In Silico and in Vitro-Guided Identification of Inhibitors of Alkylquinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa

Quorum-Sensing Systems as Targets for Antivirulence Therapy

(2018) Tom Defoirdt   TRENDS IN MICROBIOLOGY

Synthesis of novel quinoline–based 4,5–dihydro–1 H –pyrazoles as potential anticancer, antifungal, antibacterial and antiprotozoal agents

(2017) Jonathan Ramírez–Prada et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pseudomonas aeruginosa Alters Staphylococcus aureus Sensitivity to Vancomycin in a Biofilm Model of Cystic Fibrosis Infection

(2017) Giulia Orazi et al.   mBio

Mechanisms of envelope permeability and antibiotic influx and efflux in Gram-negative bacteria

(2017) Muriel Masi et al.   Nature Microbiology

Evaluation of Risk Factors for Antibiotic Resistance in Patients with Nosocomial Infections Caused byPseudomonas aeruginosa

(2016) Meliha Cagla Sonmezer et al.   Canadian Journal of Infectious Diseases & Medical Microbiology

Fine-Tuning Covalent Inhibition of Bacterial Quorum Sensing

(2016) Neri Amara et al.   CHEMBIOCHEM

Antibiotic resistance in Pseudomonas aeruginosa and alternative therapeutic options

(2016) Maitrayee Chatterjee et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Antimicrobial Resistance

(2016) Hilary D. Marston et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Quorum sensing signal–response systems in Gram-negative bacteria

(2016) Kai Papenfort et al.   NATURE REVIEWS MICROBIOLOGY

A new Pseudomonas quinolone signal (PQS) binding partner: MexG

(2016) James T. Hodgkinson et al.   Chemical Science

Unravelling the Genome-Wide Contributions of Specific 2-Alkyl-4-Quinolones and PqsE to Quorum Sensing in Pseudomonas aeruginosa

(2016) Giordano Rampioni et al.   PLoS Pathogens

Enzyme-Mediated Quenching of the Pseudomonas Quinolone Signal (PQS) Promotes Biofilm Formation of Pseudomonas aeruginosa by Increasing Iron Availability

(2016) Beatrix Tettmann et al.   Frontiers in Microbiology

Emerging broad-spectrum resistance in Pseudomonas aeruginosa and Acinetobacter baumannii : Mechanisms and epidemiology

(2015) Anaïs Potron et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

A Comparative Analysis of Synthetic Quorum Sensing Modulators in Pseudomonas aeruginosa: New Insights into Mechanism, Active Efflux Susceptibility, Phenotypic Response, and Next-Generation Ligand Design

(2015) Joseph D. Moore et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hit and lead criteria in drug discovery for infectious diseases of the developing world

(2015) Kei Katsuno et al.   NATURE REVIEWS DRUG DISCOVERY

Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium

(2015) Luca Freschi et al.   Frontiers in Microbiology

The art of antibacterial warfare: Deception through interference with quorum sensing–mediated communication

(2014) Giordano Rampioni et al.   BIOORGANIC CHEMISTRY

Optimization of anti-virulence PqsR antagonists regarding aqueous solubility and biological properties resulting in new insights in structure–activity relationships

(2014) Cenbin Lu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel approaches for the design and discovery of quorum-sensing inhibitors

(2014) Sara Scutera et al.   Expert Opinion on Drug Discovery

Identification of Anti-virulence Compounds That Disrupt Quorum-Sensing Regulated Acute and Persistent Pathogenicity

(2014) Melissa Starkey et al.   PLoS Pathogens

Overcoming the Unexpected Functional Inversion of a PqsR Antagonist inPseudomonas aeruginosa: An In Vivo Potent Antivirulence Agent TargetingpqsQuorum Sensing

(2013) Cenbin Lu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Resistance to Quorum-Quenching Compounds

(2013) Rodolfo García-Contreras et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Ligand Binding Kinetics of the Quorum Sensing Regulator PqsR

(2013) Martin Welch et al.   BIOCHEMISTRY

Discovery and Biophysical Characterization of 2-Amino-oxadiazoles as Novel Antagonists of PqsR, an Important Regulator of Pseudomonas aeruginosa Virulence

(2013) Michael Zender et al.   JOURNAL OF MEDICINAL CHEMISTRY

A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation

(2013) C. T. O'Loughlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR)

(2013) Aravindan Ilangovan et al.   PLoS Pathogens

Pseudomonas aeruginosa: new insights into pathogenesis and host defenses

(2013) Shaan L. Gellatly et al.   Pathogens and Disease

Identification of Small-Molecule Antagonists of the Pseudomonas aeruginosa Transcriptional Regulator PqsR: Biophysically Guided Hit Discovery and Optimization

(2012) Tobias Klein et al.   ACS Chemical Biology

Discovery of Antagonists of PqsR, a Key Player in 2-Alkyl-4-quinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa

(2012) Cenbin Lu et al.   CHEMISTRY & BIOLOGY

Quorum-sensing and cheating in bacterial biofilms

(2012) R. Popat et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Quorum quenching quandary: resistance to antivirulence compounds

(2011) Toshinari Maeda et al.   ISME Journal

Principles of early drug discovery

(2010) JP Hughes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Bacterial Quorum-Sensing Network Architectures

(2009) Wai-Leung Ng et al.   Annual Review of Genetics

Quorum sensing and environmental adaptation in Pseudomonas aeruginosa: a tale of regulatory networks and multifunctional signal molecules

(2009) Paul Williams et al.   CURRENT OPINION IN MICROBIOLOGY

Covalent Inhibition of Bacterial Quorum Sensing

(2009) Neri Amara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY