Natural flavonoids for the prevention of colon cancer: A comprehensive review of preclinical and clinical studies

Deciphering the molecular mechanism and apoptosis underlying the in-vitro and in-vivo chemotherapeutic efficacy of vanadium luteolin complex in colon cancer

(2018) Souvik Roy et al.   CELL BIOCHEMISTRY AND FUNCTION

Green tea extracts for the prevention of metachronous colorectal polyps among patients who underwent endoscopic removal of colorectal adenomas: A randomized clinical trial

(2018) Cheol Min Shin et al.   CLINICAL NUTRITION

Comparison of Western and Asian Guidelines Concerning the Management of Colon Cancer

(2018) Gianluca Pellino et al.   DISEASES OF THE COLON & RECTUM

Silybin counteracts doxorubicin resistance by inhibiting GLUT1 expression

(2018) Daniela Catanzaro et al.   FITOTERAPIA

Potential role of nucleoside diphosphate kinase in myricetin-induced selective apoptosis in colon cancer HCT-15 cells

(2018) Jeong Hyun Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Comparison of the effect of chemical composition of anthocyanin-rich plant extracts on colon cancer cell proliferation and their potential mechanism of action using in vitro, in silico, and biochemical assays

(2018) Candice Mazewski et al.   FOOD CHEMISTRY

Chrysin Attenuates Cell Viability of Human Colorectal Cancer Cells through Autophagy Induction Unlike 5-Fluorouracil/Oxaliplatin

(2018) Yueh-Ming Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deciphering the biochemical and molecular mechanism underlying the in vitro and in vivo chemotherapeutic efficacy of ruthenium quercetin complex in colon cancer

(2018) Souvik Roy et al.   MOLECULAR CARCINOGENESIS

Differences in the Effects of EGCG on Chromosomal Stability and Cell Growth between Normal and Colon Cancer Cells

(2018) Juan Ni et al.   MOLECULES

Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients

(2018) Alireza Farsad-Naeimi et al.   Food & Function

A metabolite of nobiletin, 4′-demethylnobiletin and atorvastatin synergistically inhibits human colon cancer cell growth by inducing G0/G1 cell cycle arrest and apoptosis

(2018) Xian Wu et al.   Food & Function

Colorectal Cancers: An Update on Their Molecular Pathology

(2018) Kentaro Inamura   Cancers

Icariin reduces human colon carcinoma cell growth and metastasis by enhancing p53 activities

(2018) Meili Tian et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Baicalein Inhibits Proliferation Activity of Human Colorectal Cancer Cells HCT116 Through Downregulation of Ezrin

(2018) Zhi Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Lyophilized açaí pulp (Euterpe oleracea Mart) attenuates colitis-associated colon carcinogenesis while its main anthocyanin has the potential to affect the motility of colon cancer cells

(2018) Mariana F. Fragoso et al.   FOOD AND CHEMICAL TOXICOLOGY

Enhancing the Cancer Cell Growth Inhibitory Effects of Table Grape Anthocyanins

(2018) Karnell L. Grimes et al.   JOURNAL OF FOOD SCIENCE

Epigallocatechin-3-gallate Enhances Radiation Sensitivity in Colorectal Cancer Cells Through Nrf2 Activation and Autophagy

(2018) TUMENJIN ENKHBAT et al.   ANTICANCER RESEARCH

Alpinumisoflavone causes DNA damage in Colorectal Cancer Cells via blocking DNA repair mediated by RAD51

(2018) Dong Li et al.   LIFE SCIENCES

Differential cytotoxic activity of Quercetin on colonic cancer cells depends on ROS generation through COX-2 expression

(2017) Subramaniya Bharathi Raja et al.   FOOD AND CHEMICAL TOXICOLOGY

Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort

(2017) Raul Zamora-Ros et al.   INTERNATIONAL JOURNAL OF CANCER

Novel Structurally Related Flavones Augment Cell Death Induced by rhsTRAIL

(2017) Joanna Bronikowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Luteolin induces apoptotic cell death via antioxidant activity in human colon cancer cells

(2017) Kyoung Ah Kang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Luteolin inhibits colorectal cancer cell epithelial-to-mesenchymal transition by suppressing CREB1 expression revealed by comparative proteomics study

(2017) Yuan Liu et al.   Journal of Proteomics

Apoptosis induction of colorectal cancer cells HTL-9 in vitro by the transformed products of soybean isoflavones by Ganoderma lucidum

(2017) Mei-lin Cui et al.   Journal of Zhejiang University-SCIENCE B

Combination of oncolytic adenovirus and luteolin exerts synergistic antitumor effects in colorectal cancer cells and a mouse model

(2017) Boduan Xiao et al.   Molecular Medicine Reports

A comprehensive meta-analysis on dietary flavonoid and lignan intake and cancer risk: Level of evidence and limitations

(2017) Giuseppe Grosso et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Oral naringenin nanocarriers: Fabrication, optimization, pharmacokinetic and chemotherapeutic efficacy assessments

(2017) Sundeep Chaurasia et al.   Nanomedicine

Co-Delivery of Curcumin and Chrysin by Polymeric Nanoparticles Inhibit Synergistically Growth and hTERT Gene Expression in Human Colorectal Cancer Cells

(2017) Javid Lotfi-Attari et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

The anti-metastatic effect of baicalein on colorectal cancer

(2017) Yuxia Chai et al.   ONCOLOGY REPORTS

Antioxidant polyphenols in cancer treatment: Friend, foe or foil?

(2017) Gian Luigi Russo et al.   SEMINARS IN CANCER BIOLOGY

Structural shift of gut microbiota during chemo-preventive effects of epigallocatechin gallate on colorectal carcinogenesis in mice

(2017) Xin Wang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

(−)-Epigallocatechin-3-Gallate Inhibits Colorectal Cancer Stem Cells by Suppressing Wnt/β-Catenin Pathway

(2017) Yue Chen et al.   Nutrients

The association of dietary quality with colorectal cancer among normal weight, overweight and obese men and women: a prospective longitudinal study in the USA

(2017) Rosalie A Torres Stone et al.   BMJ Open

Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway

(2017) Hsien-Chuen Soo et al.   PLoS One

The Natural Flavonoid Fisetin Inhibits Cellular Proliferation of Hepatic, Colorectal, and Pancreatic Cancer Cells through Modulation of Multiple Signaling Pathways

(2017) Mаhmoud Youns et al.   PLoS One

Calycosin induces apoptosis in colorectal cancer cells, through modulating the ERβ/MiR-95 and IGF-1R, PI3K/Akt signaling pathways

(2016) Xinge Zhao et al.   GENE

Diet, microorganisms and their metabolites and colon cancer

(2016) Stephen J. D. O'Keefe   Nature Reviews Gastroenterology & Hepatology

Anti-inflammatory and anticancer effects of flavonol glycosides from Diplotaxis harra through GSK3β regulation in intestinal cells

(2016) Imen Nasri et al.   PHARMACEUTICAL BIOLOGY

Isoliquiritigenin decreases the incidence of colitis-associated colorectal cancer by modulating the intestinal microbiota

(2016) Minna Wu et al.   Oncotarget

Habitual intake of flavonoid subclasses and risk of colorectal cancer in 2 large prospective cohorts1,2

(2015) Katharina Nimptsch et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Possible Protective Effects of Quercetin and Sodium Gluconate Against Colon Cancer Induction by Dimethylhydrazine in Mice

(2015) TH Saleem et al.   Asian Pacific Journal of Cancer Prevention

Resveratrol elicits anti-colorectal cancer effect by activating miR-34c-KITLG in vitro and in vivo

(2015) Shu Yang et al.   BMC CANCER

Protective effects of spray-dried açaí ( Euterpe oleracea Mart) fruit pulp against initiation step of colon carcinogenesis

(2015) Guilherme Ribeiro Romualdo et al.   FOOD RESEARCH INTERNATIONAL

Dietary cocoa inhibits colitis associated cancer: a crucial involvement of the IL-6/STAT3 pathway

(2015) Zeinab Saadatdoust et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

EGCG synergizes the therapeutic effect of cisplatin and oxaliplatin through autophagic pathway in human colorectal cancer cells

(2015) Fen Hu et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Isoflavone and Soyfood Intake and Colorectal Cancer Risk: A Case-Control Study in Korea

(2015) Aesun Shin et al.   PLoS One

Luteolin, a Bioflavonoid, Attenuates Azoxymethane-Induced Effects on Mitochondrial Enzymes in Balb/c Mice

(2014) Ashok Kumar Pandurangan et al.   Asian Pacific Journal of Cancer Prevention

Luteolin Sensitizes Two Oxaliplatin-Resistant Colorectal Cancer Cell Lines to Chemotherapeutic Drugs Via Inhibition of the Nrf2 Pathway

(2014) Song Chian et al.   Asian Pacific Journal of Cancer Prevention

Dietary cocoa protects against colitis-associated cancer by activating the Nrf2/Keap1 pathway

(2014) Ashok Kumar Pandurangan et al.   BIOFACTORS

Anthocyanins as a Potential Therapy for Diabetic Retinopathy

(2014) S.F. Nabavi et al.   CURRENT MEDICINAL CHEMISTRY

Luteolin inhibits matrix metalloproteinase 9 and 2 in azoxymethane-induced colon carcinogenesis

(2014) AK Pandurangan et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Quercetin Supplementation Attenuates the Progression of Cancer Cachexia in ApcMin/+Mice

(2014) Kandy T. Velázquez et al.   JOURNAL OF NUTRITION

Luteolin supplementation adjacent to aspirin treatment reduced dimethylhydrazine-induced experimental colon carcinogenesis in rats

(2014) Neamt H. A. Osman et al.   TUMOR BIOLOGY

Probing 3-Hydroxyflavone forIn VitroGlycorandomization of Flavonols by YjiC

(2013) Ramesh Prasad Pandey et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Synergistic anti-proliferative effect of resveratrol and etoposide on human hepatocellular and colon cancer cell lines

(2013) Fatemehsadat Amiri et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Potential for preventive effects of cocoa and cocoa polyphenols in cancer

(2013) Maria Angeles Martin et al.   FOOD AND CHEMICAL TOXICOLOGY

Açai (Euterpe oleracea Mart.) feeding attenuates dimethylhydrazine-induced rat colon carcinogenesis

(2013) Mariana F. Fragoso et al.   FOOD AND CHEMICAL TOXICOLOGY

Naringin accelerates the regression of pre-neoplastic lesions and the colorectal structural reorganization in a murine model of chemical carcinogenesis

(2013) Priscila L. Sequetto et al.   FOOD AND CHEMICAL TOXICOLOGY

Apigenin Sensitizes Colon Cancer Cells to Antitumor Activity of ABT-263

(2013) H. Shao et al.   MOLECULAR CANCER THERAPEUTICS

Effects of Dark Chocolate on Azoxymethane-Induced Colonic Aberrant Crypt Foci

(2013) Mee Young Hong et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Flavonoid Bioavailability and Attempts for Bioavailability Enhancement

(2013) Surangi Thilakarathna et al.   Nutrients

The flavonolignan silibinin potentiates TRAIL-induced apoptosis in human colon adenocarcinoma and in derived TRAIL-resistant metastatic cells

(2012) Henriette Kauntz et al.   APOPTOSIS

Effect of Luteolin on the Levels of Glycoproteins During Azoxymethane-induced Colon Carcinogenesis in Mice

(2012) Ashok Kumar Pandurangan et al.   Asian Pacific Journal of Cancer Prevention

Oroxylin A improves the sensitivity of HT-29 human colon cancer cells to 5-FU through modulation of the COX-2 signaling pathway

(2012) Jun Ha et al.   Biochemistry and Cell Biology

Cocoa polyphenols prevent inflammation in the colon of azoxymethane-treated rats and in TNF-α-stimulated Caco-2 cells

(2012) Ildefonso Rodríguez-Ramiro et al.   BRITISH JOURNAL OF NUTRITION

Green tea: An effective synergist with anticancer drugs for tertiary cancer prevention

(2012) Hirota Fujiki et al.   CANCER LETTERS

Vitexin-2-O-xyloside, raphasatin and (−)-epigallocatechin-3-gallate synergistically affect cell growth and apoptosis of colon cancer cells

(2012) Alessio Papi et al.   FOOD CHEMISTRY

Quercetin Liposome Sensitizes Colon Carcinoma to Thermotherapy and Thermochemotherapy in Mice Models

(2012) Bing He et al.   INTEGRATIVE CANCER THERAPIES

Hesperidin Inhibits Cyclophosphamide-Induced Tumor Growth Delay in Mice

(2012) Seyed Jalal Hosseinimehr et al.   INTEGRATIVE CANCER THERAPIES

Association of Dietary Quercetin With Reduced Risk of Proximal Colon Cancer

(2012) Zora Djuric et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

The Synergistic Apoptotic Interaction of Panaxadiol and Epigallocatechin Gallate in Human Colorectal Cancer Cells

(2012) Guang-Jian Du et al.   PHYTOTHERAPY RESEARCH

Antiproliferative Efficacy of Hesperetin (Citrus Flavanoid) in 1,2-Dimethylhydrazine-Induced Colon Cancer

(2012) Selvaraj Aranganathan et al.   PHYTOTHERAPY RESEARCH

Chemopreventive efficacy of hesperetin (citrus flavonone) against 1,2-dimethylhydrazine-induced rat colon carcinogenesis

(2012) N. Nalini et al.   TOXICOLOGY MECHANISMS AND METHODS

Epigallocatechin Gallate (EGCG) Is the Most Effective Cancer Chemopreventive Polyphenol in Green Tea

(2012) Guang-Jian Du et al.   Nutrients

Protocol for MInimizing the Risk of Metachronous Adenomas of the CoLorectum with Green Tea Extract (MIRACLE): a randomised controlled trial of green tea extract versus placebo for nutriprevention of metachronous colon adenomas in the elderly population

(2011) Julia C Stingl et al.   BMC CANCER

Resveratrol Potentiates the Cytotoxic Oxidative Stress Induced by Chemotherapy in Human Colon Cancer Cells

(2011) Francisca M. Santandreu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cocoa-rich diet prevents azoxymethane-induced colonic preneoplastic lesions in rats by restraining oxidative stress and cell proliferation and inducing apoptosis

(2011) Ildefonso Rodríguez-Ramiro et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Quercetin's Effects on Intestinal Polyp Multiplicity and Macrophage Number in the ApcMin/+ Mouse

(2011) E. Angela Murphy et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Cocoa consumption reduces NF-κB activation in peripheral blood mononuclear cells in humans

(2011) M. Vázquez-Agell et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Letter to the Editor: Panaxadiol's Anticancer Activity is Enhanced by Epicatechin

(2010) Miguel Rodriguez et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Habitual intake of flavonoid subclasses and incident hypertension in adults

(2010) Aedín Cassidy et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: The roles of caspase-6 and p53

(2010) Jason Yongsheng Chan et al.   CANCER BIOLOGY & THERAPY

Interleukin-6 as a Potential Indicator for Prevention of High-Risk Adenoma Recurrence by Dietary Flavonols in the Polyp Prevention Trial

(2010) G. Bobe et al.   Cancer Prevention Research

Apigenin and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated rats

(2010) Tety Leonardi et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Suppression of Colonic Aberrant Crypt Foci by Soy Isoflavones Is Dose-Independent in Dimethylhydrazine-Treated Rats

(2010) Won-Kyung Min et al.   JOURNAL OF MEDICINAL FOOD

Effect of hesperetin, a citrus flavonoid, on bacterial enzymes and carcinogen-induced aberrant crypt foci in colon cancer rats: a dose-dependent study

(2010) Selvaraj Aranganathan et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Dietary intake of selected flavonols, flavones, and flavonoid-rich foods and risk of cancer in middle-aged and older women

(2009) Lu Wang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Dietary flavonoid intake and colorectal cancer: a case–control study

(2009) Janet A. M. Kyle et al.   BRITISH JOURNAL OF NUTRITION

Effect of dark chocolate on plasma epicatechin levels, DNA resistance to oxidative stress and total antioxidant activity in healthy subjects

(2009) A. Spadafranca et al.   BRITISH JOURNAL OF NUTRITION

Proanthocyanidins and the risk of colorectal cancer in Italy

(2009) Marta Rossi et al.   CANCER CAUSES & CONTROL

Quercetin Inhibit Human SW480 Colon Cancer Growth in Association with Inhibition of Cyclin D1and Survivin Expression through Wnt/β-Catenin Signaling Pathway

(2009) Bao-En Shan et al.   CANCER INVESTIGATION

Flavones as Colorectal Cancer Chemopreventive Agents--Phenol-O-Methylation Enhances Efficacy

(2009) H. Cai et al.   Cancer Prevention Research

Modulatory efficacy of hesperetin (citrus flavanone) on xenobiotic-metabolizing enzymes during 1,2-dimethylhydrazine-induced colon carcinogenesis

(2009) S. Aranganathan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Colorectal cancer: Can nutrients modulate NF-κB and apoptosis?

(2009) Paula Ravasco et al.   CLINICAL NUTRITION

Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1,2-dimethylhydrazine induced colon carcinogenesis

(2009) S. Aranganathan et al.   FOOD AND CHEMICAL TOXICOLOGY

Combination of curcumin and green tea catechins prevents dimethylhydrazine-induced colon carcinogenesis

(2009) Gang Xu et al.   FOOD AND CHEMICAL TOXICOLOGY

Dietary flavonol, flavone and catechin intake and risk of colorectal cancer in the Netherlands Cohort Study

(2009) Colinda C.J.M. Simons et al.   INTERNATIONAL JOURNAL OF CANCER

Cancer Protective Properties of Cocoa: A Review of the Epidemiologic Evidence

(2009) Gertraud Maskarinec   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Comparative Antioxidant, Prooxidant and Cytotoxic Activity of Sigmoidin A and Eriodictyol

(2009) Solomon Habtemariam et al.   PLANTA MEDICA

Protective role of luteolin on the status of lipid peroxidation and antioxidant defense against azoxymethane-induced experimental colon carcinogenesis

(2008) Pandurangan Ashokkumar et al.   BIOMEDICINE & PHARMACOTHERAPY

(−)-Epigallocatechin-3-gallate prevents lipopolysaccharide-induced elevation of beta-amyloid generation and memory deficiency

(2008) Young Kyoung Lee et al.   BRAIN RESEARCH

No Effect of Red Clover-Derived Isoflavone Intervention on the Insulin-Like Growth Factor System in Women at Increased Risk of Colorectal Cancer

(2008) A. Vrieling et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Green Tea Extracts for the Prevention of Metachronous Colorectal Adenomas: A Pilot Study

(2008) M. Shimizu et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

(-)-Epigallocatechin Gallate Suppresses Azoxymethane-Induced Colonic Premalignant Lesions in Male C57BL/KsJ-db/db Mice

(2008) M. Shimizu et al.   Cancer Prevention Research

Effect of genistein on the bioavailability and intestinal cancer chemopreventive activity of (-)-epigallocatechin-3-gallate

(2008) J. D. Lambert et al.   CARCINOGENESIS

Chemical studies of anthocyanins: A review

(2008) Araceli Castañeda-Ovando et al.   FOOD CHEMISTRY

A Green Tea Component Suppresses Posttranslational Expression of Basic Fibroblast Growth Factor in Colorectal Cancer

(2008) Mugdha Sukhthankar et al.   GASTROENTEROLOGY

Hesperetin exerts dose dependent chemopreventive effect against 1,2-dimethyl hydrazine induced rat colon carcinogenesis

(2008) Selvaraj Aranganathan et al.   INVESTIGATIONAL NEW DRUGS

Cancer phytotherapeutics: role for flavonoids at the cellular level

(2008) Anup Kale et al.   PHYTOTHERAPY RESEARCH

Prospective cohort comparison of flavonoid treatment in patients with resected colorectal cancer to prevent recurrence

(2008) Harald Hoensch et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Flavan-3-ols: Nature, occurrence and biological activity

(2007) Patricia M. Aron et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Transcriptome and proteome profiling of colon mucosa from quercetin fed F344 rats point to tumor preventive mechanisms, increased mitochondrial fatty acid degradation and decreased glycolysis

(2007) Ashwin A. Dihal et al.   PROTEOMICS