Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex

Identification and Characterization of a Novel Aspergillus fumigatus Rhomboid Family Putative Protease, RbdA, Involved in Hypoxia Sensing and Virulence

(2016) Yakir Vaknin et al.   INFECTION AND IMMUNITY

An Antifungal Benzimidazole Derivative Inhibits Ergosterol Biosynthesis and Reveals Novel Sterols

(2015) Petra Keller et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

International expert opinion on the management of infection caused by azole-resistant Aspergillus fumigatus

(2015) Paul E. Verweij et al.   DRUG RESISTANCE UPDATES

Deciphering the Combinatorial DNA-binding Code of the CCAAT-binding Complex and the Iron-regulatory Basic Region Leucine Zipper (bZIP) Transcription Factor HapX

(2015) Peter Hortschansky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Determination by GC-IT/MS of Phytosterols in Herbal Medicinal Products for the Treatment of Lower Urinary Tract Symptoms and Food Products Marketed in Europe

(2015) Christoph Müller et al.   PLANTA MEDICA

How to bolster the antifungal pipeline

(2015) D. W. Denning et al.   SCIENCE

The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess

(2014) F. Gsaller et al.   EMBO JOURNAL

Zinc Finger Transcription Factors Displaced SREBP Proteins as the Major Sterol Regulators during Saccharomycotina Evolution

(2014) Sarah L. Maguire et al.   PLoS Genetics

ChIP-seq and In Vivo Transcriptome Analyses of the Aspergillus fumigatus SREBP SrbA Reveals a New Regulator of the Fungal Hypoxia Response and Virulence

(2014) Dawoon Chung et al.   PLoS Pathogens

Novel Antifungal Drug Discovery Based on Targeting Pathways Regulating the Fungus-Conserved Upc2 Transcription Factor

(2013) Christina Gallo-Ebert et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Aspergillosis due to Voriconazole Highly Resistant Aspergillus fumigatus and Recovery of Genetically Related Resistant Isolates From Domiciles

(2013) Jan W. M. van der Linden et al.   CLINICAL INFECTIOUS DISEASES

The cdr1B efflux transporter is associated with non-cyp51a-mediated itraconazole resistance in Aspergillus fumigatus 

(2013) Marcin G. Fraczek et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Targeting Fungal Genes by Diced siRNAs: A Rapid Tool to Decipher Gene Function in Aspergillus nidulans

(2013) Natarajaswamy Kalleda et al.   PLoS One

A convenient cellular assay for the identification of the molecular target of ergosterol biosynthesis inhibitors and quantification of their effects on total ergosterol biosynthesis

(2013) Christoph Müller et al.   STEROIDS

Regulatory interactions for iron homeostasis in Aspergillus fumigatus inferred by a Systems Biology approach

(2012) Jörg Linde et al.   BMC Systems Biology

EUCAST Technical Note on Aspergillus and amphotericin B, itraconazole, and posaconazole

(2012) M.C. Arendrup et al.   CLINICAL MICROBIOLOGY AND INFECTION

Analysis of Promoter Function in Aspergillus fumigatus

(2012) Sanjoy Paul et al.   EUKARYOTIC CELL

Gain-of-Function Mutations in UPC2 Are a Frequent Cause of ERG11 Upregulation in Azole-Resistant Clinical Isolates of Candida albicans

(2012) Stephanie A. Flowers et al.   EUKARYOTIC CELL

The interplay between vacuolar and siderophore-mediated iron storage in Aspergillus fumigatus

(2012) Fabio Gsaller et al.   Metallomics

HapX-Mediated Iron Homeostasis Is Essential for Rhizosphere Competence and Virulence of the Soilborne Pathogen Fusarium oxysporum

(2012) M. S. Lopez-Berges et al.   PLANT CELL

Discovery of a hapE Mutation That Causes Azole Resistance in Aspergillus fumigatus through Whole Genome Sequencing and Sexual Crossing

(2012) Simone M. T. Camps et al.   PLoS One

DNA Minor Groove Sensing and Widening by the CCAAT-Binding Complex

(2012) Eva M. Huber et al.   STRUCTURE

SREBP-Dependent Triazole Susceptibility in Aspergillus fumigatus Is Mediated through Direct Transcriptional Regulation oferg11A(cyp51A)

(2011) Sara J. Blosser et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Azole Resistance in Aspergillus fumigatus Isolates from the ARTEMIS Global Surveillance Study Is Primarily Due to the TR/L98H Mutation in thecyp51AGene

(2011) Shawn R. Lockhart et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

NF-Y and the transcriptional activation of CCAAT promoters

(2011) Diletta Dolfini et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The structure–function relationship of the Aspergillus fumigatus cyp51A L98H conversion by site-directed mutagenesis: The mechanism of L98H azole resistance

(2011) Eveline Snelders et al.   FUNGAL GENETICS AND BIOLOGY

SREBP Coordinates Iron and Ergosterol Homeostasis to Mediate Triazole Drug and Hypoxia Responses in the Human Fungal Pathogen Aspergillus fumigatus

(2011) Michael Blatzer et al.   PLoS Genetics

Candida albicans Hap43 Is a Repressor Induced under Low-Iron Conditions and Is Essential for Iron-Responsive Transcriptional Regulation and Virulence

(2010) Po-Chen Hsu et al.   EUKARYOTIC CELL

Azole antifungal resistance in Aspergillus fumigatus: 2008 and 2009

(2010) A. Bueid et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Development of Azole Resistance in Aspergillus fumigatus during Azole Therapy Associated with Change in Virulence

(2010) Maiken Cavling Arendrup et al.   PLoS One

HapX-Mediated Adaption to Iron Starvation Is Crucial for Virulence of Aspergillus fumigatus

(2010) Markus Schrettl et al.   PLoS Pathogens

HapX Positively and Negatively Regulates the Transcriptional Response to Iron Deprivation in Cryptococcus neoformans

(2010) Won Hee Jung et al.   PLoS Pathogens

Azole resistance in Aspergillus fumigatus: a side-effect of environmental fungicide use?

(2009) Paul E Verweij et al.   LANCET INFECTIOUS DISEASES

EUCAST Technical Note on the method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for conidia–forming moulds

(2008)   CLINICAL MICROBIOLOGY AND INFECTION

Emergence of Azole Resistance in Aspergillus fumigatus and Spread of a Single Resistance Mechanism

(2008) Eveline Snelders et al.   PLOS MEDICINE

A Sterol-Regulatory Element Binding Protein Is Required for Cell Polarity, Hypoxia Adaptation, Azole Drug Resistance, and Virulence in Aspergillus fumigatus

(2008) Sven D. Willger et al.   PLoS Pathogens

Ergosterol biosynthesis pathway in Aspergillus fumigatus

(2007) Laura Alcazar-Fuoli et al.   STEROIDS