Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo

Binding mode exploration of LuxR-thiazolidinedione analogues, e-pharmacophore-based virtual screening in the designing of LuxR inhibitors and its biological evaluation

(2016) Sundaraj Rajamanikandan et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Access to effective antimicrobials: a worldwide challenge

(2016) Ramanan Laxminarayan et al.   LANCET

Socio-economic burden of rare diseases: A systematic review of cost of illness evidence

(2015) Aris Angelis et al.   HEALTH POLICY

Acyl-Homoserine Lactone Quorum Sensing: From Evolution to Application

(2013) Martin Schuster et al.   Annual Review of Microbiology

Quo vadis quorum quenching?

(2013) Jie Zhu et al.   CURRENT OPINION IN PHARMACOLOGY

Respiratory bacterial infections in cystic fibrosis

(2013) Oana Ciofu et al.   CURRENT OPINION IN PULMONARY MEDICINE

Thiazolidinedione derivatives as novel agents againstPropionibacterium acnesbiofilms

(2013) G. Brackman et al.   JOURNAL OF APPLIED MICROBIOLOGY

Biofilm-Grown Burkholderia cepacia Complex Cells Survive Antibiotic Treatment by Avoiding Production of Reactive Oxygen Species

(2013) Heleen Van Acker et al.   PLoS One

Phenotypic and Genotypic Characterisation of Burkholderia cenocepacia J2315 Mutants Affected in Homoserine Lactone and Diffusible Signal Factor-Based Quorum Sensing Systems Suggests Interplay between Both Types of Systems

(2013) Claudia Udine et al.   PLoS One

A high-throughput screen for quorum-sensing inhibitors that target acyl-homoserine lactone synthases

(2013) Quin H. Christensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two quorum sensing systems control biofilm formation and virulence in members of theBurkholderia cepaciacomplex

(2013) Angela Suppiger et al.   Virulence

Treatment of lung infection in patients with cystic fibrosis: Current and future strategies

(2012) Gerd Döring et al.   Journal of Cystic Fibrosis

Quorum Sensing Inhibitors Increase the Susceptibility of Bacterial Biofilms to Antibiotics In Vitro and In Vivo

(2011) Gilles Brackman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Small-molecule inhibitor binding to an N-acyl-homoserine lactone synthase

(2011) J. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Acyl-homoserine Lactone-Dependent Signaling

(2010) Mair E. A. Churchill et al.   CHEMICAL REVIEWS

Burkholderia cenocepacia in cystic fibrosis: epidemiology and molecular mechanisms of virulence

(2010) P. Drevinek et al.   CLINICAL MICROBIOLOGY AND INFECTION

Social interactions in theBurkholderia cepaciacomplex: biofilms and quorum sensing

(2010) Tom Coenye   Future Microbiology

Medicinal Chemistry as a Conduit for the Modulation of Quorum Sensing

(2010) Colin A. Lowery et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-virulence strategies to combat bacteria-mediated disease

(2010) David A. Rasko et al.   NATURE REVIEWS DRUG DISCOVERY

New and Unexpected Insights into the Modulation of LuxR-Type Quorum Sensing by Cyclic Dipeptides

(2009) Jennifer Campbell et al.   ACS Chemical Biology

A Burkholderia cenocepacia Orphan LuxR Homolog Is Involved in Quorum-Sensing Regulation

(2009) R. J. Malott et al.   JOURNAL OF BACTERIOLOGY

Revisiting AI-2 Quorum Sensing Inhibitors: Direct Comparison of Alkyl-DPD Analogues and a Natural Product Fimbrolide

(2009) Colin A. Lowery et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Susceptibility of Caenorhabditis elegans to Burkholderia Infection Depends on Prior Diet and Secreted Bacterial Attractants

(2009) Vaughn S. Cooper et al.   PLoS One