et al.   FUNGAL GENETICS AND BIOLOGY

Activity of MGCD290, a Hos2 Histone Deacetylase Inhibitor, in Combination with Azole Antifungals against Opportunistic Fungal Pathogens

(2009) M. A. Pfaller et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Major roles of isocitrate lyase and malate synthase in bacterial and fungal pathogenesis

(2009) M. F. Dunn et al.   MICROBIOLOGY-SGM

In Vitro and In Vivo Antifungal Activities of T-2307, a Novel Arylamidine

(2008) J. Mitsuyama et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Systematic Genetic Analysis of Virulence in the Human Fungal Pathogen Cryptococcus neoformans

(2008) Oliver W. Liu et al.   CELL

Candida albicanstranscription factor Rim101 mediates pathogenic interactions through cell wall functions

(2008) Clarissa J. Nobile et al.   CELLULAR MICROBIOLOGY

Two-Component Signal Transduction Proteins as Potential Drug Targets in Medically Important Fungi

(2008) N. Chauhan et al.   INFECTION AND IMMUNITY

How Do Azoles Inhibit Cytochrome P450 Enzymes? A Density Functional Study†

(2008) Philip R. Balding et al.   JOURNAL OF PHYSICAL CHEMISTRY A

The activity of the glyoxylate cycle in peroxisomes of Candida albicans depends on a functional  -oxidation pathway: evidence for reduced metabolite transport across the peroxisomal membrane

(2008) K. Piekarska et al.   MICROBIOLOGY-SGM

Systematic functional analysis of calcium-signalling proteins in the genome of the rice-blast fungus,Magnaporthe oryzae, using a high-throughput RNA-silencing system

(2008) Quoc Bao Nguyen et al.   MOLECULAR MICROBIOLOGY