Arsenic Trioxide and (−)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Arsenic Trioxide and (−)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling
Authors
Keywords
-
Journal
Cancers
Volume 11, Issue 3, Pages 350
Publisher
MDPI AG
Online
2019-03-13
DOI
10.3390/cancers11030350
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells
- (2018) Nina Meyer et al. Autophagy
- Arsenic trioxide induces apoptosis and the formation of reactive oxygen species in rat glioma cells
- (2018) Yuanyuan Sun et al. CELLULAR & MOLECULAR BIOLOGY LETTERS
- Notch after cleavage
- (2018) Sarah J Bray et al. CURRENT OPINION IN CELL BIOLOGY
- Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61
- (2018) Andrea Calcaterra et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- BAG3 Overexpression and Cytoprotective Autophagy Mediate Apoptosis Resistance in Chemoresistant Breast Cancer Cells
- (2018) Chandan Kanta Das et al. NEOPLASIA
- Inhibition of PIM1 blocks the autophagic flux to sensitize glioblastoma cells to ABT-737-induced apoptosis
- (2018) J. Remy et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Molecular markers in glioma
- (2017) Kirsten Ludwig et al. JOURNAL OF NEURO-ONCOLOGY
- Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy
- (2017) Xiaoyang Lan et al. NATURE
- A Two-Phase Expansion Protocol Combining Interleukin (IL)-15 and IL-21 Improves Natural Killer Cell Proliferation and Cytotoxicity against Rhabdomyosarcoma
- (2017) Juliane Wagner et al. Frontiers in Immunology
- The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary
- (2016) David N. Louis et al. ACTA NEUROPATHOLOGICA
- GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment
- (2016) Jianlong Li et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Interference with the HSF1/HSP70/BAG3 Pathway Primes Glioma Cells to Matrix Detachment and BH3 Mimetic–Induced Apoptosis
- (2016) Patrick Antonietti et al. MOLECULAR CANCER THERAPEUTICS
- Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma
- (2016) Itay Tirosh et al. NATURE
- 2016 update of the PRIDE database and its related tools
- (2016) Juan Antonio Vizcaíno et al. NUCLEIC ACIDS RESEARCH
- The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible
- (2016) Damian Szklarczyk et al. NUCLEIC ACIDS RESEARCH
- Survivin, a novel target of the Hedgehog/GLI signaling pathway in human tumor cells
- (2016) K Vlčková et al. Cell Death & Disease
- AT101 exerts a synergetic efficacy in gastric cancer patients with 5-FU based treatment through promoting apoptosis and autophagy
- (2016) Xi Wei et al. Oncotarget
- Notch Activity Modulates the Responsiveness of Neural Progenitors to Sonic Hedgehog Signaling
- (2015) Jennifer H. Kong et al. DEVELOPMENTAL CELL
- Modulation of Sonic hedgehog signaling and WW domain containing oxidoreductase WOX1 expression enhances radiosensitivity of human glioblastoma cells
- (2015) Ming-Fu Chiang et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- A Functional and Putative Physiological Role of Calcitriol in Patched1/Smoothened Interaction
- (2015) Benedikt Linder et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Natural product (−)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1
- (2015) Lan Lan et al. Molecular Oncology
- Notch is a direct negative regulator of the DNA-damage response
- (2015) Jelena Vermezovic et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Notch is a direct negative regulator of the DNA-damage response
- (2015) Jelena Vermezovic et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Arsenic trioxide disrupts glioma stem cells via promoting PML degradation to inhibit tumor growth
- (2015) Wenchao Zhou et al. Oncotarget
- Transmembrane protein CD9 is glioblastoma biomarker, relevant for maintenance of glioblastoma stem cells
- (2015) Neža Podergajs et al. Oncotarget
- Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and Chemoresistance
- (2015) Komaraiah Palle et al. Cancers
- Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis
- (2015) Chuan Bian Lim et al. Oncotarget
- Primary glioblastoma cultures: can profiling of stem cell markers predict radiotherapy sensitivity?
- (2014) Dieter Lemke et al. JOURNAL OF NEUROCHEMISTRY
- Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ
- (2014) Jürgen Cox et al. MOLECULAR & CELLULAR PROTEOMICS
- Hedgehog
- (2014) Julien Ferent et al. NEUROSCIENTIST
- Arsenic trioxide inhibits Hedgehog, Notch and stem cell properties in glioblastoma neurospheres
- (2014) Dacheng Ding et al. Acta Neuropathologica Communications
- Arsenic trioxide induces unfolded protein response in vascular endothelial cells
- (2013) Ching-Yi Weng et al. ARCHIVES OF TOXICOLOGY
- Itraconazole and Arsenic Trioxide Inhibit Hedgehog Pathway Activation and Tumor Growth Associated with Acquired Resistance to Smoothened Antagonists
- (2013) James Kim et al. CANCER CELL
- Arsenic Binding to Proteins
- (2013) Shengwen Shen et al. CHEMICAL REVIEWS
- Essential Role of Gli Proteins in Glioblastoma Multiforme
- (2013) Matteo Santoni et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- The mechanisms of Hedgehog signalling and its roles in development and disease
- (2013) James Briscoe et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The novel HDAC inhibitor NDACI054 sensitizes human cancer cells to radiotherapy
- (2013) Stephanie Hehlgans et al. RADIOTHERAPY AND ONCOLOGY
- Unfolded protein response (UPR) signaling regulates arsenic trioxide-mediated macrophage innate immune function disruption
- (2013) Ritesh K. Srivastava et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation
- (2013) J. Cadet et al. Cold Spring Harbor Perspectives in Biology
- Amplification of the STOML3, FREM2, and LHFP Genes Is Associated with Mesenchymal Differentiation in Gliosarcoma
- (2012) Masaya Nagaishi et al. AMERICAN JOURNAL OF PATHOLOGY
- Suppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells
- (2012) Josep Domingo-Domenech et al. CANCER CELL
- Status Quo—Standard-of-Care Medical and Radiation Therapy for Glioblastoma
- (2012) Kevin P. Becker et al. CANCER JOURNAL
- Malignant Glioma: Lessons from Genomics, Mouse Models, and Stem Cells
- (2012) Jian Chen et al. CELL
- Fiji: an open-source platform for biological-image analysis
- (2012) Johannes Schindelin et al. NATURE METHODS
- Notch-1 signaling facilitates survivin expression in human non-small cell lung cancer cells
- (2011) Yuqing Chen et al. CANCER BIOLOGY & THERAPY
- Targeting apoptosis pathways in cancer stem cells
- (2011) Michele Signore et al. CANCER LETTERS
- Essential role of the Hedgehog signaling pathway in human glioma-initiating cells
- (2011) Tatsuya Takezaki et al. CANCER SCIENCE
- A novel vaccine containing EphA2 epitope and LIGHT plasmid induces robust cellular immunity against glioma U251 cells
- (2011) Hongjie Chen et al. CELLULAR IMMUNOLOGY
- Role of sonic hedgehog signaling in migration of cell lines established from CD133-positive malignant glioma cells
- (2011) Hiroyuki Uchida et al. JOURNAL OF NEURO-ONCOLOGY
- Unknown
- (2011) Ilya Ulasov et al. MOLECULAR MEDICINE
- The functional role of Notch signaling in human gliomas
- (2011) M.-T. Stockhausen et al. NEURO-ONCOLOGY
- Role of Eph/ephrin tyrosine kinase in malignant glioma
- (2011) M. Nakada et al. NEURO-ONCOLOGY
- REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms
- (2011) Fran Supek et al. PLoS One
- -Secretase Inhibitors Enhance Temozolomide Treatment of Human Gliomas by Inhibiting Neurosphere Repopulation and Xenograft Recurrence
- (2010) C. A. Gilbert et al. CANCER RESEARCH
- Radiation-Induced Survivin Nuclear Accumulation is Linked to DNA Damage Repair
- (2010) Gianni Capalbo et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway
- (2010) Elspeth M. Beauchamp et al. JOURNAL OF CLINICAL INVESTIGATION
- The Pan-Bcl-2 Inhibitor (-)-Gossypol Triggers Autophagic Cell Death in Malignant Glioma
- (2010) V. Voss et al. MOLECULAR CANCER RESEARCH
- Gossypol Induces Apoptosis by Activating p53 in Prostate Cancer Cells and Prostate Tumor-Initiating Cells
- (2010) S. R. Volate et al. MOLECULAR CANCER THERAPEUTICS
- Arsenic Trioxide Controls the Fate of the PML-RAR Oncoprotein by Directly Binding PML
- (2010) X. W. Zhang et al. SCIENCE
- Arsenic trioxide-mediated Notch pathway inhibition depletes the cancer stem-like cell population in gliomas
- (2009) Yunbo Zhen et al. CANCER LETTERS
- ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays
- (2009) Yifang Hu et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Speciation of arsenic trioxide penetrates into cerebrospinal fluid in patients with acute promyelocytic leukemia
- (2009) Toru Kiguchi et al. LEUKEMIA RESEARCH
- Inhibition of tissue factor/protease-activated receptor-2 signaling limits proliferation, migration and invasion of malignant glioma cells
- (2009) F. Gessler et al. NEUROSCIENCE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started