Article
Biochemistry & Molecular Biology
Kehong Chen, Taihao Zheng, Cai Chen, Liangzhong Liu, Zhengjun Guo, Yuan Peng, Xiaoyue Zhang, Zhenzhou Yang
Summary: Pregnancy zone protein (PZP) expression is significantly reduced in lung adenocarcinoma (LUAD) and is closely correlated with clinical stage, making it a potential independent unfavorable prognostic factor. The high expression of PZP is mainly involved in immune-related molecules and shows significant correlation with immune cell infiltrations.
Review
Clinical Neurology
Saiyet de la C. Baez, Diana Garcia del Barco, Anette Hardy-Sosa, Gerardo Guillen Nieto, Maria Luisa Bringas-Vega, Jorge J. Llibre-Guerra, Pedro Valdes-Sosa
Summary: The systematic review highlights the potential of utilizing blood-based panels of protein biomarkers to enhance the diagnosis of stroke. Brain-specific markers such as NR2 peptide and glial fibrillary acidic protein (GFAP) are shown to be related to stroke. Further research is needed to validate and introduce these novel biomarker combinations for more effective stroke diagnosis and prevention.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Cosimo De Nunzio, Aldo Brassetti, Fabiana Cancrini, Francesco Prata, Luca Cindolo, Petros Sountoulides, Chrysovalantis Toutziaris, Mauro Gacci, Riccardo Lombardo, Antonio Cicione, Giorgia Tema, Luigi Schips, Giuseppe Simone, Sergio Serni, Andrea Tubaro
Summary: Insufficient physical activity is associated with an increased risk of prostate cancer diagnosis and high-grade disease. A nomogram was developed to predict tumor diagnosis in patients undergoing prostate biopsy, and it showed fair discrimination and calibration.
Article
Infectious Diseases
Xiaoli Zhu, Jinxi Hu
Summary: This study found that serum adenosine deaminase (ADA) levels were significantly elevated in patients with HFRS and had a strong positive correlation with the disease. ADA could potentially serve as a molecular marker for the diagnosis and prognosis of HFRS patients.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Oncology
Zhendong Liu, Zhishuai Ren, Cheng Zhang, Rongjun Qian, Hongbo Wang, Jialin Wang, Wang Zhang, Binfeng Liu, Xiaoyu Lian, Yanbiao Wang, Yuqi Guo, Yanzheng Gao
Summary: High expression of ELK3 in gliomas is associated with poor patient prognosis and serves as an independent biomarker. Overexpression of ELK3 promotes proliferation and migration of glioma cells, potentially by regulating the JAK-STAT signaling pathway to drive malignant progression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Meitong Liu, Yaning Zhao, Zhuoyun Xiao, Rongmiao Zhou, Xiaodong Chen, Saijin Cui, Shiru Cao, Xi Huang, Tianyu Chen, Xiangran Huo, Guoqiang Zhang, Ziqiang Tian, Na Wang
Summary: This study aimed to explore the effect of CD39 expression on CD8(+) T cells and on the diagnosis and prognosis of esophageal squamous cell carcinoma (ESCC). By analyzing 95 ESCC samples, a nomogram model was established to better predict the probability of patients' survival. The study found that CD39 expression was higher on CD8(+) T cells in cancer tissues. High CD39-expressing CD8(+) T cells were an independent risk factor for the prognosis of ESCC and its expression was significantly positively correlated with the expression of PDCD1, CTLA4, and HAVCR2. Inhibiting CD39 to restore partially exhausted CD8(+) T cells may be a new strategy for treating ESCC.
Article
Medicine, Research & Experimental
Le Li, Zheng Chao, Un Waikeong, Jun Xiao, Yue Ge, Yanan Wang, Zezhong Xiong, Sheng Ma, Zhihua Wang, Zhiquan Hu, Xing Zeng
Summary: This study proposed a new metabolic classification method for renal cell carcinoma and revealed associations between metabolic profiles and immune infiltration. The subcluster with low metabolic profiles had the worst prognosis, highest invasiveness, enhanced immune infiltration but suppressive immunophenotypes. ACAA2 was identified as a tumor suppressor gene associated with increased immune infiltration and elevated PD-1 expression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Neurosciences
Tamara Kobiec, Claudia Mardaraz, Nicolas Toro-Urrego, Rodolfo Kolliker-Frers, Francisco Capani, Matilde Otero-Losada
Summary: Metabolic syndrome (MetS) is a combination of metabolic conditions, including obesity, hypertension, dyslipidemia, and hyperglycemia, and its incidence has been increasingly rising globally. MetS has detrimental effects on the central nervous system and neurological development. Environmental enrichment (EE) stands as a promising non-invasive therapeutic approach for MetS, as it has been shown to improve health across the lifespan by promoting neuroplasticity. This article provides a brief overview of the milestones in neurodevelopment at each life stage, the impact of MetS on neurodevelopment, and the potential benefits of EE in managing MetS.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Andrea Santos, Ion Cristobal, Jaime Rubio, Cristina Carames, Melani Luque, Marta Sanz-Alvarez, Miriam Morales-Gallego, Juan Madoz-Gurpide, Federico Rojo, Jesus Garcia-Foncillas
Summary: miR-199b shows functional relevance and potential value as a novel circulating marker in locally advanced rectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Zhimin Sun, Xiaoli Sun, Yaqin Yuan, Hongsheng Li, Xiaona Li, Zhigang Yao
Summary: The expression of FCGR2B is higher in glioma compared to normal tissues and is associated with poor prognosis. FCGR2B is closely related to immune-related functions and may play an important role in tumor microenvironment and immunosuppression.
Article
Multidisciplinary Sciences
Yida Huang, Shaoqian Du, Jun Liu, Weiyi Huang, Wanshan Liu, Mengji Zhang, Ning Li, Ruimin Wang, Jiao Wu, Wei Chen, Mengyi Jiang, Tianhao Zhou, Jing Cao, Jing Yang, Lin Huang, An Gu, Jingyang Niu, Yuan Cao, Wei-Xing Zong, Xin Wang, Kun Qian, Hongxia Wang
Summary: High-performance metabolic analysis using fast nanoparticle-enhanced laser desorption/ionization mass spectrometry (NPELDI-MS) was used to record serum metabolic fingerprints (SMFs) of breast cancer patients. The SMFs were used for machine learning to distinguish breast cancer from non-breast cancer, and also for constructing a metabolic prognosis scoring system. Additionally, a panel of differentially enriched metabolites and related pathways in breast cancer serum were identified.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Oncology
Zonglei Zhao, Xixiu Wang, Yan Ding, Xuefeng Cao, Xingyuan Zhang
Summary: SMC4 is a member of the ATPase family of chromosomes and is involved in various biological functions such as compression and dissociation of sister chromatids, DNA damage repair, and transcription. It also plays a role in embryonic cell division cycle, immune response regulation, and tumor development. High expression of SMC4 is consistently associated with worse overall survival in tumors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Pinghua Yang, Fengliang Song, Xinwei Yang, Xingzhou Yan, Xinyu Huang, Zhengjun Qiu, Zhijian Wen, Chi Liang, Xianglei Xin, Zhengqin Lei, Kecheng Zhang, Jue Yang, Hu Liu, Hongcheng Wang, Shijun Xiang, Liang Li, Baohua Zhang, Hongyang Wang
Summary: Through biomarker discovery, training, and validation, we have identified a combination of miRNAs that can evaluate the risk of gallbladder carcinoma. This biomarker outperforms standard markers and can be used for early diagnosis. It is also associated with clinicopathological features and prognosis, and regulates cell functions and signaling pathways. This biomarker combination has potential for noninvasive diagnosis, screening, and prognosis prediction for gallbladder carcinoma.
Review
Oncology
Yuhao Zou, Chenming Zhong, Zekai Hu, Shiwei Duan
Summary: miR-873, located on chromosome 9p21.1, is a microRNA family consisting of miR-873-5p and miR-873-3p. The expression level of miR-873-5p varies in different cancers and impacts cancer development through multiple signaling pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Shan Cong, Shanshan Bai, Minghao Zhang, Yanfang Bi, Yu Wang, Shi Jin, Hui He
Summary: This study identified significant heterogeneity in tumor cell metabolism and its association with prognosis, gene mutation, and subtype. By analyzing expression data and clinical information, four metabolic subtypes and four gene signatures were constructed. The worst prognosis was observed in MC1 subtype, which was mainly related to drug metabolism, while other subtypes were associated with glucose metabolism pathways. Additionally, metabolic typing was linked to chemotherapeutic drug response and tumor heterogeneity, highlighting its importance in drug efficacy and gene-targeted therapy.
CANCER BIOLOGY & THERAPY
(2023)
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)