Azole-Resistant Aspergillosis: Epidemiology, Molecular Mechanisms, and Treatment

Epidemiology of invasive aspergillosis and azole resistance in patients with acute leukaemia: the SEPIA Study

(2017) Philipp Koehler et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Triazole resistance in Aspergillus fumigatus isolates from patients with cystic fibrosis in Italy

(2017) Anna Prigitano et al.   Journal of Cystic Fibrosis

Azole-resistant Aspergillus fumigatus harboring TR34/L98H, TR46/Y121F/T289A and TR53 mutations related to flower fields in Colombia

(2017) Carlos Alvarez-Moreno et al.   Scientific Reports

Preclinical Evaluation of the Stability, Safety, and Efficacy of CD101, a Novel Echinocandin

(2016) Voon Ong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Screening and Characterization of a Non- cyp51A Mutation in an Aspergillus fumigatus cox10 Strain Conferring Azole Resistance

(2016) Xiaolei Wei et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Aspergillus fumigatus carrying TR34/L98H resistance allele causing complicated suppurative otitis media in Tanzania: Call for improved diagnosis of fungi in sub-Saharan Africa

(2016) Martha F. Mushi et al.   BMC INFECTIOUS DISEASES

Home Environment as a Source of Life-Threatening Azole-ResistantAspergillus fumigatusin Immunocompromised Patients: Table 1.

(2016) Rose-Anne Lavergne et al.   CLINICAL INFECTIOUS DISEASES

Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America

(2016) Thomas F. Patterson et al.   CLINICAL INFECTIOUS DISEASES

Azole-resistant Aspergillus fumigatus in Denmark: a laboratory-based study on resistance mechanisms and genotypes

(2016) R.H. Jensen et al.   CLINICAL MICROBIOLOGY AND INFECTION

Emerging aspergillosis by azole-resistantAspergillus fumigatusat an intensive care unit in the Netherlands, 2010 to 2013

(2016) Judith van Paassen et al.   Eurosurveillance

Azole resistance surveillance inAspergillus fumigatus: beneficial or biased?

(2016) Paul E. Verweij et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

New therapeutic strategies for invasive aspergillosis in the era of azole resistance: how should the prevalence of azole resistance be defined?: Table 1.

(2016) Alexandre Alanio et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Multi-azole resistant Aspergillus fumigatus harboring Cyp51A TR46/Y121F/T289A isolated in Japan

(2016) Daisuke Hagiwara et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

In-host adaptation and acquired triazole resistance in Aspergillus fumigatus : a dilemma for clinical management

(2016) Paul E Verweij et al.   LANCET INFECTIOUS DISEASES

Clinical implications of globally emerging azole resistance inAspergillus fumigatus

(2016) Jacques F. Meis et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Examination of cyp51A and cyp51B expression level of the first Polish azole resistant clinical Aspergillus fumigatus isolate

(2015) Anna Brillowska-Dąbrowska et al.   ACTA BIOCHIMICA POLONICA

First Description of Azole-Resistant Aspergillus fumigatus Due to TR46/Y121F/T289A Mutation in France

(2015) Rose-Anne Lavergne et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacodynamics of Isavuconazole in an Aspergillus fumigatus Mouse Infection Model

(2015) Seyedmojtaba Seyedmousavi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular Characterization of a Voriconazole-Resistant, Posaconazole-Susceptible Aspergillus fumigatus Isolate in a Lung Transplant Recipient in the United States

(2015) Jose A. Vazquez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Environmental Isolates of Azole-Resistant Aspergillus fumigatus in Germany

(2015) Oliver Bader et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Azole Resistance inAspergillus fumigatus: Can We Retain the Clinical Use of Mold-Active Antifungal Azoles?

(2015) Paul E. Verweij et al.   CLINICAL INFECTIOUS DISEASES

Isavuconazole: A New Broad-Spectrum Triazole Antifungal Agent

(2015) Marisa H. Miceli et al.   CLINICAL INFECTIOUS DISEASES

International expert opinion on the management of infection caused by azole-resistant Aspergillus fumigatus

(2015) Paul E. Verweij et al.   DRUG RESISTANCE UPDATES

Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management

(2015) David W. Denning et al.   EUROPEAN RESPIRATORY JOURNAL

High prevalence of azole resistance inAspergillus fumigatusisolates from high-risk patients

(2015) J. Fuhren et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Emergence of azole-resistant invasive aspergillosis in HSCT recipients in Germany

(2015) J. Steinmann et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

First Detection of TR34 L98H and TR46 Y121F T289A Cyp51 Mutations in Aspergillus fumigatus Isolates in the United States

(2015) Nathan P. Wiederhold et al.   JOURNAL OF CLINICAL MICROBIOLOGY

First determination of azole resistance in Aspergillus fumigatus strains carrying the TR34/L98H mutations in Turkey

(2015) Gülşah Ece Özmerdiven et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Prospective evaluation of azole resistance inAspergillus fumigatusclinical isolates in France: Table 1.

(2015) F. Choukri et al.   MEDICAL MYCOLOGY

Multi-triazole-resistantAspergillus fumigatusinfections in Australia

(2015) Sarah E. Kidd et al.   MYCOSES

Azole-resistantAspergillus fumigatusisolates carrying TR34/L98H mutations in Taiwan

(2015) Chi-Jung Wu et al.   MYCOSES

Diagnosis and management of aspergillosis in the Netherlands: a national survey

(2015) Pieter P. A. Lestrade et al.   MYCOSES

Triazole-resistant Aspergillus fumigatus harbouring G54 mutation: Is it de novo or environmentally acquired?

(2015) Cheshta Sharma et al.   Journal of Global Antimicrobial Resistance

First Detection of TR46/Y121F/T289A and TR34/L98H Alterations in Aspergillus fumigatus Isolates from Azole-Naive Patients in Denmark despite Negative Findings in the Environment

(2014) K. M. T. Astvad et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Exploring azole antifungal drug resistance in Aspergillus fumigatus with special reference to resistance mechanisms

(2014) Anuradha Chowdhary et al.   Future Microbiology

New case of azole-resistant Aspergillus fumigatus due to TR46/Y121F/T289A mutation in Belgium

(2014) I. Montesinos et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Concomitant occurrence of itraconazole-resistant and -susceptible strains of Aspergillus fumigatus in routine cultures

(2014) Suhail Ahmad et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Azole, polyene and echinocandin MIC distributions for wild-type, TR34/L98H and TR46/Y121F/T289A Aspergillus fumigatus isolates in the Netherlands

(2014) J. van Ingen et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Whole-Genome Comparison of Aspergillus fumigatus Strains Serially Isolated from Patients with Aspergillosis

(2014) D. Hagiwara et al.   JOURNAL OF CLINICAL MICROBIOLOGY

The clinical spectrum of pulmonary aspergillosis

(2014) C. Kosmidis et al.   THORAX

Population-Based Survey of Filamentous Fungi and Antifungal Resistance in Spain (FILPOP Study)

(2013) A. Alastruey-Izquierdo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Determination of Isavuconazole Susceptibility of Aspergillus and Candida Species by the EUCAST Method

(2013) Susan J. Howard et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Impact ofIn VivoTriazole and Echinocandin Combination Therapy for Invasive Pulmonary Aspergillosis: Enhanced Efficacy againstCyp51Mutant Isolates

(2013) Alexander J. Lepak et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

cyp51A-Based Mechanisms of Aspergillus fumigatus Azole Drug Resistance Present in Clinical Samples from Germany

(2013) Oliver Bader et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Isavuconazole (BAL4815) Pharmacodynamic Target Determination in anIn VivoMurine Model of Invasive Pulmonary Aspergillosis against Wild-Type andcyp51Mutant Isolates of Aspergillus fumigatus

(2013) Alexander J. Lepak et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroSusceptibility of Aspergillus fumigatus to Isavuconazole: Correlation with Itraconazole, Voriconazole, and Posaconazole

(2013) Lea Gregson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Aspergillosis due to Voriconazole Highly Resistant Aspergillus fumigatus and Recovery of Genetically Related Resistant Isolates From Domiciles

(2013) Jan W. M. van der Linden et al.   CLINICAL INFECTIOUS DISEASES

Emergence of Azole-Resistant Aspergillus fumigatus Strains due to Agricultural Azole Use Creates an Increasing Threat to Human Health

(2013) Anuradha Chowdhary et al.   PLoS Pathogens

Correlation between Triazole Treatment History and Susceptibility in Clinically Isolated Aspergillus fumigatus

(2012) Masato Tashiro et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

First Reported Case of Azole-Resistant Aspergillus fumigatus Due to the TR/L98H Mutation in Germany

(2012) P.-M. Rath et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

High prevalence of triazole resistance in Aspergillus fumigatus, especially mediated by TR/L98H, in a French cohort of patients with cystic fibrosis

(2012) F. Morio et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Resistance to Voriconazole Due to a G448S Substitution in Aspergillus fumigatus in a Patient with Cerebral Aspergillosis

(2012) T. Pelaez et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Global burden of allergic bronchopulmonary aspergillosis with asthma and its complication chronic pulmonary aspergillosis in adults

(2012) David W. Denning et al.   MEDICAL MYCOLOGY

Triazole Fungicides Can Induce Cross-Resistance to Medical Triazoles in Aspergillus fumigatus

(2012) Eveline Snelders et al.   PLoS One

Clonal Expansion and Emergence of Environmental Multiple-Triazole-Resistant Aspergillus fumigatus Strains Carrying the TR34/L98H Mutations in the cyp51A Gene in India

(2012) Anuradha Chowdhary et al.   PLoS One

Discovery of a hapE Mutation That Causes Azole Resistance in Aspergillus fumigatus through Whole Genome Sequencing and Sexual Crossing

(2012) Simone M. T. Camps et al.   PLoS One

Interrogation of Related Clinical Pan-Azole-Resistant Aspergillus fumigatus Strains: G138C, Y431C, and G434C Single Nucleotide Polymorphisms incyp51A, Upregulation ofcyp51A, and Integration and Activation of TransposonAtf1in thecyp51APromoter

(2011) Ahmed M. Albarrag et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Aspergillus fumigatus Strains with Mutations in thecyp51AGene Do Not Always Show Phenotypic Resistance to Itraconazole, Voriconazole, or Posaconazole

(2011) Pilar Escribano et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Failure of Posaconazole Therapy in a Renal Transplant Patient with Invasive Aspergillosis Due to Aspergillus fumigatus with Attenuated Susceptibility to Posaconazole

(2011) Saskia Kuipers et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

High Prevalence of Azole-Resistant Aspergillus fumigatus in Adults with Cystic Fibrosis Exposed to Itraconazole

(2011) Pierre-Régis Burgel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Rapid Induction of Multiple Resistance Mechanisms in Aspergillus fumigatus during Azole Therapy: a Case Study and Review of the Literature

(2011) Simone M. T. Camps et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Azole Resistance of Aspergillus fumigatus Biofilms Is Partly Associated with Efflux Pump Activity

(2011) Ranjith Rajendran et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Azole Resistance in Aspergillus fumigatus Isolates from the ARTEMIS Global Surveillance Study Is Primarily Due to the TR/L98H Mutation in thecyp51AGene

(2011) Shawn R. Lockhart et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Isolation of multiple-triazole-resistant Aspergillus fumigatus strains carrying the TR/L98H mutations in the cyp51A gene in India

(2011) A. Chowdhary et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Aspergillus Species and Other Molds in Respiratory Samples from Patients with Cystic Fibrosis: a Laboratory-Based Study with Focus on Aspergillus fumigatus Azole Resistance

(2011) Klaus Leth Mortensen et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Molecular typing and in-vitro activity of azoles against clinical isolates of Aspergillus fumigatus and A. niger in Japan

(2011) Moe Asano et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Azole antifungal resistance in Aspergillus fumigatus: 2008 and 2009

(2010) A. Bueid et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Low prevalence of resistance to azoles in Aspergillus fumigatus in a French cohort of patients treated for haematological malignancies

(2010) A. Alanio et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Acquired resistance to voriconazole and itraconazole in a patient with pulmonary aspergilloma

(2010) Bahrie Bellete et al.   MEDICAL MYCOLOGY

Possible Environmental Origin of Resistance of Aspergillus fumigatus to Medical Triazoles

(2009) E. Snelders et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Patterns of Susceptibility of Aspergillus Isolates Recovered from Patients Enrolled in the Transplant-Associated Infection Surveillance Network

(2009) J. W. Baddley et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Epidemiological Cutoffs and Cross-Resistance to Azole Drugs in Aspergillus fumigatus

(2008) J. L. Rodriguez-Tudela et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multiple-azole-resistantAspergillus fumigatusosteomyelitis in a patient with chronic granulomatous disease successfully treated with long-term oral posaconazole and surgery

(2008) Caspar J. Hodiamont et al.   MEDICAL MYCOLOGY

Emergence of Azole Resistance in Aspergillus fumigatus and Spread of a Single Resistance Mechanism

(2008) Eveline Snelders et al.   PLOS MEDICINE

A Sterol-Regulatory Element Binding Protein Is Required for Cell Polarity, Hypoxia Adaptation, Azole Drug Resistance, and Virulence in Aspergillus fumigatus

(2008) Sven D. Willger et al.   PLoS Pathogens