Structural Insight into a Fatty-Acyl Chaperone for Wnt Proteins

Wnt signaling proteins are fatty-acylated and bind to the protein afamin. The afamin-Wnt complex increases Wnt solubility dramatically and is likely involved in Wnt trafficking. In this issue of Structure, Naschberger et al. (2017) determine the crystal structure of afamin in complex with palmitoleic acid, revealing how afamin binds palmitoleoylated Wnt.