Selective Chemical Inhibition of agr Quorum Sensing in Staphylococcus aureus Promotes Host Defense with Minimal Impact on Resistance

Discovery of Antivirulence Agents against Methicillin-Resistant Staphylococcus aureus

(2013) Varandt Khodaverdian et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Induction kinetics of the Staphylococcus aureus cell wall stress stimulon in response to different cell wall active antibiotics

(2013) Vanina Dengler et al.   BMC MICROBIOLOGY

Quo vadis quorum quenching?

(2013) Jie Zhu et al.   CURRENT OPINION IN PHARMACOLOGY

Attenuating Staphylococcus aureus Virulence Gene Regulation: A Medicinal Chemistry Perspective

(2013) Christopher P. Gordon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antibiotic resistance—the need for global solutions

(2013) Ramanan Laxminarayan et al.   LANCET INFECTIOUS DISEASES

Compartmentalized and systemic control of tissue immunity by commensals

(2013) Yasmine Belkaid et al.   NATURE IMMUNOLOGY

Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function

(2013) Anna Sokolovska et al.   NATURE IMMUNOLOGY

The Future of Antibiotics and Resistance

(2013) Brad Spellberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting agr- and agr-Like Quorum Sensing Systems for Development of Common Therapeutics to Treat Multiple Gram-Positive Bacterial Infections

(2013) Brian Gray et al.   SENSORS

Quorum sensing inhibitors: how strong is the evidence?

(2013) Tom Defoirdt et al.   TRENDS IN MICROBIOLOGY

Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control

(2013) S. T. Rutherford et al.   Cold Spring Harbor Perspectives in Medicine

Nox2 Modification of LDL Is Essential for Optimal Apolipoprotein B-mediated Control of agr Type III Staphylococcus aureus Quorum-sensing

(2013) Pamela R. Hall et al.   PLoS Pathogens

In Vivo Bioluminescence Imaging To Evaluate Systemic and Topical Antibiotics against Community-Acquired Methicillin-Resistant Staphylococcus aureus-Infected Skin Wounds in Mice

(2012) Y. Guo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Further Insights into the Mode of Action of the Lipoglycopeptide Telavancin through Global Gene Expression Studies

(2012) Yang Song et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of a Hydrophobic Cleft in the LytTR Domain of AgrA as a Locus for Small Molecule Interactions That Inhibit DNA Binding

(2012) Paul G. Leonard et al.   BIOCHEMISTRY

Challenges for a Universal Staphylococcus aureus Vaccine

(2012) R. A. Proctor   CLINICAL INFECTIOUS DISEASES

Nasal Carriage as a Source of agr-Defective Staphylococcus aureus Bacteremia

(2012) Davida S. Smyth et al.   JOURNAL OF INFECTIOUS DISEASES

Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA

(2012) F. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

To Treat or Not to Treat: Adjunctive Antibiotics for Uncomplicated Abscesses

(2011) Brad Spellberg et al.   ANNALS OF EMERGENCY MEDICINE

Global Analysis of the Staphylococcus aureus Response to Mupirocin

(2011) Swantje Reiß et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Host–pathogen interactions between the skin and Staphylococcus aureus

(2011) Sheila Krishna et al.   CURRENT OPINION IN MICROBIOLOGY

Role of the Accessory Gene Regulatoragrin Community-Associated Methicillin-Resistant Staphylococcus aureus Pathogenesis

(2011) Gordon Y. C. Cheung et al.   INFECTION AND IMMUNITY

Staphylococcus aureus regulates the expression and production of the staphylococcal superantigen-like secreted proteins in a Rot-dependent manner

(2011) Meredith A. Benson et al.   MOLECULAR MICROBIOLOGY

SwissDock, a protein-small molecule docking web service based on EADock DSS

(2011) A. Grosdidier et al.   NUCLEIC ACIDS RESEARCH

Global Changes in Staphylococcus aureus Gene Expression in Human Blood

(2011) Natalia Malachowa et al.   PLoS One

Colonization, pathogenicity, host susceptibility, and therapeutics for Staphylococcus aureus: what is the clinical relevance?

(2011) Steven Y. C. Tong et al.   Seminars in Immunopathology

Basis of Virulence in Community-Associated Methicillin-ResistantStaphylococcus aureus

(2010) Michael Otto   Annual Review of Microbiology

Peptide Signaling in the Staphylococci

(2010) Matthew Thoendel et al.   CHEMICAL REVIEWS

Mutations inagrDo Not Persist in Natural Populations of Methicillin‐ResistantStaphylococcus aureus

(2010) Bo Shopsin et al.   JOURNAL OF INFECTIOUS DISEASES

Noninvasive In Vivo Imaging to Evaluate Immune Responses and Antimicrobial Therapy against Staphylococcus aureus and USA300 MRSA Skin Infections

(2010) John S. Cho et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Membrane Damage Elicits an Immunomodulatory Program in Staphylococcus aureus

(2010) Ahmed S. Attia et al.   PLoS Pathogens

Can Bacteria Evolve Resistance to Quorum Sensing Disruption?

(2010) Tom Defoirdt et al.   PLoS Pathogens

Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era

(2009) Frank R. DeLeo et al.   JOURNAL OF CLINICAL INVESTIGATION

Symmetric signalling within asymmetric dimers of theStaphylococcus aureusreceptor histidine kinase AgrC

(2009) Elizabeth A. George Cisar et al.   MOLECULAR MICROBIOLOGY

Skin microbiota: a source of disease or defence?

(2008) A.L. Cogen et al.   BRITISH JOURNAL OF DERMATOLOGY

Apolipoprotein B Is an Innate Barrier against Invasive Staphylococcus aureus Infection

(2008) M. Michal Peterson et al.   Cell Host & Microbe

Virulence Gene Expression in Human Community‐AcquiredStaphylococcus aureusInfection

(2008) Jennifer A. Loughman et al.   JOURNAL OF INFECTIOUS DISEASES

Differential Recognition of Staphylococcus aureus Quorum-Sensing Signals Depends on Both Extracellular Loops 1 and 2 of the Transmembrane Sensor AgrC

(2008) Rasmus O. Jensen et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the Staphylococcus aureus AgrA LytTR Domain Bound to DNA Reveals a Beta Fold with an Unusual Mode of Binding

(2008) David J. Sidote et al.   STRUCTURE