Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway

The PI3K/AKT Pathway as a Target for Cancer Treatment

(2016) Ingrid A. Mayer et al.   Annual Review of Medicine

Portrait of the PI3K/AKT pathway in colorectal cancer

(2015) Stine Aske Danielsen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Cytochrome P450 2W1 (CYP2W1) in Colorectal Cancers

(2015) Felicia Fei-Lei Chung et al.   CURRENT CANCER DRUG TARGETS

Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF)

(2015) B S Tan et al.   Cell Death & Disease

GPX2 overexpression is involved in cell proliferation and prognosis of castration-resistant prostate cancer

(2014) Taku Naiki et al.   CARCINOGENESIS

Chalcones with electron-withdrawing and electron-donating substituents: Anticancer activity against TRAIL resistant cancer cells, structure–activity relationship analysis and regulation of apoptotic proteins

(2014) Chun Wai Mai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Betulinic acid isolated from Vitis amurensis root inhibits 3-isobutyl-1-methylxanthine induced melanogenesis via the regulation of MEK/ERK and PI3K/Akt pathways in B16F10 cells

(2014) Kyong-Suk Jin et al.   FOOD AND CHEMICAL TOXICOLOGY

Novel antitumour indole alkaloid, Jerantinine A, evokes potent G2/M cell cycle arrest targeting microtubules

(2014) Vijay J. Raja et al.   INVESTIGATIONAL NEW DRUGS

PBI-05204, a supercritical CO2 extract of Nerium oleander, inhibits growth of human pancreatic cancer via targeting the PI3K/mTOR pathway

(2014) Yong Pan et al.   INVESTIGATIONAL NEW DRUGS

SwissTargetPrediction: a web server for target prediction of bioactive small molecules

(2014) David Gfeller et al.   NUCLEIC ACIDS RESEARCH

Antipsychotic agent thioridazine sensitizes renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated inhibition of Akt signaling and downregulation of Mcl-1 and c-FLIP(L)

(2014) K-j Min et al.   Cell Death & Disease

Targeting PI3K/Akt/mTOR Signaling in Cancer

(2014) Camillo Porta et al.   Frontiers in Oncology

Shaping the interaction landscape of bioactive molecules

(2013) David Gfeller et al.   BIOINFORMATICS

6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor γ (PPARγ)

(2013) Boon Shing Tan et al.   CANCER LETTERS

Cell survival and metastasis regulation by Akt signaling in colorectal cancer

(2013) Ekta Agarwal et al.   CELLULAR SIGNALLING

NSAIDs may regulate EGR-1-mediated induction of reactive oxygen species and non-steroidal anti-inflammatory drug-induced gene (NAG)-1 to initiate intrinsic pathway of apoptosis for the chemoprevention of colorectal cancer

(2013) Vivek Vaish et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

LY294002 and Rapamycin promote coxsackievirus-induced cytopathic effect and apoptosis via inhibition of PI3K/AKT/mTOR signaling pathway

(2013) Zhiheng Chen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Development of PI3K inhibitors: lessons learned from early clinical trials

(2013) Jordi Rodon et al.   Nature Reviews Clinical Oncology

Prenylated flavonoids from Artocarpus altilis: Antioxidant activities and inhibitory effects on melanin production

(2013) Wen-Chun Lan et al.   PHYTOCHEMISTRY

Growth Inhibition and Apoptosis-Inducing Effects of Cudraflavone B in Human Oral Cancer Cells via MAPK, NF-κB, and SIRT1 Signaling Pathway

(2013) Hwa-Jeong Lee et al.   PLANTA MEDICA

Targeting PI3K in Cancer: Any Good News?

(2013) Miriam Martini et al.   Frontiers in Oncology

Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells

(2012) Sokbom Kang et al.   APOPTOSIS

New Isoprenylated Flavones and Stilbene Derivative from Artocarpus hypargyreus

(2012) Mei-Hua Yu et al.   CHEMISTRY & BIODIVERSITY

Tyrosinase inhibition constituents from the roots of Morus australis

(2012) Zong-Ping Zheng et al.   FITOTERAPIA

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

(2012) Claire Palles et al.   NATURE GENETICS

Functional Characterization of an Isoform-Selective Inhibitor of PI3K-p110β as a Potential Anticancer Agent

(2012) Jing Ni et al.   Cancer Discovery

Suppression of BCL-2 synergizes cisplatin sensitivity in nasopharyngeal carcinoma cells

(2011) Soon Yang Low et al.   CANCER LETTERS

Targeting PI3K Signaling as a Therapeutic Approach for Colorectal Cancer

(2011) Jing Zhang et al.   GASTROENTEROLOGY

Invasiveness and anchorage independent growth ability augmented by PTEN inactivation through the PI3K/AKT/NFkB pathway in lung cancer cells

(2011) Hakan Akca et al.   LUNG CANCER

SMG1 and NIK regulate apoptosis induced by Smac mimetic compounds

(2011) H H Cheung et al.   Cell Death & Disease

New isoprenylated flavonoids and cytotoxic constituents fromArtocarpus tonkinensis

(2010) Jian-Ping Ma et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Wortmannin inhibits K562 lukemic cells by regulating PI3k/Akt channel in vitro

(2010) Qing Wu et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

High cyclin B1 expression is associated with poor survival in breast cancer

(2009) K Aaltonen et al.   BRITISH JOURNAL OF CANCER

Loss of Phosphatase and Tensin Homologue Deleted on Chromosome 10 Engages ErbB3 and Insulin-Like Growth Factor-I Receptor Signaling to Promote Antiestrogen Resistance in Breast Cancer

(2009) T. W. Miller et al.   CANCER RESEARCH

Isoprenoid-substituted flavonoids from wood of Artocarpus heterophyllus on B16 melanoma cells: Cytotoxicity and structural criteria

(2009) Enos Tangke Arung et al.   FITOTERAPIA

Analysis of PTEN, BRAF, and EGFR Status in Determining Benefit From Cetuximab Therapy in Wild-Type KRAS Metastatic Colon Cancer

(2009) Pierre Laurent-Puig et al.   JOURNAL OF CLINICAL ONCOLOGY

Blocking Phosphoinositide 3-Kinase Activity in Colorectal Cancer Cells Reduces Proliferation but Does Not Increase Apoptosis Alone or in Combination with Cytotoxic Drugs

(2009) C. Martin-Fernandez et al.   MOLECULAR CANCER RESEARCH

Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling

(2009) Aruna D. Balgi et al.   PLoS One

Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival

(2008) Hirozumi Sawai et al.   BMC GASTROENTEROLOGY

An Integrative Genomic and Proteomic Analysis of PIK3CA, PTEN, and AKT Mutations in Breast Cancer

(2008) K. Stemke-Hale et al.   CANCER RESEARCH

PIK3CA Mutation/PTEN Expression Status Predicts Response of Colon Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor Cetuximab

(2008) M. Jhawer et al.   CANCER RESEARCH

Antiangiogenic Therapy with Mammalian Target of Rapamycin Inhibitor RAD001 (Everolimus) Increases Radiosensitivity in Solid Cancer

(2008) P. C. Manegold et al.   CLINICAL CANCER RESEARCH