Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens

Interrogation of Related Clinical Pan-Azole-Resistant Aspergillus fumigatus Strains: G138C, Y431C, and G434C Single Nucleotide Polymorphisms incyp51A, Upregulation ofcyp51A, and Integration and Activation of TransposonAtf1in thecyp51APromoter

(2011) Ahmed M. Albarrag et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

An Improved Model of the Aspergillus fumigatus CYP51A Protein

(2011) M. G. Fraczek et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Azole Resistance in Aspergillus fumigatus Isolates from the ARTEMIS Global Surveillance Study Is Primarily Due to the TR/L98H Mutation in thecyp51AGene

(2011) Shawn R. Lockhart et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Impact of Recently Emerged Sterol 14α-Demethylase (CYP51) Variants of Mycosphaerella graminicola on Azole Fungicide Sensitivity

(2011) Hans J. Cools et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

PdCYP51B, a new putative sterol 14α-demethylase gene of Penicillium digitatum involved in resistance to imazalil and other fungicides inhibiting ergosterol synthesis

(2011) Xuepeng Sun et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Heterologous expression and characterization of the sterol 14α-demethylase CYP51F1 from Candida albicans

(2011) Hyoung-Goo Park et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Homology modeling, molecular docking and spectra assay studies of sterol 14α-demethylase from Penicillium digitatum

(2011) Shuxiang Li et al.   BIOTECHNOLOGY LETTERS

Development of a novel multiplex DNA microarray for Fusarium graminearum and analysis of azole fungicide responses

(2011) Rayko Becher et al.   BMC GENOMICS

Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) fromLeishmania infantum

(2011) Tatiana Y. Hargrove et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aspergillus Species and Other Molds in Respiratory Samples from Patients with Cystic Fibrosis: a Laboratory-Based Study with Focus on Aspergillus fumigatus Azole Resistance

(2011) Klaus Leth Mortensen et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Molecular Modelling of the Emergence of Azole Resistance in Mycosphaerella graminicola

(2011) Jonathan G. L. Mullins et al.   PLoS One

Amino Acid Substitutions at the Major Insertion Loop of Candida albicans Sterol 14alpha-Demethylase Are Involved in Fluconazole Resistance

(2011) Nidia Alvarez-Rueda et al.   PLoS One

Azole Resistance Profile of Amino Acid Changes in Aspergillus fumigatus CYP51A Based on Protein Homology Modeling

(2010) E. Snelders et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Azole Binding Properties of Candida albicans Sterol 14-  Demethylase (CaCYP51)

(2010) A. G. S. Warrilow et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (Sterol 14 -Demethylase) Doxycycline-Regulated Mutant and Screening of the Azole Sensitivity of Aspergillus fumigatus Isoenzymes CYP51A and CYP51B

(2010) C. M. Martel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Heterologous Expression of Mutated Eburicol 14 -Demethylase (CYP51) Proteins of Mycosphaerella graminicola To Assess Effects on Azole Fungicide Sensitivity and Intrinsic Protein Function

(2010) H. J. Cools et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Structural basis for conservation in the CYP51 family

(2010) Galina I. Lepesheva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Epidemiology of Opportunistic Fungal Infections in Latin America

(2010) Marcio Nucci et al.   CLINICAL INFECTIOUS DISEASES

Epidemiology of Invasive Mycoses in North America

(2010) Michael A. Pfaller et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature

(2010) Florent Morio et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

A sterol 14α-demethylase is required for conidiation, virulence and for mediating sensitivity to sterol demethylation inhibitors by the rice blast fungus Magnaporthe oryzae

(2010) Xia Yan et al.   FUNGAL GENETICS AND BIOLOGY

Paralogous cyp51 genes in Fusarium graminearum mediate differential sensitivity to sterol demethylation inhibitors

(2010) Xin Liu et al.   FUNGAL GENETICS AND BIOLOGY

Homology Modeling and Screening of New 14α-Demethylase Inhibitor (DMI) Fungicides Based on Optimized Expression of CYP51 from Ustilago maydis in Escherichia coli

(2010) Rui Han et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Structural Insights into Inhibition of Sterol 14α-Demethylase in the Human PathogenTrypanosoma cruzi

(2010) Galina I. Lepesheva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wild-Type MIC Distributions and Epidemiological Cutoff Values for Posaconazole and Voriconazole and Candida spp. as Determined by 24-Hour CLSI Broth Microdilution

(2010) M. A. Pfaller et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Structural Basis of Human CYP51 Inhibition by Antifungal Azoles

(2010) Natallia Strushkevich et al.   JOURNAL OF MOLECULAR BIOLOGY

Probing the role of point mutations in thecyp51A genefrom Aspergillus fumigatusin the model yeastSaccharomyces cerevisiae

(2010) L. Alcazar-Fuoli et al.   MEDICAL MYCOLOGY

Acquired antifungal drug resistance inAspergillus fumigatus:epidemiology and detection

(2010) Susan Julie Howard et al.   MEDICAL MYCOLOGY

Assessment of fungicide resistance and pathogen diversity in Erysiphe necator using quantitative real-time PCR assays

(2010) Marie-Cécile Dufour et al.   PEST MANAGEMENT SCIENCE

Multiple mechanisms account for resistance to sterol 14α-demethylation inhibitors in field isolates of Mycosphaerella graminicola

(2010) Pierre Leroux et al.   PEST MANAGEMENT SCIENCE

Molecular insights into fungicide resistance in sensitive and resistant Penicillium digitatum strains infecting citrus

(2010) Paloma Sánchez-Torres et al.   POSTHARVEST BIOLOGY AND TECHNOLOGY

Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole

(2010) Chiung-Kuang Chen et al.   PLoS Neglected Tropical Diseases

Cryptococcus neoformans Overcomes Stress of Azole Drugs by Formation of Disomy in Specific Multiple Chromosomes

(2010) Edward Sionov et al.   PLoS Pathogens

Three-Dimensional Model of Lanosterol 14 -Demethylase from Cryptococcus neoformans: Active-Site Characterization and Insights into Azole Binding

(2009) C. Sheng et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Heteroresistance to Fluconazole in Cryptococcus neoformans Is Intrinsic and Associated with Virulence

(2009) E. Sionov et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Possible Environmental Origin of Resistance of Aspergillus fumigatus to Medical Triazoles

(2009) E. Snelders et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Gene transcription profiling of Fusarium graminearum treated with an azole fungicide tebuconazole

(2009) Xin Liu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Fluconazole Modulates Membrane Rigidity, Heterogeneity, and Water Penetration into the Plasma Membrane inSaccharomyces cerevisiae

(2009) Fumiyoshi Abe et al.   BIOCHEMISTRY

Efflux-Mediated Antifungal Drug Resistance

(2009) R. D. Cannon et al.   CLINICAL MICROBIOLOGY REVIEWS

A real-time PCR assay for quantification of the Y136F allele in the CYP51 gene associated with Blumeria graminis f.sp. tritici resistance to sterol demethylase inhibitors

(2009) Leiyan Yan et al.   CROP PROTECTION

Role of the Y134F mutation in cyp51 and overexpression of cyp51 in the sensitivity response of Puccinia triticina to epoxiconazole

(2009) G. Stammler et al.   CROP PROTECTION

Sterol content analysis suggests altered eburicol 14α-demethylase (CYP51) activity in isolates ofMycosphaerella graminicolaadapted to azole fungicides

(2009) Tim P. Bean et al.   FEMS MICROBIOLOGY LETTERS

Regulation of multidrug resistance in pathogenic fungi

(2009) Joachim Morschhäuser   FUNGAL GENETICS AND BIOLOGY

Crystal Structures of Trypanosoma brucei Sterol 14α-Demethylase and Implications for Selective Treatment of Human Infections

(2009) Galina I. Lepesheva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Azole resistance in Aspergillus fumigatus: a side-effect of environmental fungicide use?

(2009) Paul E Verweij et al.   LANCET INFECTIOUS DISEASES

Expression and homology modelling of sterol 14α-demethylase ofMagnaporthe griseaand its interaction with azoles

(2009) Jiaoyan Yang et al.   PEST MANAGEMENT SCIENCE

Analysis of the CYP51 gene and encoded protein in propiconazole-resistant isolates ofMycosphaerella fijiensis

(2009) Gloria P Cañas-Gutiérrez et al.   PEST MANAGEMENT SCIENCE

Molecular characterization and detection of overexpressed C-14 alpha-demethylase-based DMI resistance in Cercospora beticola field isolates

(2009) D. Nikou et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Epidemiological Cutoffs and Cross-Resistance to Azole Drugs in Aspergillus fumigatus

(2008) J. L. Rodriguez-Tudela et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Frequency of different CYP51-haplotypes of Mycosphaerella graminicola and their impact on epoxiconazole-sensitivity and -field efficacy

(2008) G. Stammler et al.   CROP PROTECTION

A Gain-of-Function Mutation in the Transcription Factor Upc2p Causes Upregulation of Ergosterol Biosynthesis Genes and Increased Fluconazole Resistance in a ClinicalCandida albicansIsolate

(2008) Nico Dunkel et al.   EUKARYOTIC CELL

An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1

(2008) Anna Selmecki et al.   MOLECULAR MICROBIOLOGY

Evolution of the CYP51 gene in Mycosphaerella graminicola: evidence for intragenic recombination and selective replacement

(2008) P. C. BRUNNER et al.   MOLECULAR PLANT PATHOLOGY

Adaptation to Fungicides in Monilinia fructicola Isolates with Different Fungicide Resistance Phenotypes

(2008) Chao-Xi Luo et al.   PHYTOPATHOLOGY

Emergence of Azole Resistance in Aspergillus fumigatus and Spread of a Single Resistance Mechanism

(2008) Eveline Snelders et al.   PLOS MEDICINE